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Effectiveness of Intensive Inpatient Rehabilitation Treatment on Disease Progression in Parkinsonian Patients: A Randomized Controlled Trial With 1-Year Follow-up
Open accessAbstract
BACKGROUND: Rehabilitation treatments have acute beneficial effects in Parkinson's disease (PD) patients, but whether the effects persist over time is unclear. OBJECTIVE: To assess whether an intensive rehabilitation treatment (IRT) is effective in improving motor performance compared with a control group in a 12-month follow-up, to investigate whether a second cycle administered after 1 year has the same efficacy as the first treatment, and to determine whether IRT reduces the need for increasing levodopa dosage. METHODS: A total of 50 PD patients were randomly assigned to 2 groups; 25 participants had 4 weeks of inpatient physical therapy that included treadmill and stabilometric platform training. At discharge, these patients were invited to continue doing the learned exercises. After 12 months, the same treatment was repeated. The control group of 25 patients received only pharmacological treatment and was invited to practice generic physical exercise at home. The rating scales used for the clinical evaluation were the Unified Parkinson's Disease Rating Scale Sections II and III (UPDRS II and III) and total (UPDRS tot). RESULTS: The authors found that the beneficial effects of IRT persisted over time. A second rehabilitation cycle administered after 1 year was as effective as the first treatment. At the end of the study, daily medication dosage was reduced in treated patients, whereas it was significantly increased in control patients. CONCLUSION: These findings suggest that the natural worsening of symptoms associated with PD can be effectively counteracted by a properly designed IRT.
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“Both immediate (upon completion of training 4 to 12 weeks) and long-term retention (lasting several months) of gait improvements have been reported following cessation of treadmill exercise 24, 28, 29.”
From Exercise-enhanced neuroplasticity targeting motor and cognitive circuitry in Parkinson's disease (2013) · cites this paper as [29]
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“For example, the benefits of increased movement amplitude and speed in gait (stride length and velocity) appear to transfer to increased amplitude and speed of finger and foot tapping 28, 29.”
From Exercise-enhanced neuroplasticity targeting motor and cognitive circuitry in Parkinson's disease (2013) · cites this paper as [29]
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“Interestingly benefits of treadmill training, a largely lower extremity task, have also been shown to transfer to improvements in the Unified Parkinson’s Disease Rating Scale (UPDRS) motor score.”
From Exercise-enhanced neuroplasticity targeting motor and cognitive circuitry in Parkinson's disease (2013) · cites this paper as [29]
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Cites
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282
Parkinsonism: onset, progression, and mortality
Hoehn, M. M., & Yahr, M. D. (1967) · Neurology · doi:10.1212/wnl.17.5.427 · Cited by 12,107
Unified Parkinson's Disease Rating Scale
(2012) · Springer eBooks · doi:10.1007/springerreference_184495 · Cited by 3,071
Diagnostic Criteria for Parkinson Disease
Gelb, D. J., Oliver, E., & Gilman, S. (1999) · Archives of Neurology · doi:10.1001/archneur.56.1.33 · Cited by 2,822
Recent Developments in Parkinson's Disease
Hurtig, H. I. (1987) · Neurology · doi:10.1212/wnl.37.5.893 · Cited by 1,925
Goodwin, V. A., Richards, S. H., Taylor, R. S., Taylor, A. H., & Campbell, J. L. (2008) · Movement Disorders · doi:10.1002/mds.21922 · Cited by 922 · cited 1×
“The first session comprised cardiovascular warm-up activities; relaxation exercises; muscle stretching (scapular, hip flexor, hamstring, and gastrocnemius muscles); exercises to improve the range of motion of spinal, pelvic, and scapular joints; and exercises to improve the functionality of abdominal muscles and postu…”
MethodCueing training in the home improves gait-related mobility in Parkinson's disease: the RESCUE trial
Nieuwboer, A., Kwakkel, G., Rochester, L., Jones, D., van Wegen, E., Willems, A. M., Chavret, F., Hetherington, V, Baker, K., & Lim, I. (2007) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.200x.097923 · Cited by 857
The Clinically Important Difference on the Unified Parkinson's Disease Rating Scale
Shulman, L. M., Gruber-Baldini, A. L., Anderson, K. E., Fishman, P. S., Reich, S. G., & Weiner, W. J. (2010) · Archives of Neurology · doi:10.1001/archneurol.2009.295 · Cited by 494
Lim, I., van Wegen, E. E. H., de Goede, C. J. T., Deutekom, M. D. L. F., Nieuwboer, A., Willems, A., Jones, D. E., Rochester, L., & Kwakkel, G. (2005) · Clinical Rehabilitation · doi:10.1191/0269215505cr906oa · Cited by 494
Intensive voice treatment (LSVT(R)) for patients with Parkinson's disease: a 2 year follow up
Ramig, L. O. (2001) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.71.4.493 · Cited by 481
Research works printed but not linked: 3
- Deane KHO, 2001, Cochrane Database Syst Rev, CD002817
- Deane KHO, 2001, Cochrane Database Syst Rev, CD002817
- Mehrholz J, 2010, Cochrane Database Syst Rev, CD007830
Cited by
Sorted by citations
Fox, S. H., Katzenschlager, R., Lim, S., Barton, B. R., de Bie, R. M. A., Seppi, K., Coelho, M. M., & Sampaio, C. (2018) · Movement Disorders · doi:10.1002/mds.27372 · Cited by 1,009
Exercise-enhanced neuroplasticity targeting motor and cognitive circuitry in Parkinson's disease
Petzinger, G. M., Fisher, B. E., McEwen, S., Beeler, J. A., Walsh, J. P., & Jakowec, M. W. (2013) · The Lancet Neurology · doi:10.1016/s1474-4422(13)70123-6 · Cited by 798
Effects of exercise on mobility in people with Parkinson's disease
van der Kolk, N. M., & King, L. A. (2013) · Movement Disorders · doi:10.1002/mds.25658 · Cited by 244
Osborne, J. A., Botkin, R., Colón-Semenza, C., DeAngelis, T. R., Gallardo, O. G., Kosakowski, H., Martello, J. P., Pradhan, S. D., Rafferty, M. R., Readinger, J. L., et al. (2021) · Physical Therapy · doi:10.1093/ptj/pzab302 · Cited by 268
Sturkenboom, I. H. W. M., Graff, M. J. L., Hendriks, J. C. M., Veenhuizen, Y., Munneke, M., Bloem, B. R., & der Sanden, M. W. G. N. (2014) · The Lancet Neurology · doi:10.1016/s1474-4422(14)70055-9 · Cited by 246
Physiotherapy for Parkinson's disease: a comparison of techniques
Tomlinson, C. L., Herd, C. P., Clarke, C. E., Meek, C., Patel, S., Stowe, R. L., Deane, K. H., Shah, L., Sackley, C. M., Wheatley, K., et al. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002815.pub2 · Cited by 241
Physical exercise for people with Parkinson’s disease: a systematic review and network meta-analysis
Ernst, M., Folkerts, A., Gollan, R., Lieker, E., Caro-Valenzuela, J., Adams, A., Cryns, N., Monsef, I., Dresen, A., Roheger, M., et al. (2023) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd013856.pub2 · Cited by 251
Intensive Rehabilitation Treatment in Early Parkinson’s Disease
Frazzitta, G., Maestri, R., Bertotti, G., Riboldazzi, G., Boveri, N., Perini, M., Uccellini, D., Turla, M., Comi, C., Pezzoli, G., et al. (2014) · Neurorehabilitation and neural repair · doi:10.1177/1545968314542981 · Cited by 191
“These results, obtained in the early stage of disease, are similar to the ones reported in our previous study, with patients in more advanced stages.(12) Usually, the presence of some motor symptoms is the reason why patients consult a neurologist and, at that time, the diagnosis is made.”
MethodResultThe many facets of motor learning and their relevance for Parkinson's disease
Marinelli, L., Quartarone, A., Hallett, M., Frazzitta, G., & Ghilardi, M. F. (2017) · Clinical Neurophysiology · doi:10.1016/j.clinph.2017.03.042 · Cited by 168
Intensive Rehabilitation Increases BDNF Serum Levels in Parkinsonian Patients
Frazzitta, G., Maestri, R., Ghilardi, M. F., Riboldazzi, G., Perini, M., Bertotti, G., Boveri, N., Buttini, S., Lombino, F. L., Uccellini, D., et al. (2013) · Neurorehabilitation and neural repair · doi:10.1177/1545968313508474 · Cited by 160
“These results provide a further link between BDNF and the effectiveness of intensive rehabilitation treatment in the early stage of PD, and as suggested by our earlier studies with patients in Hoehn & Yahr Stage 3, also in the advanced stages of the disease.(45) Since BDNF can cross the blood–brain barrier in both dir…”
ResultShu, H., Yang, T., Yu, S., Huang, H., Jiang, L.-L., Gu, J., & Kuang, Y.-Q. (2014) · PLoS ONE · doi:10.1371/journal.pone.0100503 · Cited by 144
Ferrazzoli, D., Ortelli, P., Zivi, I., Cian, V., Urso, E., Ghilardi, M. F., Maestri, R., & Frazzitta, G. (2018) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2017-316437 · Cited by 148
Ferrazzoli, D., Ortelli, P., Madeo, G., Giladi, N., Petzinger, G. M., & Frazzitta, G. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.05.007 · Cited by 112
A Technological Review of Wearable Cueing Devices Addressing Freezing of Gait in Parkinson’s Disease
Sweeney, D., Quinlan, L. R., Browne, P., Richardson, M., Meskell, P., & ÓLaighin, G. (2019) · Sensors · doi:10.3390/s19061277 · Cited by 103
Fritz, N. E., Rao, A. K., Kegelmeyer, D. A., Kloos, A., Busse, M. E., Hartel, L. J., Carrier, J., & Quinn, L. (2017) · Journal of Huntington s Disease · doi:10.3233/jhd-170260 · Cited by 102
“…both the feasibility and efficacy of physical therapy and exercise interventions in individuals with neurodegenerative diseases highlighting the potential to not only improve daily activity performance, function, cognition and quality of life, [3–6] but also to slow disease progression [7, 8].”
BackgroundThe Beneficial Role of Intensive Exercise on Parkinson Disease Progression
Frazzitta, G., Balbi, P., Maestri, R., Bertotti, G., Boveri, N., & Pezzoli, G. (2013) · American Journal of Physical Medicine & Rehabilitation · doi:10.1097/phm.0b013e31828cd254 · Cited by 99
Goldman, J. G., Volpe, D., Ellis, T. D., Hirsch, M. A., Johnson, J. A., Wood, J., Vinagre‐Aragón, A., Biundo, R., Rocco, A. D., Kasman, G. S., et al. (2024) · Journal of Parkinson s Disease · doi:10.3233/jpd-230117 · Cited by 93
Physical exercise for people with Parkinson’s disease: a systematic review and network meta-analysis
Ernst, M., Folkerts, A., Gollan, R., Lieker, E., Caro-Valenzuela, J., Adams, A., Cryns, N., Monsef, I., Dresen, A., Roheger, M., et al. (2024) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd013856.pub3 · Cited by 94
The evidence for multidisciplinary care in Parkinson’s disease
Lidstone, S. C., Bayley, M. T., & Lang, A. E. (2020) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2020.1771184 · Cited by 73
“Other studies have shown deterioration in the benefit 6 months following intensive rehabilitation [68], arguing for a tune-up model of dosing rehabilitation, which has also been shown to be effective [69].”
BackgroundRobotic Gait Training Is not Superior to Conventional Treadmill Training in Parkinson Disease
Carda, S., Invernizzi, M., Baricich, A., Comi, C., Croquelois, A., & Cisari, C. (2012) · Neurorehabilitation and neural repair · doi:10.1177/1545968312446753 · Cited by 74
Potential Therapeutic Effects of Neurotrophins for Acute and Chronic Neurological Diseases
Cai, J., Hua, F., Yuan, L., Tang, W., Lu, J., Yu, S., Wang, X., & Hu, Y. (2014) · BioMed Research International · doi:10.1155/2014/601084 · Cited by 66
Interdisciplinary Teamwork for the Treatment of People with Parkinson’s Disease and Their Families
Giladi, N., Manor, Y., Hilel, A., & Gurevich, T. (2014) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-014-0493-1 · Cited by 63
Rose, M. H., Løkkegaard, A., Sonne‐Holm, S., & Jensen, B. R. (2012) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2012.11.025 · Cited by 64
Okada, Y., Ohtsuka, H., Kamata, N., Yamamoto, S., Sawada, M., Nakamura, J., Okamoto, M., Narita, M., Nikaido, Y., Urakami, H., et al. (2021) · Journal of Parkinson s Disease · doi:10.3233/jpd-212782 · Cited by 58
“Only one study of multidisciplinary rehabilitation mainly consisting of physiotherapy showed positive effects [12].”
BackgroundResultInfluentialMultidisciplinary intensive rehabilitation treatment improves sleep quality in Parkinson’s disease
Frazzitta, G., Maestri, R., Ferrazzoli, D., Riboldazzi, G., Bera, R., Fontanesi, C., Rossi, R. P., Pezzoli, G., & Ghilardi, M. F. (2015) · Journal of Clinical Movement Disorders · doi:10.1186/s40734-015-0020-9 · Cited by 58
Fontanesi, C., Kvint, S., Frazzitta, G., Bera, R., Ferrazzoli, D., Di Rocco, A., Rebholz, H., Friedman, E., Pezzoli, G., Quartarone, A., et al. (2016) · Neurorehabilitation and neural repair · doi:10.1177/1545968315600272 · Cited by 54
Cassimatis, C., Liu, K. P. Y., Fahey, P. P., & Bissett, M. (2016) · International Journal of Rehabilitation Research · doi:10.1097/mrr.0000000000000171 · Cited by 54
Muscle-targeted nutritional support for rehabilitation in patients with parkinsonian syndrome
Barichella, M., Cereda, E., Pinelli, G., Iorio, L., Caroli, D., Masiero, I., Ferri, V., Cassani, E., Bolliri, C., Caronni, S., et al. (2019) · Neurology · doi:10.1212/wnl.0000000000007858 · Cited by 53
Arcolin, I., Pisano, F., Delconte, C., Godi, M., Schieppati, M., Mezzani, A., Picco, D., Grasso, M., & Nardone, A. (2015) · Restorative Neurology and Neuroscience · doi:10.3233/rnn-150506 · Cited by 50
Effort training in Parkinson's disease: A systematic review
Tambosco, L., Percebois-Macadré, L., Rapin, A., Nicomette-Bardel, J., & Boyer, F. C. (2014) · Annals of Physical and Rehabilitation Medicine · doi:10.1016/j.rehab.2014.01.003 · Cited by 56
The continuum between neurodegeneration, brain plasticity, and movement: a critical appraisal
Schirinzi, T., Canevelli, M., Suppa, A., Bologna, M., & Marsili, L. (2020) · Reviews in the Neurosciences · doi:10.1515/revneuro-2020-0011 · Cited by 50
Quinn, L., & Morgan, D. W. (2017) · Neurology Report · doi:10.1097/npt.0000000000000166 · Cited by 46
Forte, R., Tocci, N., & VITO, G. D. (2021) · Brain Sciences · doi:10.3390/brainsci11060685 · Cited by 43
Cabreira, V., Soares-da-Silva, P., & Massano, J. (2019) · Drugs · doi:10.1007/s40265-019-01098-w · Cited by 42
Severe Constipation in Parkinson's Disease and in Parkinsonisms: Prevalence and Affecting Factors
Frazzitta, G., Ferrazzoli, D., Folini, A., Palamara, G., & Maestri, R. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00621 · Cited by 42
Ferrazzoli, D., Carter, A., Üstün, F. S., Palamara, G., Ortelli, P., Maestri, R., Yücel, M., & Frazzitta, G. (2016) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2016.00121 · Cited by 40
Type, Timing, Frequency, and Durability of Outcome of Physical Therapy for Parkinson Disease
Hayek, M. E., Lopes, J. L. M. L. J., LeLaurin, J. H., Gregory, M. E., Nehme, A. M. A., McCall-Junkin, P., Au, K. L. K., Okun, M. S., & Salloum, R. G. (2023) · JAMA Network Open · doi:10.1001/jamanetworkopen.2023.24860 · Cited by 35
Therapeutic effects of intensive inpatient rehabilitation in advanced Parkinson's disease
Kaseda, Y., Ikeda, J., Sugihara, K., Yamawaki, T., Kohriyama, T., & Matsumoto, M. (2016) · Neurology and Clinical Neuroscience · doi:10.1111/ncn3.12088 · Cited by 31
Yao, B., Ye, Z., Lou, X. Y., Yan, Q., Han, Z., Dong, Y., Qu, S., & Wang, Z. (2022) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.2c01630 · Cited by 29
Occupational Therapy Practice Guidelines for People With Parkinson’s Disease
Wood, J., Henderson, W. L., & Foster, E. R. (2022) · American Journal of Occupational Therapy · doi:10.5014/ajot.2022.763001 · Cited by 28
Paker, N., Buğdaycı, D. S., Gökşenoğlu, G., Şen, A., & Kesiktaş, F. N. (2013) · Neurorehabilitation · doi:10.3233/nre-130962 · Cited by 28
“In a recent study, it is concluded that warm-up, stretching, relaxation, range of motion exercises combined with gait and balance training and occupational therapy for 4 weeks inpatient rehabilitation program, could prevent the impairment in the motor symptoms and the necessity (requirement) of increase in drug dosage…”
BackgroundFang, B., Chen, K., Jin, Z., Gao, L., Lin, Q., Zhen, Q., Liu, C., Wang, P., Liu, Y.-H., Wang, R.-D., et al. (2020) · Neural Regeneration Research · doi:10.4103/1673-5374.301029 · Cited by 27
Treatment of Motor Symptoms of Parkinson’s Disease
Marsili, L., Bologna, M., Chen, L. Y., & Espay, A. J. (2025) · Neurologic Clinics · doi:10.1016/j.ncl.2024.12.010 · Cited by 26
Living with Parkinson's—past, present and future: a qualitative study of the subjective perspective
Maffoni, M., Pierobon, A., Frazzitta, G., Callegari, S., & Giardini, A. (2019) · British Journal of Nursing · doi:10.12968/bjon.2019.28.12.764 · Cited by 23
Tai Chi for Patients with Parkinson's Disease
Corcos, D. M., Comella, C. L., & Goetz, C. G. (2012) · New England Journal of Medicine · doi:10.1056/nejmc1202921 · Cited by 23
Cognition and Activity of Daily Living Function in people with Parkinson’s disease
Bode, M., Kalbe, E., & Liepelt‐Scarfone, I. (2024) · Journal of Neural Transmission · doi:10.1007/s00702-024-02796-w · Cited by 27
Doucet, B. M. M., Franc, I., & Hunter, E. G. (2021) · American Journal of Occupational Therapy · doi:10.5014/ajot.2021.048314 · Cited by 22
Hackney, M. E., Bay, A. A., Jackson, J. M., Nocera, J. R., Krishnamurthy, V., Crosson, B., Evatt, M. L., Langley, J. A., Cui, X., McKay, J. L., et al. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.00943 · Cited by 22
“Moreover, 6-month and 1-year follow-up scores on the UPDRSIII (clinical motor examination) were better than the admission scores although the therapy had been discontinued several months prior (9).”
BackgroundFrazzitta, G., Bossio, F., Maestri, R., Palamara, G., Bera, R., & Ferrazzoli, D. (2015) · BioMed Research International · doi:10.1155/2015/878472 · Cited by 21
Ortelli, P., Ferrazzoli, D., Bera, R., Caremani, L., Giladi, N., Maestri, R., & Frazzitta, G. (2018) · Journal of Parkinson s Disease · doi:10.3233/jpd-171247 · Cited by 21
Frazzitta, G., Bertotti, G., Morelli, M., Riboldazzi, G., Pelosin, E., Balbi, P., Boveri, N., Comi, C., Turla, M., Leva, S., et al. (2012) · Neurorehabilitation · doi:10.3233/nre-2012-0758 · Cited by 22
Multi-Modal Rehabilitation Therapy in Parkinson's Disease and Related Disorders
Saluja, A., Goyal, V., & Dhamija, R. K. (2022) · Annals of Indian Academy of Neurology · doi:10.4103/aian.aian_164_22 · Cited by 25
Cui, W., Li, D., Yue, L., & Xie, J. (2023) · Journal of Neurology · doi:10.1007/s00415-023-11887-9 · Cited by 27
“Comprehensive rehabilitation approaches such as intensive rehabilitation therapy and multimodal rehabilitation therapy [74, 75] that combine pharmacological and non-pharmacological treatments are also crucial.”
BackgroundFocused and Sustained Attention Is Modified by a Goal-Based Rehabilitation in Parkinsonian Patients
Ferrazzoli, D., Ortelli, P., Maestri, R., Bera, R., Gargantini, R., Palamara, G., Zarucchi, M., Giladi, N., & Frazzitta, G. (2017) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2017.00056 · Cited by 19
Meloni, M., Saibene, F. L., Tella, S. D., Cesare, M. D., Borgnis, F., Nemni, R., & Baglio, F. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.626041 · Cited by 18
Does Cognitive Impairment Affect Rehabilitation Outcome in Parkinson’s Disease?
Ferrazzoli, D., Ortelli, P., Maestri, R., Bera, R., Giladi, N., Ghilardi, M. F., Pezzoli, G., & Frazzitta, G. (2016) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2016.00192 · Cited by 18
Berardi, A., Napoli, G. D., Ernesto, M., Fabbrini, G., Conte, A., Ferrazzano, G., Viselli, F., & Galeoto, G. (2022) · Healthcare · doi:10.3390/healthcare10030561 · Cited by 23
Exercícios terapêuticos domiciliares na doença de Parkinson: uma revisão integrativa
Gondim, I. T. G. D. O., Lins, C. C. D. S. A., & Coriolano, M. D. G. W. D. S. (2016) · Revista Brasileira de Geriatria e Gerontologia · doi:10.1590/1809-98232016019.150040 · Cited by 17
Asymmetric Dopaminergic Degeneration and Attentional Resources in Parkinson’s Disease
Ortelli, P., Ferrazzoli, D., Zarucchi, M., Maestri, R., & Frazzitta, G. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00972 · Cited by 17
Meng, L., Wang, D., Shi, Y., Li, Z., Zhang, J., Lu, H., Zhu, X., & Ming, D. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1252610 · Cited by 16
“The intervention has also been regarded as a complementary option for PD management (Frazzitta et al., 2011; Bloem et al., 2015).”
BackgroundLowry, K. A., Woods, T., Malone, A., Krajek, A. C., Smiley‐Oyen, A. L., & Swearingen, J. V. (2020) · Physiotherapy Theory and Practice · doi:10.1080/09593985.2020.1774948 · Cited by 15
Cohen, M., Herman, T., Ganz, N., Badichi, I., Gurevich, T., & Hausdorff, J. M. (2023) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph20053806 · Cited by 14
“These positive benefits in the clinic are in line with previously reported studies [1,3,5].”
BackgroundResultRate of motor progression in Parkinson’s disease: a systematic review and meta-analysis
Pauwels, A., Phan, A. L. G., Ding, C., Phan, T. G., & Kempster, P. A. (2024) · Frontiers in Neurology · doi:10.3389/fneur.2024.1452741 · Cited by 14
Zarucchi, A., Vismara, L., Frazzitta, G., Mauro, A., Priano, L., Maestri, R., Bergna, A., & Tarantino, A. G. (2020) · Neurorehabilitation · doi:10.3233/nre-203068 · Cited by 14
Effectiveness of an intensive rehabilitation treatment on different Parkinson's disease subtypes
Frazzitta, G., Abbruzzese, G., Bertotti, G., Boveri, N., Pezzoli, G., & Maestri, R. (2013) · Neurorehabilitation · doi:10.3233/nre-130959 · Cited by 13
Occupational Therapy for Parkinsonian Patients: A Retrospective Study
Franciotta, M., Maestri, R., Ortelli, P., Ferrazzoli, D., Mastalli, F., & Frazzitta, G. (2019) · Parkinson s Disease · doi:10.1155/2019/4561830 · Cited by 14
Ferrazzoli, D., Ortelli, P., Riboldazzi, G., Maestri, R., & Frazzitta, G. (2018) · Journal of Neurology · doi:10.1007/s00415-018-8792-0 · Cited by 12
Rehabilitation in movement disorders: From basic mechanisms to clinical strategies
Ferrazzoli, D., Ortelli, P., Iansek, R., & Volpe, D. (2022) · Handbook of clinical neurology · doi:10.1016/b978-0-12-819410-2.00019-9 · Cited by 12
Frazzitta, G., Morelli, M., Bertotti, G., Felicetti, G., Pezzoli, G., & Maestri, R. (2012) · Parkinson s Disease · doi:10.1155/2012/910454 · Cited by 13
Ziegler, K., Messner, M., Paulig, M., Starrost, K., Reuschenbach, B., Fietzek, U. M., & Ceballos-Baumann, A. (2022) · Movement Disorders Clinical Practice · doi:10.1002/mdc3.13578 · Cited by 11
Goudy, L., Rigby, B. R., Silliman-French, L. M., & Becker, K. A. (2019) · Adapted Physical Activity Quarterly · doi:10.1123/apaq.2019-0008 · Cited by 11
Physical Exercise as Intervention in Parkinsonism
Archer, T., & Fredriksson, A. (2014) · Springer eBooks · doi:10.1007/978-1-4614-5836-4_105 · Cited by 10
Quality of life predicts rehabilitation prognosis in Parkinson's disease patients
Meng, D., Jin, Z., Chen, K., Yu, X., Wang, Y., Du, W., Wei, J., Xi, J., & Fang, B. (2022) · Brain and Behavior · doi:10.1002/brb3.2579 · Cited by 10
Zhang, H., Hou, T.-T., Jin, Z., Zhang, T., Wang, Y.-H., Cheng, Z.-H., Liu, Y.-H., Fang, J., Yan, H., Zhen, Y., et al. (2024) · Trials · doi:10.1186/s13063-024-08045-5 · Cited by 10
Effect of Treadmill Walking on Leg Muscle Activation in Parkinson's Disease
Bello, O., Márquez, G., & Fernández‐del‐Olmo, M. (2018) · Rejuvenation Research · doi:10.1089/rej.2018.2084 · Cited by 10
Steendam-Oldekamp, E., & van Laar, T. (2024) · Journal of Parkinson s Disease · doi:10.3233/jpd-230271 · Cited by 9
“…including the German PD-Multimodel Complex Treatment (MCT) model [14–17], the Italian Multidisciplinary Intensive Rehabilitation Treatment concept [18–22], the Dutch inpatient rehabilitation program at Parkinson Expertise Centers (Point for Parkinson), and the Hamburg Parkinson Day-Clinic,…”
BackgroundScherbaum, R., Höllerhage, M., Klebe, S., Riederer, P., Müller, T., Schröter, N., Weise, D., Woitalla, D., & Tönges, L. (2025) · Journal of Neural Transmission · doi:10.1007/s00702-025-02963-7 · Cited by 9
“In general, inpatient multidisciplinary therapies improved motor symptoms, everyday functions, and quality of life in four international randomized controlled trials (Monticone et al. 2015; Ferrazzoli et al. 2018; Marumoto et al. 2019; Frazzitta et al. 2012).”
An equation to calculate UPDRS motor severity for online and rural assessments of Parkinson's
Sangarapillai, K., Norman, B. M., & Almeida, Q. J. (2021) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2021.11.028 · Cited by 9
Effects of rTMS and intensive rehabilitation in Parkinson’s Disease on learning and retention
Marchesi, G., Albanese, G. A., Ferrazzoli, D., George, S., Ricci, S., Tatti, E., Rocco, A. D., Quartarone, A., Frazzitta, G., & Ghilardi, M. F. (2019) · International Conference on Rehabilitation Robotics · doi:10.1109/icorr.2019.8779471 · Cited by 8
Cosentino, G., Todisco, M., & Blandini, F. (2022) · Handbook of clinical neurology · doi:10.1016/b978-0-12-819410-2.00010-2 · Cited by 9
Shih, H.-J. S., Quinn, L., Morgan-Jones, P., Long, K., Schreier, A. R., & Friel, C. P. (2023) · Neurodegenerative Disease Management · doi:10.2217/nmt-2022-0028 · Cited by 9
Multidisziplinäre Komplextherapie der Parkinson-Krankheit
Scherbaum, R., & Tönges, L. (2024) · Der Nervenarzt · doi:10.1007/s00115-024-01666-w · Cited by 7
Baldassarre, I., Rotondo, R., Piccardi, L., Leonardi, L., Lanni, D., Gaglione, M., Stocchi, F., Fini, M., Goffredo, M., Padua, E., et al. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13133884 · Cited by 9
“…that a multidisciplinary rehabilitation program (physical therapy, occupational therapy, and speech therapy) significatively improved cognitive performance in the early–moderate PD stages [20], and it appears to improve the QoL in patients with PD in both the short-term and long-term [17,18,20].”
BackgroundJi, X., Lu, D., Yang, Q., Xiao, L., Wang, J., & Wang, G. (2022) · Computational and Mathematical Methods in Medicine · doi:10.1155/2022/3393191 · Cited by 7
“Although the multidisciplinary therapy included in the literature mainly consisted of physical therapy, it also had some visual and auditory guidance training to improve gait and posture [24, 26].”
MethodResultCardini, R., Gervasoni, E., Giannoni‐Luza, S., Cavalca, A., Piva, A., Cattaneo, D., Pelosin, E., Bocci, T., Marceglia, S. R. F., Priori, A., et al. (2026) · npj Parkinson s Disease · doi:10.1038/s41531-026-01326-7 · Cited by 5
Neuropsychiatric Treatments for Parkinson's Disease: Nonpharmacological Approaches
Mathur, N., Bhatt, H., & Lidstone, S. C. (2022) · Seminars in Neurology · doi:10.1055/s-0041-1742266 · Cited by 5
Disexecutive Functions and Depression in Patients with Parkinson Disease
Pierobon, A., Giardini, A., Maestri, R., Farina, C., Callegari, S., Torlaschi, V., Bertotti, G., Majani, G., & Frazzitta, G. (2014) · American Journal of Physical Medicine & Rehabilitation · doi:10.1097/phm.0000000000000092 · Cited by 5
Specialized Allied Health Care for Parkinson’s Disease: State of the Art and Future Directions
Sturkenboom, I. H. W. M., Talebi, A. H., Maas, B. R., de Vries, N. M., Darweesh, S. K. L., & Kalf, J. G. (2024) · Journal of Parkinson s Disease · doi:10.3233/jpd-230307 · Cited by 4
“67 , 68 , 70 , 71 , 73 , 74 Thus, three trials showed no improvement.”
Exercise Training and Rehabilitation of the Brain in Parkinson´s Disease
Al-Jarrah, M. D. (2013) · Clinical Medicine Research · doi:10.11648/j.cmr.20130202.12 · Cited by 4
Ortelli, P., Maestri, R., Zarucchi, M., Cian, V., Urso, E., Giacomello, F., Ferrazzoli, D., & Frazzitta, G. (2017) · Journal of Clinical Movement Disorders · doi:10.1186/s40734-017-0059-x · Cited by 5
Harris, C., Ignatowicz, A., & Lasserson, D. S. (2019) · International Journal of Clinical Practice · doi:10.1111/ijcp.13462 · Cited by 4
A rehabilitation system for upper limbs in Adult Patients using video games
Chacha, F., Bermeo, J. P., & Huerta, M. (2017) · IEEE Central America and Panama Convention (CONCAPAN) · doi:10.1109/concapan.2017.8278510 · Cited by 3
Shin, S., & Lee, Y. (2026) · Frontiers in Medicine · doi:10.3389/fmed.2026.1546672 · Cited by 2
Hasani, M., Sidiropoulou, I., Christakou, Α., Marazioti, A., Konitsiotis, S., & Lyros, E. (2026) · NeuroSci · doi:10.3390/neurosci7020042 · Cited by 2
Readinger, J. L., Eastlack, M., von Nieda, K., Kantak, S. S., & Sawyer, K. L. (2021) · Physiotherapy Theory and Practice · doi:10.1080/09593985.2021.1952667 · Cited by 2
“…of life than usual care or moderate to low challenge exercises (Allen, Sherrington, Paul, and Canning, 2011; Conradsson et al., 2015; Ebersbach et al., 2010; Fisher et al., 2008; Frazzitta et al., 2012; Landers et al., 2019a; Schenkman et al., 2018; Sparrow et al., 2016; Van der Kolk et al., 2019).”
BackgroundResultMoondra, P., Rubin, L., McCrossin, M., Persaud, A. D., Rocco, A. D., Quartarone, A., & Ghilardi, M. F. (2024) · Biomedicines · doi:10.3390/biomedicines12081658 · Cited by 2
“These results are the first ones coming from a U.S. center and provide an initial validation in the U.S. of previous European findings, mostly from randomized controlled trials and other studies [16–23,26 ,27 ].”
BackgroundResultBae, S., Hong, I., & Baek, M. S. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1428972 · Cited by 2
Multimodale Therapieangebote bei der Parkinson-Krankheit
Ziegler, K., Fietzek, U. M., & Ceballos-Baumann, A. (2025) · Nervenheilkunde · doi:10.1055/a-2449-1461 · Cited by 2
Rehabilitation and Parkinson’s Disease: A Happy Marriage!
Frazzitta, G. (2013) · International Journal of Physical Medicine & Rehabilitation · doi:10.4172/2329-9096.1000109 · Cited by 2
Evaluation and delivery of ambulatory rehabilitation for people with Parkinson's disease
Goodwin, L. S., & Lan, L. (2014) · Reviews in Clinical Gerontology · doi:10.1017/s0959259813000257 · Cited by 3
Metadata
- Authors
- Frazzitta, G., Bertotti, G., Riboldazzi, G., Turla, M., Uccellini, D., Boveri, N., Guaglio, G., Perini, M., Comi, C., Balbi, P., & Maestri, R.
- Affiliations
- Scientific Institute of Montescano, S. Maugeri Foundation IRCCS, Montescano, Italy
- “Le Terrazze” Hospital, Cunardo, Italy
- Valle Camonica Hospital, Esine, Italy
- Tradate Hospital, Tradate, Italy
- Azienda Ospedaliera Sant’Antonio Abate di Gallarate (IT)
- Università degli Studi del Piemonte Orientale “Amedeo Avogadro” (IT)
- Venue
- Neurorehabilitation and neural repair
- Publisher
- SAGE Publications
- Published
- 2011-08-15
- Volume
- 26
- Issue
- 2
- Pages
- 144-150
- ISSN
- 0888-4390 (ISSN-L)
- 1545-9683
- 1552-6844
- OpenAlex
- W2017404241
- Cited by
- 116
- References
- 37
- Citations by year
- 2026: 6 · 2025: 4 · 2024: 16 · 2023: 6 · 2022: 10 · 2021: 7 · 2020: 8 · 2019: 10 · 2018: 7 · 2017: 8 · 2016: 5 · 2015: 4 · 2014: 10 · 2013: 9 · 2012: 6
- FWCI
- 5.07
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Neurorehabilitation and neural repair (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Balance, Gait, and Falls Prevention
- Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
- Keywords
- Parkinson's disease, motor performance, treadmill training, home-based exercise, levodopa dosage, disease progression, long-term treatment efficacy
- MeSH terms
- Acoustic Stimulation, Activities of Daily Living, Aged, Antiparkinson Agents, Critical Care, Cues, Exercise Test, Female, Follow-Up Studies, Humans, Levodopa, Male, Parkinson Disease, Photic Stimulation, Pilot Projects, Treatment Outcome, Disease Progression, Statistics, Nonparametric, Physical Therapy Modalities
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