The DOI matches its Crossref record; 105 of the 105 references it cites were found in a registry or an index.
The Frontoparietal Control System: A Central Role in Mental Health
Open accessAbstract
Recent findings suggest the existence of a frontoparietal control system consisting of flexible hubs that regulate distributed systems (e.g., visual, limbic, motor) according to current task goals. A growing number of studies are reporting alterations of this control system across a striking range of mental diseases. We suggest this may reflect a critical role for the control system in promoting and maintaining mental health. Specifically, we propose that this system implements feedback control to regulate symptoms as they arise (e.g., excessive anxiety reduced via regulation of amygdala), such that an intact control system is protective against a variety of mental illnesses. Consistent with this possibility, recent results indicate that several major mental illnesses involve altered brain-wide connectivity of the control system, likely altering its ability to regulate symptoms. These results suggest that this "immune system of the mind" may be an especially important target for future basic and clinical research.
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“The frontoparietal control network (FPCN), with nodes in the dorsolateral prefrontal cortex (DLPFC) and posterior parietal cortex (PPC) is involved in “top-down control,” monitoring attention, and regulating sensory, and internal networks according to current task goals (Cole et al., 2014).”
From Changes in functional connectivity following treatment with emotion regulation therapy (2019) · cites this paper as Cole et al., 2014
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Cites
Diamond, A. (2013) · Annual Review of Psychology · doi:10.1146/annurev-psych-113011-143750 · Cited by 13,268
Control of goal-directed and stimulus-driven attention in the brain
Corbetta, M., & Shulman, G. L. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn755 · Cited by 12,881
An Integrative Theory of Prefrontal Cortex Function
Miller, E. K., & Cohen, J. D. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.167 · Cited by 12,803
The organization of the human cerebral cortex estimated by intrinsic functional connectivity
Thomas Yeo, B. T., Krienen, F. M., Sepulcre, J., Sabuncu, M. R., Lashkari, D., Hollinshead, M., Roffman, J. L., Smoller, J. W., Zöllei, L., Polimeni, J. R., et al. (2011) · Journal of Neurophysiology · doi:10.1152/jn.00338.2011 · Cited by 9,182
The organization of the human cerebellum estimated by intrinsic functional connectivity
Buckner, R. L., Krienen, F. M., Castellanos, A., Diaz, J. C., & Yeo, B. T. T. (2011) · Journal of Neurophysiology · doi:10.1152/jn.00339.2011 · Cited by 7,304
Insel, T., Cuthbert, B., Garvey, M., Heinssen, R., Pine, D. S., Quinn, K., Sanislow, C., & Wang, P. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2010.09091379 · Cited by 7,067
A gradient of childhood self-control predicts health, wealth, and public safety
Moffitt, T. E., Arseneault, L., Belsky, D., Dickson, N., Hancox, R. J., Harrington, H., Houts, R., Poulton, R., Roberts, B. W., Ross, S., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010076108 · Cited by 4,885
Functional Network Organization of the Human Brain
Power, J. D., Cohen, A. L., Nelson, S. M., Wig, G. S., Barnes, K. A., Church, J. A., Vogel, A. C., Laumann, T. O., Miezin, F. M., Schlaggar, B. L., et al. (2011) · Neuron · doi:10.1016/j.neuron.2011.09.006 · Cited by 4,124
The empirical status of cognitive-behavioral therapy: A review of meta-analyses
Butler, A. C., Chapman, J. E., Forman, E. M., & Beck, A. T. (2006) · Clinical Psychology Review · doi:10.1016/j.cpr.2005.07.003 · Cited by 3,215
Toward the future of psychiatric diagnosis: the seven pillars of RDoC
Cuthbert, B. N., & Insel, T. R. (2013) · BMC Medicine · doi:10.1186/1741-7015-11-126 · Cited by 3,053
Research works printed but not linked: 4
- Anticevic A, 2013, Cereb Cortex
- Anticevic A, 2013, Biol Psychiatry
- Henriques GR, 2002, Sci Rev Ment Health Pract, 1, 157
- Wakefield JC, 2007, World Psychiatry, 6, 149
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The brain’s default network: updated anatomy, physiology and evolving insights
Buckner, R. L., & DiNicola, L. M. (2019) · Nature Reviews Neuroscience · doi:10.1038/s41583-019-0212-7 · Cited by 1,058
Insel, T. R., & Cuthbert, B. N. (2015) · Science · doi:10.1126/science.aab2358 · Cited by 840
Marek, S., & Dosenbach, N. U. F. (2018) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2018.20.2/smarek · Cited by 836
Dixon, M. L., De La Vega, A., Mills, C., Andrews-Hanna, J., Spreng, R. N., Cole, M. W., & Christoff, K. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1715766115 · Cited by 595
Mapping the human brain's cortical-subcortical functional network organization
Ji, J. L., Spronk, M., Kulkarni, K. R., Repovš, G., Anticevic, A., & Cole, M. W. (2018) · NeuroImage · doi:10.1016/j.neuroimage.2018.10.006 · Cited by 604
Metadata
- Authors
- Cole, M. W., Repovš, G., & Anticevic, A.
- Affiliations
- Rutgers, The State University of New Jersey (US)
- University of Ljubljana (SI)
- Yale University (US)
- Venue
- The Neuroscientist
- Publisher
- SAGE Publications
- Published
- 2014-03-12
- Volume
- 20
- Issue
- 6
- Pages
- 652-664
- ISSN
- 1073-8584 (ISSN-L)
- 1089-4098
- PMC
- PMC4162869
- OpenAlex
- W2146083743
- Cited by
- 461
- References
- 105
- Citations by year
- 2026: 37 · 2025: 37 · 2024: 40 · 2023: 43 · 2022: 25 · 2021: 46 · 2020: 48 · 2019: 43 · 2018: 43 · 2017: 58 · 2016: 20 · 2015: 20 · 2014: 1
- FWCI
- 3.11
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Neuroscientist (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (DP5OD01210901, DP5OD012109, UL1TR000142)
- National Institute of Mental Health (K99MH096801, MH096801, R00MH096801, R01MH108590)
- National Center for Advancing Translational Sciences
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- cognitive control, feedback control, mental illness, brain connectivity, anxiety regulation, amygdala, mental health
- MeSH terms
- Mental Disorders, Frontal Lobe, Humans, Mental Health, Mental Processes, Nerve Net, Parietal Lobe, Feedback, Physiological
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