Depression is the main determinant of quality of life in multiple sclerosis: a classification-regression (CART) study
Abstract
PURPOSE: Quality of life in multiple sclerosis has been often measured through the SF-36 questionnaire. In this study, validation of the SF-36 summary scores, its 'physical' component, and its 'mental' component was attempted by exploring the joint predictive power of disability (EDSS score), of anxiety and depression (HADS-A and -D scores, respectively), and of disease duration, progression type, age, gender and marital status. METHOD: The sample consisted of 75 patients suffering from multiple sclerosis admitted to an inpatient rehabilitation unit. The interplay between potential predictors was assessed through a particular regression model (classification and regression tree, CART). Two main advantages of this technique are its robustness with respect to distributional assumptions (rarely met by scores coming in from questionnaires) and its sensitivity to high-order interactions, between independent variables, difficult to detect through conventional multiple regression. RESULTS: Predictive variables for physical component of the SF-36 were EDSS and HADS-D (36.8% variance explanation). The only predictive variable for mental component of SF-36 was HADS-D (39.1% variance explanation). CONCLUSION: Results confirm previous findings showing that in patients with multiple sclerosis quality of life is heavily determined by person's mood, whatever his/her neurological or functional severity. The usefulness and validity of the SF-36 as an index representative of quality of life is debatable, as long as depression explains much of its variance. Further refinement of quality of life definition and measurement is worth further psychometric and statistical research.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Quality of life is reduced in people with multiple sclerosis.
“Reductions in quality of life (QOL) exist among individuals with multiple sclerosis (MS).”
From Quality of life and psychological well-being in the early stages of multiple sclerosis (MS): importance of adopting a biopsychosocial model (2018) · cites this paper as [15]
Depression is the strongest determinant of quality of life in multiple sclerosis among psychological and social factors.
“Of the multitude of psychological and social factors thought to influence QOL in MS, depression has been consistently shown to be the greatest determinant.34,35”
From Quality of life and psychological well-being in the early stages of multiple sclerosis (MS): importance of adopting a biopsychosocial model (2018) · cites this paper as [34]
Cites
The Hospital Anxiety and Depression Scale
Zigmond, A. S., & Snaith, R. P. (1983) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1983.tb09716.x · Cited by 47,139 · see citing works
Classification and Regression Trees.
Ryzin, J. V., Breiman, L., Friedman, J. H., Olshen, R. A., & Stone, C. J. (1986) · Journal of the American Statistical Association · doi:10.2307/2288003 · Cited by 21,028 · see citing works
Rating neurologic impairment in multiple sclerosis: An expanded disability status scale (EDSS)
Kurtzke, J. F. (1983) · Neurology · doi:10.1212/wnl.33.11.1444 · Cited by 15,011 · see citing works
SF-36 health survey: Manual and interpretation guide
Ware, J. (2003) · Medical Entomology and Zoology · Cited by 11,424 · see citing works
Classification and regression trees
Praagman, J. (1985) · European Journal of Operational Research · doi:10.1016/0377-2217(85)90321-2 · Cited by 10,053 · see citing works
The validity of the Hospital Anxiety and Depression Scale
Bjelland, I., Dahl, A. A., Haug, T. T., & Neckelmann, D. (2002) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(01)00296-3 · Cited by 9,779 · see citing works
Classificação Internacional de Funcionalidade (CIF)
Battistella, L. R., & de Brito, C. M. M. (2002) · Acta Fisiátrica · doi:10.5935/0104-7795.20020003 · Cited by 4,470 · see citing works
McHorney, C. A., Ware, J. E., Rachel Lu, J. F., & Sherbourne, C. D. (1994) · Medical Care · doi:10.1097/00005650-199401000-00004 · Cited by 4,458 · see citing works
(1994) · Medical Entomology and Zoology · Cited by 4,156 · see citing works
International Classification of Functioning, Disability and Health (ICF) 2001
Jiménez-Buñuales, M. T., Diego, P. G., & Moreno, J. M. ª. M. (2002) · Revista Española de Salud Pública · doi:10.1590/s1135-57272002000400002 · Cited by 3,267 · see citing works
Statistical data analysis in the computer age
Efron, B., & Tibshirani, R. (1991) · Science · doi:10.1126/science.253.5018.390 · Cited by 1,192 · see citing works
The Italian SF-36 Health Survey
Apolone, G., & Mosconi, P. (1998) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(98)00094-8 · Cited by 1,150 · see citing works
A health-related quality of life measure for multiple sclerosis
Vickrey, B. G., Hays, R. D., Harooni, R., Myers, L. W., & Ellison, G. W. (1995) · Quality of Life Research · doi:10.1007/bf02260859 · Cited by 1,132 · see citing works
Turner‐Bowker, D. M., DeRosa, M., & Ware, J. E. (2008) · eScholarship@UMassChan · Cited by 954 · see citing works
Ware, J. E., Gandek, B., Kosinski, M. R., Aaronson, N. K., Apolone, G., Brazier, J. E., Bullinger, M., Kaasa, S., Leplège, A., Prieto, L. M., et al. (1998) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(98)00108-5 · Cited by 561 · see citing works
Depression and multiple sclerosis
Sadovnick, A. D., Remick, R. A., Allen, J. B., Swartz, E. S., Yee, I. M. L., Eisen, K., Farquhar, R., Hashimoto, S. A., Hooge, J. P., Kastrukoff, L. F., et al. (1996) · Neurology · doi:10.1212/wnl.46.3.628 · Cited by 536 · see citing works
Quality of life in multiple sclerosis: the impact of depression, fatigue and disability
Amato, M. P., Ponziani, G., Rossi, F., Liedl, C. L., Stefanile, C., & Rossi, L. (2001) · Multiple Sclerosis Journal · doi:10.1177/135245850100700511 · Cited by 506 · see citing works
Affective Disorders in Multiple Sclerosis Review and Recommendations for Clinical Research
Minden, S. L., & Schiffer, R. B. (1990) · Archives of Neurology · doi:10.1001/archneur.1990.00530010124031 · Cited by 415 · see citing works
Recommendations from the national multiple sclerosis society clinical outcomes assessment task force
Rudick, R. A., Antel, J. P., Confavreux, C., Cutter, G., Ellison, G. W., Fischer, J. S., LUBLIN, F. D., Miller, A., Petkau, J., Rao, S. M., et al. (1997) · Annals of Neurology · doi:10.1002/ana.410420318 · Cited by 370 · see citing works
Quality of Life Among Persons with Multiple Sclerosis and their Caregivers
Aronson, K. J. (1997) · Neurology · doi:10.1212/wnl.48.1.74 · Cited by 342 · see citing works
Recent developments in the assessment of quality of life in Multiple Sclerosis (MS)
Fischer, J. S., LaRocca, N. G., Miller, D. M., Ritvo, P. G., Andrews, H., & Paty, D. W. (1999) · Multiple Sclerosis Journal · doi:10.1177/135245859900500410 · Cited by 334 · see citing works
Quality of life in multiple sclerosis
Nortvedt, M. W., Riise, T., Myhr, K., & Nyland, H. (1999) · Neurology · doi:10.1212/wnl.53.5.1098 · Cited by 302 · see citing works
Depression and anxiety in multiple sclerosis. A clinical and MRI study in 95 subjects
Zorzon, M., de Masi, R., Nasuelli, D., Ukmar, M., Pozzi Mucelli, R., Cazzato, G., Bratina, A., & Zivadinov, R. (2001) · Journal of Neurology · doi:10.1007/s004150170184 · Cited by 249 · cited 1× · see citing works
“Presumably due to a combination of brain lesions and reactive behaviors [35,36] depression and/or anxiety are highly prevalent in MS patients [37 – 39].”
BackgroundHobart, J. C., Lamping, D. L., Freeman, J. A., Langdon, D. W., McLellan, D. L., Greenwood, R., & Thompson, A. J. (2001) · Neurology · doi:10.1212/wnl.57.4.639 · Cited by 240 · see citing works
Physical rehabilitation has a positive effect on disability in multiple sclerosis patients
Solari, A., Filippini, G., Gascó, P., Colla, L., Salmaggi, A., Mantia, L. L., Farinotti, M., Eoli, M., & Mendozzi, L. (1999) · Neurology · doi:10.1212/wnl.52.1.57 · Cited by 238 · see citing works
Hess, K. R., Abbruzzese, M. C., Lenzi, R., Raber, M. N., & Abbruzzese, J. L. (1999) · PubMed · Cited by 230 · see citing works
Depression and quality of life in multiple sclerosis: Depression and QoL in MS
Fruewald, S., Loeffler-Stastka, H., Eher, R., Saletu, B., & Baumhacki, U. (2001) · Acta Neurologica Scandinavica · doi:10.1034/j.1600-0404.2001.00022.x · Cited by 211 · see citing works
Janssens, A. C. J. W., van Doorn, P. A., de Boer, J. B., Kalkers, N. F., van der Meché, F. G. A., Passchier, J., & Hintzen, R. Q. (2003) · Multiple Sclerosis Journal · doi:10.1191/1352458503ms930oa · Cited by 209 · see citing works
Validation of Italian multiple sclerosis quality of life 54 questionnaire
Solari, A., Filippini, G., Mendozzi, L., Ghezzi, A., Cifani, S., Barbieri, E., Baldini, S., Salmaggi, A., Mantia, L. L., Farinotti, M., et al. (1999) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.67.2.158 · Cited by 200 · see citing works
Quality of Life Measurement After Stroke
Hobart, J. C., Williams, L. S., Moran, K. A., & Thompson, A. J. (2002) · Stroke · doi:10.1161/01.str.0000015030.59594.b3 · Cited by 184 · see citing works
Janardhan, V., & Bakshi, R. (2000) · Archives of Neurology · doi:10.1001/archneur.57.10.1485 · Cited by 137 · see citing works
Gold, S. M., Schulz, H., Mönch, A., Schulz, K., & Heesen, C. (2003) · Multiple Sclerosis Journal · doi:10.1191/1352458503ms927oa · Cited by 130 · see citing works
Health-related quality of life and depression in an Italian sample of multiple sclerosis patients
Patti, F., Cacopardo, M., Palermo, F., Ciancio, M. R., Lopes, R., Restivo, D. A., & Reggio, A. (2003) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(03)00040-6 · Cited by 126 · see citing works
Burden of Illness of Multiple Sclerosis: Part I: Cost of Illness
The Canadian Burden of Illness Study Group (1998) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/s0317167100033448 · Cited by 126 · see citing works
Freeman, J. A. (2000) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.68.2.150 · Cited by 124 · see citing works
Quality of life and impairment in patients with multiple sclerosis
Isaksson, A.-K. (2004) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2003.029660 · Cited by 111 · see citing works
Measurement of Health-Related Quality of Life in Multiple Sclerosis Patients
Brunei, D. G., Hopman, W. M., Singer, M. A., Edgar, C. M., & MacKenzie, T. A. (1996) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/s0317167100038798 · Cited by 99 · see citing works
A multidimensional assessment of multiple sclerosis: relationships between disability domains
Provinciali, L., Ceravolo, M. G., Bartolini, M., Logullo, F. O., & Danni, M. C. (2009) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1999.tb00731.x · Cited by 95 · see citing works
Correlates of quality of life among persons with multiple sclerosis.
Gulick, E. (1997) · Nursing Research · doi:10.1097/00006199-199711000-00002 · Cited by 94 · see citing works
Rehabilitation still the only way to improve function in multiple sclerosis
Kraft, G. H. (1999) · The Lancet · doi:10.1016/s0140-6736(99)90035-1 · Cited by 92 · see citing works
Sex Differences in Cognitive Impairment in Multiple Sclerosis
Beatty, W. W., & Aupperle, R. L. (2002) · The Clinical Neuropsychologist · doi:10.1076/clin.16.4.472.13904 · Cited by 90 · see citing works
Memory for famous people in patients with unilateral temporal lobe epilepsy and excisions.
Viskontas, I. V., McAndrews, M. P., & Moscovitch, M. (2002) · Neuropsychology · doi:10.1037/0894-4105.16.4.472 · Cited by 76 · see citing works
Quality of life as a measure of rehabilitation outcome in patients with multiple sclerosis
Jønsson, A., Dock, J., & Ravnborg, M. H. (2009) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1996.tb00512.x · Cited by 68 · see citing works
Jenkinson, C., Hobart, J. C., Chandola, T., Fitzpatrick, R. M., Peto, V., Swash, M., & The ALS-HPS Steering Group (2002) · Journal of Neurology · doi:10.1007/pl00007861 · Cited by 60 · see citing works
Multiple sclerosis: the impact on family and social life.
Stenager, E., Stenager, E. N., Knudsen, L., & Jensen, K. (1994) · PubMed · Cited by 35 · see citing works
Depression Associated with Multiple Sclerosis: An Etiological Conundrum
Feinstein, A. (1995) · The Canadian Journal of Psychiatry · doi:10.1177/070674379504001002 · Cited by 19 · see citing works
Affective disorders and multiple sclerosis: a controlled study on 65 Italian patients
Salmaggi, A., Palumbo, R. A., Fontanillas, L., Eoli, M., Mantia, L. L., Solari, A., Pareyson, D., & Milanese, C. (1998) · The Italian Journal of Neurological Sciences · doi:10.1007/bf00831567 · Cited by 14 · see citing works
Lavretsky, H., Kitchen, C., Mintz, J., Kim, M.-D., Estanol, L., & Kumar, A. A. (2002) · CNS Spectrums · doi:10.1017/s1092852900008701 · Cited by 11 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Bittencourt, N. F. N., Meeuwisse, W. H., Mendonça, L. D., Nettel-Aguirre, A., Ocarino, J. M., & Fonseca, S. T. (2016) · British Journal of Sports Medicine · doi:10.1136/bjsports-2015-095850 · Cited by 833 · see citing works
Relation between depression and sociodemographic factors
Akhtar-Danesh, N., & Landeen, J. (2007) · International Journal of Mental Health Systems · doi:10.1186/1752-4458-1-4 · Cited by 438 · see citing works
Multiple sclerosis and depression
Feinstein, A. (2011) · Multiple Sclerosis Journal · doi:10.1177/1352458511417835 · Cited by 337 · see citing works
Hanna, M., & Strober, L. B. (2020) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2020.102261 · Cited by 202 · see citing works
Hind, D., Cotter, J., Thake, A., Bradburn, M., Cooper, C., Isaac, C., & House, A. (2014) · BMC Psychiatry · doi:10.1186/1471-244x-14-5 · Cited by 180 · see citing works
The neuropsychiatry of multiple sclerosis: Focus on disorders of mood, affect and behaviour
Paparrigopoulos, T. J., Ferentinos, P. P., Kouzoupis, A. B., Koutsis, G., & Papadimitriou, G. N. (2010) · International Review of Psychiatry · doi:10.3109/09540261003589323 · Cited by 173 · see citing works
Ensari, I., Motl, R. W., & Pilutti, L. A. (2014) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2014.03.014 · Cited by 171 · see citing works
Multiple sclerosis beyond EDSS: depression and fatigue.
Ziemssen, T. (2009) · Journal of Neurological Sciences · doi:10.1016/s0022-510x(09)70011-5 · Cited by 168 · see citing works
Barin, L., Salmen, A., Disanto, G., Babačić, H., Calabrese, P., Chan, A., Kamm, C. P., Kesselring, J., Kühle, J., Gobbi, C., et al. (2018) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2018.07.013 · Cited by 147 · see citing works
Depression and the risk of rheumatoid arthritis
Vallerand, I. A., Patten, S. B., & Barnabe, C. C. M. (2019) · Current Opinion in Rheumatology · doi:10.1097/bor.0000000000000597 · Cited by 128 · see citing works
Stepleman, L. M., Goodworth, M.-C. R., Hibbard, J. H., Johns, L., Wright, D. E., & Hughes, M. D. (2010) · Disability and Rehabilitation · doi:10.3109/09638280903567885 · Cited by 114 · see citing works
Fernández, Ó., Baumstarck, K., Siméoni, M.-C., Auquier, P., & on behalf of the MusiQoL study group (2011) · Multiple Sclerosis Journal · doi:10.1177/1352458511407951 · Cited by 108 · see citing works
Foley, F. W., Zemon, V. M., Campagnolo, D. I., Marrie, R. A., Cutter, G., Tyry, T. M., Beier, M. L., Farrell, E., Vollmer, T. L., & Schairer, L. C. (2013) · Multiple Sclerosis Journal · doi:10.1177/1352458512471876 · Cited by 100 · see citing works
Strober, L. B. (2018) · Disability and health journal · doi:10.1016/j.dhjo.2018.05.003 · Cited by 99 · see citing works
Thom, R. P., Silbersweig, D., & BOLAND, R. J. (2019) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000678 · Cited by 96 · see citing works
Multivariate prediction of upper limb prosthesis acceptance or rejection
Biddiss, E. A., & Chau, T. T. (2008) · Disability and Rehabilitation Assistive Technology · doi:10.1080/17483100701869826 · Cited by 87 · see citing works
Factors Associated with Depression among University Students in Malaysia: A Cross-sectional Study
Islam, M. A., Low, W. Y., Tong, W. T., Yuen, C. C. W., & Abdullah, A. (2018) · KnE Life Sciences · doi:10.18502/kls.v4i4.2302 · Cited by 86 · see citing works
Large-Scale Crop Mapping From Multisource Remote Sensing Images in Google Earth Engine
Liu, X., Zhai, H., Shen, Y., Lou, B., Jiang, C., Li, T., Hussain, S. B., & Shen, G. (2020) · IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing · doi:10.1109/jstars.2019.2963539 · Cited by 85 · see citing works
Schmidt, S., & Jöstingmeyer, P. (2019) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2019.07.029 · Cited by 75 · see citing works
Life issues in multiple sclerosis
Simmons, R. D. (2010) · Nature Reviews Neurology · doi:10.1038/nrneurol.2010.143 · Cited by 75 · see citing works
Bai, Z., Xu, Z., Xu, X., Qin, X., Hu, W., & Hu, Z. (2020) · BMC Public Health · doi:10.1186/s12889-020-09657-7 · Cited by 77 · see citing works
Rasch analysis of the Beck Depression Inventory-II in a neurological rehabilitation sample
Siegert, R. J., Tennant, A., & Turner‐Stokes, L. F. (2009) · Disability and Rehabilitation · doi:10.3109/09638280902971398 · Cited by 73 · see citing works
Contribution of symptom clusters to multiple sclerosis consequences
Shahrbanian, S., Duquette, P., Kuspinar, A., & Mayo, N. E. (2014) · Quality of Life Research · doi:10.1007/s11136-014-0804-7 · Cited by 70 · see citing works
Thomson, C. A., McColl, A., Graham, G. J., & Cavanagh, J. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01759-8 · Cited by 66 · see citing works
Taylor, K. L., Hadgkiss, E. J., Jelinek, G. A., Weiland, T. J., Pereira, N. G., Marck, C. H., & van der Meer, D. M. (2014) · BMC Psychiatry · doi:10.1186/s12888-014-0327-3 · Cited by 70 · see citing works
Symptom management in patients with multiple sclerosis
Ziemssen, T. (2011) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(11)70009-0 · Cited by 66 · see citing works
Batterham, P. J., & Christensen, H. M. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.05.021 · Cited by 63 · see citing works
Cognitive and neurobehavioral features in multiple sclerosis
Arnett, P. A., & Strober, L. B. (2011) · Expert Review of Neurotherapeutics · doi:10.1586/ern.11.12 · Cited by 59 · see citing works
Kargarfard, M., Eetemadifar, M., Mehrabi, M., Maghzi, A., & Hayatbakhsh, M. R. (2011) · European Journal of Neurology · doi:10.1111/j.1468-1331.2011.03535.x · Cited by 59 · see citing works
Factors associated with depression among the Lebanese population: Results of a cross‐sectional study
Obeïd, S., Lahoud, N., Haddad, C., Sacre, H., Akel, M., Fares, K., Salameh, P., & Hallit, S. R. (2020) · Perspectives In Psychiatric Care · doi:10.1111/ppc.12518 · Cited by 59 · see citing works
Citizens as consumers: Profiling e-government services’ users in Egypt via data mining techniques
Mostafa, M. M., & El-Masry, A. A. (2013) · International Journal of Information Management · doi:10.1016/j.ijinfomgt.2013.03.007 · Cited by 60 · see citing works
Batterham, P. J., Christensen, H. M., & Mackinnon, A. J. (2009) · BMC Psychiatry · doi:10.1186/1471-244x-9-75 · Cited by 58 · see citing works
Gender Issues in Multiple Sclerosis: An Update
Jobin, C., Larochelle, C., Parpal, H., Coyle, P., & Duquette, P. (2010) · Women's Health · doi:10.2217/whe.10.69 · Cited by 51 · see citing works
Cognitive and neuropsychiatric disease manifestations in MS.
Feinstein, A., DeLuca, J., Baune, B., Filippi, M., & Lassman, H. (2013) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2012.08.001 · Cited by 68 · see citing works
Kern, S., Schrempf, W., Schneider, H., Schultheiß, T., Reichmann, H., & Ziemssen, T. (2009) · Multiple Sclerosis Journal · doi:10.1177/1352458509103300 · Cited by 65 · see citing works
Antidepressant activity of fingolimod in mice
di Nuzzo, L., Orlando, R., Tognoli, C., Pietro, P. D., Bertini, G., Miele, J., Bucci, D., Motolese, M., Scaccianoce, S., Caruso, A., et al. (2015) · Pharmacology Research & Perspectives · doi:10.1002/prp2.135 · Cited by 55 · see citing works
Mental Health Comorbidity in MS: Depression, Anxiety, and Bipolar Disorder
Turner, A., Alschuler, K., Hughes, A., Beier, M., Haselkorn, J., Sloan, A., & Ehde, D. (2016) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-016-0706-x · Cited by 49 · see citing works
Jelinek, G. A., Livera, A. M. D., Marck, C. H., Brown, C. R., Neate, S. L., Taylor, K. L., & Weiland, T. J. (2016) · BMC Neurology · doi:10.1186/s12883-016-0763-4 · Cited by 51 · see citing works
Forman, A., & Lincoln, N. (2010) · Clinical Rehabilitation · doi:10.1177/0269215509343492 · Cited by 54 · see citing works
Kirchner, T., & Lara, S. H. (2010) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.2010.01422.x · Cited by 48 · see citing works
Impaired body image in patients with multiple sclerosis
Pfaffenberger, N. M., Gutweniger, S., Kopp, M., Seeber, B., Stürz, K., Berger, T., & Günther, V. (2011) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.2010.01460.x · Cited by 48 · see citing works
Factors that differentiate level of ambulation in hospitalised older adults
Fisher, S. R., Graham, J. E., Brown, C. J., Galloway, R. V., Ottenbacher, K. J., Allman, R. M., & Ostir, G. V. (2011) · Age and Ageing · doi:10.1093/ageing/afr110 · Cited by 47 · see citing works
Carta, M. G., Moro, M. F., Lorefice, L., Picardi, A., Trincas, G., Fenu, G., Cocco, E. E., Floris, F., Bessonov, D., Akiskal, H. S., et al. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.05.024 · Cited by 46 · see citing works
Machuca, C., Vettore, M. V., Krasuska, M., Baker, S. R., & Robinson, P. G. (2017) · BMC Medical Research Methodology · doi:10.1186/s12874-017-0396-3 · Cited by 46 · see citing works
Review: Brain—immune communication psychoneuroimmunology of multiple sclerosis
Kern, S., & Ziemssen, T. (2008) · Multiple Sclerosis Journal · doi:10.1177/1352458507079657 · Cited by 45 · see citing works
Predictors and patterns of problematic Internet game use using a decision tree model
Rho, M. J., Jeong, J.-E., Chun, J., Cho, H., Jung, D. J., Choi, I. Y., & Kim, D. (2016) · Journal of Behavioral Addictions · doi:10.1556/2006.5.2016.051 · Cited by 43 · see citing works
Alsaadi, T. M., Hammasi, K. E., Shahrour, T. M., Shakra, M., Turkawi, L., Mudhafar, A., Diab, L., & Raoof, M. (2015) · Multiple Sclerosis International · doi:10.1155/2015/487159 · Cited by 41 · see citing works
Determinants and incidence of depression in multiple sclerosis: A prospective cohort study.
Berzins, S., Bulloch, A., Burton, J., Dobson, K., Fick, G. H., & Patten, S. (2017) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2017.06.012 · Cited by 38 · see citing works
Strober, L. B., Becker, A., & Randolph, J. J. (2018) · Applied Neuropsychology Adult · doi:10.1080/23279095.2018.1458518 · Cited by 38 · see citing works
Davis, B. E., Lakin, L., Binns, C. C., Currie, K. M., & Rensel, M. R. (2021) · Neurology and Therapy · doi:10.1007/s40120-021-00240-9 · Cited by 37 · see citing works
Taylor, K. L., Simpson, S., Jelinek, G. A., Neate, S. L., Livera, A. M. D., Brown, C. R., O’Kearney, E., Marck, C. H., & Weiland, T. J. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00526 · Cited by 37 · see citing works
Exercising away the blues: can it help multiple sclerosis-related depression?
Feinstein, A., Rector, N. A., & Motl, R. W. (2013) · Multiple Sclerosis Journal · doi:10.1177/1352458513508837 · Cited by 35 · see citing works
Hunter, S. F., Agius, M. A., Miller, D. M., Cutter, G., Barbato, L., McCague, K., Meng, X., Agashivala, N., Chin, P., & Hollander, E. (2016) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2016.03.024 · Cited by 34 · see citing works
Coping Strategies and Mood Profiles in Patients with Multiple Sclerosis
Milanlioglu, A., Özdemir, P. G., Cilingir, V., Gülec, T. Ç., Aydin, M. N., & Tombul, T. (2014) · Arquivos de Neuro-Psiquiatria · doi:10.1590/0004-282x20140089 · Cited by 33 · see citing works
Mindfulness in Motion for People with Multiple Sclerosis: A Feasibility Study.
Gilbertson, R. M., & Klatt, M. D. (2017) · International Journal of MS Care · doi:10.7224/1537-2073.2015-095 · Cited by 32 · see citing works
Amtmann, D., Bamer, A. M., Johnson, K. L., Ehde, D. M., Beier, M. L., Elzea, J. L., & Bombardier, C. H. (2015) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2015.08.007 · Cited by 32 · see citing works
The impact of wealth and income on the depression of older adults across European welfare regimes
Kourouklis, D., Verropoulou, G., & Tsimbos, C. (2019) · Ageing and Society · doi:10.1017/s0144686x19000679 · Cited by 32 · see citing works
Rural–Urban Analyses of Health‐Related Quality of Life Among People With Multiple Sclerosis
Buchanan, R. J., Zhu, L., Schiffer, R. B., Radin, D., & James, W. (2008) · The Journal of Rural Health · doi:10.1111/j.1748-0361.2008.00165.x · Cited by 32 · see citing works
A Framework of Care in Multiple Sclerosis, Part 2
Newsome, S. D., Aliotta, P. J., Bainbridge, J. L., Bennett, S. E., Cutter, G., Fenton, K. M., LUBLIN, F. D., Northrop, D. E., Rintell, D. J., Walker, B. D., et al. (2017) · International Journal of MS Care · doi:10.7224/1537-2073.2016-062 · Cited by 30 · see citing works
Conroy, S. K., Brownlowe, K. B., & McAllister, T. W. (2020) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/appi.focus.20200004 · Cited by 29 · see citing works
Comorbid anxiety disorders and treatment of depression in people with multiple sclerosis.
Burns, M. N., Siddique, J., Fokuo, J. K., & Mohr, D. C. (2010) · Rehabilitation Psychology · doi:10.1037/a0020492 · Cited by 27 · see citing works
Preference-based Health status in a German outpatient cohort with multiple sclerosis
Reese, J. P., Wienemann, G., John, A., Linnemann, A., Balzer‐Geldsetzer, M., Mueller, U. O., Eienbröker, C., Tackenberg, B., & Dodel, R. C. (2013) · Health and Quality of Life Outcomes · doi:10.1186/1477-7525-11-162 · Cited by 26 · see citing works
Depressive Symptoms in Postmenopausal Women: Results from the MEDIS Study
Tsiligianni, I., Tyrovolas, S., Bountziouka, V., Zeimbekis, A., Gotsis, E., Metallinos, G., Tyrovola, D., Polychronopoulos, E., Lionis, C., & Panagiotakos, D. (2014) · Women & health · doi:10.1080/03630242.2014.897678 · Cited by 19 · see citing works
Tesio, L., Simone, A. M., Zebellin, G., Rota, V., Malfitano, C., & Perucca, L. (2015) · International Journal of Rehabilitation Research · doi:10.1097/mrr.0000000000000145 · Cited by 24 · see citing works
Self-citationVerma, D., Jansen, D., Bach, K., Poel, M., Mork, P. J., & Nijeweme-d’Hollosy, W. O. (2022) · BMC Medical Informatics and Decision Making · doi:10.1186/s12911-022-01973-9 · Cited by 24 · see citing works
Alsaadi, T. M., Hammasi, K. E., Shahrour, T. M., Shakra, M., Turkawi, L., Nasreddine, W., Kassie, S. A., & Raoof, M. (2017) · Neurology International · doi:10.4081/ni.2017.7343 · Cited by 23 · see citing works
Neate, S. L., Taylor, K. L., Jelinek, G. A., Livera, A. M. D., Simpson, S., Bevens, W., & Weiland, T. J. (2019) · Health & Social Care in the Community · doi:10.1111/hsc.12822 · Cited by 22 · see citing works
Giordano, A., Ferrari, G., Radice, D., Randi, G., Bisanti, L., Solari, A., & study, T. P. (2012) · European Journal of Neurology · doi:10.1111/ene.12028 · Cited by 22 · see citing works
The Use of Focus Groups to Characterize Symptoms in Persons With Multiple Sclerosis
Newland, P., Thomas, F. P., Riley, M., Flick, L. H., & Fearing, A. (2012) · Journal of Neuroscience Nursing · doi:10.1097/jnn.0b013e318268308b · Cited by 22 · see citing works
Liu, Y., Li, Y., Huang, Y., Zhang, J., Ding, J., Zeng, Q., Tian, T., Ma, Q., Liu, X., Yu, H., et al. (2022) · World Neurosurgery · doi:10.1016/j.wneu.2022.11.046 · Cited by 21 · see citing works
Rimaz, S., Mohammad, K., Dastoorpoor, M., Jamshidi, E., & Majdzadeh, R. (2014) · Global Journal of Health Science · doi:10.5539/gjhs.v6n6p261 · Cited by 21 · see citing works
Quality of life in patients with multiple sclerosis in Eastern Slovakia
Szilasiová, J., Krokavcova, M., Gdovinová, Z., Rosenberger, J., & van Dijk, J. V. (2011) · Disability and Rehabilitation · doi:10.3109/09638288.2010.540292 · Cited by 27 · see citing works
Disease Management for Depression in an Ms Clinic
Patten, S. B., Newman, S. C., Becker, M., Riddell, C., & Metz, L. M. (2007) · The International Journal of Psychiatry in Medicine · doi:10.2190/pm.37.4.h · Cited by 21 · see citing works
Zwibel, H. (2009) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(09)71295-x · Cited by 20 · see citing works
Ghahremani, A., Farkhani, S. M., Baniasadi, M., Hojjat, S. K., Ahmadabad, H. N., Salarbashi, D., Elyasi, S., & Davoodian, N. (2022) · Brain and Behavior · doi:10.1002/brb3.2596 · Cited by 18 · see citing works
Ferreira, V. M. L. M., de Oliveira, R. R., Nazareno, T. S., de Freitas, L. V., & Mendonça, L. D. M. (2020) · Physical Therapy in Sport · doi:10.1016/j.ptsp.2020.06.006 · Cited by 19 · see citing works
Determinants of age-related decline in walking speed in older women
Martins, V. F., Tesio, L., Simone, A., Gonçalves, A. K., & Peyré‐Tartaruga, L. A. (2023) · PeerJ · doi:10.7717/peerj.14728 · Cited by 18 · see citing works
Self-citationA psychoeducation program for stress management and psychosocial problems in multiple sclerosis
Öz, H. S., & Öz, F. (2020) · Nigerian Journal of Clinical Practice · doi:10.4103/njcp.njcp_462_19 · Cited by 18 · see citing works
Therapieadhärenz in der neurologischen Praxis
Kern, S., Reichmann, H., & Ziemssen, T. (2008) · Der Nervenarzt · doi:10.1007/s00115-008-2419-0 · Cited by 17 · see citing works
Lee, E.-W., & Park, J. (2015) · Journal of Korean Medical Science · doi:10.3346/jkms.2015.30.2.186 · Cited by 17 · see citing works
Patel, V. P., & Feinstein, A. (2018) · Multiple Sclerosis Journal · doi:10.1177/1352458518770086 · Cited by 17 · see citing works
Quality of Life in Patients Suffering from Parkinson and #8217;s Disease and Multiple Sclerosis
Šehanović, A., Dostović, Z., Smajlović, D., & Avdibegović, E. (2011) · Medical Archives · doi:10.5455/medarh.2011.65.291-294 · Cited by 16 · see citing works
Health-Related Quality of Life Among Young Adults with Multiple Sclerosis
Buchanan, R. J., Huang, C., & Kaufman, M. (2010) · International Journal of MS Care · doi:10.7224/1537-2073-12.4.190 · Cited by 15 · see citing works
Tahan, A. A., Aljumah, M., Bohlega, S. M., Al-Shammari, S. N., Alsharoqi, I. A., Dahdaleh, M. P., Hosny, H. M., & Yamout, B. (2011) · Neurosciences · doi:10.17712/1658-3183.1847 · Cited by 13 · see citing works
Hynčicová, E., Kalina, A., Vyhnálek, M., Nikolai, T., Martinkovič, L., Lisý, J., Hort, J., Meluzínová, E., & Laczó, J. (2018) · PLoS ONE · doi:10.1371/journal.pone.0200254 · Cited by 14 · see citing works
Gedik, Z. (2020) · Dusunen Adam The Journal of Psychiatry and Neurological Sciences · doi:10.14744/dajpns.2019.00061 · Cited by 14 · see citing works
Lin, S. (2023) · The Journals of Gerontology Series B · doi:10.1093/geronb/gbad036 · Cited by 13 · see citing works
Efficacy and safety outcomes in vitamin D supplement users in the fingolimod phase 3 trials
Hongell, K., Silva, D. G., Ritter, S., Meier, D. P., & Soilu‐Hänninen, M. (2017) · Journal of Neurology · doi:10.1007/s00415-017-8697-3 · Cited by 13 · see citing works
Malygin, V., Boyko, A., Konovalova, O. E., Pahtusova, E. E., Dumbrova, E. V., Tishina, I. A., & Malygin, Y. (2019) · Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova · doi:10.17116/jnevro20191192258 · Cited by 12 · see citing works
Depression as a predictor of occupational transition in a multiple sclerosis cohort.
Patten, S. B., Williams, J. V. A., Lavorato, D. H., Koch, M. W., & Metz, L. M. (2013) · Europe PMC (PubMed Central) · Cited by 13 · see citing works
Depression screening in Black Americans with multiple sclerosis
Stepleman, L. M., Decker, M., Rollock, M. J. D., Casillas, R. S., & Brands, T. (2013) · Psychology Health & Medicine · doi:10.1080/13548506.2013.775466 · Cited by 13 · see citing works
Kyriakatis, G. M., Lykou, P. M., Dimitriadis, Z., & Besios, T. (2023) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2023.105067 · Cited by 12 · see citing works
Antidepressant Treatment for Major Depression in Multiple Sclerosis
Patten, S. B. (2009) · International Journal of MS Care · doi:10.7224/1537-2073-11.4.174 · Cited by 12 · see citing works
Verropoulou, G., Serafetinidou, E., & Tsimbos, C. (2019) · Ageing and Society · doi:10.1017/s0144686x19000977 · Cited by 12 · see citing works
The Safety and Efficacy of ECT and Anesthesia in the Setting of Multiple Sclerosis
Fitzsimons, M. G., WELCH, C. A., Haspel, K. L., & Gorman, J. M. (2007) · Journal of Psychiatric Practice · doi:10.1097/01.pra.0000271662.40211.1f · Cited by 12 · see citing works
Spiegelberg, N., Breuer, S., Nielsen, J., Saliger, J., Montag, C., Karbe, H., & Markett, S. A. (2020) · Archives of Clinical Neuropsychology · doi:10.1093/arclin/acaa118 · Cited by 11 · see citing works
Sharafkhah, M., Mosayebi, G., Massoudifar, A., Seddigh, S. H., Abdolrazaghnejad, A., Alamdara, M. A., Mokarian, P., Mohammadbeigi, A., & Ebrahimi-Monfared, M. (2022) · Neurology India · doi:10.4103/0028-3886.338707 · Cited by 10 · see citing works
Quality of life measurement: one size fits all. Rehabilitation medicine makes no exception
Tesio, L. (2009) · Journal of Medicine and the Person · doi:10.1007/s12682-009-0002-5 · Cited by 10 · see citing works
Self-citationHealth-Related Quality of Life Among Latinos With Multiple Sclerosis
Buchanan, R. J., Johnson, O., Zúniga, M. A., Carrillo, G., & Chakravorty, B. J. (2012) · Journal of Social Work in Disability & Rehabilitation · doi:10.1080/1536710x.2012.730846 · Cited by 9 · see citing works
Peute, L., Scheeve, T., & Jaspers, M. (2019) · Journal of Medical Internet Research · doi:10.2196/12509 · Cited by 9 · see citing works
- Authors
- D'Alisa, S., Miscio, G., Baudo, S., Simone, A., Tesio, L., & Mauro, A.
- Affiliations
- IRCCS Istituto Auxologico Italiano (IT)
- Corresponding author
- D'Alisa, S.
- Venue
- Disability and Rehabilitation
- Publisher
- Informa UK Limited
- Published
- 2006-01
- Volume
- 28
- Issue
- 5
- Pages
- 307-314
- ISSN
- 0963-8288 (ISSN-L)
- 1464-5165
- OpenAlex
- W2006486879
- Cited by
- 182
- References
- 48
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 3 · 2023: 15 · 2022: 8 · 2021: 6 · 2020: 18 · 2019: 12 · 2018: 9 · 2017: 11 · 2016: 9 · 2015: 9 · 2014: 13 · 2013: 12 · 2012: 8
- FWCI
- 2.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Disability and Rehabilitation (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Health Systems, Economic Evaluations, Quality of Life
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Keywords
- multiple sclerosis, quality of life, depression, anxiety, SF-36, Expanded Disability Status Scale, inpatient rehabilitation, disability severity, disease duration, psychometric validation
- MeSH terms
- Adult, Aged, Decision Trees, Depression, Female, Humans, Male, Middle Aged, Multiple Sclerosis, Psychiatric Status Rating Scales, Quality of Life, Surveys and Questionnaires, Regression Analysis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
