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Cited by 108Magnesium in Health and DiseaseTreatment of Major DepressionMagnesium Alloys: Properties and Applications

The DOI matches its Crossref record; 80 of the 80 references it cites were found in a registry or an index.

Magnesium and depression: a systematic review

Derom, Marie-Laure, Sayón-Orea, Carmen, Martínez-Ortega, José María, Martínez-González, Miguel A.·2013·Nutritional Neuroscience
DOI 10.1179/1476830512y.0000000044
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Abstract

INTRODUCTION: The incidence of depression is increasing worldwide. Much is still unknown about the possible role of magnesium in depression prevention and treatment. Magnesium has an effect on biological and transduction pathways implicated in the pathophysiology of depression. The possible role of magnesium in depression prevention and treatment remains unclear. OBJECTIVES: We systematically reviewed the possible links between magnesium and depression in humans. METHODS: Twenty-one cross-sectional studies, three intervention trials, one prospective study, one case only study, and one case series study were included based on specific selection criteria. RESULTS: A higher intake of dietary magnesium seems to be associated with lower depression symptoms though reverse causality cannot be excluded. The results assessing the association between blood and cerebrospinal fluid magnesium and depression are inconclusive. DISCUSSION: Magnesium seems to be effective in the treatment of depression but data are scarce and incongruous. Disturbance in magnesium metabolism might be related to depression. Oral magnesium supplementation may prevent depression and might be used as an adjunctive therapy. However, more interventional and prospective studies are needed in order to further evaluate the benefits of magnesium intake and supplementation for depression.

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Citations

Cites

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Research works printed but not linked: 18

  1. Andrade L, 2000, Bull World Health Organ, 78, 413
  2. World Health Organization, 2008, The global burden of disease: 2004 update
  3. Kessler RC, 2007, World Psychiatry, 6, 168
  4. American Psychiatric Association, 2000, Diagnostic and statistical manual of mental disorders: DSM-IV-TR
  5. Food and Nutrition Board IoM.Magnesium. Dietary reference intakes for calcium, phosphorus, magnesium, vitamin D, and fluoride. Washington, DC: National Academy Press; 1997. p. 190–249.
  6. Galan P, 1997, Magnesium Res, 10, 321
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  8. Barragan-Rodriguez L, 2008, Magnesium Res, 21, 218
  9. 10.2169/internalmedicine.43.410 · DOI
  10. 10.1016/j.mehy.2006.01.047 · DOI
  11. Jimerson DC, 1979, Biol Psychiatry, 14, 37
  12. Ebel H, 1980, J Clin Chem Clin Biol, 18, 257
  13. Morris ME, 1992, Magnesium Res, 5, 303
  14. Daini S, 2006, Magnesium Res, 19, 162
  15. Mark LP, 2001, Am J Neuroradiol, 22, 1813
  16. Golf SW, 1990, Magnesium-Bulletin, 12, 144
  17. Henrotte JG, 1988, Magnesium, 7, 306
  18. Jekel JF, 2007, Epidemiology, biostatics, and preventive medicine, 197

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Metadata

Authors
Derom, M.-L., Sayón-Orea, C., Martínez-Ortega, J. M., & Martínez-González, M. A.
Affiliations
Universidad de Navarra (ES)
ORCID
Sayón-Orea, Carmen
Venue
Nutritional Neuroscience
Publisher
Informa UK Limited
Published
2013-09
Volume
16
Issue
5
Pages
191-206
ISSN
  • 1028-415X (ISSN-L)
  • 1476-8305
DOI
10.1179/1476830512y.0000000044
OpenAlex
W2015569119
Cited by
108
References
80
Citations by year
2026: 3 · 2025: 9 · 2024: 9 · 2023: 7 · 2022: 10 · 2021: 8 · 2020: 10 · 2019: 10 · 2018: 14 · 2017: 9 · 2016: 6 · 2015: 7 · 2014: 3 · 2013: 3
FWCI
0.71
Type
journal article
Language
en
Open access
closed
Locations
  • Nutritional Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Magnesium in Health and Disease
  • Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
  • Physical Sciences › Materials Science › Biomaterials › Magnesium Alloys: Properties and Applications
Keywords
magnesium, depression, dietary magnesium, magnesium supplementation, blood magnesium, cerebrospinal fluid magnesium, magnesium metabolism, depression prevention, adjunctive therapy, reverse causality
MeSH terms
Animals, Calcium, Cross-Sectional Studies, Depression, Diet, Humans, Magnesium, Prospective Studies, Neuroprotective Agents, Dietary Supplements

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