The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
An electron microscopic histochemical and analytical X-ray microprobe study of calcification in Bruch’s membrane from human eyes
Open accessAbstract
Transmission electron microscopy, electron microprobe analysis, high temperature microincineration, and electron microscopic histochemical procedures were used to study the electron-dense deposits characteristic of the macular aspect of aged human eyes. These inorganic deposits were rich in calcium and phosphorus and selectively removed by flotation on formic acid. The amorphous decalcified masses showed a significant sulfur peak and were readily stained with acidic phosphotungstic acid. The latter observations are indicative of the presence of organic matrical proteoglycan. Such data may be a further indication that proteoglycans are retained at sites of calcification.
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“Calcification with calcium phosphate deposition is also detected in the CEL with ageing [58], causing BrM to become stiffer.”
From Bruch’s Membrane: A Key Consideration with Complement-Based Therapies for Age-Related Macular Degeneration (2023) · cites this paper as [58]
Citations
Cites
Formalin Fixation for Electron Microscopy: A Re-evaluation
Carson, F. L., Martin, J. H., & Lynn, J. A. (1973) · American Journal of Clinical Pathology · doi:10.1093/ajcp/59.3.365 · Cited by 397
Recent modifications of the glycol methacrylate embedding procedure
Leduc, E. H., & Bernhard, W. (1967) · Journal of Ultrastructure Research · doi:10.1016/s0022-5320(67)80068-6 · Cited by 358
An electron microscopic study of initial intramembranous osteogenesis
Bernard, G. W., & Pease, D. C. (1969) · American Journal of Anatomy · doi:10.1002/aja.1001250303 · Cited by 299
Protein- Polysaccharide Loss during Endochondral Ossification: Immunochemical Evidence
Hirschman, A. O. H., & Dziewiatkowski, D. D. (1966) · Science · doi:10.1126/science.154.3747.393 · Cited by 138
Proteoglycans of mineralizing rib and epiphyseal cartilage
Lohmander, S. L., & Hjerpe, A. (1975) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(75)90151-8 · Cited by 119
Studies on the Human Macula: IV. Aging Changes in Bruch's Membrane
Hogan, M. J. (1967) · Archives of Ophthalmology · doi:10.1001/archopht.1967.00980020412022 · Cited by 116
Shepard, N., & Mitchell, N. (1976) · Journal of Histochemistry & Cytochemistry · doi:10.1177/24.5.132503 · Cited by 115
Wuthier, R. E. (1969) · Calcified Tissue International · doi:10.1007/bf02279103 · Cited by 99
THE ORGANIC-INORGANIC RELATIONSHIP IN CALCIFIED MITOCHONDRIA
Bonucci, E., Derenzini, M., & Marinozzi, V. (1973) · The Journal of Cell Biology · doi:10.1083/jcb.59.1.185 · Cited by 83
Chemical modifications in osteones during calcification
Pugliarello, M. C., Vittur, F., Bernard, B., BONUCCI, E., & Ascenzi, A. (1970) · Calcified Tissue International · doi:10.1007/bf02017541 · Cited by 81
Cited by
Spraul, C. W., Lang, G. E., Grossniklaus, H. E., & Lang, G. K. (1999) · Survey of Ophthalmology · doi:10.1016/s0039-6257(99)00086-7 · Cited by 259
Structure, Function, and Pathology of Bruch's Membrane
Curcio, C. A., & Johnson, M. (2012) · Elsevier eBooks · doi:10.1016/b978-1-4557-0737-9.00020-5 · Cited by 180
Spraul, C. W. (1997) · Archives of Ophthalmology · doi:10.1001/archopht.1997.01100150269022 · Cited by 169
Tan, A. C. S., Pilgrim, M. G., Fearn, S., Bertazzo, S., Tsolaki, E., Morrell, A. P., Li, M., Messinger, J. D., Dolz‐Marco, R., Lei, J., et al. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aat4544 · Cited by 163
Thompson, R. B., Reffatto, V., Bundy, J. G., Körtvely, E., Flinn, J. M., Lanzirotti, A., Jones, E. A., McPhail, D. S., Fearn, S., Boldt, K., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1413347112 · Cited by 132
Metadata
- Authors
- Davis, W. L., Jones, R. G., & Hagler, H. K.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Venue
- Journal of Histochemistry & Cytochemistry
- Publisher
- SAGE Publications
- Published
- 1981-05
- Volume
- 29
- Issue
- 5
- Pages
- 601-608
- ISSN
- 0022-1554 (ISSN-L)
- 1551-5044
- OpenAlex
- W2145524477
- Cited by
- 34
- References
- 19
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 1 · 2018: 1 · 2017: 1 · 2015: 2 · 2014: 1 · 2013: 2 · 2012: 3
- FWCI
- 0.75
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
- Locations
- Journal of Histochemistry & Cytochemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Dermatological and Skeletal Disorders
- Health Sciences › Medicine › Ophthalmology › Retinal Development and Disorders
- Keywords
- Bruch's membrane, calcification, macular degeneration, age-related macular degeneration, calcium deposits, phosphorus, proteoglycans, sulfur, phosphotungstic acid staining, human eye
- MeSH terms
- Calcinosis, Electron Probe Microanalysis, Eye, Eye Diseases, Humans, Microscopy, Electron
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Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: An electron microscopic histochemical and analytical X-ray microprobe study of calcification in Bruch’s membrane from human eyes. https://app.cochat.ai/papers/10.1177/29.5.7252127
- The paper
- Davis, W. L., Jones, R. G., & Hagler, H. K. (1981). An electron microscopic histochemical and analytical X-ray microprobe study of calcification in Bruch’s membrane from human eyes. Journal of Histochemistry & Cytochemistry. https://doi.org/10.1177/29.5.7252127
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
