The Circulating Proangiogenic Factors CYR61 (CCN1) and NOV (CCN3) Are Significantly Decreased in Placentae and Sera of Preeclamptic Patients
Abstract
It is thought that preeclampsia results from a shallow invasion of the extravillous trophoblast into the decidua and maternal vessels, which in turn leads to hypoxia and uteroplacental insufficiency. Here, the authors focus on the expression of the proangiogenic secreted molecules CYR61 (CCN1) and NOV (CCN3) in human placentae during normal pregnancy compared with preeclamptic placentae. CYR61 and NOV are strongly expressed in endothelial cells as well as in the extravillous trophoblast, with increasing levels during placental development. Interestingly, the authors found significantly decreased levels in early preeclamptic placentae compared with matched controls. Whereas both CYR61 and NOV proteins are present at constant high levels in the sera of nonpregnant and pregnant women, in the sera of patients with early-onset preeclampsia, levels were significantly reduced. The authors suggest that the reduction of both CCN molecules in preeclampsia could be 1 reason underlying the failure of uterine vascular remodeling. Moreover, their low maternal serum levels could serve as biomarkers for early diagnosis of this disease.
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This finding is consistent with a role for CCN1 in placental angiogenesis and decidual tissue remodeling, and evidence suggests serum CCN1 levels may serve as a marker for early diagnosis of pre-eclampsia.
“This finding is consistent with a role for CCN1 in placental angiogenesis and decidual tissue remodeling, and evidence suggests that serum levels of CCN1 may serve as a marker for early diagnosis of pre-eclampsia [96].”
From CCN1/CYR61: the very model of a modern matricellular protein (2011) · cites this paper as [96]
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- Authors
- Gellhaus, A., Schmidt, M., Dunk, C., Lye, S. J., & Winterhager, E.
- Affiliations
- Essen University Hospital (DE)
- Mount Sinai Hospital (CA)
- Corresponding author
- Gellhaus, Alexandra
- Venue
- Reproductive Sciences
- Published
- 2007-12
- Volume
- 14
- Issue
- S8
- Pages
- 46-52
- ISSN
- 1933-7191 (ISSN-L)
- 1933-7205
- OpenAlex
- W2114645446
- Cited by
- 37
- References
- 23
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 2 · 2020: 1 · 2019: 2 · 2017: 2 · 2016: 2 · 2015: 1 · 2014: 5 · 2013: 1 · 2012: 4
- FWCI
- 2.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Reproductive Sciences (publishedVersion)
- PubMed (publishedVersion)
- UWA Profiles and Research Repository (University of Western Australia) (submittedVersion)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Psychiatry and Mental health › Neurological Complications and Syndromes
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Keywords
- preeclampsia, CYR61, NOV, CCN3, connective tissue growth factor, placenta, extravillous trophoblast, angiogenesis, placental insufficiency, uterine vascular remodeling, maternal serum biomarkers, endothelial cells
- MeSH terms
- Female, Germany, Gestational Age, Humans, Ontario, Placenta, Pre-Eclampsia, Pregnancy, Biomarkers, Down-Regulation, Case-Control Studies, Immediate-Early Proteins, Intercellular Signaling Peptides and Proteins, Angiogenic Proteins, Connective Tissue Growth Factor, Nephroblastoma Overexpressed Protein, Cysteine-Rich Protein 61
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