The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Effectiveness of Intensive Inpatient Rehabilitation Treatment on Disease Progression in Parkinsonian Patients: A Randomized Controlled Trial With 1-Year Follow-up
Open accessAbstract
BACKGROUND: Rehabilitation treatments have acute beneficial effects in Parkinson's disease (PD) patients, but whether the effects persist over time is unclear. OBJECTIVE: To assess whether an intensive rehabilitation treatment (IRT) is effective in improving motor performance compared with a control group in a 12-month follow-up, to investigate whether a second cycle administered after 1 year has the same efficacy as the first treatment, and to determine whether IRT reduces the need for increasing levodopa dosage. METHODS: A total of 50 PD patients were randomly assigned to 2 groups; 25 participants had 4 weeks of inpatient physical therapy that included treadmill and stabilometric platform training. At discharge, these patients were invited to continue doing the learned exercises. After 12 months, the same treatment was repeated. The control group of 25 patients received only pharmacological treatment and was invited to practice generic physical exercise at home. The rating scales used for the clinical evaluation were the Unified Parkinson's Disease Rating Scale Sections II and III (UPDRS II and III) and total (UPDRS tot). RESULTS: The authors found that the beneficial effects of IRT persisted over time. A second rehabilitation cycle administered after 1 year was as effective as the first treatment. At the end of the study, daily medication dosage was reduced in treated patients, whereas it was significantly increased in control patients. CONCLUSION: These findings suggest that the natural worsening of symptoms associated with PD can be effectively counteracted by a properly designed IRT.
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“Both immediate (upon completion of training 4 to 12 weeks) and long-term retention (lasting several months) of gait improvements have been reported following cessation of treadmill exercise 24, 28, 29.”
From Exercise-enhanced neuroplasticity targeting motor and cognitive circuitry in Parkinson's disease (2013) · cites this paper as [29]
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“For example, the benefits of increased movement amplitude and speed in gait (stride length and velocity) appear to transfer to increased amplitude and speed of finger and foot tapping 28, 29.”
From Exercise-enhanced neuroplasticity targeting motor and cognitive circuitry in Parkinson's disease (2013) · cites this paper as [29]
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“Interestingly benefits of treadmill training, a largely lower extremity task, have also been shown to transfer to improvements in the Unified Parkinson’s Disease Rating Scale (UPDRS) motor score.”
From Exercise-enhanced neuroplasticity targeting motor and cognitive circuitry in Parkinson's disease (2013) · cites this paper as [29]
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Metadata
- Authors
- Frazzitta, G., Bertotti, G., Riboldazzi, G., Turla, M., Uccellini, D., Boveri, N., Guaglio, G., Perini, M., Comi, C., Balbi, P., & Maestri, R.
- Affiliations
- Scientific Institute of Montescano, S. Maugeri Foundation IRCCS, Montescano, Italy
- “Le Terrazze” Hospital, Cunardo, Italy
- Valle Camonica Hospital, Esine, Italy
- Tradate Hospital, Tradate, Italy
- Azienda Ospedaliera Sant’Antonio Abate di Gallarate (IT)
- Università degli Studi del Piemonte Orientale “Amedeo Avogadro” (IT)
- Venue
- Neurorehabilitation and neural repair
- Publisher
- SAGE Publications
- Published
- 2011-08-15
- Volume
- 26
- Issue
- 2
- Pages
- 144-150
- ISSN
- 0888-4390 (ISSN-L)
- 1545-9683
- 1552-6844
- OpenAlex
- W2017404241
- Cited by
- 116
- References
- 37
- Citations by year
- 2026: 6 · 2025: 4 · 2024: 16 · 2023: 6 · 2022: 10 · 2021: 7 · 2020: 8 · 2019: 10 · 2018: 7 · 2017: 8 · 2016: 5 · 2015: 4 · 2014: 10 · 2013: 9 · 2012: 6
- FWCI
- 5.07
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Neurorehabilitation and neural repair (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Balance, Gait, and Falls Prevention
- Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
- Keywords
- Parkinson's disease, motor performance, treadmill training, home-based exercise, levodopa dosage, disease progression, long-term treatment efficacy
- MeSH terms
- Acoustic Stimulation, Activities of Daily Living, Aged, Antiparkinson Agents, Critical Care, Cues, Exercise Test, Female, Follow-Up Studies, Humans, Levodopa, Male, Parkinson Disease, Photic Stimulation, Pilot Projects, Treatment Outcome, Disease Progression, Statistics, Nonparametric, Physical Therapy Modalities
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