The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Preventive Zinc Supplementation among Infants, Preschoolers, and Older Prepubertal Children
Abstract
Zinc supplementation trials carried out among children have produced variable results, depending on the specific outcomes considered and the initial characteristics of the children who were enrolled. We completed a series of meta-analyses to examine the impact of preventive zinc supplementation on morbidity; mortality; physical growth; biochemical indicators of zinc, iron, and copper status; and indicators of behavioral development, along with possible modifying effects of the intervention results. Zinc supplementation reduced the incidence of diarrhea by ∼20%, but the impact was limited to studies that enrolled children with a mean initial age greater than 12 months. Among the subset of studies that enrolled children with mean initial age greater than 12 months, the relative risk of diarrhea was reduced by 27%. Zinc supplementation reduced the incidence of acute lower respiratory tract infections by ∼15%. Zinc supplementation yielded inconsistent impacts on malaria incidence, and too few trials are currently available to allow definitive conclusions to be drawn. Zinc supplementation had a marginal 6% impact on overall child mortality, but there was an 18% reduction in deaths among zinc-supplemented children older than 12 months of age. Zinc supplementation increased linear growth and weight gain by a small, but highly significant, amount. The interventions yielded a consistent, moderately large increase in mean serum zinc concentrations, and they had no significant adverse effects on indicators of iron and copper status. There were no significant effects on children's behavioral development, although the number of available studies is relatively small. The available evidence supports the need for intervention programs to enhance zinc status to reduce child morbidity and mortality and to enhance child growth. Possible strategies for delivering preventive zinc supplements are discussed.
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Black, R. E., Victora, C. G., Walker, S. P., Bhutta, Z. A., Christian, P., de Onis, M., Ezzati, M., Grantham-McGregor, S., Katz, J., Martorell, R., et al. (2013) · The Lancet · doi:10.1016/s0140-6736(13)60937-x · Cited by 8,475
Bhutta, Z. A., Das, J. K., Rizvi, A., Gaffey, M. F., Walker, N., Horton, S., Webb, P., Lartey, A., & Black, R. E. (2013) · The Lancet · doi:10.1016/s0140-6736(13)60996-4 · Cited by 3,093
Nutrition and brain development in early life
Prado, E. L., & Dewey, K. G. (2014) · Nutrition Reviews · doi:10.1111/nure.12102 · Cited by 1,036
Diarrhea incidence in low- and middle-income countries in 1990 and 2010: a systematic review
Fischer Walker, C. L., Perin, J., Aryee, M. J., Boschi-Pinto, C., & Black, R. E. (2012) · BMC Public Health · doi:10.1186/1471-2458-12-220 · Cited by 471
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Warthon-Medina, M., Moran, V. H., Stammers, A.-L., Dillon, S., Qualter, P., Nissensohn, M., Serra-Majem, L., & Lowe, N. M. (2015) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2015.60 · Cited by 96
De-Regil, L. M., Jefferds, M. E. D., & Peña-Rosas, J. P. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd009666.pub2 · Cited by 92
The Impact of Nutritional Interventions on Child Health and Cognitive Development
Bommer, C., Mittal, N., & Vollmer, S. (2020) · Annual Review of Resource Economics · doi:10.1146/annurev-resource-110519-093256 · Cited by 12
Metadata
- Authors
- Brown, K. H., Peerson, J. M., Baker, S. K., & Hess, S. Y.
- Venue
- Food and Nutrition Bulletin
- Publisher
- SAGE Publications
- Published
- 2009-03
- Volume
- 30
- Issue
- 1_suppl1
- Pages
- S12-S40
- ISSN
- 0379-5721 (ISSN-L)
- 1564-8265
- OpenAlex
- W2289991757
- Cited by
- 309
- References
- 8
- FWCI
- 18.84
- Type
- journal article
- Language
- en
- Open access
- closed
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