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Cited by 113Obstructive Sleep Apnea ResearchHormonal and reproductive studiesAdipokines, Inflammation, and Metabolic Diseases

Testosterone levels in obese male patients with obstructive sleep apnea syndrome: Relation to oxygen desaturation, body weight, fat distribution and the metabolic parameters

Gambineri, Alessandra, Pelusi, C., Pasquali, R.·2003·Journal of Endocrinological Investigation
DOI 10.1007/bf03345209
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Abstract

To investigate the impact of obstructive sleep apnea syndrome (OSAS) on testosterone levels and on the main parameters of the metabolic syndrome in abdominally obese men, 15 male subjects with abdominal obesity phenotype and polysomnographic diagnosis of OSAS (OB-OSAS) and 15 controls matched for age and anthropometric parameters (OB) were investigated. Anthropometry, SHBG, sex hormones and several parameters of the metabolic syndrome were measured. Only subjects with an Epworth Sleepiness Score greater than 10 underwent a polysomnographic study with calculation of the number of desaturation rates per sleeping hour (ODI), the minimal oxygen saturation during each desaturation episode (minSaO2) and the mean minimal arterial oxygen saturation for the whole night period (MminSaO2). Both total and free testosterone levels were lower in OB-OSAS than in OB patients. A negative correlation between polysomnographic parameters (ODI, minSaO2 and MminSaO2) and testosterone levels was found. The relationship between total and free testosterone and ODI persisted after adjusting for body mass index (BMI) and waist (W) values. Triglyceride and uric acid levels were significantly higher in OB-OSAS than in OB patients. A negative correlation between testosterone and acid uric level and a positive correlation between testosterone and HDL-cholesterol level was found, regardless of BMI and W circumference, particularly in the OB-OSAS group. Our study suggests that, in patients with obesity and OSAS, the severity of hypoxia during sleeping hours may be an additional factor in reducing testosterone levels, regardless of BMI and abdominal fatness. This may contribute in worsening metabolic abnormalities which, in men with OSAS, exceed those expected on the basis of degree of obesity and pattern of fat distribution.

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  • In older men, higher degrees of hypoxemia, as a marker of more severe OSA, are associated with lower testosterone concentrations.

    “higher degrees of hypoxemia, as a marker of more severe OSA, are associated with lower testosterone concentrations [37, 104–106].”

    From Sleep, testosterone and cortisol balance, and ageing men (2022) · cites this paper as [106]

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Authors
Gambineri, A., Pelusi, C., & Pasquali, R.
Affiliations
IRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola (IT)
Corresponding author
Gambineri, Alessandra
ORCID
Venue
Journal of Endocrinological Investigation
Publisher
Springer Science and Business Media LLC
Published
2003-06
Volume
26
Issue
6
Pages
493-498
ISSN
  • 0391-4097 (ISSN-L)
  • 1720-8386
DOI
10.1007/bf03345209
OpenAlex
W2087035336
Cited by
113
References
48
Citations by year
2025: 7 · 2023: 6 · 2022: 7 · 2021: 8 · 2020: 5 · 2019: 7 · 2018: 6 · 2017: 4 · 2016: 8 · 2015: 5 · 2014: 7 · 2013: 5 · 2012: 2
FWCI
2.69
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Journal of Endocrinological Investigation (publishedVersion)
  • PubMed (publishedVersion)
  • Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Obstructive Sleep Apnea Research
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Keywords
obstructive sleep apnea, testosterone, free testosterone, obesity, abdominal obesity, hypoxemia, oxygen desaturation, metabolic syndrome, uric acid, triglycerides, HDL cholesterol, sex hormone-binding globulin, body fat distribution
MeSH terms
Adipose Tissue, Adult, Anthropometry, Arteries, Body Weight, Humans, Cholesterol, HDL, Male, Middle Aged, Obesity, Oxygen, Gonadal Steroid Hormones, Testosterone, Triglycerides, Uric Acid, Sleep Apnea, Obstructive

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