GABAergic Interneurons Shape the Functional Maturation of the Cortex
Open accessAbstract
From early embryonic development to adulthood, GABA release participates in the construction of the mammalian cerebral cortex. The maturation of GABAergic neurotransmission is a protracted process which takes place in discrete steps and results from the dynamic interaction between developmentally directed gene expression and brain activity. During the course of development, GABAergic interneurons contribute to key aspects of the functional maturation of the cortex in different ways, from exerting a trophic role to pacing immature neural networks. In this review, we provide an overview of the maturation of GABAergic neurotransmission and discuss the role of GABAergic interneurons in cortical wiring, plasticity, and network activity during pre- and postnatal development. We also discuss psychiatric diseases that may be considered at least in part developmental disorders of the GABAergic system.
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The activity of these inhibitory neurons has previously been implicated in psychiatric disorders.
“The activity of these inhibitory neurons has previously been implicated in psychiatric disorders, 37 providing an example of how studying a specific cell population may reveal unique disease relevant mechanisms that may have otherwise not been identified.”
From Epigenetics and depression (2019) · cites this paper as [37]
Approximately 10% of all NeuN+ neurons in cortex are PV+.
“In agreement with the literature24–26, ~10% of all NeuN+ neurons in cortex were PV+ (Fig. 1b, c)”
From Perineuronal nets decrease membrane capacitance of peritumoral fast spiking interneurons in a model of epilepsy (2018) · cites this paper as [25]
Autism and schizophrenia are characterized by impaired PV-cell circuits.
“which are in turn marked by impaired PV-cell circuits (Gogolla et al., 2009; Le Magueresse and Monyer, 2013; Marin, 2012).”
From Clock Genes Control Cortical Critical Period Timing (2015) · cites this paper as Le Magueresse and Monyer, 2013
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- Authors
- Le Magueresse, C., & Monyer, H.
- Affiliations
- German Cancer Research Center (DE)
- Corresponding author
- Monyer, Hannah
- ORCID
- Monyer, Hannah
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2013-02
- Volume
- 77
- Issue
- 3
- Pages
- 388-405
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2086069938
- Cited by
- 425
- References
- 27
- Citations by year
- 2026: 19 · 2025: 18 · 2024: 23 · 2023: 30 · 2022: 28 · 2021: 45 · 2020: 38 · 2019: 45 · 2018: 35 · 2017: 28 · 2016: 28 · 2015: 35 · 2014: 34 · 2013: 18
- FWCI
- 3.89
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- GABAergic interneurons, GABAergic neurotransmission, cortical development, synaptic plasticity, neuronal network activity, developmental disorders, mental illness
- MeSH terms
- Animals, Mental Disorders, Cerebral Cortex, Humans, Interneurons, Nerve Net, Nervous System Diseases, Neural Pathways, Signal Transduction, GABAergic Neurons
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