The DOI matches its Crossref record; 188 of the 188 references it cites were found in a registry or an index.
NREM and REM Sleep: Complementary Roles in Recovery after Wakefulness
Open accessAbstract
The overall function of sleep is hypothesized to provide "recovery" after preceding waking activities, thereby ensuring optimal functioning during subsequent wakefulness. However, the functional significance of the temporal dynamics of sleep, manifested in the slow homeostatic process and the alternation between non-rapid eye movement (NREM) and REM sleep remains unclear. We propose that NREM and REM sleep have distinct and complementary contributions to the overall function of sleep. Specifically, we suggest that cortical slow oscillations, occurring within specific functionally interconnected neuronal networks during NREM sleep, enable information processing, synaptic plasticity, and prophylactic cellular maintenance ("recovery process"). In turn, periodic excursions into an activated brain state-REM sleep-appear to be ideally placed to perform "selection" of brain networks, which have benefited from the process of "recovery," based on their offline performance. Such two-stage modus operandi of the sleep process would ensure that its functions are fulfilled according to the current need and in the shortest time possible. Our hypothesis accounts for the overall architecture of normal sleep and opens up new perspectives for understanding pathological conditions associated with abnormal sleep patterns.
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“REM sleep occurs after slow-wave sleep and allows for emotional memory processing, while NREM sleep is required for optimal wakefulness and cognitive function the following day [19,20,21,22,23].”
From The Cyclical Battle of Insomnia and Mental Health Impairment in Firefighters: A Narrative Review (2024) · cites this paper as [22]
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“REM sleep occurs after slow-wave sleep and allows for emotional memory processing, while NREM sleep is required for optimal wakefulness and cognitive function the following day [19,20,21,22,23].”
From The Cyclical Battle of Insomnia and Mental Health Impairment in Firefighters: A Narrative Review (2024) · cites this paper as [22]
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Cited by
Sorted by citations
Sleep, circadian rhythms and health
Foster, R. G. (2020) · Interface Focus · doi:10.1098/rsfs.2019.0098 · Cited by 286
Light and Cognition: Roles for Circadian Rhythms, Sleep, and Arousal
Fisk, A. S., Tam, S. K. E., Brown, L. A., Vyazovskiy, V. V., Bannerman, D. M., & Peirson, S. N. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.00056 · Cited by 295
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Metadata
- Authors
- Vyazovskiy, V. V., & Delogu, A.
- Affiliations
- University of Oxford (GB)
- King's College London (GB)
- Venue
- The Neuroscientist
- Publisher
- SAGE Publications
- Published
- 2014-03-04
- Volume
- 20
- Issue
- 3
- Pages
- 203-219
- ISSN
- 1073-8584 (ISSN-L)
- 1089-4098
- OpenAlex
- W2103230563
- Cited by
- 169
- References
- 188
- Citations by year
- 2026: 10 · 2025: 17 · 2024: 13 · 2023: 12 · 2022: 20 · 2021: 19 · 2020: 16 · 2019: 13 · 2018: 17 · 2017: 9 · 2016: 8 · 2015: 10 · 2014: 4
- FWCI
- 5.77
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- The Neuroscientist (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Research Portal (King's College London) (publishedVersion, cc-by-nc)
- Funders
- Wellcome Trust (098461)
- European Commission (322050)
- Medical Research Council
- FP7 People: Marie-Curie Actions
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
- Keywords
- NREM sleep, REM sleep, sleep function, synaptic plasticity, sleep homeostasis, sleep architecture, sleep disorders
- MeSH terms
- Animals, Brain, Humans, Sleep Stages, Wakefulness, Brain Waves
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