Low Testosterone Levels Are Associated With Poor Peripheral Bone Mineral Density and Quantitative Bone Ultrasound at Phalanges and Calcaneus in Healthy Elderly Men
Abstract
Variations in sex hormones influence bone health in men. Aging in men is associated with a decrease in testosterone (T) levels. We examined the relationship between T levels and changes in bone health status as measured by quantitative ultrasound (QUS) at the phalanges and the os calcis and by peripheral bone mineral density (pBMD) at the phalanges in healthy elderly Spanish men. We examined 162 men aged 65-88 years and assessed total serum T concentrations. Total serum T .05 for all the comparisons). All measured bone parameters were higher in the normal serum T group (p < .05). Multiple regression analysis revealed that serum T was an independent predictor of both QUS at the calcaneus and phalangeal pBMD. Our data indicate that T is an independent determinant of QUS at the os calcis and pBMD at the phalanges in elderly Spanish men.
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Men with a history of unexplained anemia, bone density loss, diabetes, exposure to chemotherapy, direct or scatter radiation therapy to the testes, HIV, chronic narcotic use, infertility, pituitary disorders, or chronic corticosteroid use are at risk for low testosterone.
“A meta-analysis of the literature suggests that men who have a history of unexplained anemia, 7 bone density loss, 8 diabetes, 9 exposure to chemotherapy, 10 direct or scatter radiation therapy to the testes, 11 HIV, 12 a history of chronic narcotic use, 13 infertility, 14 pituitary disorders, 15 and chronic corticosteroid use 16 are at risk for low testosterone.”
From Evaluation and Management of Testosterone Deficiency: AUA Guideline (2018) · cites this paper as [8]
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Evaluation and Management of Testosterone Deficiency: AUA Guideline
Mulhall, J. P., Trost, L. W., Brannigan, R. E., Kurtz, E. G., Redmon, J. B., Chiles, K. A., Lightner, D. J., Miner, M. M., Murad, M. H., Nelson, C. J., et al. (2018) · Journal of Urology · doi:10.1016/j.juro.2018.03.115 · Cited by 766 · see citing works
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- Authors
- Moran, J. M., Martin, R. R., Pedrera-Canal, M., Alonso-Terron, J., Rodriguez-Velasco, F. J., & Pedrera-Zamorano, J. D.
- Affiliations
- Metabolic Bone Diseases Research Group, School of Nursing, University of Extremadura, Avd., Caceres, Spain
- Universidad de Extremadura (ES)
- Venue
- Biological Research For Nursing
- Publisher
- SAGE Publications
- Published
- 2014-05-07
- Volume
- 17
- Issue
- 2
- Pages
- 169-174
- ISSN
- 1099-8004 (ISSN-L)
- 1552-4175
- OpenAlex
- W2045634215
- Cited by
- 16
- References
- 33
- Citations by year
- 2026: 2 · 2025: 2 · 2023: 2 · 2022: 1 · 2021: 1 · 2018: 3 · 2017: 1 · 2016: 3 · 2015: 1
- FWCI
- 1.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Research For Nursing (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Keywords
- androgen deficiency, hypogonadism, bone mineral density, quantitative ultrasound, phalanges, calcaneus, older men, aging, sex hormones, bone health, serum testosterone
- MeSH terms
- Aged, Aged, 80 and over, Calcaneus, Humans, Male, Testosterone, Ultrasonography, Bone Density, Finger Phalanges
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