The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Cognitive reserve in multiple sclerosis
Open accessAbstract
Cognitive impairment is common among persons with multiple sclerosis (MS), but some patients are able to withstand considerable disease burden (e.g. white matter lesions, cerebral atrophy) without cognitive impairment (cognitive inefficiency, memory decline). What protects these patients from cognitive impairment? We review the literature on cognitive reserve in MS, which shows that heritable (larger maximal lifetime brain growth) and environmental (greater intellectual enrichment) factors attenuate the negative effect of disease burden on cognitive status. That is, persons with larger maximal lifetime brain growth, greater vocabulary knowledge, and/or greater early life participation in cognitive leisure activities (e.g. reading, hobbies) are better able to cope with MS disease without cognitive impairment. We review evidence that benefits of intellectual enrichment on cognitive status may stem from more efficient patterns of brain function. We discuss clinical implications and highlight important unanswered questions for future research on reserve against cognitive impairment in MS.
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“This finding is somewhat consistent with previous findings supporting the cognitive reserve hypothesis, that higher education mitigates cognitive problems associated with MS73–75.”
From Ecological momentary assessment of pain, fatigue, depressive, and cognitive symptoms reveals significant daily variability in multiple sclerosis (2017) · cites this paper as [74]
Citations
Cites
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Validity of the minimal assessment of cognitive function in multiple sclerosis (MACFIMS)
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Education modifies the relation of AD pathology to level of cognitive function in older persons
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Research works printed but not linked: 1
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Cited by
Sorted by citations
Clinical and imaging assessment of cognitive dysfunction in multiple sclerosis
Rocca, M. A., Amato, M. P., De Stefano, N., Enzinger, C., Geurts, J. J., Penner, I.-K., Rovira, A., Sumowski, J. F., Valsasina, P., & Filippi, M. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(14)70250-9 · Cited by 557
Self-citationCognition in multiple sclerosis
Sumowski, J. F., Benedict, R. H. B., Enzinger, C., Filippi, M., Geurts, J. J. G., Hämäläinen, P. I., Hulst, H. E., Inglese, M., Leavitt, V. M., Rocca, M. A., et al. (2018) · Neurology · doi:10.1212/wnl.0000000000004977 · Cited by 551
Self-citationBrain reserve and cognitive reserve protect against cognitive decline over 4.5 years in MS
Sumowski, J. F., Rocca, M. A., Leavitt, V. M., Dackovic, J. R., Mesaroš, Š., Drulovic, J. S., DeLuca, J., & Filippi, M. (2014) · Neurology · doi:10.1212/wnl.0000000000000433 · Cited by 203
Self-citationIdentifying the Distinct Cognitive Phenotypes in Multiple Sclerosis
Meo, E. D., Portaccio, E., Giorgio, A., Ruano, L., Goretti, B., Niccolai, C., Patti, F., Chisari, C. G., Gallo, P., Grossi, P., et al. (2021) · JAMA Neurology · doi:10.1001/jamaneurol.2020.4920 · Cited by 190
Cognitive impairment in multiple sclerosis – a review of current knowledge and recent research
Grzegorski, T., & Losy, J. (2017) · Reviews in the Neurosciences · doi:10.1515/revneuro-2017-0011 · Cited by 206
“Greater intellectual enrichment and larger MLBG are thought to protect individuals from developing cognitive decline in MS (Sumowski and Leavitt, 2013).”
Background
Metadata
- Authors
- Sumowski, J. F., & Leavitt, V. M.
- Affiliations
- Kessler Foundation (US)
- Venue
- Multiple Sclerosis Journal
- Publisher
- SAGE Publications
- Published
- 2013-07-29
- Volume
- 19
- Issue
- 9
- Pages
- 1122-1127
- ISSN
- 1352-4585 (ISSN-L)
- 1477-0970
- OpenAlex
- W2095723566
- Semantic Scholar
- 432cbdd4a7e844d9d6371ed10495dc761a5a0d88
- Cited by
- 185
- References
- 35
- Citations by year
- 2026: 13 · 2025: 14 · 2024: 12 · 2023: 17 · 2022: 13 · 2021: 12 · 2020: 15 · 2019: 13 · 2018: 11 · 2017: 17 · 2016: 17 · 2015: 19 · 2014: 11 · 2013: 1
- FWCI
- 2.36
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Multiple Sclerosis Journal (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Oncology › Cancer-related cognitive impairment studies
- Keywords
- cognitive reserve, multiple sclerosis, cognitive impairment, vocabulary, disease burden, white matter lesions, brain atrophy
- MeSH terms
- Cognition Disorders, Humans, Multiple Sclerosis, Cognitive Reserve
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