The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
S-phase–specific interaction of the Fanconi anemia protein, FANCD2, with BRCA1 and RAD51
Abstract
Fanconi anemia (FA) is a human autosomal recessive cancer susceptibility disorder characterized by cellular sensitivity to mitomycin C and defective cell-cycle progression. Six FA genes (corresponding to subtypes A, C, D2, E, F, and G) have been cloned, and the encoded FA proteins interact in a common pathway. DNA damage activates this pathway, leading to monoubiquitination of the downstream FANCD2 protein and targeting to nuclear foci containing BRCA1. In the current study, we demonstrate that FANCD2 also undergoes monoubiquitination during S phase of the cell cycle. Monoubiquitinated FANCD2 colocalizes with BRCA1 and RAD51 in S-phase–specific nuclear foci. Monoubiquitination of FANCD2 is required for normal cell-cycle progression following cellular exposure to mitomycin C. Our data indicate that the monoubiquitination of FANCD2 is highly regulated, and they suggest that FANCD2/BRCA1 complexes and FANCD2/RAD51 complexes participate in an S-phase–specific cellular process, such as DNA repair by homologous recombination.
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Citations
Cites
Association of BRCA1 with Rad51 in Mitotic and Meiotic Cells
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Brca1 Controls Homology-Directed DNA Repair
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Interaction of the Fanconi Anemia Proteins and BRCA1 in a Common Pathway
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Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage
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ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage
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“Consistent with this model, recent studies have shown that ATM-dependent phosphorylation of another ubiquitin ligase, MDM2, may regulate its ability to ubiquitinate p53 [41].”
ResultInitiation of genetic recombination and recombination-dependent replication
Kowalczykowski, S. C. (2000) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(00)01569-3 · Cited by 672
Cloning of cDNAs for Fanconi's anaemia by functional complementation
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The emerging genetic and molecular basis of Fanconi anaemia
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Cited by
Triple-negative breast cancer: challenges and opportunities of a heterogeneous disease
Bianchini, G., Balko, J. M., Mayer, I. A., Sanders, M. E., & Gianni, L. (2016) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2016.66 · Cited by 3,079
McCabe, N., Turner, N. C., Lord, C. J., Kluzek, K., Białkowska, A., Swift, S., Giavara, S., O'Connor, M. J., Tutt, A. N., Zdzienicka, M. Z., et al. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-0140 · Cited by 1,310
The Fanconi anaemia/BRCA pathway
D'Andrea, A. D., & Grompe, M. (2003) · Nature Reviews Cancer · doi:10.1038/nrc970 · Cited by 822
Self-citationMaintaining genome stability at the replication fork
Branzei, D., & Foiani, M. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2852 · Cited by 786
Emergence of a DNA-damage response network consisting of Fanconi anaemia and BRCA proteins
Wang, W. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2159 · Cited by 663
Metadata
- Authors
- Taniguchi, T., Garcia-Higuera, I., Andreassen, P. R., Gregory, R. C., Grompe, M., & D'Andrea, A. D.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2002-10-01
- Volume
- 100
- Issue
- 7
- Pages
- 2414-2420
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2028637581
- Cited by
- 461
- References
- 43
- FWCI
- 8.21
- Type
- journal article
- Language
- en
- Open access
- closed
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- Taniguchi, T., Garcia-Higuera, I., Andreassen, P. R., Gregory, R. C., Grompe, M., & D'Andrea, A. D. (2002). S-phase–specific interaction of the Fanconi anemia protein, FANCD2, with BRCA1 and RAD51. Blood. https://doi.org/10.1182/blood-2002-01-0278
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