The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Short-term Effects of Intensive Periodontal Therapy on Serum Inflammatory Markers and Cholesterol
Abstract
Severe periodontitis has been associated with increased systemic inflammation. In a three-arm preliminary randomized trial, we investigated the impact of standard (SPT) and intensive periodontal therapy (IPT) on serum inflammatory markers and cholesterol levels. Medical and periodontal parameters, C-reactive protein (CRP), interleukin-6 (IL-6), total cholesterol, and LDL cholesterol were evaluated in 65 systemically healthy subjects suffering from severe generalized periodontitis. Two months after treatment, both SPT and IPT resulted in significant reductions in serum CRP compared with the untreated control (0.5 ± 0.2 mg/L for SPT, P = 0.030 and 0.8 ± 0.2 mg/L for IPT, P = 0.001). Similar results were observed for IL-6. Changes in inflammation were independent of age, gender, body mass index, and ethnicity, but a significant interaction between cigarette smoking and treatment regimen was found. The IPT group also showed a decrease in total and LDL cholesterol after 2 months. Analysis of these data indicates that periodontitis causes moderate systemic inflammation in systemically healthy subjects.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Inflammation and Atherosclerosis
Libby, P., Ridker, P. M., & Maseri, A. (2002) · Circulation · doi:10.1161/hc0902.104353 · Cited by 7,724
Acute-Phase Proteins and Other Systemic Responses to Inflammation
Gabay, C., & Kushner, I. (1999) · New England Journal of Medicine · doi:10.1056/nejm199902113400607 · Cited by 6,734
Pearson, T. A., Mensah, G. A., Alexander, R. W., Anderson, J. L., Cannon, R. O., Criqui, M., Fadl, Y. Y., Fortmann, S. P., Hong, Y., Myers, G. L., et al. (2003) · Circulation · doi:10.1161/01.cir.0000052939.59093.45 · Cited by 6,401
Identification of Periodontal Pathogens in Atheromatous Plaques
Haraszthy, V. I., Zambon, J. J., Trevisan, M., Zeid, M., & Genco, R. J. (2000) · Journal of Periodontology · doi:10.1902/jop.2000.71.10.1554 · Cited by 1,120
Insulin Resistance and Chronic Cardiovascular Inflammatory Syndrome
Fernández-Real, J. M., & Ricart, W. (2003) · Endocrine Reviews · doi:10.1210/er.2002-0010 · Cited by 886
Loos, B. G., Craandijk, J., Hoek, F. J., Dillen, P. M. E. W., & Van Der Velden, U. (2000) · Journal of Periodontology · doi:10.1902/jop.2000.71.10.1528 · Cited by 810
Periodontal Diseases: Epidemiology
Papapanou, P. N. (1996) · Annals of Periodontology · doi:10.1902/annals.1996.1.1.1 · Cited by 788
D’Aiuto, F., Parkar, M., Andreou, G., Suvan, J., Brett, P. M., Ready, D., & Tonetti, M. S. (2004) · Journal of Dental Research · doi:10.1177/154405910408300214 · Cited by 746
Self-citationPeriodontal Infections Contribute to Elevated Systemic C‐Reactive Protein Level
Noack, B., Genco, R. J., Trevisan, M., Grossi, S., Zambon, J. J., & De Nardin, E. (2001) · Journal of Periodontology · doi:10.1902/jop.2000.72.9.1221 · Cited by 680
Pradhan, A. D., Manson, J. E., Rossouw, J. E., Siscovick, D. S., Mouton, C. P., Rifai, N., Wallace, R. B., Jackson, R. D., Pettinger, M. B., & Ridker, P. M. (2002) · JAMA · doi:10.1001/jama.288.8.980 · Cited by 680
Cited by
Tonetti, M. S., Greenwell, H., & Kornman, K. S. (2018) · Journal of Periodontology · doi:10.1002/jper.18-0006 · Cited by 3,239
Self-citationTreatment of periodontitis and endothelial function
Tonetti, M. S., D'Aiuto, F., Nibali, L., Donald, A., Storry, C., Parkar, M., Suvan, J., Hingorani, A. D., Vallance, P., & Deanfield, J. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa063186 · Cited by 1,326
Self-citationLockhart, P. B., Bolger, A. F., Papapanou, P. N., Osinbowale, O., Trevisan, M., Levison, M. E., Taubert, K. A., Newburger, J. W., Gornik, H. L., Gewitz, M. H., et al. (2012) · Circulation · doi:10.1161/cir.0b013e31825719f3 · Cited by 1,038
Tonetti, M. S., Greenwell, H., & Kornman, K. S. (2018) · Journal of Clinical Periodontology · doi:10.1111/jcpe.12945 · Cited by 1,033
Self-citationA systematic review and meta‐analyses on C‐reactive protein in relation to periodontitis
Paraskevas, S., Huizinga, J. D., & Loos, B. G. (2008) · Journal of Clinical Periodontology · doi:10.1111/j.1600-051x.2007.01173.x · Cited by 757
Metadata
- Authors
- D’Aiuto, F., Nibali, L., Parkar, M., Suvan, J., & Tonetti, M. S.
- Venue
- Journal of Dental Research
- Publisher
- SAGE Publications
- Published
- 2005-03
- Volume
- 84
- Issue
- 3
- Pages
- 269-273
- ISSN
- 0022-0345 (ISSN-L)
- 1544-0591
- OpenAlex
- W2018526657
- Cited by
- 416
- References
- 26
- FWCI
- 23.36
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Short-term Effects of Intensive Periodontal Therapy on Serum Inflammatory Markers and Cholesterol. https://app.cochat.ai/papers/10.1177/154405910508400312
- The paper
- D’Aiuto, F., Nibali, L., Parkar, M., Suvan, J., & Tonetti, M. S. (2005). Short-term Effects of Intensive Periodontal Therapy on Serum Inflammatory Markers and Cholesterol. Journal of Dental Research. https://doi.org/10.1177/154405910508400312
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
