The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
The Cardiovascular Continuum extended: Aging effects on the aorta and microvasculature
Open accessAbstract
The ‘Cardiovascular Continuum’ was described by Dzau and colleagues in 2006 to explain the development over many years of coronary disease with its complications, then end-stage heart failure. The Continuum identified different points along the way where the process could be interrupted by drug therapies or interventions, then described the trials that have been undertaken over the last three decades to establish their value. The approach summarized the major steps in cardiology through modern times, but it had an emphasis on coronary atherosclerosis in prosperous nations, and did not account fully for the problems of aging, which occur in all societies. Aging of the aorta and elastic arteries causes arterial stiffening and leads to development of cardiac failure and microvascular disease in highly perfused organs such as the brain and kidneys. The ‘Vascular Aging Continuum’ which we introduce, dovetails with the late phases of the Cardiovascular Continuum and provides a more comprehensive explanation, especially for vascular diseases in nations with little atherosclerosis. It will become more common in the Western World where attention to risk factors and widespread use of statins are responsible for a decrease in atherosclerotic disease, prolongation of life, and dominance of macrovascular and microvascular arterial disease, as well as of cardiac failure.
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2024 ESC Guidelines for the management of peripheral arterial and aortic diseases
Mazzolai, L., Teixido-Tura, G., Lanzi, S., Boc, V., Bossone, E., Brodmann, M., Bura-Rivière, A., De Backer, J., Deglise, S., Della Corte, A., et al. (2024) · European Heart Journal · doi:10.1093/eurheartj/ehae179 · Cited by 993
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Vascular Smooth Muscle Cells and Arterial Stiffening: Relevance in Development, Aging, and Disease
Lacolley, P., Regnault, V., Segers, P., & Laurent, S. (2017) · Physiological Reviews · doi:10.1152/physrev.00003.2017 · Cited by 734
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Metadata
- Authors
- O'Rourke, M. F., Safar, M. E., & Dzau, V.
- Venue
- Vascular Medicine
- Publisher
- SAGE Publications
- Published
- 2010-11-05
- Volume
- 15
- Issue
- 6
- Pages
- 461-468
- ISSN
- 1358-863X (ISSN-L)
- 1477-0377
- OpenAlex
- W2327226597
- Cited by
- 230
- References
- 8
- FWCI
- 4.29
- Type
- journal article
- Language
- en
- Open access
- bronze
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- O'Rourke, M. F., Safar, M. E., & Dzau, V. (2010). The Cardiovascular Continuum extended: Aging effects on the aorta and microvasculature. Vascular Medicine. https://doi.org/10.1177/1358863x10382946
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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