Accuracy of a New Patch Pump Based on a Microelectromechanical System (MEMS) Compared to Other Commercially Available Insulin Pumps: Results of the First In Vitro and In Vivo Studies
Open accessAbstract
The JewelPUMP™ (JP) is a new patch pump based on a microelectromechanical system that operates without any plunger. The study aimed to evaluate the infusion accuracy of the JP in vitro and in vivo. For the in vitro studies, commercially available pumps meeting the ISO standard were compared to the JP: the MiniMed® Paradigm® 712 (MP), Accu-Chek® Combo (AC), OmniPod® (OP), Animas® Vibe™ (AN). Pump accuracy was measured over 24 hours using a continuous microweighing method, at 0.1 and 1 IU/h basal rates. The occlusion alarm threshold was measured after a catheter occlusion. The JP, filled with physiological serum, was then tested in 13 patients with type 1 diabetes simultaneously with their own pump for 2 days. The weight difference was used to calculate the infused insulin volume. The JP showed reduced absolute median error rate in vitro over a 15-minute observation window compared to other pumps (1 IU/h): ±1.02% (JP) vs ±1.60% (AN), ±1.66% (AC), ±2.22% (MP), and ±4.63% (OP), P < .0001. But there was no difference over 24 hours. At 0.5 IU/h, the JP was able to detect an occlusion earlier than other pumps: 21 (19; 25) minutes vs 90 (85; 95), 58 (42; 74), and 143 (132; 218) minutes (AN, AC, MP), P < .05 vs AN and MP. In patients, the 24-hour flow error was not significantly different between the JP and usual pumps (-2.2 ± 5.6% vs -0.37 ± 4.0%, P = .25). The JP was found to be easier to wear than conventional pumps. The JP is more precise over a short time period, more sensitive t…
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The MEMS-based micropump provides outstanding delivery accuracy and failure detection capabilities.
“In addition, this MEMS-based micropump provides outstanding delivery accuracy and failure detection capabilities, as reported in recent in vitro and in vivo studies comparing the pumping capability of several pump systems [8].”
From Insulin Micropump with Embedded Pressure Sensors for Failure Detection and Delivery of Accurate Monitoring (2014) · cites this paper as [8]
Occlusion of an insulin infusion set can massively interfere with glycemic control in patients with diabetes.
“an occlusion of IIS can massively interfere with glycemic control”
From Insulin Pump Occlusions: For Patients Who Have Been Around the (Infusion) Block (2017) · cites this paper as [13]
If insulin delivery is suspended for less than two hours, it is still unlikely to lead to ketoacidosis.
“This amount of time of that insulin delivery is suspended, if not greater than two hours, is still unlikely to lead to ketoacidosis;13”
From Insulin Pump Occlusions: For Patients Who Have Been Around the (Infusion) Block (2017) · cites this paper as [13]
A layer of paraffin oil of less than 3 mm thickness floated on the water eliminates evaporation and is shown to produce more accurate results.
“A layer of paraffin oil of <3 mm thickness was floated on the water to eliminate evaporation and is shown to produce more accurate results.20,22,23”
From Bench-Side Dose Accuracy of an Open-Source Ultra-Low-Cost Insulin-Pump, With Testing Conducted to IEC 60601-2-24 (2024) · cites this paper as [23]
Percentage errors are known to increase with smaller dose sizes.
“Percentage errors are known to increase with smaller dose sizes23 -25”
From Bench-Side Dose Accuracy of an Open-Source Ultra-Low-Cost Insulin-Pump, With Testing Conducted to IEC 60601-2-24 (2024) · cites this paper as [23]
Cites
Yeh, H.-C., Brown, T. T., Maruthur, N., Ranasinghe, P., Berger, Z., Suh, Y. D., Wilson, L. M., Haberl, E. B., Brick, J., Bass, E. B., et al. (2012) · Annals of Internal Medicine · doi:10.7326/0003-4819-157-5-201209040-00508 · Cited by 493 · see citing works
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Insulin Pump Occlusions: For Patients Who Have Been Around the (Infusion) Block
Klonoff, D. C., Freckmann, G., & Heinemann, L. (2017) · Journal of Diabetes Science and Technology · doi:10.1177/1932296817700545 · Cited by 41 · see citing works
Dumont-Fillon, D., Tahriou, H., Conan, C., & Chappel, E. (2014) · Micromachines · doi:10.3390/mi5041161 · Cited by 38 · see citing works
Occlusion Detection Time in Insulin Pumps at Two Different Basal Rates
Freckmann, G., Kamecke, U., Waldenmaier, D., Haug, C., & Ziegler, R. (2018) · Journal of Diabetes Science and Technology · doi:10.1177/1932296817750404 · Cited by 18 · see citing works
Payne, M., Pooke, F., Holder-Pearson, L., Chase, J. G., de Bock, M., Campbell, J., & Knopp, J. (2024) · Journal of Diabetes Science and Technology · doi:10.1177/19322968221142316 · Cited by 9 · see citing works
- Authors
- Borot, S., Franc, S., Cristante, J., Penfornis, A., Benhamou, P.-Y., Guerci, B., Hanaire, H., Renard, E., Reznik, Y., Simon, C., Charpentier, G., & on behalf of the Diabeloop Study Group
- Affiliations
- Centre Hospitalier Universitaire de Besançon (FR)
- Centre Hospitalier Sud Francilien (FR)
- Université Joseph Fourier (FR)
- Université de Lorraine (FR)
- Centre Hospitalier Universitaire de Toulouse (FR)
- Department of Endocrinology, Diabetes, and Nutrition and Clinical Investigation Centre, Montpellier University Hospital, Montpellier, France
- Centre Hospitalier Universitaire de Caen Normandie (FR)
- Hospices Civils de Lyon (FR)
- ORCID
- Venue
- Journal of Diabetes Science and Technology
- Publisher
- SAGE Publications
- Published
- 2014-07-30
- Volume
- 8
- Issue
- 6
- Pages
- 1133-1141
- ISSN
- 1932-2968 (ISSN-L)
- PMC
- PMC4455475
- OpenAlex
- W2029870085
- Cited by
- 47
- References
- 1
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2023: 3 · 2022: 4 · 2021: 5 · 2020: 5 · 2019: 7 · 2018: 4 · 2017: 7 · 2016: 3 · 2015: 2 · 2014: 1
- FWCI
- 3.49
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Diabetes Science and Technology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Funders
- Sanofi
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Physical Sciences › Engineering › Biomedical Engineering › Intravenous Infusion Technology and Safety
- Health Sciences › Health Professions › Emergency Medical Services › Patient Safety and Medication Errors
- Keywords
- infusion accuracy, type 1 diabetes, artificial pancreas, patient acceptability, pump comparison
- MeSH terms
- Adult, Diabetes Mellitus, Type 1, Female, Humans, Hypoglycemic Agents, Insulin, Insulin Infusion Systems, Male, Middle Aged, Pilot Projects, Patient Satisfaction, Micro-Electrical-Mechanical Systems, Transdermal Patch, In Vitro Techniques
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