The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Effects of Robot-Assisted Therapy for the Upper Limb After Stroke: A Systematic Review and Meta-analysis
Open accessAbstract
Background . Robot technology for poststroke rehabilitation is developing rapidly. A number of new randomized controlled trials (RCTs) have investigated the effects of robot-assisted therapy for the paretic upper limb (RT-UL). Objective . To systematically review the effects of poststroke RT-UL on measures of motor control of the paretic arm, muscle strength and tone, upper limb capacity, and basic activities of daily living (ADL) in comparison with nonrobotic treatment. Methods . Relevant RCTs were identified in electronic searches. Meta-analyses were performed for measures of motor control (eg, Fugl-Meyer Assessment of the arm; FMA arm), muscle strength and tone, upper limb capacity, and basic ADL. Subgroup analyses were applied for the number of joints involved, robot type, timing poststroke, and treatment contrast. Results . Forty-four RCTs (N = 1362) were included. No serious adverse events were reported. Meta-analyses of 38 trials (N = 1206) showed significant but small improvements in motor control (~2 points FMA arm) and muscle strength of the paretic arm and a negative effect on muscle tone. No effects were found for upper limb capacity and basic ADL. Shoulder/elbow robotics showed small but significant effects on motor control and muscle strength, while elbow/wrist robotics had small but significant effects on motor control. Conclusions . RT-UL allows patients to increase the number of repetitions and hence intensity of practice poststroke, and appears to be a safe therapy. Effects on motor control are small and specific to the joints targeted by RT-UL, whereas no generalization is found to improvements in upper limb capacity. The impact of RT-UL started in the first weeks poststroke remains unclear. These limited findings could mainly be related to poor understanding of robot-induced motor learning as well as inadequate designing of RT-UL trials, by not applying an appropriate selection of stroke patients with a potential to recovery at baseline as well as the lack of fixed timing of baseline assessments and using an insufficient treatment contrast early poststroke.
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Lozano, R., Naghavi, M., Foreman, K., Lim, S., Shibuya, K., Aboyans, V., Abraham, J., Adair, T., Aggarwal, R., Ahn, S. Y., et al. (2012) · The Lancet · doi:10.1016/s0140-6736(12)61728-0 · Cited by 14,070
Murray, C. J. L., Vos, T., Lozano, R., Naghavi, M., Flaxman, A. D., Michaud, C., Ezzati, M., Shibuya, K., Salomon, J. A., Abdalla, S., et al. (2012) · The Lancet · doi:10.1016/s0140-6736(12)61689-4 · Cited by 8,888
Publication and related bias in meta-analysis
Sterne, J. A. C., Gavaghan, D., & Egger, M. (2000) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(00)00242-0 · Cited by 2,282 · cited 1×
“Finally, safety and acceptance of RT-UL were investigated by assessing the incidence of adverse events, as were the number of dropouts from the studies during the study period and the impact of small study effects, acknowledging that small numbered trials with neutral or negative results are less likely to be publishe…”
BackgroundPlasticity during stroke recovery: from synapse to behaviour
Murphy, T. H., & Corbett, D. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2735 · Cited by 1,938
Robot-Assisted Therapy for Long-Term Upper-Limb Impairment after Stroke
Lo, A. C., Guarino, P. D., Richards, L. G., Haselkorn, J. K., Wittenberg, G. F., Federman, D. G., Ringer, R. J., Wagner, T. H., Krebs, H. I., Volpe, B. T., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa0911341 · Cited by 1,397
What Is the Evidence for Physical Therapy Poststroke? A Systematic Review and Meta-Analysis
Veerbeek, J. M., van Wegen, E., van Peppen, R., van der Wees, P. J., Hendriks, E., Rietberg, M., & Kwakkel, G. (2014) · PLoS ONE · doi:10.1371/journal.pone.0087987 · Cited by 1,203
Self-citationLum, P. S., Burgar, C. G., Shor, P. C., Majmundar, M., & Van der Loos, M. (2002) · Archives of Physical Medicine and Rehabilitation · doi:10.1053/apmr.2001.33101 · Cited by 1,159
Effects of Augmented Exercise Therapy Time After Stroke: A Meta-Analysis
Kwakkel, G., van Peppen, R., Wagenaar, R. C., Wood Dauphinee, S., Richards, C., Ashburn, A., Miller, K., Lincoln, N., Partridge, C., Wellwood, I., et al. (2004) · Stroke · doi:10.1161/01.str.0000143153.76460.7d · Cited by 1,081
Self-citationThe impact of physical therapy on functional outcomes after stroke: what's the evidence?
Van Peppen, R. P., Kwakkel, G., Wood-Dauphinee, S., Hendriks, H. J., Van der Wees, P. J., & Dekker, J. (2004) · Clinical Rehabilitation · doi:10.1191/0269215504cr843oa · Cited by 942
Self-citationLohse, K. R., Hilderman, C. G. E., Cheung, K. L., Tatla, S., & Van der Loos, H. F. M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0093318 · Cited by 501
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Intensive upper limb neurorehabilitation in chronic stroke: outcomes from the Queen Square programme
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Metadata
- Authors
- Veerbeek, J. M., Langbroek-Amersfoort, A. C., van Wegen, E. E. H., Meskers, C. G. M., & Kwakkel, G.
- Venue
- Neurorehabilitation and Neural Repair
- Publisher
- SAGE Publications
- Published
- 2016-09-24
- Volume
- 31
- Issue
- 2
- Pages
- 107-121
- ISSN
- 0888-4390 (ISSN-L)
- 1545-9683
- 1552-6844
- OpenAlex
- W2511163921
- Cited by
- 633
- References
- 10
- FWCI
- 40.18
- Type
- journal article
- Language
- en
- Open access
- green
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