The DOI matches its Crossref record; 64 of the 64 references it cites were found in a registry or an index.
Differential DNA methylation with age displays both common and dynamic features across human tissues that are influenced by CpG landscape
Open accessAbstract
Background: DNA methylation is an epigenetic modification that changes with age in human tissues, although the mechanisms and specificity of this process are still poorly understood. We compared CpG methylation changes with age across 283 human blood, brain, kidney, and skeletal muscle samples using methylation arrays to identify tissue-specific age effects. Results: We found age-associated CpGs (ageCGs) that are both tissue-specific and common across tissues. Tissue-specific ageCGs are frequently located outside CpG islands with decreased methylation, and common ageCGs show the opposite trend. AgeCGs are significantly associated with poorly expressed genes, but those with decreasing methylation are linked with higher tissue-specific expression levels compared with increasing methylation. Therefore, tissue-specific gene expression may protect against common age-dependent methylation. Distinguished from other tissues, skeletal muscle ageCGs are more associated with expression, enriched near genes related to myofiber contraction, and closer to muscle-specific CTCF binding sites. Kidney-specific ageCGs are more increasingly methylated compared to other tissues as measured by affiliation with kidney-specific expressed genes. Underlying chromatin features also mark common and tissue-specific age effects reflective of poised and active chromatin states, respectively. In contrast with decreasingly methylated ageCGs, increasingly methylated ageCGs are also generally further from CTCF binding sites and enriched within lamina associated domains. Conclusions: Our data identified common and tissue-specific DNA methylation changes with age that are reflective of CpG landscape and suggests both common and unique alterations within human tissues. Our findings also indicate that a simple epigenetic drift model is insufficient to explain all age-related changes in DNA methylation.
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Aging of blood can be tracked by DNA methylation changes at just three CpG sites
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Epigenetic clock analysis of diet, exercise, education, and lifestyle factors
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Self-citationAn epigenetic clock analysis of race/ethnicity, sex, and coronary heart disease
Horvath, S., Gurven, M., Levine, M. E., Trumble, B. C., Kaplan, H., Allayee, H., Ritz, B. R., Chen, B., Lu, A. T., Rickabaugh, T. M., et al. (2016) · Genome Biology · doi:10.1186/s13059-016-1030-0 · Cited by 733
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Metadata
- Authors
- Day, K., Waite, L. L., Thalacker-Mercer, A., West, A., Bamman, M. M., Brooks, J. D., Myers, R. M., & Absher, D.
- Venue
- Genome Biology
- Published
- 2013-09-13
- Volume
- 14
- Issue
- 9
- Pages
- R102-R102
- ISSN
- 1465-6906 (ISSN-L)
- 1474-760X
- OpenAlex
- W1986462247
- Cited by
- 364
- References
- 64
- FWCI
- 11.03
- Type
- journal article
- Language
- en
- Open access
- gold
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- Day, K., Waite, L. L., Thalacker-Mercer, A., West, A., Bamman, M. M., Brooks, J. D., Myers, R. M., & Absher, D. (2013). Differential DNA methylation with age displays both common and dynamic features across human tissues that are influenced by CpG landscape. Genome Biology. https://doi.org/10.1186/gb-2013-14-9-r102
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