Cited by 4,511Mesenchymal stem cell researchHematopoietic Stem Cell TransplantationImmunotherapy and Immune Responses

The DOI matches its Crossref record; 73 of the 73 references it cites were found in a registry or an index.

Human mesenchymal stem cells modulate allogeneic immune cell responses

Open access

Aggarwal, Sudeepta, Pittenger, Mark F.·2005·Blood

DOI 10.1182/blood-2004-04-1559

Open this paper in CoChat — free account Open PDF

Abstract

Mesenchymal stem cells (MSCs) are multipotent cells found in several adult tissues. Transplanted allogeneic MSCs can be detected in recipients at extended time points, indicating a lack of immune recognition and clearance. As well, a role for bone marrow-derived MSCs in reducing the incidence and severity of graft-versus-host disease (GVHD) during allogeneic transplantation has recently been reported; however, the mechanisms remain to be investigated. We examined the immunomodulatory functions of human MSCs (hMSCs) by coculturing them with purified subpopulations of immune cells and report here that hMSCs altered the cytokine secretion profile of dendritic cells (DCs), naive and effector T cells (T helper 1 [TH1] and TH2), and natural killer (NK) cells to induce a more anti-inflammatory or tolerant phenotype. Specifically, the hMSCs caused mature DCs type 1 (DC1) to decrease tumor necrosis factor α (TNF-α) secretion and mature DC2 to increase interleukin-10 (IL-10) secretion; hMSCs caused TH1 cells to decrease interferon γ (IFN-γ) and caused the TH2 cells to increase secretion of IL-4; hMSCs caused an increase in the proportion of regulatory T cells (TRegs) present; and hMSCs decreased secretion of IFN-γ from the NK cells. Mechanistically, the hMSCs produced elevated prostaglandin E2 (PGE2) in co-cultures, and inhibitors of PGE2 production mitigated hMSC-mediated immune modulation. These data offer insight into the interactions between allogeneic MSCs and immune cells and provide mechanisms likely involved with the in vivo MSC-mediated induction of tolerance that could be therapeutic for reduction of GVHD, rejection, and modulation of inflammation. (Blood. 2005;105:1815-1822)

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1182/blood-2004-04-1559

Cites

73 of 73 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Multilineage potential of adult human mesenchymal stem cells
Pittenger, M. F., Mackay, A. M., Beck, S. C., Jaiswal, R. K., Douglas, R., Mosca, J. D., Moorman, M. A., Simonetti, D. W., Craig, S., & Marshak, D. R. (1999) · Science · doi:10.1126/science.284.5411.143 · Cited by 21,052
Self-citation
Mesenchymal stem cells
Caplan, A. I. (1991) · Journal of Orthopaedic Research® · doi:10.1002/jor.1100090504 · Cited by 6,559
Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli
Di Nicola, M., Carlo-Stella, C., Magni, M., Milanesi, M., Longoni, P. D., Matteucci, P., Grisanti, S., & Gianni, A. M. (2002) · Blood · doi:10.1182/blood.v99.10.3838 · Cited by 3,226
Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells
Le Blanc, K., Rasmusson, I., Sundberg, B., Götherström, C., Hassan, M., Uzunel, M., & Ringdén, O. (2004) · The Lancet · doi:10.1016/s0140-6736(04)16104-7 · Cited by 2,734
THE DEVELOPMENT OF FIBROBLAST COLONIES IN MONOLAYER CULTURES OF GUINEA‐PIG BONE MARROW AND SPLEEN CELLS
Friedenstein, A. J., Chailakhjan, R. K., & Lalykina, K. S. (1970) · Cell Proliferation · doi:10.1111/j.1365-2184.1970.tb00347.x · Cited by 2,724
Human Mesenchymal Stem Cells Differentiate to a Cardiomyocyte Phenotype in the Adult Murine Heart
Toma, C., Pittenger, M. F., Cahill, K. S., Byrne, B. J., & Kessler, P. (2002) · Circulation · doi:10.1161/hc0102.101442 · Cited by 2,234
Self-citation
CD4+CD25+ suppressor T cells: more questions than answers
Shevach, E. M. (2002) · Nature reviews. Immunology · doi:10.1038/nri821 · Cited by 2,097
Isolated allogeneic bone marrow-derived mesenchymal cells engraft and stimulate growth in children with osteogenesis imperfecta: Implications for cell therapy of bone
Horwitz, E. M., Gordon, P. L., Koo, W. K. K., Marx, J. C., Neel, M. D., McNall, R. Y., Muul, L., & Hofmann, T. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.132252399 · Cited by 1,650
Marrow stromal cells migrate throughout forebrain and cerebellum, and they differentiate into astrocytes after injection into neonatal mouse brains
Kopen, G. C., Prockop, D. J., & Phinney, D. G. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.19.10711 · Cited by 1,643
Human bone marrow stromal cells inhibit allogeneic T-cell responses by indoleamine 2,3-dioxygenase–mediated tryptophan degradation
Meisel, R., Zibert, A., Laryea, M. D., Göbel, U., Däubener, W., & Dilloo, D. (2004) · Blood · doi:10.1182/blood-2003-11-3909 · Cited by 1,638

Show all 73 references

Research works printed but not linked: 1

Archambault MP, McIntosh KR, Duty A, Peter SJ. Allogeneic rat mesenchymal stem cells do not elicit an immune response after implantation in immunocompetent recipients [abstract]. Blood.2000;96: 762a. Abstract 3295.

Sorted by citations

Items 901–1,000 of 1,012

Concise Review: Immunomodulatory Properties of Mesenchymal Stem Cells in Cellular Transplantation: Update, Controversies, and Unknowns
Atoui, R., & Chiu, R. C. (2012) · Stem Cells Translational Medicine · doi:10.5966/sctm.2011-0012 · Cited by 86
Mesenchymal stem cells and their therapeutic applications in inflammatory bowel disease
Mao, F., Tu, Q., Wang, L., Chu, F., Li, X., Li, H. S., & Xu, W. (2017) · Oncotarget · doi:10.18632/oncotarget.16682 · Cited by 86
Microenvironmental cues enhance mesenchymal stem cell-mediated immunomodulation and regulatory T-cell expansion
Kadle, R. L., Abdou, S. A., VILLARREAL-PONCE, A. P., Soares, M. A., Sultan, D. L., David, J. A., Massie, J. P., Rifkin, W. J., Rabbani, P. S., & Ceradini, D. J. (2018) · PLoS ONE · doi:10.1371/journal.pone.0193178 · Cited by 87
OUP accepted manuscript
Yi, S., Zhang, Y., Gu, X., Huang, L., Zhang, K., Qian, T., & Gu, X. (2020) · Burns & Trauma · doi:10.1093/burnst/tkaa002 · Cited by 87
Intracellular role of IL-6 in mesenchymal stromal cell immunosuppression and proliferation
Dorronsoro, A., Lang, V., Ferrin, I., Fernández‐Rueda, J., Zabaleta, L., Pérez-Ruiz, E., Sepúlveda, P., & Trigueros, C. (2020) · Scientific Reports · doi:10.1038/s41598-020-78864-4 · Cited by 89
Mesenchymal stem cell-based therapy for burn wound healing
Wang, M., Xu, X., Lei, X., Tan, J., & Xie, H. (2021) · Burns & Trauma · doi:10.1093/burnst/tkab002 · Cited by 90
Mesenchymal stromal cells for improvement of cardiac function following acute myocardial infarction: a matter of timing
Barrère‐Lemaire, S., Vincent, A., Jørgensen, C., Piot, C. A., Nargeot, J., & Djouad, F. (2023) · Physiological Reviews · doi:10.1152/physrev.00009.2023 · Cited by 88
Potential of mesenchymal stem cells as immune therapy in solid-organ transplantation
Crop, M. J., Baan, C. C., Weimar, W., & Hoogduijn, M. J. (2008) · Transplant International · doi:10.1111/j.1432-2277.2008.00786.x · Cited by 86
RETRACTED ARTICLE: Reduced immunomodulation potential of bone marrow-derived mesenchymal stem cells induced CCR4+CCR6+Th/Treg cell subset imbalance in ankylosing spondylitis
Wu, Y., Mingliang, R., Yang, R., Liang, X., Ma, Y., Tang, Y., Huang, L. C., Ye, J., Chen, K., Wang, P., et al. (2011) · Arthritis Research & Therapy · doi:10.1186/ar3257 · Cited by 87
Retracted
Human Mesenchymal Stromal Cells from Adult and Neonatal Sources: A Comparative In Vitro Analysis of Their Immunosuppressive Properties Against T Cells
Castro-Manrreza, M. E., Mayani, H., Monroy, A., Figueroa, E. F., Chávez-Rueda, A. K., Legorreta-Haquet, M. V., Santiago‐Osorio, E., & Montesinos, J. J. (2014) · Stem Cells and Development · doi:10.1089/scd.2013.0363 · Cited by 85
Serum IFN-γ levels predict the therapeutic effect of mesenchymal stem cell transplantation in active rheumatoid arthritis
Yang, Y., He, X., Zhao, R., Guo, W., Zhu, M., Xing, W., Jiang, D., Liu, C., & Xu, X. M. (2018) · Journal of Translational Medicine · doi:10.1186/s12967-018-1541-4 · Cited by 85
Effect of mesenchymal stem cells‐derived exosomes on tumor microenvironment: Tumor progression versus tumor suppression
Shojaei, S., Hashemi, S. M., Ghanbarian, H., Salehi, M., & Mohammadi‐Yeganeh, S. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.27326 · Cited by 89
Tendon tissue engineering: An overview of biologics to promote tendon healing and repair
Citro, V., Clerici, M., Boccaccini, A. R., Porta, G. D., Maffulli, N., & Forsyth, N. R. (2023) · Journal of Tissue Engineering · doi:10.1177/20417314231196275 · Cited by 86
Highly efficient magnetic targeting of mesenchymal stem cells in spinal cord injury
Vaněček, V., Zablotskii, V., Forostyak, S., Růžička, Herynek, V., Babič, M., Jendelová, P., Kubinová, Š., Dejneka, A., & Syková, E. (2012) · International Journal of Nanomedicine · doi:10.2147/ijn.s32824 · Cited by 84
Direct Intrathecal Implantation of Mesenchymal Stromal Cells Leads to Enhanced Neuroprotection via an NFκB-Mediated Increase in Interleukin-6 Production
Walker, P. A., Harting, M. T., Jiménez, F., Shah, S. K., Pati, S., Dash, P. K., & Cox, C. S. (2009) · Stem Cells and Development · doi:10.1089/scd.2009.0188 · Cited by 85
Lung stem cells
Kotton, D. N., & Fine, A. (2007) · Cell and Tissue Research · doi:10.1007/s00441-007-0479-2 · Cited by 85
Endogenous IL-6 of mesenchymal stem cell improves behavioral outcome of hypoxic-ischemic brain damage neonatal rats by supressing apoptosis in astrocyte
Gu, Y., He, M., Zhou, X., Liu, J., Hou, N., Tan, B., Zhang, Y., Li, T., & Chen, J. (2016) · Scientific Reports · doi:10.1038/srep18587 · Cited by 89
Mesenchymal stromal cells: a key player in ‘innate tolerance’?
Dazzi, F., Lopes, L. M., & Weng, L. (2012) · Immunology · doi:10.1111/j.1365-2567.2012.03621.x · Cited by 84
Study of Bone Marrow and Embryonic Stem Cell-Derived Human Mesenchymal Stem Cells for Treatment ofEscherichia coliEndotoxin-Induced Acute Lung Injury in Mice
Hao, Q., Zhu, Y., Monsel, A., Gennai, S., Lee, T., Xu, F., & Lee, J. W. (2015) · Stem Cells Translational Medicine · doi:10.5966/sctm.2015-0006 · Cited by 86
An update on stem cell therapy for Asherman syndrome
Benor, A. Z., Gay, S., & DeCherney, A. H. (2020) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-020-01801-x · Cited by 84
The Immunomodulatory Effects of Mesenchymal Stem Cells on Regulatory B Cells
Liu, J., Liu, Q., & Chen, X. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01843 · Cited by 88
Human umbilical cord mesenchymal stem cells-derived exosomal microRNA-451a represses epithelial–mesenchymal transition of hepatocellular carcinoma cells by inhibiting ADAM10
Xu, Y., Lai, Y., Cao, L., Li, Y., Chen, G., Chen, L., Weng, H., Chen, T., Wang, L., & Ye, Y. (2020) · RNA Biology · doi:10.1080/15476286.2020.1851540 · Cited by 84
Immunomodulation by mesenchymal stem cells in veterinary species.
Carrade, D. D., & Borjesson, D. L. (2013) · Europe PMC (PubMed Central) · Cited by 84
In vivo autologous recellularization of a tissue-engineered heart valve: Are bone marrow mesenchymal stem cells the best candidates?
Vincentelli, A., Wautot, F., Juthier, F., Fouquet, O., Corseaux, D., Maréchaux, S., Tourneau, T. L., Fabre, O. H., Susen, S., BELLE, E. V., et al. (2007) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2007.05.005 · Cited by 84
The Negative Co-Signaling Molecule B7-H4 Is Expressed by Human Bone Marrow–Derived Mesenchymal Stem Cells and Mediates its T-Cell Modulatory Activity
Xue, Q., Luan, X.-Y., Gu, Y.-Z., Wu, H.-Y., Zhang, G.-B., Yu, G.-H., Zhu, H.-T., Wang, M., Dong, W., Geng, Y., et al. (2009) · Stem Cells and Development · doi:10.1089/scd.2009.0076 · Cited by 84
Paracrine Molecules of Mesenchymal Stem Cells for Hematopoietic Stem Cell Niche
Li, T., & Wu, Y. (2011) · Bone Marrow Research · doi:10.1155/2011/353878 · Cited by 84
Human mesenchymal stromal cells enhance the immunomodulatory function of CD8+CD28− regulatory T cells
Liu, Q., Zheng, H., Chen, X., Peng, Y., Huang, W., Li, X., Li, G., Xia, W., Sun, Q., & Xiang, A. P. (2014) · Cellular and Molecular Immunology · doi:10.1038/cmi.2014.118 · Cited by 83
Chondrogenic Differentiation Alters the Immunosuppressive Property of Bone Marrow-Derived Mesenchymal Stem Cells, and the Effect Is Partially due to the Upregulated Expression of B7 Molecules
Chen, X., McClurg, A. E., Zhou, G., McCaigue, M. D., Armstrong, M. A., & Li, G. (2006) · Stem Cells · doi:10.1634/stemcells.2006-0268 · Cited by 84
Automated microscopy as a quantitative method to measure differences in adipogenic differentiation in preparations of human mesenchymal stromal cells
Surdo, J. L., Millis, B. A., & Bauer, S. R. (2013) · Cytotherapy · doi:10.1016/j.jcyt.2013.04.010 · Cited by 84
Tumor Induced Inactivation of Natural Killer Cell Cytotoxic Function; Implication in Growth, Expansion and Differentiation of Cancer Stem Cells
Jewett, A., & Tseng, H.-C. (2011) · Journal of Cancer · doi:10.7150/jca.2.443 · Cited by 86
Immunomodulatory Activity of Mesenchymal Stem Cells
Kaplan, J. M., Youd, M. E., & Lodie, T. A. (2011) · Current Stem Cell Research & Therapy · doi:10.2174/157488811797904353 · Cited by 84
Fluorescent magnetic nanoparticle-labeled mesenchymal stem cells for targeted imaging and hyperthermia therapy of in vivo gastric cancer
Ruan, J., Ji, J., Song, H., Qian, Q., Wang, K., Wang, C., & Cui, D. (2012) · Nanoscale Research Letters · doi:10.1186/1556-276x-7-309 · Cited by 84
Concise Review: Spinal Cord Injuries: How Could Adult Mesenchymal and Neural Crest Stem Cells Take Up the Challenge?
Neirinckx, V., Cantinieaux, D., Coste, C., Rogister, B., Franzen, R., & Wislet‐Gendebien, S. (2013) · Stem Cells · doi:10.1002/stem.1579 · Cited by 84
Update on mesenchymal stem cell-based therapy in lupus and scleroderma
Cras, A., Farge, D., Carmoi, T., Lataillade, J., Wang, D., & Sun, L. (2015) · Arthritis Research & Therapy · doi:10.1186/s13075-015-0819-7 · Cited by 83
Bone marrow–derived and synovium‐derived mesenchymal cells promote Th17 cell expansion and activation through caspase 1 activation: Contribution to the chronicity of rheumatoid arthritis
Eljaafari, A., Tartelin, M.-L., Aissaoui, H., Chevrel, G., Osta, B., Lavocat, F., & Miossec, P. (2012) · Arthritis & Rheumatism · doi:10.1002/art.34391 · Cited by 87
NK Cell Autoreactivity and Autoimmune Diseases
Poggi, A. D., & Zocchi, M. R. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00027 · Cited by 86
Potential application of mesenchymal stem cells and their exosomes in lung injury: an emerging therapeutic option for COVID-19 patients
Al‐Khawaga, S., & Abdelalim, E. M. (2020) · Stem Cell Research & Therapy · doi:10.1186/s13287-020-01963-6 · Cited by 84
Mesenchymal Stromal Cells Affect Disease Outcomes via Macrophage Polarization
Zheng, G., Ge, M., Qiu, G., Shu, Q., & Xu, J. (2015) · Stem Cells International · doi:10.1155/2015/989473 · Cited by 83
Human Mesenchymal Stroma/Stem Cells Exchange Membrane Proteins and Alter Functionality During Interaction with Different Tumor Cell Lines
Yang, Y., Otte, A., & Hass, R. (2014) · Stem Cells and Development · doi:10.1089/scd.2014.0413 · Cited by 87
Review of Mesenchymal Stem Cells and Tumors: Executioner or Coconspirator?
Feng, B., & Chen, L. (2009) · Cancer Biotherapy and Radiopharmaceuticals · doi:10.1089/cbr.2009.0652 · Cited by 83
Progenitor cell therapies for traumatic brain injury: barriers and opportunities in translation
Walker, P. A., Shah, S. K., Harting, M. T., & Cox, C. S. (2009) · Disease Models & Mechanisms · doi:10.1242/dmm.001198 · Cited by 83
More insight into mesenchymal stem cells and their effects inside the body
Zou, Z., Zhang, Y., Hao, L., Wang, F., Liu, D., Su, Y., & Sun, H. (2010) · Expert Opinion on Biological Therapy · doi:10.1517/14712590903456011 · Cited by 84
Neural stem/progenitor cells modulate immune responses by suppressing T lymphocytes with nitric oxide and prostaglandin E2
Wang, L., Shi, J. N., van Ginkel, F. W., Lan, L., Niemeyer, G. P., Martin, D. R., Snyder, E. Y., & Cox, N. R. (2008) · Experimental Neurology · doi:10.1016/j.expneurol.2008.11.017 · Cited by 82
Induction of Split Anergy Conditions Natural Killer Cells to Promote Differentiation of Stem Cells through Cell–Cell Contact and Secreted Factors
Tseng, H.-C., Bui, V. T., Man, Y., Cacalano, N. A., & Jewett, A. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00269 · Cited by 80
On the interactions between mesenchymal stem cells and regulatory T cells for immunomodulation in transplantation
Engela, A. U., Baan, C. C., Dor, F. J. M. F., Weimar, W., & Hoogduijn, M. J. (2012) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00126 · Cited by 82
Microencapsulated equine mesenchymal stromal cells promote cutaneous wound healing in vitro
Bussche, L., Harman, R. M., Syracuse, B., Plante, É., Lu, Y., Curtis, T. M., Ma, M., & de Walle, G. R. V. (2015) · Stem Cell Research & Therapy · doi:10.1186/s13287-015-0037-x · Cited by 83
Mesenchymal stromal cells’ role in tumor microenvironment: involvement of signaling pathways
Kamdje, A. H. N., Kamga, P. T., Simo, R. T., Vecchio, L., Etet, P. F. S., Jm, M., Bassi, G., Lukong, K. E., Goel, R. K., Amvene, J. M., et al. (2017) · Cancer Biology and Medicine · doi:10.20892/j.issn.2095-3941.2016.0033 · Cited by 81
Stem Cells for Cartilage Repair: Preclinical Studies and Insights in Translational Animal Models and Outcome Measures
Monaco, M. L., Merckx, G., Ratajczak, J., Gervois, P., Hilkens, P., Clegg, P., Bronckaers, A., Vandeweerd, J., & Lambrichts, I. (2018) · Stem Cells International · doi:10.1155/2018/9079538 · Cited by 85
Mesenchymal Stromal Cells for Transplant Tolerance
Podestà, M. A., Remuzzi, G., & Casiraghi, F. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01287 · Cited by 83
Immunosuppressive properties of mesenchymal stromal cells derived from amnion, placenta, W harton's jelly and umbilical cord
Manochantr, S., U‐pratya, Y., Kheolamai, P., Rojphisan, S., Chayosumrit, M., Tantrawatpan, C., Supokawej, A., & Issaragrisil, S. (2012) · Internal Medicine Journal · doi:10.1111/imj.12044 · Cited by 82
Interleukin-25 Mediates Transcriptional Control of PD-L1 via STAT3 in Multipotent Human Mesenchymal Stromal Cells (hMSCs) to Suppress Th17 Responses
Wang, W., Yen, M., Liu, K., Hsu, P., Sytwu, H., Chen, P., Sudhir, P., Chen, C., Chen, C., Hk, S., et al. (2015) · Stem Cell Reports · doi:10.1016/j.stemcr.2015.07.013 · Cited by 81
Good manufacturing practice-compliant animal-free expansion of human bone marrow derived mesenchymal stroma cells in a closed hollow-fiber-based bioreactor
Nold, P., Brendel, C. A., Neubauer, A., Bein, G., & Hackstein, H. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.11.001 · Cited by 82
Mesenchymal stem cells and cancer: Friends or enemies?
Hong, I.-S., Lee, H.-Y., & Kang, K.-S. (2014) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/j.mrfmmm.2014.01.006 · Cited by 82
Opposing effect of mesenchymal stem cells on Th1 and Th17 cell polarization according to the state of CD4+ T cell activation
Carrión, F., Nova‐Lamperti, E., Luz, P., Apablaza, F., & Figueroa, F. E. (2010) · Immunology Letters · doi:10.1016/j.imlet.2010.09.006 · Cited by 82
Neuroprotective effects and magnetic resonance imaging of mesenchymal stem cells labeled with SPION in a rat model of Huntington's disease
Moraes, L., Vasconcelos-dos-Santos, A., Santana, F. C., de Godoy, M. A., Rosado-de-Castro, P. H., Jasmin, J., Azevedo-Pereira, R. L., Cintra, W. M., Gasparetto, E. L., Santiago, M. F., et al. (2012) · Stem Cell Research · doi:10.1016/j.scr.2012.05.005 · Cited by 81
TNFα and IL-1β influence the differentiation and migration of murine MSCs independently of the NF-κB pathway
Sullivan, C., Porter, R. M., Evans, C. H., Ritter, T., Shaw, G., Barry, F., & Murphy, J. M. (2014) · Stem Cell Research & Therapy · doi:10.1186/scrt492 · Cited by 82
Lipopolysaccharide preconditioning of adipose-derived stem cells improves liver-regenerating activity of the secretome
Lee, S. C., Jeong, H. J., Lee, S. K., & Kim, S.-J. (2015) · Stem Cell Research & Therapy · doi:10.1186/s13287-015-0072-7 · Cited by 82
Autologous mesenchymal stem cells in chronic spinal cord injury
Bhanot, Y., Rao, S., Ghosh, D., Balaraju, S., Radhika, C. R., & V., S. K. K. (2011) · British Journal of Neurosurgery · doi:10.3109/02688697.2010.550658 · Cited by 82
Therapeutic Implications of Mesenchymal Stem Cells in Liver Injury
Puglisi, M. A., Tesori, V., Lattanzi, W., Piscaglia, A. C., Gasbarrini, G. B., D’Ugo, D., & Gasbarrini, A. (2011) · BioMed Research International · doi:10.1155/2011/860578 · Cited by 81
Perinatal Brain Injury As a Consequence of Preterm Birth and Intrauterine Inflammation: Designing Targeted Stem Cell Therapies
Paton, M. C. B., McDonald, C., Allison, B. J., Fahey, M. C., Jenkin, G., & Miller, S. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00200 · Cited by 83
Adipose tissue-derived mesenchymal stromal cells as part of therapy for chronic graft-versus-host disease: A phase I/II study
Jurado, M., Mata, C. D. L., Ruiz‐García, A., López‐Fernández, E., Espinosa, O., Remigia, M. J., Moratalla, L., Goterris, R., García-Martín, P., Ruiz‐Cabello, F., et al. (2017) · Cytotherapy · doi:10.1016/j.jcyt.2017.05.002 · Cited by 81
Current biocompatible materials in oral regeneration: a comprehensive overview of composite materials
Tahmasebi, E., Alam, M. M. R., Yazdanıan, M., Tebyanian, H., Yazdanian, A., Seifalian, A. M., & Mosaddad, S. A. (2020) · Journal of Materials Research and Technology · doi:10.1016/j.jmrt.2020.08.042 · Cited by 81
New Insights into Mesenchymal Stromal Cell‐Mediated T‐Cell Suppression Through Galectins
Sioud, M. (2010) · Scandinavian Journal of Immunology · doi:10.1111/j.1365-3083.2010.02491.x · Cited by 80
Chronic Graft-Versus-Host Disease
P??rez-Sim??n, J. A., nchez-Abarca, I. S., Díez‐Campelo, M., Caballero, D. M., & Miguel, J. S. (2006) · Drugs · doi:10.2165/00003495-200666080-00002 · Cited by 81
Cell recruitment by amnion chorion grafts promotes neovascularization
Maan, Z. N., Rennert, R. C., Koob, T. J., Januszyk, M., Li, W. W., & Gurtner, G. C. (2014) · Journal of Surgical Research · doi:10.1016/j.jss.2014.08.045 · Cited by 81
The role of the immunosuppressive microenvironment in acute myeloid leukemia development and treatment
Isidori, A., Salvestrini, V., Ciciarello, M., Loscocco, F., Visani, G., Parisi, S., Lecciso, M., Očadlíková, D., Rossi, L., Gabucci, E., et al. (2014) · Expert Review of Hematology · doi:10.1586/17474086.2014.958464 · Cited by 85
Stem cells in sepsis and acute lung injury
Cribbs, S. K., Matthay, M. A., & Martin, G. S. (2010) · Critical Care Medicine · doi:10.1097/ccm.0b013e3181f96f5f · Cited by 79
Differentiation by NK cells is a prerequisite for effective targeting of cancer stem cells/poorly differentiated tumors by chemopreventive and chemotherapeutic drugs
Kozłowska, A. K., Topchyan, P., Kaur, K., Tseng, H.-C., Teruel, A., Hiraga, T., & Jewett, A. (2017) · Journal of Cancer · doi:10.7150/jca.15989 · Cited by 80
Bone Marrow Aspirate Concentrate-Enhanced Marrow Stimulation of Chondral Defects
Madry, H., Gao, L., Eichler, H., Orth, P., & Cucchiarini, M. (2017) · Stem Cells International · doi:10.1155/2017/1609685 · Cited by 80
Wharton’s jelly mesenchymal stem cells: a concise review of their secretome and prospective clinical applications
Drobiova, H., Sindhu, S. T. A. K., Ahmad, R., Haddad, D., Al‐Mulla, F., & Madhoun, A. S. A. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1211217 · Cited by 95
Role of mesenchymal stromal cells in solid organ transplantation
Hematti, P. (2008) · Transplantation Reviews · doi:10.1016/j.trre.2008.05.002 · Cited by 80
Reciprocal Th1 and Th17 regulation by mesenchymal stem cells: Implication for multiple sclerosis
Darlington, P. J., Boivin, M., Renoux, C., François, M., Galipeau, J., Freedman, M. S., Atkins, H. L., Cohen, J. A., Solchaga, L. A., & Bar‐Or, A. (2010) · Annals of Neurology · doi:10.1002/ana.22065 · Cited by 80
Preserving Prostaglandin E2 Level Prevents Rejection of Implanted Allogeneic Mesenchymal Stem Cells and Restores Postinfarction Ventricular Function
Dhingra, S., Li, P., Huang, X., Guo, J., Wu, J., Mihic, A., Li, S., Zang, W., Shen, D., Weisel, R. D., et al. (2013) · Circulation · doi:10.1161/circulationaha.112.000324 · Cited by 80
Crosstalk Between Mesenchymal Stem Cells and Endothelial Cells Leads to Downregulation of Cytokine-Induced Leukocyte Recruitment
Luu, N. T., McGettrick, H. M., Buckley, C. D., Newsome, P. N., Rainger, G. E., Frampton, J., & Nash, G. B. (2013) · Stem Cells · doi:10.1002/stem.1511 · Cited by 81
Cell-based approaches to the engineering of vascularized bone tissue
Rao, R. R., & Stegemann, J. P. (2013) · Cytotherapy · doi:10.1016/j.jcyt.2013.06.005 · Cited by 78
Regeneration of Periodontal Tissues Using Allogeneic Periodontal Ligament Stem Cells in an Ovine Model
Mrozik, K. M., Wada, N., Marino, V., Richter, W. R., Shi, S., Wheeler, D. L., Gronthos, S., & Bartold, P. M. (2013) · Regenerative Medicine · doi:10.2217/rme.13.66 · Cited by 79
Allogeneic Transplantation of Periodontal Ligament-Derived Multipotent Mesenchymal Stromal Cell Sheets in Canine Critical-Size Supra-Alveolar Periodontal Defect Model
Tsumanuma, Y., Iwata, T., Kinoshita, A., Washio, K., Yoshida, T., Yamada, A., Takagi, R., Yamato, M., Okano, T., & Izumi, Y. (2016) · BioResearch open access · doi:10.1089/biores.2015.0043 · Cited by 79
Single-stage cell-based cartilage repair in a rabbit model: cell tracking and in vivo chondrogenesis of human umbilical cord blood-derived mesenchymal stem cells and hyaluronic acid hydrogel composite
Park, Y., Ha, C., Kim, J. A., Han, W., Rhim, J., Lee, H. J., Kim, K. J., Park, Y. G., & Chung, J. Y. (2016) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2016.10.012 · Cited by 79
Mesenchymal stem cells immunomodulation: The road to IFN-γ licensing and the path ahead
de Carvalho, A. É. S., Sousa, M. R. R., Alencar‐Silva, T., Carvalho, J. L., & Saldanha‐Araújo, F. (2019) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2019.05.006 · Cited by 79
Potential Treatment of Cerebral Global Ischemia with Oct-4+ Umbilical Cord Matrix Cells
Jomura, S., Uy, M. J. A., Mitchell, K. E., Dallasen, R., Bode, C. J., & Xu, Y. (2006) · Stem Cells · doi:10.1634/stemcells.2006-0055 · Cited by 78
Dexamethasone has variable effects on mesenchymal stromal cells
Wang, H., Pang, B., Li, Y., Zhu, D., Pang, T., & Liu, Y.-J. (2012) · Cytotherapy · doi:10.3109/14653249.2011.652735 · Cited by 79
Immunological Properties of Extraembryonic Human Mesenchymal Stromal Cells Derived from Gestational Tissue
Stubbendorff, M., Deuse, T., Hua, X., Phan, T. T., Bieback, K., Atkinson, K., EIERMANN, T. H., Velden, J., Schröder, C., Reichenspurner, H. C., et al. (2013) · Stem Cells and Development · doi:10.1089/scd.2013.0043 · Cited by 78
Cell therapy for human ischemic heart diseases: Critical review and summary of the clinical experiences
Pávó, N., Charwat, S., Nyolczas, N., András, J., Murlasits, Z., Bergler-Klein, J. K., Nikfardjam, M., Benedek, I., Benedek, T., Pavo, I. J., et al. (2014) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2014.06.016 · Cited by 77
Immunogenicity of Allogeneic Mesenchymal Stromal Cells: What Has Been Seen in Vitro and in Vivo ?
Consentius, C., Reinke, P., & Volk, H. (2015) · Regenerative Medicine · doi:10.2217/rme.15.14 · Cited by 78
Mesenchymal stem cells (MSCs) as skeletal therapeutics–an update
Saeed, H., Ahsan, M., Saleem, Z., Iqtedar, M., Islam, M. F., Danish, Z., & Khan, A. M. (2016) · Journal of Biomedical Science · doi:10.1186/s12929-016-0254-3 · Cited by 77
Human Neural Stem Cell Therapy for Chronic Ischemic Stroke: Charting Progress from Laboratory to Patients
Sinden, J. D., Hicks, C. A., Stroemer, P., Vishnubhatla, I., & Corteling, R. L. (2017) · Stem Cells and Development · doi:10.1089/scd.2017.0009 · Cited by 79
Addressing Stem Cell Therapeutic Approaches in Pathobiology of Diabetes and Its Complications
Peng, B., Dubey, N. K., Mishra, V. K., Tsai, F.-C., Dubey, R., Deng, W., & Wei, H.-J. (2018) · Journal of Diabetes Research · doi:10.1155/2018/7806435 · Cited by 82
Dental Follicle Stem Cells: Tissue Engineering and Immunomodulation
Zhang, J., Ding, H. Y., Liu, X., Sheng, Y., Liu, X., & Jiang, C. (2019) · Stem Cells and Development · doi:10.1089/scd.2019.0012 · Cited by 78
MSC: immunoregulatory effects, roles on neutrophils and evolving clinical potentials.
Joel, M. D. M., Yuan, J., Wang, J., Yan, Y., Qian, H., Zhang, X., Xu, W., & Mao, F. (2019) · Europe PMC (PubMed Central) · Cited by 78
Characterization and therapeutic applications of mesenchymal stem cells for regenerative medicine
Wang, J., Chen, Z., Sun, M., Xu, H., Gao, Y., Liu, J., & Li, M. (2020) · Tissue and Cell · doi:10.1016/j.tice.2020.101330 · Cited by 78
Mesenchymal stem cells as a potential therapy for COVID-19
Liu, S., Peng, D.-Y., Qiu, H., Yang, K., Fu, Z., & Zou, L. (2020) · Stem Cell Research & Therapy · doi:10.1186/s13287-020-01678-8 · Cited by 78
Cell therapy in patients with COVID-19 using Wharton’s jelly mesenchymal stem cells: a phase 1 clinical trial
Saleh, M., Vaezi, A. A., Aliannejad, R., Sohrabpour, A. A., Kiaei, S. Z. F., Shadnoush, M., Siavashi, V., Aghaghazvini, L., Khoundabi, B., Abdoli, S., et al. (2021) · Stem Cell Research & Therapy · doi:10.1186/s13287-021-02483-7 · Cited by 78
Umbilical cord tissue-derived mesenchymal stem cells grow best under GMP-compliant culture conditions and maintain their phenotypic and functional properties
Hartmann, I., Hollweck, T., Haffner, S., Krebs, M., Meiser, B., Reichart, B., & Eißner, G. (2010) · Journal of Immunological Methods · doi:10.1016/j.jim.2010.10.008 · Cited by 78
Glial cell line‐derived neurotrophic factor–secreting genetically modified human bone marrow‐derived mesenchymal stem cells promote recovery in a rat model of Parkinson's disease
Glavaski‐Joksimovic, A., Virág, T., Mangatu, T. A., McGrogan, M. P., Wang, X. S., & Bohn, M. C. (2010) · Journal of Neuroscience Research · doi:10.1002/jnr.22435 · Cited by 77
Notch1 modulates mesenchymal stem cells mediated regulatory T ‐cell induction
Papa, B. D., Sportoletti, P., Cecchini, D., Rosati, E., Balucani, C., Baldoni, S., Fettucciari, K., Marconi, P., Martelli, M. F., Falzetti, F., et al. (2012) · European Journal of Immunology · doi:10.1002/eji.201242643 · Cited by 82
Activation of Human Mesenchymal Stem Cells Impacts Their Therapeutic Abilities in Lung Injury by Increasing Interleukin (IL)-10 and IL-1RN Levels
Bustos, M. L., Huleihel, L., Meyer, E. M., Donnenberg, A. D., Donnenberg, V. S., Sciurba, J., Mroz, L., McVerry, B. J., Ellis, B. M., Kaminski, N., et al. (2013) · Stem Cells Translational Medicine · doi:10.5966/sctm.2013-0033 · Cited by 79
Intravenous hMSCs Ameliorate Acute Pancreatitis in Mice via Secretion of Tumor Necrosis Factor-α Stimulated Gene/Protein 6
He, Z., Hua, J., Qian, D., Gong, J. F., Lin, S., Xu, C., Wei, G., Meng, H., Yang, T., Zhou, B., et al. (2016) · Scientific Reports · doi:10.1038/srep38438 · Cited by 78
Mechanisms of Immune Suppression Utilized by Canine Adipose and Bone Marrow-Derived Mesenchymal Stem Cells
Chow, L., Johnson, V., Coy, J. W., Regan, D. P., & DOW, S. W. (2016) · Stem Cells and Development · doi:10.1089/scd.2016.0207 · Cited by 78
Cells as advanced therapeutics: State-of-the-art, challenges, and opportunities in large scale biomanufacturing of high-quality cells for adoptive immunotherapies
Dwarshuis, N., Parratt, K. H., Santiago-Miranda, A. N., & Roy, K. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2017.06.005 · Cited by 80
SIRT3 Enhances Mesenchymal Stem Cell Longevity and Differentiation
Denu, R. A. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/5841716 · Cited by 79

Authors: Aggarwal, S., & Pittenger, M. F.
Affiliations: Osiris Therapeutics (United States) (US)
ORCID: Pittenger, Mark F.
Venue: Blood
Publisher: American Society of Hematology
Published: 2005-02-15
Volume: 105
Issue: 4
Pages: 1815-1822
ISSN: 0006-4971 (ISSN-L)
1528-0020
DOI: 10.1182/blood-2004-04-1559
OpenAlex: W2095666785
Cited by: 4,511
References: 73
Citations by year: 2026: 51 · 2025: 82 · 2024: 118 · 2023: 158 · 2022: 187 · 2021: 253 · 2020: 236 · 2019: 209 · 2018: 233 · 2017: 251 · 2016: 312 · 2015: 284 · 2014: 299 · 2013: 338 · 2012: 328
FWCI: 47.59
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Blood (publishedVersion)
PubMed (publishedVersion)
Funders: Osiris Therapeutics
Defense Advanced Research Projects Agency
Advanced Research Projects Agency
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Keywords: mesenchymal stem cells, immunomodulation, graft-versus-host disease, allogeneic transplantation, dendritic cells, T helper cells, natural killer cells, regulatory T cells, prostaglandin E2, cytokine production, immune tolerance, bone marrow-derived stem cells
MeSH terms: Cell Communication, Cells, Cultured, Dendritic Cells, Humans, Immunologic Factors, Immunosuppression Therapy, Killer Cells, Natural, Leukocytes, Mononuclear, Lymphocyte Activation, Mesoderm, T-Lymphocytes, Transplantation, Homologous, Dinoprostone, Coculture Techniques, Multipotent Stem Cells

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Human mesenchymal stem cells modulate allogeneic immune cell responses

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks