The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Effectiveness of Intensive Inpatient Rehabilitation Treatment on Disease Progression in Parkinsonian Patients: A Randomized Controlled Trial With 1-Year Follow-up
Open accessAbstract
BACKGROUND: Rehabilitation treatments have acute beneficial effects in Parkinson's disease (PD) patients, but whether the effects persist over time is unclear. OBJECTIVE: To assess whether an intensive rehabilitation treatment (IRT) is effective in improving motor performance compared with a control group in a 12-month follow-up, to investigate whether a second cycle administered after 1 year has the same efficacy as the first treatment, and to determine whether IRT reduces the need for increasing levodopa dosage. METHODS: A total of 50 PD patients were randomly assigned to 2 groups; 25 participants had 4 weeks of inpatient physical therapy that included treadmill and stabilometric platform training. At discharge, these patients were invited to continue doing the learned exercises. After 12 months, the same treatment was repeated. The control group of 25 patients received only pharmacological treatment and was invited to practice generic physical exercise at home. The rating scales used for the clinical evaluation were the Unified Parkinson's Disease Rating Scale Sections II and III (UPDRS II and III) and total (UPDRS tot). RESULTS: The authors found that the beneficial effects of IRT persisted over time. A second rehabilitation cycle administered after 1 year was as effective as the first treatment. At the end of the study, daily medication dosage was reduced in treated patients, whereas it was significantly increased in control patients. CONCLUSION: These findings suggest that the natural worsening of symptoms associated with PD can be effectively counteracted by a properly designed IRT.
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“Both immediate (upon completion of training 4 to 12 weeks) and long-term retention (lasting several months) of gait improvements have been reported following cessation of treadmill exercise 24, 28, 29.”
From Exercise-enhanced neuroplasticity targeting motor and cognitive circuitry in Parkinson's disease (2013) · cites this paper as [29]
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“For example, the benefits of increased movement amplitude and speed in gait (stride length and velocity) appear to transfer to increased amplitude and speed of finger and foot tapping 28, 29.”
From Exercise-enhanced neuroplasticity targeting motor and cognitive circuitry in Parkinson's disease (2013) · cites this paper as [29]
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“Interestingly benefits of treadmill training, a largely lower extremity task, have also been shown to transfer to improvements in the Unified Parkinson’s Disease Rating Scale (UPDRS) motor score.”
From Exercise-enhanced neuroplasticity targeting motor and cognitive circuitry in Parkinson's disease (2013) · cites this paper as [29]
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Citations
Cites
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“The first session comprised cardiovascular warm-up activities; relaxation exercises; muscle stretching (scapular, hip flexor, hamstring, and gastrocnemius muscles); exercises to improve the range of motion of spinal, pelvic, and scapular joints; and exercises to improve the functionality of abdominal muscles and postu…”
MethodCueing training in the home improves gait-related mobility in Parkinson's disease: the RESCUE trial
Nieuwboer, A., Kwakkel, G., Rochester, L., Jones, D., van Wegen, E., Willems, A. M., Chavret, F., Hetherington, V, Baker, K., & Lim, I. (2007) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.200x.097923 · Cited by 857
The Clinically Important Difference on the Unified Parkinson's Disease Rating Scale
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Intensive voice treatment (LSVT(R)) for patients with Parkinson's disease: a 2 year follow up
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Cited by
Sorted by citations
Items 101–116 of 116
Pierobon, A., Giardini, A., Callegari, S., Farina, C., Torlaschi, V., Bernini, S., Frazzitta, G., & Majani, G. (2013) · PubMed · Cited by 2
Friedrich, I., Gutschow, L., Weise, D., Rumpf, J.-J., Classen, J. F., & Fricke, C. (2026) · Journal of Neurology · doi:10.1007/s00415-026-13697-1 · Cited by 1
Dyskinesia in Parkinson's Disease Therapy
Carta, A. R., Giuffrida, A., & Fisone, G. (2012) · Parkinson s Disease · doi:10.1155/2012/639080 · Cited by 1
Berli, B. K., Dalen, I., Oldren, B., & Rundmo, T. (2019) · International Journal of Physical Medicine & Rehabilitation · Cited by 1
Ghilardi, M. F., Quartarone, A., Rocco, A. D., Calabrò, R. S., Luo, S., Liu, H., Norcini, M., Canesi, M., Cian, V., Zarucchi, M., et al. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13102999 · Cited by 2
“The present findings are in line with previous results that showed an improvement in both motor function (including TUG evaluation) and HRQL in patients that underwent intensive rehabilitation at the IR centers [11,24,25].”
ResultA Novel Concept of the Rehabilitation Training Coach Robot for Patients with Disability
Han, S. H., Kim, H., & Choi, H. (2017) · IEEE International Conference on Mobile Data Management (MDM) · doi:10.1109/mdm.2017.65
“The rehabilitation treatment plays important role in helping patients recover from various physical or neurological diseases, such as multiple sclerosis [1], [2], Parkinsons disease [3], [4] and stroke [5].”
BackgroundClarkin, C. M. (2020) · Digital Commons - URI (University of Rhode Island) · doi:10.23860/diss-clarkin-christine-2020 · Cited by 1
Rehabilitative Movement Approaches and Dance Interventions in Parkinson’s Disease
Fontanesi, C. (2020) · CUNY Academic Works (City University of New York)
Kaseda, Y., Ikeda, J., Sugihara, K., Ishii, Y., & Kohriyama, T. (2017) · リハビリテーション医学 : 日本リハビリテーション医学会誌 · doi:10.2490/jjrmc.54.455
Intérêt du réentraînement à l’effort pour les patients parkinsoniens
Prestini, M. (2024) · Soins · doi:10.1016/j.soin.2023.12.025
Gasser, A., & McIntyre, M. (2024) · Physical & Occupational Therapy In Geriatrics · doi:10.1080/02703181.2024.2324334
Tschentscher, V., Oppermann, J., Welzel, J., Geritz, J., Gold, R., Muhlack, S., Hansen, C., Maetzler, W., Tönges, L., & Scherbaum, R. (2025) · Neurological Research and Practice · doi:10.1186/s42466-025-00409-9
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Zhang, H., Hou, T., Jin, Z.-H., Zhang, T., Wang, Y.-H., Cheng, Z., Liu, Y.-H., Fang, J.-P., 闫红娇, Zhen, Y., et al. (2024) · Figshare · doi:10.6084/m9.figshare.25449179
Boer, A. B. D., Olson, H. S. N., Kusar, L., Kubes, L. H., Ashe, J., Lewis, S. M., McGovern, R. A., & Sim, A. H. (2026) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2026.01.001
Improvement in quality of life in Parkinson's disease after an inpatient rehabilitation program
de Almeida, P. N. S., Souza, N., Macedo, R. C., & Oliveira, J. (2026) · Heliyon · doi:10.1016/j.heliyon.2026.e45534
Metadata
- Authors
- Frazzitta, G., Bertotti, G., Riboldazzi, G., Turla, M., Uccellini, D., Boveri, N., Guaglio, G., Perini, M., Comi, C., Balbi, P., & Maestri, R.
- Affiliations
- Scientific Institute of Montescano, S. Maugeri Foundation IRCCS, Montescano, Italy
- “Le Terrazze” Hospital, Cunardo, Italy
- Valle Camonica Hospital, Esine, Italy
- Tradate Hospital, Tradate, Italy
- Azienda Ospedaliera Sant’Antonio Abate di Gallarate (IT)
- Università degli Studi del Piemonte Orientale “Amedeo Avogadro” (IT)
- Venue
- Neurorehabilitation and neural repair
- Publisher
- SAGE Publications
- Published
- 2011-08-15
- Volume
- 26
- Issue
- 2
- Pages
- 144-150
- ISSN
- 0888-4390 (ISSN-L)
- 1545-9683
- 1552-6844
- OpenAlex
- W2017404241
- Cited by
- 116
- References
- 37
- Citations by year
- 2026: 6 · 2025: 4 · 2024: 16 · 2023: 6 · 2022: 10 · 2021: 7 · 2020: 8 · 2019: 10 · 2018: 7 · 2017: 8 · 2016: 5 · 2015: 4 · 2014: 10 · 2013: 9 · 2012: 6
- FWCI
- 5.07
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Neurorehabilitation and neural repair (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Balance, Gait, and Falls Prevention
- Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
- Keywords
- Parkinson's disease, motor performance, treadmill training, home-based exercise, levodopa dosage, disease progression, long-term treatment efficacy
- MeSH terms
- Acoustic Stimulation, Activities of Daily Living, Aged, Antiparkinson Agents, Critical Care, Cues, Exercise Test, Female, Follow-Up Studies, Humans, Levodopa, Male, Parkinson Disease, Photic Stimulation, Pilot Projects, Treatment Outcome, Disease Progression, Statistics, Nonparametric, Physical Therapy Modalities
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