Indian Hedgehog: A Mechanotransduction Mediator in Condylar Cartilage
Abstract
Indian hedgehog (Ihh) is a critical mediator transducing mechanical signals to stimulate chondrocyte proliferation. To clarify the cellular signal transduction pathway that senses and converts mechanical signals into tissue growth in mandibular condyle, we evaluated Ihh expression and its relation to the kinetics of replicating mesenchymal cells in condylar cartilage during natural growth and mandibular advancement. Thirty-five-day-old Sprague-Dawley rats were fitted with functional appliances. Experimental animals with matched controls were doubly labeled with iododeoxyuridine and bromodeoxyuridine so that we could evaluate the cycles of the proliferative mesenchymal cells. Mandibular advancement triggered Ihh expression in condylar cartilage. A higher level of Ihh expression coincided with the increase of the replicating mesenchymal cells’ population and the shortening of the turnover time. These findings suggested that Ihh acts as a mediator of mechanotransduction that converts mechanical signals resulting from anterior mandibular displacement to stimulate cellular proliferation in condylar cartilage.
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A RandomForest classifier is a form of ensemble learning that creates multiple decision tree classifiers and aggregates their predictions using a voting mechanism.
“A RandomForest classifier is one form of ensemble learning that creates multiple decision tree classifiers and aggregates their predictions using a voting mechanism [54], [55].”
From Detecting Developers' Task Switches and Types (2022) · cites this paper as [55]
A Random Forest classifier can deal well with a larger number of features, making prior feature dimensionality reduction obsolete.
“ARandom Forest classifier can deal well with a larger number of features which makes prior feature dimensionality reduction of our 84 features obsolete [54], [55].”
From Detecting Developers' Task Switches and Types (2022) · cites this paper as [55]
Cites
Gratzner, H. G. (1982) · Science · doi:10.1126/science.7123245 · Cited by 2,653 · see citing works
St‐Jacques, B., Hammerschmidt, M., & McMahon, A. P. (1999) · Genes & Development · doi:10.1101/gad.13.16.2072 · Cited by 1,742 · see citing works
Integrins as mechanochemical transducers
Ingber, D. E. (1991) · Current Opinion in Cell Biology · doi:10.1016/0955-0674(91)90058-7 · Cited by 675 · see citing works
Long, F., Zhang, X. M., Karp, S. J., Yang, Y., & McMahon, A. P. (2001) · Development · doi:10.1242/dev.128.24.5099 · Cited by 654 · see citing works
Quantitative analysis of temporomandibular joint adaptations to protrusive function
McNamara, J. A., & Carlson, D. S. (1979) · American Journal of Orthodontics · doi:10.1016/0002-9416(79)90206-9 · Cited by 284 · see citing works
MOLECULAR MODELING OF MECHANOTRANSDUCTION IN THE NEMATODE CAENORHABDITIS ELEGANS
Tavernarakis, N., & Driscoll, M. (1997) · Annual Review of Physiology · doi:10.1146/annurev.physiol.59.1.659 · Cited by 234 · see citing works
More Surprises in the Hedgehog Signaling Pathway
McMahon, A. P. (2000) · Cell · doi:10.1016/s0092-8674(00)81555-x · Cited by 218 · see citing works
Krailassiri, S., Anuwongnukroh, N., & Dechkunakorn, S. (2002) · PubMed · doi:10.1043/0003-3219(2002)072 · Cited by 205 · see citing works
Luder, H. U., Leblond, C. P., & von der Mark, K. (1988) · American Journal of Anatomy · doi:10.1002/aja.1001820302 · Cited by 200 · see citing works
Functional appliance therapy accelerates and enhances condylar growth
Rabie, A. B. M., She, T. T. F., & Hägg, U. (2003) · American Journal of Orthodontics and Dentofacial Orthopedics · doi:10.1067/mod.2003.45 · Cited by 191 · see citing works
Self-citationEffects of mandibular hyperpropulsion on the prechondroblastic zone of young rat condyle
Jp, C., Petrovic, A. G., & Herrmann-Stutzmann, J. (1969) · American Journal of Orthodontics · doi:10.1016/s0002-9416(69)90174-2 · Cited by 190 · see citing works
Wu, Q., Zhang, Y., & Chen, Q. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101055200 · Cited by 175 · see citing works
Control processes in the postnatal growth of the condylar cartilage of the mandible
Petrović, A. (1975) · Medical Entomology and Zoology · Cited by 166 · see citing works
van der Eerden, B. C. J., Karperien, M., Gevers, E. F., et al. (2000) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2000.15.6.1045 · Cited by 149 · see citing works
Factors regulating mandibular condylar growth
Rabie, A. B. M., & Hägg, U. (2002) · American Journal of Orthodontics and Dentofacial Orthopedics · doi:10.1067/mod.2002.125713 · Cited by 133 · see citing works
Self-citationWilsman, N. J., Farnum, C. E., Green, E. M., et al. (1996) · Journal of Orthopaedic Research® · doi:10.1002/jor.1100140410 · Cited by 126 · see citing works
Osteogenesis in the glenoid fossa in response to mandibular advancement
Rabie, A. B. M., Zhao, Z., Shen, G., et al. (2001) · American Journal of Orthodontics and Dentofacial Orthopedics · doi:10.1067/mod.2001.112875 · Cited by 120 · see citing works
Self-citationPTHrP Regulates Chondrocyte Maturation in Condylar Cartilage
Rabie, A. B. M., Tang, G. H., Xiong, H., et al. (2003) · Journal of Dental Research · doi:10.1177/154405910308200811 · Cited by 91 · see citing works
Self-citationDouble labeling with iodo- and bromodeoxyuridine for cell kinetics studies.
Shibui, S., Hoshino, T., Vanderlaan, M., et al. (1989) · Journal of Histochemistry & Cytochemistry · doi:10.1177/37.7.2659659 · Cited by 88 · see citing works
Kinetic Studies on Epiphyseal Growth Cartilage in the Normal Mouse
Vanky, P., Brockstedt, U., Hjerpe, A., & Wikström, B. (1998) · Bone · doi:10.1016/s8756-3282(97)00286-x · Cited by 71 · see citing works
Rabie, A. B. M., Wong, L., & Tsai, M. (2003) · American Journal of Orthodontics and Dentofacial Orthopedics · doi:10.1067/mod.2003.46 · Cited by 63 · see citing works
Self-citationCellular Kinetics within the Mandibular Joint
Følke, L. E. A., & Stallard, R. E. (1967) · Acta Odontologica Scandinavica · doi:10.3109/00016356709028750 · Cited by 37 · see citing works
Stepwise advancement using fixed functional appliances: Experimental perspective
Rabie, A. B. M., Chayanupatkul, A., & Hdgg, U. (2003) · Seminars in Orthodontics · doi:10.1053/sodo.2003.34023 · Cited by 32 · see citing works
Self-citationKantomaa, T., & Pirttiniemi, P. M. (1996) · Acta Odontologica Scandinavica · doi:10.3109/00016359609006020 · Cited by 21 · see citing works
Twyman, R. M. (2018) · Garland Science eBooks · doi:10.1201/9780203345085 · Cited by 20 · see citing works
Growth Parameters in the Epiphyseal Cartilage of Brachymorphic (bm/bm) Mice
Vanky, P., Brockstedt, U., Nurminen, M., et al. (2000) · Calcified Tissue International · doi:10.1007/s002230010073 · Cited by 10 · see citing works
Enhanced osteonectin expression in the chondroid matrix of the unloaded mandibular condyle
Haas, D. W., & Holick, M. F. (1996) · Calcified Tissue International · doi:10.1007/s002239900109 · Cited by 8 · see citing works
Collagenolytic and phosphatase activity in the rat mandible after functional protrusion
Bollen, A.-M., Mäkinen, K. K., Mäkinen, P. ‐., et al. (1989) · Archives of Oral Biology · doi:10.1016/0003-9969(89)90067-8 · Cited by 8 · see citing works
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Whalen, S., Truty, R. M., & Pollard, K. S. (2016) · Nature Genetics · doi:10.1038/ng.3539 · Cited by 456 · see citing works
A heritable subset of the core rumen microbiome dictates dairy cow productivity and emissions
Wallace, R. J., Sasson, G., Garnsworthy, P. C., Tapio, I., Gregson, E., Bani, P., Huhtanen, P., Bayat, A. R., Strozzi, F., Biscarini, F., et al. (2019) · Science Advances · doi:10.1126/sciadv.aav8391 · Cited by 410 · see citing works
Sun, W., Zheng, Y., Yang, K., Zhang, Q., Shah, A. A., Wu, Z., Sun, Y., Feng, L., Chen, D., Xiao, Z., et al. (2019) · Science Advances · doi:10.1126/sciadv.aay4275 · Cited by 344 · see citing works
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Nam, A. S., Kim, K.-T., Chaligne, R., Izzo, F., Ang, C., Taylor, J., Myers, R. M., Abu-Zeinah, G., Brand, R., Omans, N. D., et al. (2019) · Nature · doi:10.1038/s41586-019-1367-0 · Cited by 333 · see citing works
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Basu, S., Kumbier, K., Brown, J. B., & Yu, B. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1711236115 · Cited by 317 · see citing works
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Mach, K. J., Kraan, C. M., Hino, M., Siders, A. R., Johnston, E. M., & Field, C. B. (2019) · Science Advances · doi:10.1126/sciadv.aax8995 · Cited by 225 · see citing works
Subramanian, A., Sidhom, E.-H., Emani, M., Vernon, K., Sahakian, N., Zhou, Y., Kost-Alimova, M., Slyper, M., Waldman, J., Dionne, D., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-13382-0 · Cited by 211 · see citing works
Losasso, C., Eckert, E. M., Mastrorilli, E., Villiger, J., Mancin, M., Patuzzi, I., Di Cesare, A., Cibin, V., Barrucci, F., Pernthaler, J., et al. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.00317 · Cited by 125 · see citing works
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Kwon, J.-M., Jeon, K.-H., Kim, H. M., Kim, M. J., Lim, S., Kim, K.-H., Song, P. S., Park, J., Choi, R. K., & Oh, B.-H. (2019) · PLOS ONE · doi:10.1371/journal.pone.0224502 · Cited by 86 · see citing works
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Hethcoat, M. G., Edwards, D. P., Carreiras, J. M. B., Bryant, R. G., França, F. M., & Quegan, S. (2019) · Remote Sensing of Environment · doi:10.1016/j.rse.2018.11.044 · Cited by 91 · see citing works
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Hou, Q., Kwasigroch, J. M., Rooman, M., & Pucci, F. (2020) · Bioinformatics · doi:10.1093/bioinformatics/btz773 · Cited by 86 · see citing works
Zou, M., Jie, Z., Cui, B., Wang, H., Feng, Q., Zou, Y., Zhang, X., Yang, H., Wang, J., Zhang, F., et al. (2020) · FEBS Open Bio · doi:10.1002/2211-5463.12744 · Cited by 28 · see citing works
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- Authors
- Tang, G. H., Rabie, A. B. M., & Hägg, U.
- Affiliations
- Prince Philip Dental Hospital (CN)
- ORCID
- Hägg, U.
- Venue
- Journal of Dental Research
- Publisher
- SAGE Publications
- Published
- 2004-05
- Volume
- 83
- Issue
- 5
- Pages
- 434-438
- ISSN
- 0022-0345 (ISSN-L)
- 1544-0591
- OpenAlex
- W2109628770
- Cited by
- 819
- References
- 28
- Citations by year
- 2026: 27 · 2025: 70 · 2024: 101 · 2023: 52 · 2022: 57 · 2021: 87 · 2020: 115 · 2019: 98 · 2018: 86 · 2017: 42 · 2016: 14 · 2015: 6 · 2014: 4 · 2013: 5 · 2012: 8
- FWCI
- 2.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Dental Research (publishedVersion)
- PubMed (publishedVersion)
- The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
- Topics
- Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
- Health Sciences › Dentistry › Orthodontics › Orthodontics and Dentofacial Orthopedics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Hedgehog Signaling Pathway Studies
- Keywords
- Indian hedgehog, mechanotransduction, mandibular condyle, condylar cartilage, chondrocyte proliferation, mesenchymal cell proliferation, cell turnover, functional orthodontic appliances, mandibular advancement, growth plate
- MeSH terms
- Animals, Bromodeoxyuridine, Cartilage, Cell Division, Female, Idoxuridine, Mandibular Condyle, Mesoderm, Random Allocation, Staining and Labeling, Trans-Activators, S Phase, Rats, Sprague-Dawley, Mandibular Advancement, Chondrocytes, Mechanotransduction, Cellular, Rats, Hedgehog Proteins
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