The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Primary immune responses to human CMV: a critical role for IFN-γ–producing CD4+ T cells in protection against CMV disease
Abstract
The correlates of protective immunity to disease-inducing viruses in humans remain to be elucidated. We determined the kinetics and characteristics of cytomegalovirus (CMV)–specific CD4+ and CD8+ T cells in the course of primary CMV infection in asymptomatic and symptomatic recipients of renal transplants. Specific CD8+ cytotoxic T lymphocyte (CTL) and antibody responses developed regardless of clinical signs. CD45RA−CD27+CCR7− CTLs, although classified as immature effector cells in HIV infection, were the predominant CD8 effector population in the acute phase of protective immune reactions to CMV and were functionally competent. Whereas in asymptomatic individuals the CMV-specific CD4+ T-cell response preceded CMV-specific CD8+T-cell responses, in symptomatic individuals the CMV-specific effector-memory CD4+ T-cell response was delayed and only detectable after antiviral therapy. The appearance of disease symptoms in these patients suggests that functional CD8+ T-cell and antibody responses are insufficient to control viral replication and that formation of effector-memory CD4+ T cells is necessary for recovery of infection.
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Cites
Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
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Cited by
Sylwester, A. W., Mitchell, B. L., Edgar, J. B., Taormina, C., Pelte, C., Ruchti, F., Sleath, P. R., Grabstein, K. H., Hosken, N. A., Kern, F., et al. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050882 · Cited by 1,339
Cellular responses to viral infection in humans: lessons from Epstein–Barr virus
Hislop, A. D., Taylor, G. S., Sauce, D., & Rickinson, A. B. (2007) · Annual Review of Immunology · doi:10.1146/annurev.immunol.25.022106.141553 · Cited by 766
Phenotype and function of human T lymphocyte subsets: Consensus and issues
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Immune Activation and CD8+ T-Cell Differentiation towards Senescence in HIV-1 Infection
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Perruccio, K., Tosti, A., Burchielli, E., Topini, F., Ruggeri, L., Carotti, A., Capanni, M., Urbani, E., Mancusi, A., Aversa, F., et al. (2005) · Blood · doi:10.1182/blood-2005-05-1775 · Cited by 391
Metadata
- Authors
- Gamadia, L. E., Remmerswaal, E. B. M., Weel, J. F., Bemelman, F., van Lier, R. A. W., & Ten Berge, I. J. M.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2003-04-01
- Volume
- 101
- Issue
- 7
- Pages
- 2686-2692
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2053901884
- Cited by
- 422
- References
- 48
- FWCI
- 21.07
- Type
- journal article
- Language
- en
- Open access
- closed
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- Gamadia, L. E., Remmerswaal, E. B. M., Weel, J. F., Bemelman, F., van Lier, R. A. W., & Ten Berge, I. J. M. (2003). Primary immune responses to human CMV: a critical role for IFN-γ–producing CD4+ T cells in protection against CMV disease. Blood. https://doi.org/10.1182/blood-2002-08-2502
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
