The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Map kinase signaling pathways and hematologic malignancies
Abstract
Mitogen-activated protein (Map) kinases are widely expressed serine-threonine kinases that mediate important regulatory signals in the cell. Three major groups of Map kinases exist: the p38 Map kinase family, the extracellular signal-regulated kinase (Erk) family, and the c-Jun NH2-terminal kinase (JNK) family. The members of the different Map kinase groups participate in the generation of various cellular responses, including gene transcription, induction of cell death or maintenance of cell survival, malignant transformation, and regulation of cell-cycle progression. Depending on the specific family isoform involved and the cellular context, Map kinase pathways can mediate signals that either promote or suppress the growth of malignant hematopoietic cells. Over the last few years, extensive work by several groups has established that Map kinase pathways play critical roles in the pathogenesis of various hematologic malignancies, providing new molecular targets for future therapeutic approaches. In this review, the involvement of various Map kinase pathways in the pathophysiology of hematologic malignances is summarized and the clinical implications of the recent advances in the field are discussed.
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Cites
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“Ability of different MAP kinase kinases (MAPKKs) to phosphorylate/activate Map kinases from different groups Thr-Pro-Tyr Erk ϩ ϩ Ϫ Ϫ Ϫ Ϫ Ϫ p38 Ϫ Ϫ ϩ ϩ Ϫ ϩ Ϫ JNK Ϫ Ϫ Ϫ ϩ Ϫ Ϫ ϩ Erk5 Ϫ Ϫ Ϫ Ϫ ϩ Ϫ Ϫ Mkk indicates Map kinase kinase; Erk, extracellular signal-regulated kinase; JNK, c-Jun NH2-terminal kinase; ϩ, specified Map…”
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A Cytoplasmic Inhibitor of the JNK Signal Transduction Pathway
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Cited by
Mitogen-activated protein kinases in apoptosis regulation
Wada, T., & Penninger, J. M. (2004) · Oncogene · doi:10.1038/sj.onc.1207556 · Cited by 1,432
Redox Homeostasis and Cellular Antioxidant Systems: Crucial Players in Cancer Growth and Therapy
Marengo, B., Nitti, M., Furfaro, A. L., Colla, R., Ciucis, C. D., Marinari, U. M., Pronzato, M. A., Traverso, N., & Domenicotti, C. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/6235641 · Cited by 319
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Binder, S., Luciano, M., & Horejs-Hoeck, J. (2018) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2018.08.004 · Cited by 190
Kroczynska, B., Rafidi, R. L., Majchrzak-Kita, B., Kosciuczuk, E. M., Blyth, G. T., Jemielity, J., Warminska, Z., Saleiro, D., Mehrotra, S., Arslan, A. D., et al. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.664995 · Cited by 29
Self-citation
Metadata
- Authors
- Platanias, L. C.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2003-06-15
- Volume
- 101
- Issue
- 12
- Pages
- 4667-4679
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2015183783
- Cited by
- 432
- References
- 9
- FWCI
- 11.80
- Type
- journal article
- Language
- en
- Open access
- closed
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