The DOI matches its Crossref record; 137 of the 137 references it cites were found in a registry or an index.
The GABA Excitatory/Inhibitory Shift in Brain Maturation and Neurological Disorders
Abstract
Ionic currents and the network-driven patterns they generate differ in immature and adult neurons: The developing brain is not a “small adult brain.” One of the most investigated examples is the developmentally regulated shift of actions of the transmitter GABA that inhibit adult neurons but excite immature ones because of an initially higher intracellular chloride concentration [Cl−]i, leading to depolarizing and often excitatory actions of GABA instead of hyperpolarizing and inhibitory actions. The levels of [Cl−]i are also highly labile, being readily altered transiently or persistently by enhanced episodes of activity in relation to synaptic plasticity or a variety of pathological conditions, including seizures and brain insults. Among the plethora of channels, transporters, and other devices involved in controlling [Cl−]i, two have emerged as playing a particularly important role: the chloride importer NKCC1 and the chloride exporter KCC2. Here, the authors stress the importance of determining how [Cl−]i is dynamically regulated and how this affects brain operation in health and disease. In a clinical perspective, agents that control [Cl−]i and reinstate inhibitory actions of GABA open novel therapeutic perspectives in many neurological disorders, including infantile epilepsies, autism spectrum disorders, and other developmental disorders.
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Cites
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Self-citationThe K+/Cl− co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation
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Self-citationGABA: A Pioneer Transmitter That Excites Immature Neurons and Generates Primitive Oscillations
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Cited by
Semple, B. D., Blomgren, K., Gimlin, K., Ferriero, D. M., & Noble-Haeusslein, L. J. (2013) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.04.001 · Cited by 2,132
Human Gut Microbiota from Autism Spectrum Disorder Promote Behavioral Symptoms in Mice
Sharon, G., Cruz, N. J., Kang, D.-W., Gandal, M. J., Wang, B., Kim, Y.-M., Zink, E. M., Casey, C. P., Taylor, B. C., Lane, C. J., et al. (2019) · Cell · doi:10.1016/j.cell.2019.05.004 · Cited by 1,182
GABAergic Interneurons Shape the Functional Maturation of the Cortex
Le Magueresse, C., & Monyer, H. (2013) · Neuron · doi:10.1016/j.neuron.2013.01.011 · Cited by 425
Autism, oxytocin and interoception
Quattrocki, E., & Friston, K. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.09.012 · Cited by 393
Howes, O. D., Rogdaki, M., Findon, J. L., Wichers, R. H., Charman, T., King, B. H., Loth, E., McAlonan, G. M., McCracken, J. T., Parr, J. R., et al. (2018) · Journal of Psychopharmacology · doi:10.1177/0269881117741766 · Cited by 342
Metadata
- Authors
- Ben-Ari, Y., Khalilov, I., Kahle, K. T., & Cherubini, E.
- Venue
- The Neuroscientist
- Publisher
- SAGE Publications
- Published
- 2012-04-30
- Volume
- 18
- Issue
- 5
- Pages
- 467-486
- ISSN
- 1073-8584 (ISSN-L)
- 1089-4098
- OpenAlex
- W2134218486
- Cited by
- 621
- References
- 137
- FWCI
- 15.01
- Type
- journal article
- Language
- en
- Open access
- closed
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