The DOI matches its Crossref record, with a small difference in title or year; 4 of the 4 references it cites were found in a registry or an index.
Safety and efficacy of helminth treatment in relapsing-remitting multiple sclerosis: Results of the HINT 2 clinical trial
Open accessAbstract
Background: The hygiene hypothesis suggests that microbial replacement may be therapeutic in allergic and autoimmune diseases. Nevertheless, the results of helminth treatment, including in multiple sclerosis (MS), have been inconclusive. Objective: To assess safety and brain magnetic resonance imaging (MRI) activity in subjects with relapsing-remitting multiple sclerosis (RRMS) during oral administration of ova from the porcine whipworm, Trichuris suis (TSO). Methods: A total of 16 disease-modifying treatment (DMT) naive RRMS subjects were studied in a baseline versus treatment (BVT) controlled prospective study. MRI scans were performed during 5 months of screening-observation, 10 months of treatment, and 4 months of post-treatment surveillance. Results: No serious symptoms or adverse events occurred during treatment. For the cohort, there was a trend consistent with a 35% diminution in active lesions when observation MRIs were compared to treatment MRIs ( p = 0.08), and at the level of individuals, 12 of 16 subjects improved during TSO treatment. T regulatory lymphocytes were increased during TSO treatment. Conclusion: TSO is safe in RRMS subjects. Potentially favorable MRI outcomes and immunoregulatory changes were observed during TSO treatment; however, the magnitude of these effects was modest, and there was considerable variation among the responses of individual subjects.
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Modulation of Host Immunity by Helminths: The Expanding Repertoire of Parasite Effector Molecules
Maizels, R. M., Smits, H. H., & McSorley, H. J. (2018) · Immunity · doi:10.1016/j.immuni.2018.10.016 · Cited by 435
Metadata
- Authors
- Fleming, J., Hernandez, G., Hartman, L., Maksimovic, J., Nace, S., Lawler, B., Risa, T., Cook, T., Agni, R., Reichelderfer, M., Luzzio, C., Rolak, L., Field, A., & Fabry, Z.
- Affiliations
- University of Wisconsin–Madison (US)
- Marshfield Clinic (US)
- Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
- Corresponding author
- Fleming, John
- Venue
- Multiple Sclerosis Journal
- Publisher
- SAGE Publications
- Published
- 2017-10-24
- Volume
- 25
- Issue
- 1
- Pages
- 81-91
- ISSN
- 1352-4585 (ISSN-L)
- 1477-0970
- PMC
- PMC5878983
- OpenAlex
- W2766022874
- Cited by
- 74
- References
- 4
- Citations by year
- 2026: 9 · 2025: 6 · 2024: 7 · 2023: 6 · 2022: 8 · 2021: 17 · 2020: 7 · 2019: 7 · 2018: 7
- FWCI
- 4.51
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Multiple Sclerosis Journal (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (1 R56AI091462-01)
- National Multiple Sclerosis Society (RG 36113A/1)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Life Sciences › Immunology and Microbiology › Parasitology › Parasites and Host Interactions
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Keywords
- relapsing-remitting multiple sclerosis, helminth therapy, hygiene hypothesis, regulatory T cells, immune regulation, treatment safety
- MeSH terms
- Adult, Animals, Female, Helminthiasis, Humans, Immunotherapy, Magnetic Resonance Imaging, Male, Middle Aged, Ovum, Prospective Studies, Trichuris, Outcome Assessment, Health Care, Multiple Sclerosis, Relapsing-Remitting, T-Lymphocytes, Regulatory, Young Adult
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