The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Mastermind critically regulates Notch-mediated lymphoid cell fate decisions
Open accessAbstract
During lymphoid development, Notch1 plays a critical role in the T-cell/B-cell lineage decision, while Notch2 is essential for marginal zone B-cell (MZB) development. Notch pathway activation induces translocation of intracellular Notch (ICN) to the nucleus, where it interacts with the transcription factor CSL (CBF1/RBP-Jk, Suppressor of Hairless, Lag-1). In vitro, ICN binds Mastermind-like proteins, which act as potent Notch coactivators. Three MAML family members (MAML1-3) have been identified in mammals, but their importance in vivo is unknown. To investigate the function of MAMLs in hematopoietic development, we introduced a dominant negative (DN) mutant of MAML1, capable of inhibiting Notch1-4, in murine hematopoietic stem cells. DNMAML1 resulted in early inhibition of T-cell development and the appearance of intrathymic B cells, phenotypes consistent with Notch1 inhibition. The T-cell differentiation block was as profound as that produced by enforced expression of the Notch modulator Deltex1. In DNMAML1-transduced spleen cells, a dramatic decrease in MZB cells was present, consistent with Notch2 inhibition. In contrast, Deltex1 did not decrease MZB cell numbers. These results suggest a critical role for MAMLs during Notch-mediated cell fate decisions in vivo and indicate that DNMAML1, but not Deltex1, can be used to interfere with the function of multiple Notch family members. (Blood. 2004;104:1696-1702)
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Cites
Notch regulation of lymphocyte development and function
Radtke, F., Wilson, A., Mancini, S. J. C., & MacDonald, H. R. (2004) · Nature Immunology · doi:10.1038/ni1045 · Cited by 539
Notch–RBP-J signaling is involved in cell fate determination of marginal zone B cells
Tanigaki, K., Han, H., Yamamoto, N., Tashiro, K., Ikegawa, M., Kuroda, K., Suzuki, A., Nakano, T., & Honjo, T. (2002) · Nature Immunology · doi:10.1038/ni793 · Cited by 478
Cited by
Direct inhibition of the NOTCH transcription factor complex
Moellering, R. E., Cornejo, M., Davis, T. N., Bianco, C. D., Aster, J. C., Blacklow, S. C., Kung, A. L., Gilliland, D. G., Verdine, G. L., & Bradner, J. E. (2009) · Nature · doi:10.1038/nature08543 · Cited by 752
Self-citationVanDussen, K. L., Carulli, A. J., Keeley, T. M., Patel, S. R., Puthoff, B. J., Magness, S. T., Tran, I. T., Maillard, I., Siebel, C., Kolterud, Å., et al. (2012) · Development · doi:10.1242/dev.070763 · Cited by 578
Self-citationNotch Signaling in the Immune System
Radtke, F., Fasnacht, N., & MacDonald, H. R. (2010) · Immunity · doi:10.1016/j.immuni.2010.01.004 · Cited by 543
Adaptive Chromatin Remodeling Drives Glioblastoma Stem Cell Plasticity and Drug Tolerance
Liau, B. B., Sievers, C., Donohue, L. K., Gillespie, S. M., Flavahan, W. A., Miller, T. E., Venteicher, A. S., Hebert, C. H., Carey, C. D., Rodig, S. J., et al. (2017) · Cell stem cell · doi:10.1016/j.stem.2016.11.003 · Cited by 535
Self-citationPillai, S., Cariappa, A., & Moran, S. T. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115728 · Cited by 466
Metadata
- Authors
- Maillard, I., Weng, A. P., Carpenter, A. C., Rodriguez, C. G., Sai, H., Xu, L., Allman, D., Aster, J. C., & Pear, W. S.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2004-09-15
- Volume
- 104
- Issue
- 6
- Pages
- 1696-1702
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2095397411
- Cited by
- 284
- References
- 2
- FWCI
- 6.12
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Maillard, I., Weng, A. P., Carpenter, A. C., Rodriguez, C. G., Sai, H., Xu, L., Allman, D., Aster, J. C., & Pear, W. S. (2004). Mastermind critically regulates Notch-mediated lymphoid cell fate decisions. Blood. https://doi.org/10.1182/blood-2004-02-0514
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