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Cited by 82Hypothalamic control of reproductive hormonesHormonal and reproductive studiesStress Responses and Cortisol

Effects of Intravenous Cocaine and Cigarette Smoking on Luteinizing Hormone, Testosterone, and Prolactin in Men

Mendelson, Jack H., Sholar, Michelle B., Mutschler, Nicole H., Jaszyna-Gasior, Maria, Goletiani, Nathalie V., Siegel, Arthur J., Mello, Nancy K.·2003·The Journal of Pharmacology and Experimental Therapeutics
DOI 10.1124/jpet.103.052928
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Abstract

Cocaine and nicotine have a number of similar behavioral and neurobiological effects. This study compared the acute effects of cocaine and cigarette smoking on luteinizing hormone (LH), testosterone (T), and prolactin. Twenty-four men who met American Psychiatric Association Diagnostic and Statistical Manual criteria for cocaine abuse or nicotine dependence were given intravenous cocaine (0.4 mg/kg) or placebo-cocaine, or smoked a low or high nicotine cigarette under controlled conditions. Placebo-cocaine or low nicotine cigarette smoking did not change LH, T, or prolactin. Peak plasma levels of 254 +/- 18 ng cocaine/ml and 22.6 +/- 3.4 ng nicotine/ml were measured at 8 and 14 min, respectively. LH increased significantly after both i.v. cocaine and high nicotine cigarette smoking (P < 0.01). These LH increases were significantly correlated with increases in cocaine and nicotine plasma levels (P < 0.001-0.003), and high nicotine cigarette smoking stimulated significantly greater increases in LH release than i.v. cocaine (P < 0.05). Testosterone levels did not change significantly after either cocaine or after high nicotine cigarette smoking. After i.v. cocaine, prolactin decreased significantly and remained below baseline levels throughout the sampling period (P < 0.05-0.01). After high nicotine cigarette smoking, prolactin increased to hyperpro-lactinemic levels within 6 min and remained significantly above baseline levels for 42 min (P < 0.05-0.03). The rapid increases in LH and reports of subjective "high" after both i.v. cocaine and high nicotine cigarette smoking illustrate the similarities between these drugs and suggest a possible contribution of LH to their abuse-related effects.

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Crossref · 10.1124/jpet.103.052928

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  • Mendelson et al. found only a non-significant decrease of testosterone levels after an acute smoked cigarette.

    “Mendelson et al . (2003) studied the acute effect of a smoked cigarette and found only a non-significant decrease of testosterone levels.”

    From Effects of Smoking Cessation on Hormonal Levels in Men (2013) · cites this paper as Mendelson et al. (2003)

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1 of the 56 references couldn’t be matched to a known paper.

Research works printed but not linked: 1

  1. MDPH (Massachusetts Department of Public Health) (1998) Massachusetts Department of Public Health 1997 Cigarette Nicotine Disclosure Report as required by Massachusetts General Laws Chapter 307B, CMR 660,000, January 16.

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Authors
Mendelson, J. H., Sholar, M. B., Mutschler, N. H., Jaszyna-Gasior, M., Goletiani, N. V., Siegel, A. J., & Mello, N. K.
Affiliations
Harvard University (US)
ORCID
Siegel, Arthur J.
Venue
The Journal of Pharmacology and Experimental Therapeutics
Publisher
Elsevier BV
Published
2003-10
Volume
307
Issue
1
Pages
339-348
ISSN
0022-3565 (ISSN-L)
DOI
10.1124/jpet.103.052928
OpenAlex
W2010808631
Cited by
81
References
56
Citations by year
2026: 1 · 2025: 3 · 2023: 6 · 2022: 1 · 2021: 2 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 2 · 2016: 1 · 2015: 6 · 2014: 3 · 2013: 5 · 2012: 7
FWCI
4.68
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Journal of Pharmacology and Experimental Therapeutics (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute on Drug Abuse (K05DA000064, P01DA014528, K05DA000101, R01DA015067, T32DA007252)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords
cocaine, cigarette smoking, nicotine, luteinizing hormone, testosterone, prolactin, acute drug effects, men, cocaine abuse, nicotine dependence, plasma drug concentration, subjective high, drug abuse
MeSH terms
Carbon Monoxide, Cocaine, Humans, Luteinizing Hormone, Male, Nicotine, Prolactin, Smoking, Substance Withdrawal Syndrome, Testosterone, Dopamine Uptake Inhibitors, Cocaine-Related Disorders

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