Cited by 108Magnesium in Health and DiseaseTreatment of Major DepressionMagnesium Alloys: Properties and Applications

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Magnesium and depression: a systematic review

Derom, Marie-Laure, Sayón-Orea, Carmen, Martínez-Ortega, José María, Martínez-González, Miguel A.·2013·Nutritional Neuroscience

DOI 10.1179/1476830512y.0000000044

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Abstract

INTRODUCTION: The incidence of depression is increasing worldwide. Much is still unknown about the possible role of magnesium in depression prevention and treatment. Magnesium has an effect on biological and transduction pathways implicated in the pathophysiology of depression. The possible role of magnesium in depression prevention and treatment remains unclear. OBJECTIVES: We systematically reviewed the possible links between magnesium and depression in humans. METHODS: Twenty-one cross-sectional studies, three intervention trials, one prospective study, one case only study, and one case series study were included based on specific selection criteria. RESULTS: A higher intake of dietary magnesium seems to be associated with lower depression symptoms though reverse causality cannot be excluded. The results assessing the association between blood and cerebrospinal fluid magnesium and depression are inconclusive. DISCUSSION: Magnesium seems to be effective in the treatment of depression but data are scarce and incongruous. Disturbance in magnesium metabolism might be related to depression. Oral magnesium supplementation may prevent depression and might be used as an adjunctive therapy. However, more interventional and prospective studies are needed in order to further evaluate the benefits of magnesium intake and supplementation for depression.

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Authors: Derom, M.-L., Sayón-Orea, C., Martínez-Ortega, J. M., & Martínez-González, M. A.
Affiliations: Universidad de Navarra (ES)
ORCID: Sayón-Orea, Carmen
Venue: Nutritional Neuroscience
Publisher: Informa UK Limited
Published: 2013-09
Volume: 16
Issue: 5
Pages: 191-206
ISSN: 1028-415X (ISSN-L)
1476-8305
DOI: 10.1179/1476830512y.0000000044
OpenAlex: W2015569119
Cited by: 108
References: 80
Citations by year: 2026: 3 · 2025: 9 · 2024: 9 · 2023: 7 · 2022: 10 · 2021: 8 · 2020: 10 · 2019: 10 · 2018: 14 · 2017: 9 · 2016: 6 · 2015: 7 · 2014: 3 · 2013: 3
FWCI: 0.71
Type: journal article
Language: en
Open access: closed
Locations: Nutritional Neuroscience (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Magnesium in Health and Disease
Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Physical Sciences › Materials Science › Biomaterials › Magnesium Alloys: Properties and Applications
Keywords: magnesium, depression, dietary magnesium, magnesium supplementation, blood magnesium, cerebrospinal fluid magnesium, magnesium metabolism, depression prevention, adjunctive therapy, reverse causality
MeSH terms: Animals, Calcium, Cross-Sectional Studies, Depression, Diet, Humans, Magnesium, Prospective Studies, Neuroprotective Agents, Dietary Supplements

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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

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Magnesium and depression: a systematic review

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