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Cited by 142Hormonal and reproductive studiesSperm and Testicular FunctionHypothalamic control of reproductive hormones

Age-Related Changes in Serum Testosterone and Sex Hormone Binding Globulin in Australian Men: Longitudinal Analyses of Two Geographically Separate Regional Cohorts

Liu, Peter Y., Beilin, Jonathan, Meier, Christian, Nguyen, Tuan V., Center, Jacqueline R., Leedman, Peter J., Seibel, Markus J., Eisman, John A. +1 more·2007·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jc.2007-0862
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Abstract

Background: Cross-sectional studies from different populations show a variable decline in blood testosterone concentrations as men age. Few population representative cohorts have been followed up over time. Objective: The objective of the study was to quantify longitudinally the change in serum testosterone and SHBG concentrations with age in two well-defined, representative but geographically widely separated regional Australian cohorts. Subjects and Setting: The Busselton cohort comprises individuals aged 18–90 yr residing in Western Australia assessed prospectively since 1981. Sera were assayed from 910 men, from whom further samples were available 14 yr later in 480. The Dubbo cohort involves individuals aged 61–90 yr living in Eastern Australia. Baseline sera were collected from 610 men and additional sera on a second (n = 370) and third (n = 200) occasion from 1989 to 2004. Men from both cohorts are community dwelling and of predominately European origin. Results: Longitudinal analyses show the following: 1) total testosterone declines comparably (P > 0.9) by 1.3% (Busselton) and 0.9% (Dubbo) per annum with the same rates of decline when analyses were restricted to men older than 60 yr of age; 2) annual changes in SHBG were also very similar in age-restricted analyses (2.3% vs. 2.5%, P = 0.48); and 3) the annual increase in SHBG was steeper in middle-aged and older men (P < 10−3vs. young men). These longitudinal changes were all up to 4-fold greater in magnitude, compared with cross-sectional analyses of baseline data. Conclusion: In two separate regional Australian populations, blood testosterone fell and SHBG increased comparably with age. Age-related changes in blood testosterone and SHBG previously described in urban-dwelling men are the same in men who reside in smaller regional cities of another continent.

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  • Age, BMI, fasting blood glucose, triglycerides, alcohol consumption and estradiol levels have all been reported to be associated with alteration in hormone levels.

    “Age, 11,14-17 body mass index (BMI), 12 fasting blood glucose, 1,35 triglycerides, 36 alcohol consumption 13,14 and estradiol levels, 13 which have all been reported to be associated with alteration in hormone levels, were chosen as potential confounding factors in this study.”

    From Cigarette smoking has a positive and independent effect on testosterone levels (2013) · cites this paper as [17]

  • Age, cigarette smoking, BMI, alcohol consumption and physical activity have been reported to be probably or possibly associated with hormone levels.

    “Probable and possible associations of several factors, including age, cigarette smoking, body mass index (BMI), alcohol consumption and physical activity with hormone levels have been reported. 11-17”

    From Cigarette smoking has a positive and independent effect on testosterone levels (2013) · cites this paper as [17]

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Authors
Liu, P. Y., Beilin, J., Meier, C., Nguyen, T. V., Center, J. R., Leedman, P. J., Seibel, M. J., Eisman, J. A., & Handelsman, D. J.
Affiliations
  • The University of Sydney (AU)
  • Royal Perth Hospital (AU)
  • Garvan Institute of Medical Research (AU)
  • Department of Bone and Mineral Research Program (T.V.N., J.R.C., J.A.E.), Garvan Institute of Medical Research, St. Vincent’s Hospital and University of New South Wales, Sydney 2010, Australia
Corresponding author
Handelsman, David J.
ORCID
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2007-09-01
Volume
92
Issue
9
Pages
3599-3603
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jc.2007-0862
OpenAlex
W2169025780
Cited by
142
References
5
Citations by year
2026: 1 · 2025: 3 · 2024: 6 · 2023: 4 · 2022: 6 · 2021: 9 · 2020: 8 · 2019: 5 · 2018: 7 · 2017: 4 · 2016: 10 · 2015: 3 · 2014: 14 · 2013: 7 · 2012: 11
FWCI
8.13
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • UWA Profiles and Research Repository (UWA) (submittedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords
serum testosterone, sex hormone-binding globulin, age-related decline, older men, longitudinal cohort, middle-aged and older men
MeSH terms
Adolescent, Adult, Aged, Aged, 80 and over, Aging, Australia, Cross-Sectional Studies, Geography, Humans, Longitudinal Studies, Male, Middle Aged, Sex Hormone-Binding Globulin, Testosterone, Cohort Studies

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