The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
MRI with intrathecal MRI gadolinium contrast medium administration: a possible method to assess glymphatic function in human brain
Open accessAbstract
Recently, the “glymphatic system” of the brain has been discovered in rodents, which is a paravascular, transparenchymal route for clearance of excess brain metabolites and distribution of compounds in the cerebrospinal fluid. It has already been demonstrated that intrathecally administered gadolinium (Gd) contrast medium distributes along this route in rats, but so far not in humans. A 27-year-old woman underwent magnetic resonance imaging (MRI) with intrathecal administration of gadobutrol, which distributed throughout her entire brain after 1 and 4.5 h. MRI with intrathecal Gd may become a tool to study glymphatic function in the human brain.
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“However, literature reporting human in vivo CSF tracer studies is lacking, and observations made in animals have not been translated into humans.”
From Brain-wide glymphatic enhancement and clearance in humans assessed with MRI. (2018) · cites this paper as [12]
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“Two recent human studies demonstrated brain parenchyma enhancement subsequent to subarachnoid (intrathecal) administration of a MRI contrast agent, but observations were limited to selected ROIs (12, 13).”
From Brain-wide glymphatic enhancement and clearance in humans assessed with MRI. (2018) · cites this paper as [12]
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Iliff, J. J., Wang, M., Liao, Y., Plogg, B. A., Peng, W., Gundersen, G. A., Benveniste, H., Vates, G. E., Deane, R., Goldman, S. A., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003748 · Cited by 5,824
The glymphatic system: a beginner's guide
Jessen, N. A., Munk, A. S. F., Lundgaard, I., & Nedergaard, M. (2015) · Neurochemical Research · doi:10.1007/s11064-015-1581-6 · Cited by 2,075
Impairment of paravascular clearance pathways in the aging brain
Kress, B. T., Iliff, J. J., Xia, M., Wang, M., Wei, H. S., Zeppenfeld, D., Xie, L., Kang, H., Xu, Q., Liew, J. A., et al. (2014) · Annals of Neurology · doi:10.1002/ana.24271 · Cited by 1,521 · cited 1×
“Glymphatic function has also been shown to decrease dramatically with aging (2) and in the injured brain (3).”
BackgroundProduction of the Alzheimer Amyloid β Protein by Normal Proteolytic Processing
Shoji, M., Golde, T. E., Ghiso, J., Cheung, T. T., Estus, S., Shaffer, L. M., Cai, X.-D., McKay, D. M., Tintner, R., Frangione, B., et al. (1992) · Science · doi:10.1126/science.1439760 · Cited by 1,447
Impairment of Glymphatic Pathway Function Promotes Tau Pathology after Traumatic Brain Injury
Iliff, J. J., Chen, M. J., Plog, B. A., Zeppenfeld, D. M., Soltero, M., Yang, L., Singh, I., Deane, R., & Nedergaard, M. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.3020-14.2014 · Cited by 1,159
Brain-wide pathway for waste clearance captured by contrast-enhanced MRI
Iliff, J. J., Lee, H., Yu, M., Feng, T., Logan, J., Nedergaard, M., & Benveniste, H. (2013) · Journal of Clinical Investigation · doi:10.1172/jci67677 · Cited by 1,148
Impaired Glymphatic Perfusion After Strokes Revealed by Contrast-Enhanced MRI
Gaberel, T., Gakuba, C., Goulay, R., de Lizarrondo, S. M., Hanouz, J., Emery, É., Touzé, E., Vivien, D., & Gauberti, M. (2014) · Stroke · doi:10.1161/strokeaha.114.006617 · Cited by 438
Akbar, J. J., Luetmer, P. H., Schwartz, K. M., et al. (2011) · American Journal of Neuroradiology · doi:10.3174/ajnr.a2815 · Cited by 119
LOCALIZATION OF CEREBROSPINAL FLUID LEAKS BY GADOLINIUM-ENHANCED MAGNETIC RESONANCE CISTERNOGRAPHY
Aydın, K., Terzibaşioğlu, E., Sencer, S., Sencer, A., Süoğlu, Y., Karasu, A., Kiris, T., & Turantan, M. I. (2008) · Neurosurgery · doi:10.1227/01.neu.0000317306.39203.24 · Cited by 68
Adam, G., Neuerburg, J. M., Spüntrup, E., et al. (1994) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910320511 · Cited by 45
Cited by
Sorted by citations
Verkhratsky, A., & Nedergaard, M. (2018) · Physiological Reviews · doi:10.1152/physrev.00042.2016 · Cited by 1,678
The glymphatic pathway in neurological disorders.
Rasmussen, M. K., Mestre, H., & Nedergaard, M. (2018) · The Lancet Neurology · doi:10.1016/s1474-4422(18)30318-1 · Cited by 1,560
Cerebral amyloid angiopathy and Alzheimer disease — one peptide, two pathways
Greenberg, S. M., Bacskai, B. J., Hernandez-Guillamon, M., Pruzin, J., Sperling, R., & van Veluw, S. J. (2020) · Nature Reviews Neurology · doi:10.1038/s41582-019-0281-2 · Cited by 947
Aquaporin-4-dependent glymphatic solute transport in the rodent brain
Mestre, H., Hablitz, L. M., Xavier, A. L., Feng, W., Zou, W., Pu, T., Monai, H., Murlidharan, G., Castellanos Rivera, R. M., Simon, M. J., et al. (2018) · eLife · doi:10.7554/elife.40070 · Cited by 738
Glymphatic MRI in idiopathic normal pressure hydrocephalus
Ringstad, G., Vatnehol, S. A. S., & Eide, P. K. (2017) · Brain · doi:10.1093/brain/awx191 · Cited by 722
Self-citation
Metadata
- Authors
- Eide, P. K., & Ringstad, G.
- Affiliations
- Oslo University Hospital (NO)
- Corresponding author
- Eide, Per Kristian
- Venue
- Acta Radiologica Open
- Publisher
- SAGE Publications
- Published
- 2015-11-01
- Volume
- 4
- Issue
- 11
- Pages
- 205846011560963
- ISSN
- 2047-9816 (ISSN-L)
- 2058-4601
- PMC
- PMC4652208
- OpenAlex
- W2252352100
- Cited by
- 218
- References
- 10
- Citations by year
- 2026: 17 · 2025: 33 · 2024: 22 · 2023: 22 · 2022: 15 · 2021: 22 · 2020: 26 · 2019: 17 · 2018: 22 · 2017: 15 · 2016: 7
- FWCI
- 6.84
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Acta Radiologica Open (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Cerebrospinal fluid and hydrocephalus
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Keywords
- glymphatic system, gadobutrol, cerebrospinal fluid, human brain imaging
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