Treating ADHD with Agomelatine
Abstract
Objective: Agomelatine is a relatively new antidepressant, with affinities to MT1 and MT2 (responsible for the circadian rhythm) as well as to 5-HT2C receptors. Since antidepressants have demonstrated some benefit in the treatment of ADH and because of the fact, that ADHD is often associated with sleep disorders, we assumed, that it might be a therapeutic alternative also for ADHD. Method: We proved this assumption in ten ADHD patients in a placebo controlled manner. Results: Agomelatine’s effect was superior to that of placebo, but seems to be less than that of Methylphenidate or placebo. Conclusion: If ADHD therapy with Methylphenidate or Atomoxetine is not indicated e.g. because of adverse side effects and if an ADHD patient suffers from additional sleep disorders, Agomelatine might be a helpful therapeutic alternative.
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Agomelatine treatment was associated with decreased ADHD symptoms in adolescents with ADHD.
“Niederhofer (2012) report results of a small randomised placebo-controlled trial of the use of the chronobiotic antidepressant agomelatine in 10 adolescents with ADHD which indicate that agomelatine treatment was associated with decreased ADHD symptoms.”
From A systematic review of circadian function, chronotype and chronotherapy in attention deficit hyperactivity disorder (2017) · cites this paper as Niederhofer (2012)
Cites
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,841 · see citing works
Diagnostic and Statistical Manual of Mental Disorders
&NA; (1988) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-198802020-00022 · Cited by 12,603 · see citing works
(1991) · American Journal of Psychiatry · doi:10.1176/ajp.148.5.564 · Cited by 1,738 · see citing works
(1993) · American Journal of Psychiatry · doi:10.1176/ajp.150.6.885 · Cited by 1,421 · see citing works
Hunt, R. D., Minderaa, R. B., & Cohen, D. J. (1985) · Journal of the American Academy of Child Psychiatry · doi:10.1016/s0002-7138(09)60065-0 · Cited by 313 · see citing works
Rapport, M. D., Denney, C. B., DuPaul, G. J., & GARDNER, M. J. (1994) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199407000-00015 · Cited by 232 · see citing works
Faraone, S. V., Biederman, J., Keenan, K. E., & Tsuang, M. T. (1991) · Psychological Medicine · doi:10.1017/s0033291700014707 · Cited by 228 · see citing works
Factors associated with children's adherence to stimulant medication
Firestone, P. (1982) · American Journal of Orthopsychiatry · doi:10.1111/j.1939-0025.1982.tb01431.x · Cited by 143 · see citing works
Rd, H. (1987) · PubMed · Cited by 85 · see citing works
Quintana, H., Butterbaugh, G. J., Purnell, W., & Layman, A. K. (2006) · Child Psychiatry & Human Development · doi:10.1007/s10578-006-0032-7 · Cited by 33 · see citing works
New Developments in Pediatric Psychopharmacology
Gualtieri, C. T., Golden, R. N., & Fahs, J. J. (1983) · Journal of Developmental & Behavioral Pediatrics · doi:10.1097/00004703-198309000-00010 · Cited by 18 · see citing works
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Coogan, A. N., & McGowan, N. M. (2017) · ADHD Attention Deficit and Hyperactivity Disorders · doi:10.1007/s12402-016-0214-5 · Cited by 208 · see citing works
- Authors
- Niederhofer, H.
- Affiliations
- Sächsisches Krankenhaus Rodewisch (DE)
- Corresponding author
- Niederhofer, Helmut
- Venue
- Journal of Attention Disorders
- Publisher
- SAGE Publications
- Published
- 2012-04-09
- Volume
- 16
- Issue
- 4
- Pages
- 346-348
- ISSN
- 1087-0547 (ISSN-L)
- 1557-1246
- OpenAlex
- W2038020572
- Cited by
- 18
- References
- 11
- Citations by year
- 2024: 1 · 2023: 2 · 2021: 2 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 4 · 2015: 1 · 2014: 1 · 2013: 2
- FWCI
- 0.91
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Attention Disorders (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Keywords
- agomelatine, attention deficit hyperactivity disorder, methylphenidate, atomoxetine, sleep disorders, melatonin receptors, 5-HT2C receptor, antidepressants
- MeSH terms
- Acetamides, Adolescent, Attention Deficit Disorder with Hyperactivity, Female, Humans, Hypnotics and Sedatives, Male, Naphthalenes, Treatment Outcome, Young Adult
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