Obstructive Sleep Apnoea, Cigarette Smoking and Serum Testosterone Levels in a Male Sleep Clinic Cohort
Abstract
This study evaluated the impact of obstructive sleep apnoea (OSA) and smoking on total serum testosterone levels in 96 men (mean age 43.3 years; range 25-60 years) attending a sleep clinic. Fifty-five men (57.3%) had OSA, defined as an apnoea–hypopnoea index of ≥ 15 events/h, recorded during overnight polysomnography, and 42 (43.8%) were current smokers. Mean serum total testosterone levels were significantly lower in OSA subjects (3.4 ng/ml) than in non-OSA subjects (3.9 ng/ml), whereas no significant difference was observed between current smokers and non-smokers. In a multiple linear regression analysis, serum testosterone was negatively correlated with body mass index and the apnoea–hypopnoea index, but not with age and pack-years of smoking. Our results support previous observations regarding testosterone levels in men with OSA, but, contrary to some earlier reports, there was no positive relationship between smoking and total testosterone in the present cohort.
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The reported effects of smoking on testosterone levels in men are controversial, with some evidence suggesting no association and others reporting higher or lower total testosterone levels among smokers compared to nonsmokers.
“However, the reported effects of smoking on testosterone levels in men are controversial, with some evidence even suggesting no association 15,19-24 and others reporting higher 13,14,25-32 or lower 33,34 levels of TT among smokers compared to nonsmokers.”
From Cigarette smoking has a positive and independent effect on testosterone levels (2013) · cites this paper as [24]
Cites
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Risks and benefits of testosterone therapy in older men
Spitzer, M., Huang, G., Basaria, S., Travison, T. G., & Bhasin, S. (2013) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2013.73 · Cited by 154 · see citing works
Cigarette smoking has a positive and independent effect on testosterone levels
Wang, W., Yang, X., Liang, J., Liao, M., Zhang, H., Qin, X., Mo, L., Lv, W., & Mo, Z. (2013) · Hormones · doi:10.14310/horm.2002.1445 · Cited by 79 · see citing works
- Authors
- Kirbas, G., Abakay, A., Topcu, F., Kaplan, A., Ünlu, M., & Peker, Y.
- Affiliations
- Sleep Centre, Department of Chest Diseases, Dicle University, Diyarbakir, Turkey
- Dicle University (TR)
- Afyon Kocatepe University (TR)
- Skaraborg Hospital (SE)
- Venue
- Journal of International Medical Research
- Publisher
- SAGE Publications
- Published
- 2007-01
- Volume
- 35
- Issue
- 1
- Pages
- 38-45
- ISSN
- 0300-0605 (ISSN-L)
- 1473-2300
- OpenAlex
- W2083214654
- Cited by
- 32
- References
- 5
- Citations by year
- 2024: 2 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 2 · 2019: 2 · 2018: 1 · 2017: 2 · 2016: 1 · 2015: 2 · 2014: 1 · 2013: 5 · 2012: 2
- FWCI
- 0.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of International Medical Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Obstructive Sleep Apnea Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Keywords
- obstructive sleep apnea, cigarette smoking, serum testosterone, hypogonadism, men, apnea-hypopnea index, body mass index, pack-years, sleep clinic patients
- MeSH terms
- Adult, Ambulatory Care Facilities, Humans, Male, Middle Aged, Sleep, Smoking, Testosterone, Sleep Apnea, Obstructive
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