The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Responsiveness and Clinically Meaningful Improvement, According to Disability Level, of Five Walking Measures After Rehabilitation in Multiple Sclerosis: A European Multicenter Study
Abstract
Background Evaluation of treatment effects on walking requires appropriate and responsive outcome measures. Objectives To determine responsiveness of 5 walking measures and provide reference values for clinically meaningful improvements, according to disability level, in persons with multiple sclerosis (pwMS). Methods Walking tests were measured pre- and postrehabilitation in 290 pwMS from 17 European centers. Combined anchor- and distribution-based methods determined responsiveness of objective short and long walking capacity tests (Timed 25-Foot Walk [T25FW] and 2- and 6-Minute Walk Tests [2MWT and 6MWT] and of the patient-reported Multiple Sclerosis Walking Scale-12 [MSWS-12]). A global rating of change scale, from patients' and therapists' perspective, was used as external criteria to determine the area under the receiver operating characteristic curve (AUC), minimally important change (MIC), and smallest real change (SRC). Patients were stratified into disability subgroups (Expanded Disability Status Scale score ≤4 [n = 98], >4 [n = 186]). Results MSWS-12, 2MWT, and 6MWT were more responsive (AUC 0.64-0.73) than T25FW (0.50-0.63), especially in moderate to severely disabled pwMS. Clinically meaningful changes (MICs) from patient and therapist perspective were -10.4 and -11.4 for MSWS-12 (P Conclusions Long walking tests and patient-reported MSWS-12 were more appropriate than short walking tests in detecting clinically meaningful improvement after physical rehabilitation,…
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The twelve item Multiple Sclerosis Walking Scale (MSWS-12) (30), a self-reported questionnaire on walking ability in MS, is shown to correlate with improvement after rehabilitation, especially in early phases of the disease (31).”
From The instrumented single leg stance test detects early balance impairment in people with multiple sclerosis (2023) · cites this paper as [31]
Citations
Cites
The Measurement of Observer Agreement for Categorical Data
Landis, J. R., & Koch, G. G. (1977) · Biometrics · doi:10.2307/2529310 · Cited by 81,148
The meaning and use of the area under a receiver operating characteristic (ROC) curve.
Hanley, J. A., & McNeil, B. J. (1982) · Radiology · doi:10.1148/radiology.143.1.7063747 · Cited by 21,856
Rating neurologic impairment in multiple sclerosis: An expanded disability status scale (EDSS)
Kurtzke, J. F. (1983) · Neurology · doi:10.1212/wnl.33.11.1444 · Cited by 15,011
McDonald, W. I., Compston, A., Edan, G., Goodkin, D., Hartung, H., Lublin, F. D., McFarland, H. F., Paty, D. W., Polman, C. H., Reingold, S. C., et al. (2001) · Annals of Neurology · doi:10.1002/ana.1032 · Cited by 6,969
Revicki, D. A., Hays, R. D., Cella, D. F., & Sloan, J. A. (2007) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2007.03.012 · Cited by 2,384
Measuring change over time: assessing the usefulness of evaluative instruments.
Guyatt, G., Walter, S. D., & Norman, G. (1987) · Journal of Chronic Diseases · doi:10.1016/0021-9681(87)90069-5 · Cited by 1,997
Two-, six-, and 12-minute walking tests in respiratory disease.
Butland, R. J., Pang, J., Gross, E. R., Woodcock, A. A., & Geddes, D. M. (1982) · BMJ · doi:10.1136/bmj.284.6329.1607 · Cited by 1,668
The Multiple Sclerosis Impact Scale (MSIS-29): A new patient-based outcome measure
Hobart, J. (2001) · Brain · doi:10.1093/brain/124.5.962 · Cited by 1,144
Fischer, J. S., Rudick, R. A., Cutter, G., & Reingold, S. C. (1999) · Multiple Sclerosis Journal · doi:10.1177/135245859900500409 · Cited by 997
Interpreting Change Scores of Tests and Measures Used in Physical Therapy
Haley, S. M., & Fragala-Pinkham, M. A. (2006) · Physical Therapy · doi:10.1093/ptj/86.5.735 · Cited by 940
Research works printed but not linked: 2
- Filipovic GP, 2011, Med Sci Monit, 17, CR704
- Rietberg MB, 2005, Cochrane Database Syst Rev, CD003980
Cited by
Sorted by citations
Items 101–200 of 213
Andreopoulou, G., Mercer, T. H., & van der Linden, M. L. (2017) · Gait & Posture · doi:10.1016/j.gaitpost.2017.12.021 · Cited by 14
Relationship of Obesity With Gait and Balance in People With Multiple Sclerosis
Kalron, A. (2016) · American Journal of Physical Medicine & Rehabilitation · doi:10.1097/phm.0000000000000552 · Cited by 14
Self-citationNegahban, H., Monjezi, S., Mehravar, M., Mostafaee, N., & Shoeibi, A. (2017) · Journal of Bodywork and Movement Therapies · doi:10.1016/j.jbmt.2017.06.008 · Cited by 14
Normann, B., Salvesen, R., & Arntzen, E. C. (2016) · European Journal of Physiotherapy · doi:10.3109/21679169.2016.1170204 · Cited by 13
Self-citationFampridine and quality of life in individuals with multiple sclerosis
Sagawa, Y., Magnin, É., Paillot, L., Moulin, T., & Decavel, P. (2016) · SpringerPlus · doi:10.1186/s40064-016-2776-2 · Cited by 13
“A recent European multicenter study found that long walking tests were more appropriate than short walking ones in detecting clinically meaningful improvement (Baert et al. 2014).”
BackgroundMañago, M. M., Hebert, J. R., Kittelson, J. M., & Schenkman, M. L. (2018) · International Journal of Rehabilitation Research · doi:10.1097/mrr.0000000000000306 · Cited by 13
The benefits of exercise in progressive MS: some cautious optimism
Feinstein, A., & Dalgas, U. (2014) · Multiple Sclerosis Journal · doi:10.1177/1352458514521309 · Cited by 13
Self-citationBerg-Hansen, P., Moen, S. M., Klyve, T. D., Gonzalez, V., Seeberg, T. M., Celius, E. G., Austeng, A., & Meyer, F. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1227374 · Cited by 12
Kalron, A., Feys, P., Dalgas, U., Smedal, T., Freeman, J. A., Romberg, A., Conyers, H., Elorriaga, I., Gebara, B., Meriläinen, J., et al. (2019) · Neurorehabilitation and neural repair · doi:10.1177/1545968319834893 · Cited by 12
“Our main finding was that long walking tests and the self-reported Multiple Sclerosis Walking Scale–12 (MSWS12) could detect clinically meaningful improvement after physical rehabilitation.(10) The aim of the present study (a secondary analysis) was to assess real-life physical rehabilitation programs across Europe an…”
InfluentialSelf-citationNormann, B., & Arntzen, E. C. (2020) · European Journal of Physiotherapy · doi:10.1080/21679169.2020.1772870 · Cited by 12
Self-citationKalron, A., Ehling, R., Baert, I., Smedal, T., Řasová, K., Heric-Mansrud, A., Elorriage, I., Nedeljković, U., Tachino, A., Gargul, L., et al. (2020) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2020.102511 · Cited by 12
Self-citationBinshalan, T., Nair, K. P. S., & McNeill, A. (2022) · Multiple Sclerosis International · doi:10.1155/2022/2357785 · Cited by 12
Longitudinal relationships between disability and gait characteristics in people with MS
Dreyer-Alster, S., Menascu, S., Dolev, M., Givon, U., Magalashvili, D., Achiron, A., & Kalron, A. (2022) · Scientific Reports · doi:10.1038/s41598-022-07734-y · Cited by 13
Self-citationRahimibarghani, S., Azadvari, M., Razavi, S. Z. E., Harirchian, M. H., Dehgolan, S. R., & Fateh, H. R. (2022) · International Journal of MS Care · doi:10.7224/1537-2073.2021-004 · Cited by 11
Hugos, C. L., BOURDETTE, D. N., Chen, Y., Chen, Z., & Cameron, M. H. (2017) · Multiple Sclerosis Journal - Experimental Translational and Clinical · doi:10.1177/2055217317699993 · Cited by 11
“4 points, respectively.(34) Our 21% improvement in the TUG is the same as another study that reported 21% improvement is needed to show genuine improvement on the TUG in individuals with EDSS 4.”
ResultOutcome measures assisting treatment optimization in multiple sclerosis
Pardo, G., Coates, S., & Okuda, D. T. (2021) · Journal of Neurology · doi:10.1007/s00415-021-10674-8 · Cited by 14
Pommerich, U. M., Brincks, J., Skjerbæk, A. G., & Dalgas, U. (2022) · Acta Neurologica Belgica · doi:10.1007/s13760-022-01991-4 · Cited by 10
“We recommend that future studies may investigate the Timed 25-Foot Walk [48] or Global Rating Scales [30, 49] as external criteria for the responsiveness of the Six Spot Step Test.”
BackgroundMethodResultInfluentialSelf-citationWolf, F., Nielsen, J., Saliger, J., Hennecken, E., Kröber, P., Eschweiler, M., Folkerts, A., Karbe, H., & Zimmer, P. (2023) · BMC Neurology · doi:10.1186/s12883-023-03436-8 · Cited by 16
“For the 6MWT, improvements (43.9 m [MAT], 26.3 m [SET]) exceeded measurement error on group-level ( ≥ 11.1 m) and in the MAT also substantially exceeded minimal important change values for patients with mild disability ( ≥ 26.9 m) [48].”
MethodInfluentialEffects of walking interventions in persons with multiple sclerosis—A systematic review
Boková, I., Gaemelke, T., Novotná, K., Hvid, L. G., & Dalgas, U. (2024) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2024.105511 · Cited by 10
Self-citationvan der Maas, N. A. (2017) · BMC Neurology · doi:10.1186/s12883-017-0834-1 · Cited by 7
“Considering that SEM may be close to the anchor-based estimate [7, 8], it seems appropriate to take a 1-point change as the estimate of MID.”
BackgroundMethodBarin, L., Vaney, C., Puhan, M. A., & von Wyl, V. (2018) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2018.04.001 · Cited by 9
“Hence a minimum change of 20% in 9HPT or T25FW and of 5 m in 2MWT between rehabilitation entry and discharge could be detected (Baert et al., 2014; Kragt et al., 2006) .”
BackgroundMethodInfluentialZhang, Y., Xu, P., Deng, Y., Duan, W., Cui, J., Ni, C., & Wu, M. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.960328 · Cited by 8
“6m which can be considered clinically meaningful in MS (Baert et al., 2014).”
BackgroundGaemelke, T., Laustsen, C., Feys, P., Folkestad, L., Andersen, M., Jørgensen, N. R., Jørgensen, M.-L., Jespersen, S. N., Ringgaard, S., Eskildsen, S. F., et al. (2024) · Contemporary Clinical Trials Communications · doi:10.1016/j.conctc.2024.101279 · Cited by 8
“The MSWS score is transformed to a percentage score (0 – 100) of the maximum possible score (a higher score indicating larger impact of MS on walking abilities), and a change of 10.7 points is considered clinically relevant [74].”
BackgroundInfluentialSelf-citationPrigent, G., Aminian, K., Gonzenbach, R. R., April, R., & Paraschiv-Ionescu, A. (2024) · Journal of NeuroEngineering and Rehabilitation · doi:10.1186/s12984-024-01383-0 · Cited by 8
Andersen, T. M., Andersen, A. M., Riemenschneider, M., Taul-Madsen, L., Diechmann, M., Gaemelke, T., Dalgas, U., Brønd, J. C., & Hvid, L. G. (2024) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2024.106243 · Cited by 8
Self-citationSubmaximal Walking Tests: A Review of Clinical Use
Roberts, D. E., Futrell, E., & Toole, E. (2022) · Journal of Clinical Exercise Physiology · doi:10.31189/2165-6193-11.2.62 · Cited by 8
Lam, K., Bucur, I. G., van Oirschot, P., de Graaf, F., Strijbis, E. M. M., Uitdehaag, B. M. J., Heskes, T., Killestein, J., & de Groot, V. (2023) · Multiple Sclerosis Journal · doi:10.1177/13524585231152433 · Cited by 8
Differential Item Functioning of the Mini-BESTest Balance Measure: A Rasch Analysis Study
Caronni, A., Picardi, M., Scarano, S., Tropea, P., Gilardone, G., Bolognini, N., Redaelli, V., Pintavalle, G., Aristidou, E., Antoniotti, P., et al. (2023) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph20065166 · Cited by 8
“, [73]), than clinician-administered tests.”
Skjerbæk, A. G., Hvid, L. G., Boesen, F., Taul-Madsen, L., Stenager, E., & Dalgas, U. (2024) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2024.106242 · Cited by 8
Self-citationProcházková, M., Tintěra, J., Špaňhelová, Š., Prokopiusova, T., Rydlo, J., Pavlı́ková, M., Procházka, A., & Řasová, K. (2021) · European Journal of Physical and Rehabilitation Medicine · doi:10.23736/s1973-9087.20.06336-4 · Cited by 8
Kong, L., Lang, Y., Wang, X., Wang, J., Chen, H., Shi, Z., & Zhou, H. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.958441 · Cited by 8
Hvid, L. G., Steenberg, J. L., Roy, F., & Skovgaard, L. (2025) · Annals of Physical and Rehabilitation Medicine · doi:10.1016/j.rehab.2025.101985 · Cited by 8
Wanitschek, A., Seebacher, B., Muehlbacher, A., Brenneis, C., & Ehling, R. (2024) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2024.105532 · Cited by 7
Hvid, L. G., Gaemelke, T., Dalgas, U., Slipsager, M., Rasmussen, P. V., Petersen, T., Nørgaard, M., Skjerbæk, A. G., & Boesen, F. (2021) · Multiple Sclerosis Journal - Experimental Translational and Clinical · doi:10.1177/2055217321989384 · Cited by 7
Self-citationYap, S. M., Etzelmueller, M. S., O’Keeffe, C., Gaughan, M., KEARNEY, H. F., Tubridy, N. J., Reilly, R. B., & McGuigan, C. (2021) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2021.102946 · Cited by 8
Ehling, R., Seebacher, B., Harsányi, A., Ganzbiller, N., Papez, S., Haider, B., Hoertenhuber, D., Kranz, G., Tarasiewicz, R., Spatt, J., et al. (2022) · European Journal of Neurology · doi:10.1111/ene.15271 · Cited by 7
“It is noteworthy that the observed changes in mobility were clearly beyond recently reported thresholds for a clinically meaningful improvement following rehabilitation [32,33].”
BackgroundSeebacher, B., Helmlinger, B., Pinter, D., Ehling, R., Hegen, H., Ropele, S., Reishofer, G., Enzinger, C., Brenneis, C., & Deisenhammer, F. (2022) · BMJ Open · doi:10.1136/bmjopen-2021-056666 · Cited by 8
Özdoğar, A. T., Kahraman, T., Özakbaş, S., Achiron, A., & Kalron, A. (2021) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2021.103456 · Cited by 7
Self-citationMolhemi, F., Monjezi, S., Mehravar, M., Yazdi, M. J. S., & Majdinasab, N. (2022) · Physiotherapy Theory and Practice · doi:10.1080/09593985.2022.2119908 · Cited by 7
“So, based on the answers, participants were divided into “improved” (i.e. very much better and much better) or “not-improved” groups (i.e. slightly better, no change, slightly worse, much worse, and very much worse) (Baert et al., 2014; Monjezi et al., 2022).”
BackgroundKuendig, S., Kool, J., Polhemus, A. M., Schallert, W., Bansi, J., & Gonzenbach, R. R. (2022) · PLoS ONE · doi:10.1371/journal.pone.0274348 · Cited by 7
Arntzen, E. C., Braaten, T., Fikke, H. K., & Normann, B. (2024) · Frontiers in Rehabilitation Sciences · doi:10.3389/fresc.2023.1258737 · Cited by 10
Self-citationWilliams, K., Choy, N. L., & Brauer, S. (2016) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2016.03.020 · Cited by 7
Castiglia, S. F., Farra, F. D., Trabassi, D., Turolla, A., Serrao, M., Nocentini, U., Brasiliano, P., Bergamini, E., & Tramontano, M. (2025) · Archives of Physiotherapy · doi:10.33393/aop.2025.3289 · Cited by 6
Cohen, J. A., Cameron, M. H., Goldman, M. D., Goodman, A. D., Miller, A., Rollins, A., Llorens, L., Patni, R., Elfont, R. M., & Johnson, R. (2021) · Multiple Sclerosis Journal · doi:10.1177/13524585211035333 · Cited by 6
Kontaxis, S., Laporta, E., Pagès, E. G., Martinis, M., Leocani, L., Roselli, L., Buron, M. D., Guerrero, A. I., Zabalza, A., Cummins, N., et al. (2023) · Sensors · doi:10.3390/s23136017 · Cited by 6
“1% [32], an error between −30% and 30% for Di (Figure 2) may still be valid for the vast majority of patients.”
BackgroundFarber, A. E., Menascu, S., & Kalron, A. (2024) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2024.111675 · Cited by 6
Self-citationEvaluation of the T25FW in minimally disabled people with multiple sclerosis
Helmlinger, B., Pinter, D., Hechenberger, S., Bachmaier, G., Khalil, M., Heschl, B., Damulina, A., Pichler, A., & Enzinger, C. (2024) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2024.123073 · Cited by 6
“The 6MWT is a test where participants are asked to walk as far as possible for 6 min and, therefore, is considered a measure of walking endurance [20,21,19].”
Self-reported maximum walking distance in persons with MS may affect the EDSS
Berger, W., Payne, M. W. C., & Morrow, S. A. (2017) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2017.05.035 · Cited by 6
Psarakis, M., Lord, S. R., & Hoang, P. D. (2020) · International Journal of MS Care · doi:10.7224/1537-2073.2019-022 · Cited by 6
Feasibility of an International Multiple Sclerosis Rehabilitation Data Repository
Bradford, E. H., Baert, I., Finlayson, M. L., Feys, P., & Wagner, J. M. (2017) · International Journal of MS Care · doi:10.7224/1537-2073.2016-009 · Cited by 6
Self-citationMcManaman, C., Novak, B., Paul, L., & Rooney, S. (2024) · PM&R · doi:10.1002/pmrj.13255 · Cited by 8
Taul-Madsen, L., Hvid, L. G., Riis, H. C., Broløs, M. K., Lundbye‐Jensen, J., & Dalgas, U. (2024) · Multiple Sclerosis Journal · doi:10.1177/13524585241305496 · Cited by 5
Self-citationStepanova, A. D., Сергеевич, М. Г., Kulyakhtin, A. I., Kalinin, I. V., Feys, P., & Evdoshenko, E. P. (2022) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2022.103640 · Cited by 5
Self-citationTaul-Madsen, L., Hvid, L. G., Sellebjerg, F. T., Christensen, J. R., Ratzer, R. L., Sejbæk, T., Svendsen, K. B., Papp, V., Chow, H. H., Lundbye‐Jensen, J., et al. (2024) · BMJ Open · doi:10.1136/bmjopen-2024-085241 · Cited by 6
“31 Fatigue is one of the most debilitating MS symptoms and is, in the present study, assessed by the Multiple Sclerosis Fatigue Impact Scale (MFIS), 50 where the score ranges from 0 to 84 with a higher score indicating higher levels of fatigue.”
Self-citationHelmlinger, B., Seebacher, B., Ropele, S., Hechenberger, S., Heschl, B., Reishofer, G., Jordan, S., Tinauer, C., Wurth, S., Valsasina, P., et al. (2025) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2025.123426 · Cited by 4
Factors influencing employment and absenteeism in working age people with multiple sclerosis
Iron, A., Menascu, S., & Kalron, A. (2025) · Scientific Reports · doi:10.1038/s41598-025-20165-9 · Cited by 5
“It has been used in numerous clinical trials in the pwMS population due to its excellent psychometric properties 22,23 .”
Self-citationMotl, R. W., Sandroff, B. M., & McAuley, E. (2018) · Neurodegenerative Disease Management · doi:10.2217/nmt-2018-0016 · Cited by 4
Monjezi, S., Molhemi, F., Yazdi, M. J. S., Salehi, R., Mehravar, M., & Kashipazha, D. (2020) · Physiotherapy Theory and Practice · doi:10.1080/09593985.2020.1762267 · Cited by 4
“Baert et al. (2014) obtained an MCIC of 10.4 for MSWS-12; Nevertheless, they reported an MCIC of 8.85 in the latter study (Baert et al., 2018).”
BackgroundMethodInfluentialSkov, C. D., Sørensen, C. B., Thorning, M., Lambertsen, K. L., Frich, L. H., Jensen, H. B., Holsgaard‐Larsen, A., & Nielsen, H. H. (2022) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2022.104034 · Cited by 4
Thorning, M., Nielsen, H. H., Frich, L. H., Jensen, H. B., Lambertsen, K. L., & Holsgaard‐Larsen, A. (2022) · Clinical Biomechanics · doi:10.1016/j.clinbiomech.2022.105826 · Cited by 4
Hvid, L. G., Coote, S. B., Pau, M., & Kalron, A. (2025) · JMIR Research Protocols · doi:10.2196/75983 · Cited by 3
Self-citationSpieker, E. L., Hoffmann, M., Otto, C., Ruprecht, K., Harms, L., Schauer, T., Salchow-Hömmen, C., & Wenger, N. (2025) · Frontiers in Neurology · doi:10.3389/fneur.2025.1618519 · Cited by 3
Bonnyaud, C., Hameau, S., Zory, R., Sznajder, M., Heinzlef, O., Aymard, C., Chenet, A., Médée, B., Jacota, M., Gallien, P., et al. (2025) · Annals of Physical and Rehabilitation Medicine · doi:10.1016/j.rehab.2024.101898 · Cited by 3
Orthotic shorts for improving gait and walking in multiple sclerosis: a feasibility study
Snowdon, N., McLean, S. M., Piercy, H., Brodie, M. A. D., & Wheat, J. S. (2022) · Disability and Rehabilitation · doi:10.1080/09638288.2022.2114018 · Cited by 3
Veldkamp, R., Moumdjian, L., van Dun, K., Six, J., Vanbeylen, A., Kos, D., & Feys, P. (2021) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14702 · Cited by 3
Self-citationJuhl, C., Byskov, K., Hvid, L. G., Dalgas, U., Pommerich, U. M., & Skjerbæk, A. G. (2025) · Multiple Sclerosis Journal - Experimental Translational and Clinical · doi:10.1177/20552173251324600 · Cited by 3
Self-citationKalron, A. (2025) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2025.106510 · Cited by 3
Self-citationShemirani, F., Klein, A. M., Groux, A. R., Kilpatrick, R. R., Brooks, L., Ehlinger, M. A., Darling, W. G., Magnotta, V. A., Gill, C. M., Hoth, K. F., et al. (2025) · Trials · doi:10.1186/s13063-025-09157-2 · Cited by 2
Toward Brain-Computer Interface motor rehabilitation for people with Multiple Sclerosis
Sebastián-Romagosa, M., Cho, W., Ortner, R., Sieghartsleitner, S., Guger, M., von Oertzen, T. J., Meuth, S. G., Laureys, S., Allison, B. Z., & Guger, C. (2026) · Frontiers in Medicine · doi:10.3389/fmed.2025.1661972 · Cited by 4
Ramari, C., Feys, P., Gaemelke, T., Hvid, L. G., Baert, I., Kalron, A., & Dalgas, U. (2021) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2020.102706 · Cited by 2
Self-citationDorsch, E.-M., Röhling, H. M., Zocholl, D., Hafermann, L., Paul, F., & Schmitz‐Hübsch, T. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1258635 · Cited by 2
Сергеевич, М. Г., Mazur, A. P., Sadovskikh, M. O., Voinova, K. V., Chernenko, A. Y., Kalinin, I. V., & Evdoshenko, E. P. (2023) · Bulletin of Rehabilitation Medicine · doi:10.38025/2078-1962-2023-22-3-17-28 · Cited by 2
Massot, C., Guyot, M. A., Blanchard, A., Norberciak, L., & Donzé, C. (2025) · Neurorehabilitation · doi:10.1177/10538135241306674 · Cited by 2
“Indeed, the clinically meaningful improvement in this MS population for the 6MWT is around 20 m (21.6 m or 19.7 m) (Baert et al., 2014; Oosterveer et al., 2022).”
InfluentialYücekaya, B., Kemer, S. N., Asan, E., Gerdan, H., Balcı, N. Ç., Cakır, D., Kurtça, M. P., Keskin, M., & Terzi, M. (2025) · Neurological Research · doi:10.1080/01616412.2025.2490086 · Cited by 2
Pushing the Limits of Interlimb Connectivity: Neuromodulation and Beyond
Porter, J. A., Barss, T. S., Mann, D. J., Karamzadeh, Z., Okusanya, D. O., Hemakumara, S. G., Zehr, E. P., Klarner, T., & Mushahwar, V. K. (2025) · Biomedicines · doi:10.3390/biomedicines13051228 · Cited by 3
“A range of values for the MCID on the 6MWT is presented across the studies in persons with MS, with various participant cohorts: the values fall in the range of 21.56–55.06 m [57,60].”
InfluentialKhadke, S., & siddique, T. (2019) · F1000Research · doi:10.12688/f1000research.18247.1 · Cited by 2
Alt, Y., Wochatz, M., Schraplau, A., Engel, T., Sharon, H., Gurevich, M., Menascu, S., Mayer, F. O., & Kalron, A. (2024) · Therapeutic Advances in Neurological Disorders · doi:10.1177/17562864241266113 · Cited by 1
Self-citationGann, E. J., Mañago, M. M., Allen, D. D., Celnikier, E., & Block, V. J. (2024) · International Journal of MS Care · doi:10.7224/1537-2073.2023-081 · Cited by 1
Zhang, H., & Nazari, N. (2025) · BMC Psychology · doi:10.1186/s40359-025-03607-x · Cited by 1
Parkinson’s Disease and Voluntary Walking Interventions—A Systematic Review and Meta-analysis
Kloster, C. T., Bonde-Jensen, F., Langeskov‐Christensen, M., & Dalgas, U. (2026) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2026.01.024 · Cited by 1
Self-citationResting motor threshold as a predictor of rehabilitation outcomes in multiple sclerosis
Dini, M., Turchi, L., Ranieri, M., Tacchini, M., Gradassi, A., Chiveri, L. R., Rodegher, M., & Leocani, L. (2026) · Clinical Neurophysiology · doi:10.1016/j.clinph.2026.2112434 · Cited by 1
Adaptive symptom reporting for mobile patient-reported disability assessment
Engelhard, M., Lach, Schmidt, Goldman, & Patek (2016) · Wireless Health · doi:10.1109/wh.2016.7764573 · Cited by 1
Plummer, P., Markovic‐Plese, S., & Giesser, B. S. (2022) · Frontiers in Rehabilitation Sciences · doi:10.3389/fresc.2021.795306 · Cited by 1
Responsiveness of Persian 12-Item multiple sclerosis walking scale: a replication study
Naghdi, S., Ansari, N. N., Haghparast, A., Nakhostin-Ansari, A., Khalifeloo, M., Biglar, M., Lotfi, R., & Hasson, S. (2023) · BMC Research Notes · doi:10.1186/s13104-023-06316-z · Cited by 1
“The MSWS-12 may be a more appropriate measure than the T25-FW in detecting improvements after physiotherapy [22].”
BackgroundMethodBinshalan, T., Buckley, E. E., Nair, S., & McNeill, A. (2024) · Cureus · doi:10.7759/cureus.51811 · Cited by 1
“Based on the results of a large-scale EU study of 290 MS patients, MSWS-12 proved to be a superior measure (compared to the timed 25-foot walk) for detecting changes after physical therapy intervention, especially in patients with moderate to severe MS [11].”
ResultCavallo, C., Gatti, A., Pellino, V. C., Pirazzi, A., Ramat, S., Nunzio, A. M. D., Schmid, M., & Vandoni, M. (2024) · Mechanisms and machine science · doi:10.1007/978-3-031-63755-1_12 · Cited by 1
Valkenburgh, L. V., Haag, S., Cameron, M. H., & Mañago, M. M. (2025) · Journal of Women s & Pelvic Health Physical Therapy · doi:10.1097/jwh.0000000000000343 · Cited by 2
Verbesserung der Gehstrecke bei Patienten mit Multipler Sklerose
Alcántara, R., Bernhardt, L. P., Osada, N., Platen, P., & Jolk, C. (2015) · Nervenheilkunde · doi:10.1055/s-0038-1627641 · Cited by 1
“Für Patienten hat die maximale Gehstrecke einen großen Alltagsbezug (22, 49).”
BackgroundВладимировна, В. К., Сергеевич, М. Г., & Evdoshenko, E. P. (2021) · Physical and rehabilitation medicine medical rehabilitation · doi:10.36425/rehab77932 · Cited by 1
Coote, S. B., Gallagher, S., Msetfi, R. M., Larkin, A., Newell, J., Motl, R. W., & Hayes, S. (2014) · BMC Neurology · doi:10.1186/s12883-014-0241-9 · Cited by 1
“2 m [26].”
Cattaneo, D., Gervasoni, E., Montesano, A., & Jonsdottir, J. (2019) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2019.01.018 · Cited by 1
van der Maas, N. A., & Ferchichi-Barbey, S. (2020) · Physiotherapy Canada. Physiothérapie Canada · doi:10.3138/ptc-2019-0096
Gait quality and function in patients with Multiple Scleroses following Fampridine treatment
Thorning, M., Nielsen, H. H., Frich, L. H., Lambertsen, K. L., Jensen, H. B., & Holsgaard‐Larsen, A. (2021) · Gait & Posture · doi:10.1016/j.gaitpost.2021.09.140
Allen, D. D., Burchuladze, S., Grady, G., Lee, M., Mindel, L., & Widener, G. L. (2022) · Physiotherapy Practice and Research · doi:10.3233/ppr-210620
xploration of the Physical Activity Guidelines for People with Multiple Sclerosis
Humphreys, L. J. (2022) · Sheffield Hallam University · doi:10.7190/shu-thesis-00537
Mañago, M. M., Forster, J. E., Biondi, E. A., Schenkman, M. L., Cameron, M. H., & Christiansen, C. L. (2024) · Neurology Report · doi:10.1097/npt.0000000000000504
Kanetzke, N. A., & Moerchen, V. A. (2025) · Archives of Rehabilitation Research and Clinical Translation · doi:10.1016/j.arrct.2025.100451
Vaheb, S., Rajaei, Z., Shaygannejad, V., Alaei, H., Afshari-Safavi, A., & Mirmosayyeb, O. (2025) · Neurological Sciences · doi:10.1007/s10072-025-08193-9
“Nevertheless, the associa - tion between EDSS at the first relapse and IPS in PwMS may still hold clinical significance, as suggested by previous studies [41, 42].”
Cardini, R., Bertoni, R., Carpinella, I., Pegorini, C., Tacchino, A., Grange, E., Guidotti, V., Brichetto, G., Solaro, C. M., Budassi, T., et al. (2025) · Digital Health · doi:10.1177/20552076251346694
Asan, E., Ürkmez, S. S., Akyol, Z. İ., Terzi, M., & Ünver, B. (2025) · Gazi Sağlık Bilimleri Dergisi · doi:10.52881/gsbdergi.1762684
Metadata
- Authors
- Baert, I., Freeman, J., Smedal, T., Dalgas, U., Romberg, A., Kalron, A., Conyers, H., Elorriaga, I., Gebara, B., Gumse, J., Heric, A., Jensen, E., Jones, K., Knuts, K., Maertens de Noordhout, B., Martic, A., Normann, B., Eijnde, B. O., Rasova, K., Santoyo Medina, C., Truyens, V., Wens, I., & Feys, P.
- Affiliations
- Hasselt University (BE)
- University of Plymouth (GB)
- Haukeland University Hospital (NO)
- Aarhus University (DK)
- Masku Neurological Rehabilitation Center, Masku, Finland
- Sheba Medical Center (IL)
- Poole Hospital NHS Foundation Trust (GB)
- Eugenia Epalza Rehabilitation Center, Bilbao, Spain
- National MS Center Melsbroek (BE)
- Helsinki MS-Neuvola, Helsinki, Finland
- Multiple Sclerosis Center, Hakadal AS, Norway
- Danish Multiple Sclerosis Center (DK)
- Rehabilitation and Multiple Sclerosis Center, Overpelt, Belgium
- Centre Neurologique et de Réadaptation Fonctionelle, Fraiture-en-Condroz, Belgium
- University Medical Center, Ljubljana, Slovenia
- Nordland Hospital Trust (NO)
- Charles University, Prague, Czech Republic
- Hospital de Dia de Barcelona, CEMCat, Barcelona, Spain
- ORCID
- Venue
- Neurorehabilitation and Neural Repair
- Publisher
- SAGE Publications
- Published
- 2014-02-06
- Volume
- 28
- Issue
- 7
- Pages
- 621-631
- ISSN
- 0888-4390 (ISSN-L)
- 1545-9683
- 1552-6844
- OpenAlex
- W2043572283
- Cited by
- 213
- References
- 34
- Citations by year
- 2026: 9 · 2025: 22 · 2024: 18 · 2023: 10 · 2022: 22 · 2021: 25 · 2020: 17 · 2019: 16 · 2018: 17 · 2017: 23 · 2016: 17 · 2015: 12 · 2014: 5
- FWCI
- 14.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurorehabilitation and neural repair (publishedVersion)
- PubMed (publishedVersion)
- Document Server@UHasselt (UHasselt) (submittedVersion)
- Funders
- Novartis
- Universiteit Hasselt
- Novartis Pharma
- Topics
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Balance, Gait, and Falls Prevention
- Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
- Keywords
- multiple sclerosis, walking capacity, responsiveness, minimally important change, 2-minute walk test, 6-minute walk test, Timed 25-Foot Walk, physical rehabilitation, disability severity, Expanded Disability Status Scale, patient-reported outcomes
- MeSH terms
- Adult, Disability Evaluation, Europe, Humans, Male, Middle Aged, Multiple Sclerosis, Reference Standards, Walking, Treatment Outcome, Recovery of Function, Physical Therapy Modalities
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
