Neurological disability, psychological distress, and health-related quality of life in MS patients within the first three years after diagnosis
Abstract
Background Psychological distress and psychiatric co-morbidity are common in multiple sclerosis (MS) and is often associated with neurological disability as well as reduced quality of life. Objectives This study aimed to investigate psychological distress and the possible association with quality of life as well as neurological disability in MS patients within the first 3 years after diagnosis. Methods Psychological distress was measured using a standardized questionnaire (Symptom-Check-List-90-R; SCL-90-R) in 31 relapsing-remitting MS patients and 24 sex- and age-matched healthy controls. Results Psychological distress was significantly more pronounced in MS patients when compared to healthy controls. Interpersonal sensitivity and psychoticism were positively associated with neurological disability (Expanded Disability Status Scale [EDSS]). A high EDSS group (median split EDSS; 1.5) expressed significantly more psychological distress when compared to the low EDSS group and healthy controls. MS patients with minimal to no neurological disability (low EDSS group) also expressed significantly more emotional distress when compared to healthy controls. MS-related quality of life was positively associated with neurological disability as well as SCL-90-R scores. After adjusting for neurological disability, psychological distress was still significantly associated with quality of life. Conclusions Early stage MS patients significantly differ in their psychological distress when comp…
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HRQOL psychosocial impairment shows great variation among patients with multiple sclerosis.
“HRQOL psychosocial impairment shows great variation among patients with MS and is, to an important degree, independent of extent of disease.6–10”
From MS quality of life, depression, and fatigue improve after mindfulness training: A randomized trial (2010) · cites this paper as [10]
HRQOL psychosocial impairment is, to an important degree, independent of extent of disease among patients with multiple sclerosis.
“HRQOL psychosocial impairment shows great variation among patients with MS and is, to an important degree, independent of extent of disease.6–10”
From MS quality of life, depression, and fatigue improve after mindfulness training: A randomized trial (2010) · cites this paper as [10]
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MS quality of life, depression, and fatigue improve after mindfulness training: A randomized trial
Grossman, P., Kappos, L., Gensicke, H., D'Souza, M., Mohr, D. C., Penner, I. K., & Steiner, C. (2010) · Neurology · doi:10.1212/wnl.0b013e3181f4d80d · Cited by 419 · see citing works
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- Authors
- Kern, S., Schrempf, W., Schneider, H., Schultheiß, T., Reichmann, H., & Ziemssen, T.
- Affiliations
- University Hospital Carl Gustav Carus (DE)
- Corresponding author
- Kern, S
- Venue
- Multiple Sclerosis Journal
- Publisher
- SAGE Publications
- Published
- 2009-05-29
- Volume
- 15
- Issue
- 6
- Pages
- 752-758
- ISSN
- 1352-4585 (ISSN-L)
- 1477-0970
- OpenAlex
- W2090042313
- Cited by
- 65
- References
- 5
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 6 · 2020: 4 · 2019: 3 · 2018: 4 · 2017: 6 · 2016: 4 · 2015: 4 · 2014: 3 · 2013: 3 · 2012: 7
- FWCI
- 4.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Multiple Sclerosis Journal (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Technische Universität Dresden
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Health Systems, Economic Evaluations, Quality of Life
- Keywords
- multiple sclerosis, psychological distress, neurological deficit, health-related quality of life, relapsing-remitting multiple sclerosis, Expanded Disability Status Scale, interpersonal sensitivity, psychoticism, emotional distress, early multiple sclerosis
- MeSH terms
- Adult, Affective Symptoms, Disability Evaluation, Female, Humans, Male, Predictive Value of Tests, Quality of Life, Surveys and Questionnaires, Social Support, Stress, Psychological, Comorbidity, Multiple Sclerosis, Relapsing-Remitting, Young Adult
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