The DOI matches its Crossref record; 134 of the 134 references it cites were found in a registry or an index.
Factors Involved in the Regulation of Type I Collagen Gene Expression: Implication in Fibrosis
Abstract
Type I collagen, the major component of extracellular matrix in skin and other tissues, is a heterotrimer of two α1 and one α2 collagen polypeptides. The synthesis of both chains is highly regulated by different cytokines at the transcriptional level. Excessive synthesis and deposition of collagen in the dermal region causes thick and hard skin, a clinical manifestation of scleroderma. To better understand the causes of scleroderma or other tissue fibrosis, it is very Important to investigate the molecular mechanisms that cause upregulation of the Type I collagen synthesis in these tissues. Several cis-acting regulatory elements and trans-acting protein factors, which are involved in basal as well as cytokine-modulated Type I collagen gene expression, have been identified and characterized. Hypertranscription of Type I collagen in scleroderma skin fibroblasts may be due to abnormal activities of different positive or negative transcription factors In response to different abnormally induced signaling pathways. In this review, I discuss the present day understanding about the involvement of different factors in the regulation of basal as well as cytokine-modulated Type I collagen gene expression and its implication in scleroderma research.
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Cited by
Demoor, M., Ollitrault, D., Gomez-Leduc, T., Bouyoucef, M., Hervieu, M., Fabre, H., Lafont, J., Denoix, J.-M., Audigié, F., Mallein-Gerin, F., et al. (2014) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2014.02.030 · Cited by 296
Ghosh, A. K., Bhattacharyya, S., Lakos, G., Chen, S., Mori, Y., & Varga, J. (2004) · Arthritis & Rheumatism · doi:10.1002/art.20104 · Cited by 201
Self-citationSvegliati, S., Marrone, G., Pezone, A., Spadoni, T., Grieco, A., Moroncini, G., Grieco, D., Vinciguerra, M., Agnese, S., Jüngel, A., et al. (2014) · Science Signaling · doi:10.1126/scisignal.2004592 · Cited by 100
Trichostatin A blocks TGF-β-induced collagen gene expression in skin fibroblasts: Involvement of Sp1
Ghosh, A. K., Mori, Y., Dowling, E., & Varga, J. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.12.204 · Cited by 91
Self-citationDehlin, H. M., Manteufel, E. J., Monroe, A. L., Reimer, M. H., & Levick, S. P. (2013) · International Journal of Cardiology · doi:10.1016/j.ijcard.2013.07.190 · Cited by 55
Metadata
- Authors
- Ghosh, A. K.
- Venue
- Experimental Biology and Medicine
- Publisher
- Frontiers Media SA
- Published
- 2002-05
- Volume
- 227
- Issue
- 5
- Pages
- 301-314
- ISSN
- 0071-3384 (ISSN-L)
- 1535-3702
- 1535-3699
- OpenAlex
- W1760933578
- Cited by
- 259
- References
- 134
- FWCI
- 8.94
- Type
- journal article
- Language
- en
- Open access
- closed
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