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Cited by 15HIV-related health complications and treatmentsBody Composition Measurement TechniquesDiabetes, Cardiovascular Risks, and Lipoproteins

Comparison of Dual-Energy X-Ray Absorptiometry Machines for Measuring Fat Distribution Changes of HIV-Associated Lipodystrophy

Yang, Yong, Zhu, WD Jason, Paton, Nicholas I·2004·Antiviral Therapy
DOI 10.1177/135965350400900516
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Abstract

BACKGROUND: Dual-energy X-ray absorptiometry (DXA) is regarded as a useful objective method for diagnosis of HIV-associated lipodystrophy (LD). OBJECTIVE: To determine whether the use of different DXA machines may affect the diagnosis of LD. METHODS: Body composition in 24 HIV-infected patients, 12 of whom had clinically diagnosed LD, was measured on two DXA machines (Lunar and Hologic). RESULTS: Hologic gave significantly higher values than Lunar DXA for total body fat percent (22.9 vs 20.5%, P<0.001), arm fat percent (27.9 vs 14.5%, P<0.001) and leg fat percent (23.4 vs 17.5%, P<0.001), and significantly lower values than Lunar for trunk fat percent (22.3 vs 24.7%, P<0.001) and trunk-to-limb fat percent ratio (0.89 vs 1.62, P<0.001). When measured by Lunar, patients with LD had significantly lower leg fat percent (13.5 vs 21.6%, P=0.04) and higher trunk-to-limb fat percent ratio (1.85 vs 1.38; P=0.012) than those without LD. When measured by Hologic, patients with LD had values of leg fat percent (20.1 vs 26.8%, P=0.11) and trunk-to-limb fat percent ratio (0.95 vs 0.85, P=0.43) that did not differ significantly from those without LD. There was a significant difference in the contribution to a composite LD score between Lunar and Hologic measurements. CONCLUSION: DXA machines from different manufacturers give major differences in measurements of body fat content and distribution, and this may affect the ability to distinguish patients with LD from those without LD. Further standardization of DXA technology is needed before widespread application in the clinical diagnosis of LD.

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  • At least two studies, one using QDR 2000, have shown QDR overestimates Lunar.

    “However, at least two studies (14,35), one of which was conducted with the QDR 2000 (14), have shown that the QDR overestimates Lunar.”

    From Comparison of Body Composition Methods in Obese African‐American Women (2006) · cites this paper as [35]

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Authors
Yang, Y., Zhu, W. J., & Paton, N. I.
Affiliations
Tan Tock Seng Hospital (SG)
ORCID
Venue
Antiviral Therapy
Publisher
SAGE Publications
Published
2004-07
Volume
9
Issue
5
Pages
771-778
ISSN
  • 1359-6535 (ISSN-L)
  • 2040-2058
DOI
10.1177/135965350400900516
OpenAlex
W2460246814
Cited by
15
References
30
Citations by year
2015: 1 · 2012: 3
FWCI
3.72
Type
journal article
Language
en
Open access
closed
Licence
journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations
  • Antiviral Therapy (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Emergency Medicine › HIV-related health complications and treatments
  • Health Sciences › Medicine › Physiology › Body Composition Measurement Techniques
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
HIV-associated lipodystrophy, dual-energy X-ray absorptiometry, body composition, body fat distribution, Moon
MeSH terms
Adipose Tissue, Adult, Body Composition, Humans, Male, Middle Aged, Absorptiometry, Photon, HIV Infections, HIV-Associated Lipodystrophy Syndrome

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