Cited by 218Cerebrospinal fluid and hydrocephalusAdvanced MRI Techniques and ApplicationsBarrier Structure and Function Studies

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MRI with intrathecal MRI gadolinium contrast medium administration: a possible method to assess glymphatic function in human brain

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Eide, Per Kristian, Ringstad, Geir·2015·Acta Radiologica Open

DOI 10.1177/2058460115609635PMC PMC4652208

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Abstract

Recently, the “glymphatic system” of the brain has been discovered in rodents, which is a paravascular, transparenchymal route for clearance of excess brain metabolites and distribution of compounds in the cerebrospinal fluid. It has already been demonstrated that intrathecally administered gadolinium (Gd) contrast medium distributes along this route in rats, but so far not in humans. A 27-year-old woman underwent magnetic resonance imaging (MRI) with intrathecal administration of gadobutrol, which distributed throughout her entire brain after 1 and 4.5 h. MRI with intrathecal Gd may become a tool to study glymphatic function in the human brain.

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Fig. 1. Signal units (SU) measured from 3D T1W MRI before, and then 1 and 4.5 h after intrathecal administration of gadobutrol (Gadovist®), showing SU change in (a) supratentorial regions of subcortical, central white, and periventricular matter, and in (b) infratentorial regions of cerebellar and periventricular (fourth ventricle) matter, and in the brainstem and (upper cervical) spinal cord. In (c) the T1 images obtained after 1 and 4.5 h show that the SU increases in the brain can be directly acknowledged even from pure visual inspection of the images.CC BY-NC · PubMed Central

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Authors: Eide, P. K., & Ringstad, G.
Affiliations: Oslo University Hospital (NO)
Corresponding author: Eide, Per Kristian
ORCID: Eide, Per Kristian
Ringstad, Geir
Venue: Acta Radiologica Open
Publisher: SAGE Publications
Published: 2015-11-01
Volume: 4
Issue: 11
Pages: 205846011560963
ISSN: 2047-9816 (ISSN-L)
2058-4601
DOI: 10.1177/2058460115609635
PMC: PMC4652208
OpenAlex: W2252352100
Cited by: 218
References: 10
Citations by year: 2026: 17 · 2025: 33 · 2024: 22 · 2023: 22 · 2022: 15 · 2021: 22 · 2020: 26 · 2019: 17 · 2018: 22 · 2017: 15 · 2016: 7
FWCI: 6.84
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by-nc
journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: Acta Radiologica Open (publishedVersion, cc-by-nc)
Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
PubMed Central (publishedVersion, cc-by-nc)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics: Health Sciences › Medicine › Clinical Neurology › Cerebrospinal fluid and hydrocephalus
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
Keywords: glymphatic system, gadobutrol, cerebrospinal fluid, human brain imaging

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MRI with intrathecal MRI gadolinium contrast medium administration: a possible method to assess glymphatic function in human brain

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