The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
CCL19/CCL21-triggered signal transduction and migration of dendritic cells requires prostaglandin E2
Open accessAbstract
The control of dendritic cell (DC) migration is pivotal for the initiation of cellular immune responses. When activated with inflammatory stimuli, the chemokine receptor CCR7 is up-regulated on DCs. Activated DCs home to lymphoid organs, where the CCR7 ligands CCL19 and CCL21 are expressed. We previously found that human monocyte-derived DCs (MoDCs) exclusively migrated to CCL19 and CCL21 when matured in the presence of prostaglandin (PG) E2. Because PGE2 did not alter CCR7 cell surface expression, we examined whether PGE2 may exert its effect by coupling CCR7 to signal transduction modules. Indeed, stimulation with CCR7 ligands led to enhanced phosphatidylinositol-3-kinase–mediated phosphorylation of protein kinase B when MoDCs were matured in the presence of PGE2. Moreover, CCL19/CCL21-induced intracellular calcium mobilization in MoDCs occurred only when PGE2 was present during maturation. MoDC migration to CCL19 and CCL21 was dependent on phospholipase C and intracellular calcium flux but not on phosphatidylinositol-3 kinase. Hence, our data provide insight into CCL19/CCL21-triggered signal transduction pathways and identify a novel function for PGE2 in controlling the migration of mature MoDCs by facilitating CCR7 signal transduction.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Dendritic cells and the control of immunity
Banchereau, J., & Steinman, R. M. (1998) · Nature · doi:10.1038/32588 · Cited by 14,336
Förster, R., Schubel, A., Breitfeld, D., Kremmer, E., Renner-Müller, I., Wolf, E., & Lipp, M. (1999) · Cell · doi:10.1016/s0092-8674(00)80059-8 · Cited by 2,367
Central Role for G Protein-Coupled Phosphoinositide 3-Kinase γ in Inflammation
Hirsch, E., Katanaev, V. L., Garlanda, C., Azzolino, O., Pirola, L., Silengo, L., Sozzani, S., Mantovani, A., Altruda, F., & Wymann, M. P. (2000) · Science · doi:10.1126/science.287.5455.1049 · Cited by 1,209
Rapid and coordinated switch in chemokine receptor expression during dendritic cell maturation
Sallusto, F., Schaerli, P., Loetscher, P., Schaniel, C., Lenig, D., Mackay, C. R., Qin, S., & Lanzavecchia, A. (1998) · European Journal of Immunology · doi:10.1002/(sici)1521-4141(199809)28:09<2760::aid-immu2760>3.0.co;2-n · Cited by 1,183
Function of PI3Kγ in Thymocyte Development, T Cell Activation, and Neutrophil Migration
Sasaki, T., Irie-Sasaki, J., Jones, R. G., Oliveira-dos-Santos, A. J., Stanford, W. L., Bolon, B., Wakeham, A., Itie, A., Bouchard, D., Kozieradzki, I., et al. (2000) · Science · doi:10.1126/science.287.5455.1040 · Cited by 1,031
Staurosporine, K-252 and UCN-01: potent but nonspecific inhibitors of protein kinases
Rüegg, U. T., & Gillian, B. (1989) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(89)90263-0 · Cited by 897
Roles of PLC-β2 and -β3 and PI3Kγ in Chemoattractant-Mediated Signal Transduction
Li, Z., Jiang, H., Xie, W., Zhang, Z., Smrcka, A. V., & Wu, D. (2000) · Science · doi:10.1126/science.287.5455.1046 · Cited by 807
Luther, S. A., Tang, H. L., Hyman, P. L., Farr, A. G., & Cyster, J. G. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.23.12694 · Cited by 595
Anderson, G. D., Hauser, S. D., McGarity, K. L., Bremer, M. E., Isakson, P. C., & Gregory, S. A. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118717 · Cited by 571
Scandella, E., Men, Y., Gillessen, S., Förster, R., & Groettrup, M. (2002) · Blood · doi:10.1182/blood-2001-11-0017 · Cited by 500
Self-citation
Cited by
Dendritic-cell trafficking to lymph nodes through lymphatic vessels
Randolph, G. J., Angeli, V., & Swartz, M. A. (2005) · Nature Reviews Immunology · doi:10.1038/nri1670 · Cited by 1,111
Bengtsson, A. K., Ryan, E. J., Giordano, D., Magaletti, D. M., & Clark, E. A. (2004) · Blood · doi:10.1182/blood-2003-10-3380 · Cited by 161
Cell shape sensing licenses dendritic cells for homeostatic migration to lymph nodes
Alraies, Z., Rivera, C. A., Delgado, M.-G., Sanséau, D., Maurin, M., Amadio, R., Maria Piperno, G., Dunsmore, G., Yatim, A., Lacerda Mariano, L., et al. (2024) · Nature Immunology · doi:10.1038/s41590-024-01856-3 · Cited by 106
Metadata
- Authors
- Scandella, E., Men, Y., Legler, D. F., Gillessen, S., Prikler, L., Ludewig, B., & Groettrup, M.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2004-03-01
- Volume
- 103
- Issue
- 5
- Pages
- 1595-1601
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2084093396
- Cited by
- 256
- References
- 28
- FWCI
- 7.75
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: CCL19/CCL21-triggered signal transduction and migration of dendritic cells requires prostaglandin E2. https://app.cochat.ai/papers/10.1182/blood-2003-05-1643
- The paper
- Scandella, E., Men, Y., Legler, D. F., Gillessen, S., Prikler, L., Ludewig, B., & Groettrup, M. (2004). CCL19/CCL21-triggered signal transduction and migration of dendritic cells requires prostaglandin E2. Blood. https://doi.org/10.1182/blood-2003-05-1643
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
