The DOI matches its Crossref record; 73 of the 73 references it cites were found in a registry or an index.
Human mesenchymal stem cells modulate allogeneic immune cell responses
Open accessAbstract
Mesenchymal stem cells (MSCs) are multipotent cells found in several adult tissues. Transplanted allogeneic MSCs can be detected in recipients at extended time points, indicating a lack of immune recognition and clearance. As well, a role for bone marrow-derived MSCs in reducing the incidence and severity of graft-versus-host disease (GVHD) during allogeneic transplantation has recently been reported; however, the mechanisms remain to be investigated. We examined the immunomodulatory functions of human MSCs (hMSCs) by coculturing them with purified subpopulations of immune cells and report here that hMSCs altered the cytokine secretion profile of dendritic cells (DCs), naive and effector T cells (T helper 1 [TH1] and TH2), and natural killer (NK) cells to induce a more anti-inflammatory or tolerant phenotype. Specifically, the hMSCs caused mature DCs type 1 (DC1) to decrease tumor necrosis factor α (TNF-α) secretion and mature DC2 to increase interleukin-10 (IL-10) secretion; hMSCs caused TH1 cells to decrease interferon γ (IFN-γ) and caused the TH2 cells to increase secretion of IL-4; hMSCs caused an increase in the proportion of regulatory T cells (TRegs) present; and hMSCs decreased secretion of IFN-γ from the NK cells. Mechanistically, the hMSCs produced elevated prostaglandin E2 (PGE2) in co-cultures, and inhibitors of PGE2 production mitigated hMSC-mediated immune modulation. These data offer insight into the interactions between allogeneic MSCs and immune cells and provide mechanisms likely involved with the in vivo MSC-mediated induction of tolerance that could be therapeutic for reduction of GVHD, rejection, and modulation of inflammation. (Blood. 2005;105:1815-1822)
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Multilineage potential of adult human mesenchymal stem cells
Pittenger, M. F., Mackay, A. M., Beck, S. C., Jaiswal, R. K., Douglas, R., Mosca, J. D., Moorman, M. A., Simonetti, D. W., Craig, S., & Marshak, D. R. (1999) · Science · doi:10.1126/science.284.5411.143 · Cited by 21,052
Self-citationCaplan, A. I. (1991) · Journal of Orthopaedic Research® · doi:10.1002/jor.1100090504 · Cited by 6,559
Di Nicola, M., Carlo-Stella, C., Magni, M., Milanesi, M., Longoni, P. D., Matteucci, P., Grisanti, S., & Gianni, A. M. (2002) · Blood · doi:10.1182/blood.v99.10.3838 · Cited by 3,226
Le Blanc, K., Rasmusson, I., Sundberg, B., Götherström, C., Hassan, M., Uzunel, M., & Ringdén, O. (2004) · The Lancet · doi:10.1016/s0140-6736(04)16104-7 · Cited by 2,734
Friedenstein, A. J., Chailakhjan, R. K., & Lalykina, K. S. (1970) · Cell Proliferation · doi:10.1111/j.1365-2184.1970.tb00347.x · Cited by 2,724
Human Mesenchymal Stem Cells Differentiate to a Cardiomyocyte Phenotype in the Adult Murine Heart
Toma, C., Pittenger, M. F., Cahill, K. S., Byrne, B. J., & Kessler, P. (2002) · Circulation · doi:10.1161/hc0102.101442 · Cited by 2,234
Self-citationCD4+CD25+ suppressor T cells: more questions than answers
Shevach, E. M. (2002) · Nature reviews. Immunology · doi:10.1038/nri821 · Cited by 2,097
Horwitz, E. M., Gordon, P. L., Koo, W. K. K., Marx, J. C., Neel, M. D., McNall, R. Y., Muul, L., & Hofmann, T. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.132252399 · Cited by 1,650
Kopen, G. C., Prockop, D. J., & Phinney, D. G. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.19.10711 · Cited by 1,643
Meisel, R., Zibert, A., Laryea, M. D., Göbel, U., Däubener, W., & Dilloo, D. (2004) · Blood · doi:10.1182/blood-2003-11-3909 · Cited by 1,638
Research works printed but not linked: 1
- Archambault MP, McIntosh KR, Duty A, Peter SJ. Allogeneic rat mesenchymal stem cells do not elicit an immune response after implantation in immunocompetent recipients [abstract]. Blood.2000;96: 762a. Abstract 3295.
Cited by
Sorted by citations
Items 701–800 of 1,012
Donor-Derived Mesenchymal Stem Cells Suppress Alloreactivity of Kidney Transplant Patients
Crop, M. J., Baan, C. C., Korevaar, S. S., IJzermans, J. N. M., Alwayn, I. P. J., Weimar, W., & Hoogduijn, M. J. (2009) · Transplantation · doi:10.1097/tp.0b013e31819b3d72 · Cited by 110
Current perspectives in stem cell research for knee cartilage repair
Orth, P., Rey‐Rico, A., Venkatesan, J. K., Madry, H., & Cucchiarini, M. (2014) · Stem Cells and Cloning Advances and Applications · doi:10.2147/sccaa.s42880 · Cited by 110
Chen, H., Chen, H.-Y., Wang, L., Wang, F.-H., Fang, L.-W., Lai, H.-Y., Chen, H.-H., Lu, J., Hung, M., Cheng, Y., et al. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1202775 · Cited by 110
Mohr, A., Lyons, M. J., Deedigan, L., Harte, T., Shaw, G., Howard, L., Barry, F., O’Brien, T., & Zwacka, R. M. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00317.x · Cited by 112
The Cell Surface Proteome of Human Mesenchymal Stromal Cells
Niehage, C., Steenblock, C., Pursche, T., Bornhäuser, M., Corbeil, D., & Hoflack, B. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020399 · Cited by 109
Kerkelä, E., Laitinen, A., Räbinä, J., Valkonen, S., Takatalo, M. S., Larjo, A., Veijola, J., Lampinen, M., Siljander, P. R. M., Lehenkari, P. P., et al. (2016) · Stem Cells · doi:10.1002/stem.2280 · Cited by 114
Galland, S., Vuille, J. A., Martin, P., Letovanec, I., Caignard, A., Fregni, G., & Stamenkovic, I. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.08.089 · Cited by 111
Xie, Q., Xiong, X., Xiao, N., He, K., Chen, M., Peng, J., Su, X., Mei, H., Dai, Y., Wei, D., et al. (2019) · Stem Cells International · doi:10.1155/2019/9782373 · Cited by 109
Igboeli, P., Andaloussi, A. E., Sheikh, U., Takala, H., Elsharoud, A., McHugh, A., Gavrilova-Jordan, L. P., Levy, S., & Al-Hendy, A. A. (2020) · Journal of Medical Case Reports · doi:10.1186/s13256-020-02426-5 · Cited by 109
Current perspectives on mesenchymal stromal cell therapy for graft versus host disease
Kadri, N., Amu, S., Iacobaeus, E., Boberg, E., & Blanc, K. L. (2023) · Cellular and Molecular Immunology · doi:10.1038/s41423-023-01022-z · Cited by 115
Bárcia, R. N., Santos, J. M., Filipe, M., Teixeira, M., Martins, J. P., Almeida, J. M., Agua‐Doce, A., Almeida, S. C. P., Varela, A., Pohl, S., et al. (2015) · Stem Cells International · doi:10.1155/2015/583984 · Cited by 108
Wang, D., Feng, X., Lü, L., Konkel, J. E., Zhang, H., Chen, Z., Li, X., Gao, X., Lu, L., Shi, S., et al. (2014) · Arthritis & Rheumatology · doi:10.1002/art.38674 · Cited by 108
Physiologically inspired cardiac scaffolds for tailored in vivo function and heart regeneration
Kaiser, N. J., & Coulombe, K. L. K. (2015) · Biomedical Materials · doi:10.1088/1748-6041/10/3/034003 · Cited by 111
Bassi, Ê. J., de Almeida, D. C., Moraes‐Vieira, P. M., & Câmara, N. O. S. (2011) · Stem Cell Reviews and Reports · doi:10.1007/s12015-011-9311-1 · Cited by 107
Mesenchymal Stem Cell Therapy for Inflammatory Skin Diseases: Clinical Potential and Mode of Action
Shin, T., Kim, H., Choi, S. O., & Kang, K. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18020244 · Cited by 107
Sun, C., Wang, L., Wang, H., Huang, T., Yao, W., Li, J., & Zhang, X. (2020) · Stem Cell Research & Therapy · doi:10.1186/s13287-020-01660-4 · Cited by 108
Pinheiro, C. H. D. J., de Queiroz, J. C. F., Guimarães‐Ferreira, L., Vitzel, K. F., Nachbar, R. T., de Sousa, L. G. O., de Souza, A. L., Nunes, M. T., & Curi, R. (2011) · Stem Cell Reviews and Reports · doi:10.1007/s12015-011-9304-0 · Cited by 108
Gu, Y., Xue, Q., Chen, Y., Yu, G., Qing, M.-D., Shen, Y., Wang, M., Shi, Q., & Zhang, X. (2012) · Human Immunology · doi:10.1016/j.humimm.2012.12.011 · Cited by 108
Hsueh, Y., Chang, Y., Huang, T.-C., Fan, S.-C., Wang, D.-H., Chen, J. J., Wu, C., & Lin, S.-C. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.11.081 · Cited by 107
Cellular and molecular interactions of mesenchymal stem cells in innate immunity
Spaggiari, G. M., & Moretta, L. (2012) · Immunology and Cell Biology · doi:10.1038/icb.2012.62 · Cited by 107
Immunomodulatory Effects of Adipose-Derived Stem Cells: Fact or Fiction?
Barone, A. A. L., Khalifian, S., Lee, W. P. A., & Brandacher, G. (2013) · BioMed Research International · doi:10.1155/2013/383685 · Cited by 107
Transplantation of a 3D-printed tracheal graft combined with iPS cell-derived MSCs and chondrocytes
Kim, I. G., Park, S. A., Lee, S.-H., Choi, J. S., Cho, H., Lee, S. J., Kwon, Y., & Kwon, S. K. (2020) · Scientific Reports · doi:10.1038/s41598-020-61405-4 · Cited by 109
Cell- and gene-based approaches to tendon regeneration
Nixon, A. J., Watts, A. E., & Schnabel, L. V. (2012) · Journal of Shoulder and Elbow Surgery · doi:10.1016/j.jse.2011.11.015 · Cited by 107
Golay, J., Cuppini, L., Leoni, F., Micò, M. C., Barbui, V., Domenghini, M., Lombardi, L. T., Neri, A., Barbui, A. M., Salvi, A., et al. (2007) · Leukemia · doi:10.1038/sj.leu.2404860 · Cited by 107
Yamahara, K., Harada, K., Ohshima, M., Ishikane, S., Ohnishi, S., Tsuda, H., Otani, K., Taguchi, A., Soma, T., Ogawa, H., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0088319 · Cited by 107
Cho, K., Park, M.-K., Kang, S., Park, H., Hong, S., Park, H.-K., Yu, H. S., & Roh, H. (2014) · Mediators of Inflammation · doi:10.1155/2014/436476 · Cited by 106
Combining adult stem cells and polymeric devices for tissue engineering in infarcted myocardium
Karam, J., Muscari, C., & Montero‐Menei, C. N. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.04.028 · Cited by 110
Immunomodulatory effects of human amniotic membrane-derived mesenchymal stem cells
Kang, J. W., Koo, H. C., Hwang, S. Y., Kang, S. K., Ra, J. C., Lee, M. H., & Park, Y. H. (2012) · Journal of Veterinary Science · doi:10.4142/jvs.2012.13.1.23 · Cited by 107
Dental pulp stem cells: a new cellular resource for corneal stromal regeneration
Syed-Picard, F. N., Du, Y., Lathrop, K. L., Mann, M. M., Funderburgh, M. L., & Funderburgh, J. L. (2015) · Stem Cells Translational Medicine · doi:10.5966/sctm.2014-0115 · Cited by 106
Emerging therapeutic targets for treatment of leishmaniasis
Sundar, S., & Singh, B. (2018) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2018.1472241 · Cited by 109
Immunomodulatory effects of mesenchymal stem cells in peripheral nerve injury
Li, X., Guan, Y., Li, C., Zhang, T., Meng, F., Zhang, J., Li, J., Chen, S., Wang, Q., Wang, Y., et al. (2022) · Stem Cell Research & Therapy · doi:10.1186/s13287-021-02690-2 · Cited by 111
Siclari, V. A., Zhu, J., Akiyama, K., Liu, F., Zhang, X., Chandra, A., Nah, H., Shi, S., & Qin, L. (2012) · Bone · doi:10.1016/j.bone.2012.12.013 · Cited by 106
McGinley, L. M., McMahon, J. M., Strappe, P., Barry, F., Murphy, M. J., O’Toole, D. P., & O’Brien, T. (2011) · Stem Cell Research & Therapy · doi:10.1186/scrt53 · Cited by 106
Kota, D. J., Prabhakara, K. S., Furman, N. E. T., Bhattarai, D., Chen, Q., DiCarlo, B., Smith, P., Triolo, F., Wenzel, P. L., Cox, C. S., et al. (2017) · Stem Cells · doi:10.1002/stem.2603 · Cited by 105
Human Adipose Tissue-Derived Mesenchymal Stem Cells Induce Explosive T-Cell Proliferation
Crop, M. J., Baan, C. C., Korevaar, S. S., IJzermans, J. N. M., Weimar, W., & Hoogduijn, M. J. (2010) · Stem Cells and Development · doi:10.1089/scd.2009.0368 · Cited by 104
Park, K.-S., Tae, J., Choi, B., Kim, Y. S., Moon, C., Kim, S.-H., Lee, H. S., Kim, J., Kim, J., Park, J. B., et al. (2009) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2009.07.005 · Cited by 104
Deng, K., Lin, D., Hanzlicek, B., Balog, B. M., Penn, M. S., Kiedrowski, M. J., Hu, Z., Ye, Z., Zhu, H., & Damaser, M. S. (2014) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00510.2014 · Cited by 104
Cosenza, S., Ruiz, M., Maumus, M., Jørgensen, C., & Noël, D. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18040889 · Cited by 104
Ishikane, S., Ohnishi, S., Yamahara, K., Sada, M., Harada, K., Mishima, K., Iwasaki, K., Fujiwara, M., Kitamura, S., Nagaya, N., et al. (2008) · Stem Cells · doi:10.1634/stemcells.2008-0236 · Cited by 104
Lepelletier, Y., Lecourt, S., Renand, A., Arnulf, B., Vanneaux, V., Fermand, J., Menasché, P., Domet, T., Marolleau, J., Hermine, O., et al. (2009) · Stem Cells and Development · doi:10.1089/scd.2009.0212 · Cited by 104
Gieseke, F., Schüett, B. S., Viebahn, S., Kościelniak, E., Friedrich, W., Handgretinger, R., & Müller, I. (2007) · Blood · doi:10.1182/blood-2007-04-083162 · Cited by 104
Campioni, D., Rizzo, R., Stignani, M., Melchiorri, L., Ferrari, L., Moretti, S., Russo, A. D., Bagnara, G. P., Bonsi, L., Alviano, F., et al. (2008) · Cytometry Part B Clinical Cytometry · doi:10.1002/cyto.b.20461 · Cited by 104
Mesenchymal stem cells: from biology to clinical use.
Krampera, M., Franchini, M., Pizzolo, G., & Aprili, G. (2007) · PubMed Central · doi:10.2450/2007.0029-07 · Cited by 113
Rosenkranz, K., Kumbruch, S., Lebermann, K., Marschner, K., Jensen, A., Dermietzel, R., & Meier, C. (2009) · Journal of Neuroscience Research · doi:10.1002/jnr.22292 · Cited by 103
Mesenchymal Stem Cell Therapy for Cardiac Repair
Boyle, A., McNiece, I., & Hare, J. M. (2010) · Methods in molecular biology · doi:10.1007/978-1-60761-705-1_5 · Cited by 103
Ross, C. L., Ang, D. C., & Almeida-Porada, G. D. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00266 · Cited by 105
García, J. R., Quirós, M., Han, W. M., O’Leary, M. N., Cox, G. N., Nusrat, A., & Garcı́a, A. J. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.119403 · Cited by 103
Emerging understanding of apoptosis in mediating mesenchymal stem cell therapy
Fu, Y., Sui, B., Xiang, L., Yan, X., Wu, D., Shi, S., & Hu, X. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-03883-6 · Cited by 109
Kondo, M., Yamaoka, K., Sakata, K., Sonomoto, K., Lin, L., Nakano, K., & Tanaka, Y. (2015) · Arthritis & Rheumatology · doi:10.1002/art.39036 · Cited by 106
Momin, E. N., Vela, G., Zaidi, H. A., & Quiñones‐Hinojosa, A. (2010) · Current Immunology Reviews · doi:10.2174/157339510791111718 · Cited by 106
Hydrogels for in vivo‐like three‐dimensional cellular studies
DeVolder, R. J., & Kong, H. (2012) · WIREs Systems Biology and Medicine · doi:10.1002/wsbm.1174 · Cited by 105
Immune regulatory properties of multipotent mesenchymal stromal cells: Where do we stand?
Bassi, Ê. J. (2011) · World Journal of Stem Cells · doi:10.4252/wjsc.v3.i1.1 · Cited by 102
Mechanical derivation of functional myotubes from adipose-derived stem cells
Choi, Y. S., Vincent, L. G., Lee, A. R., Dobke, M. K., & Engler, A. J. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.12.004 · Cited by 103
Mesenchymal stem cells at the intersection of cell and gene therapy
Myers, T. J., Granero‐Moltó, F., Longobardi, L., Li, T., Yan, Y., & Spagnoli, A. (2010) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2010.531257 · Cited by 105
Adult stem cells in the treatment of autoimmune diseases
van Laar, J. M., & Tyndall, A. (2006) · Lara D. Veeken · doi:10.1093/rheumatology/kel158 · Cited by 102
Holt, D. D. C., Wood, J. A., Granick, J. L., Walker, N. J., Clark, K. C., & Borjesson, D. L. (2014) · Stem Cells and Development · doi:10.1089/scd.2013.0537 · Cited by 101
Liu, L., Wang, Y., Fan, H., Zhao, X., Liu, D., Hu, Y., Kidd, A. R., Bao, J., & Hou, Y. (2012) · Stem Cells · doi:10.1002/stem.1156 · Cited by 103
Extracellular Vesicles from Mesenchymal Stem Cells as Novel Treatments for Musculoskeletal Diseases
Alcaraz, M. J., Álvaro Compan, J., & Guillén, M. I. (2019) · Cells · doi:10.3390/cells9010098 · Cited by 107
Rossignol, J., Boyer, C., Thinard, R., Remy, S., Dugast, A., Dubayle, D., Dey, N. D., Boeffard, F., Delécrin, J., Heymann, D., et al. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00657.x · Cited by 101
Li, C., Zhang, W., Jiang, X., & Mao, N. (2007) · Cell and Tissue Research · doi:10.1007/s00441-007-0504-5 · Cited by 101
Ho, M. S. H., Mei, S. H. J., & Stewart, D. J. (2015) · Journal of Cellular Physiology · doi:10.1002/jcp.25028 · Cited by 100
Ha, C., Park, Y., Chung, J. Y., & Park, Y. (2015) · Stem Cells Translational Medicine · doi:10.5966/sctm.2014-0264 · Cited by 100
Cooney, D. S., Wimmers, E. G., Ibrahim, Z., Grahammer, J., Christensen, J. M., Brat, G. A., Wu, L. W., Sarhane, K. A., Lopez, J., Wallner, C., et al. (2016) · Scientific Reports · doi:10.1038/srep31306 · Cited by 100
Barrachina, L., Remacha, A. R., Romero, A., Vázquez, F. J., Albareda, J., Prades, M., Gosálvez, J., Roy, R., Zaragoza, P., Martín‐Burriel, I., et al. (2016) · Stem Cells and Development · doi:10.1089/scd.2016.0209 · Cited by 100
Immunomodulatory Effects of MSCs in Bone Healing
Medhat, D., Rodrı́guez, C. I., & Infante, A. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20215467 · Cited by 103
Periodontal Ligament Stem Cells Regulate B Lymphocyte Function via Programmed Cell Death Protein 1
Liu, O., Xu, J., Ding, G., Liu, D., Fan, Z., Zhang, C., Chen, W., Ding, Y., Tang, Z., & Wang, S. (2013) · Stem Cells · doi:10.1002/stem.1387 · Cited by 100
Mesenchymal Stem Cells for Cardiac Regenerative Therapy
Schuleri, K. H., Boyle, A., & Hare, J. M. (2007) · Handbook of experimental pharmacology · doi:10.1007/978-3-540-68976-8_9 · Cited by 98
Sbano, P., Cuccia, A., Mazzanti, B., Urbani, S., Giusti, B., Lapini, I., Rossi, L., Abbate, R., Marseglia, G., Nannetti, G., et al. (2008) · Archives of Dermatological Research · doi:10.1007/s00403-007-0827-9 · Cited by 99
Mesenchymal stem cells, autoimmunity and rheumatoid arthritis
El‐Jawhari, J. J., El-Sherbiny, Y. M., Jones, E., & McGonagle, D. G. (2014) · QJM · doi:10.1093/qjmed/hcu033 · Cited by 98
Potential implications of mesenchymal stem cells in cancer therapy
Dai, L.-J., Moniri, M. R., Zeng, Z.-R., Zhou, J. X., Rayat, J., & Warnock, G. L. (2011) · Cancer Letters · doi:10.1016/j.canlet.2011.02.012 · Cited by 99
Perlee, D., van Vught, L. A., Scicluna, B. P., Maag, A., Lutter, R., Kemper, E. M., Veer, C. V. ′., Punchard, M. A., González, J., Richard, M. P., et al. (2018) · Stem Cells · doi:10.1002/stem.2891 · Cited by 99
Stem Cells Therapy for Spinal Cord Injury: An Overview of Clinical Trials
Silvestro, S., Bramanti, P., Trubiani, O., & Mazzon, E. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21020659 · Cited by 105
Mesenchymal stem cell-mediated transfer of mitochondria: mechanisms and functional impact
Velarde, F., Ezquerra, S., Delbruyere, X., Caicedo, A., Hidalgo, Y., & Khoury, M. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04207-3 · Cited by 109
The bone marrow microenvironment as a sanctuary for minimal residual disease in CML
Nair, R. R., Tolentino, J. H. G., & Hazlehurst, L. (2010) · Biochemical Pharmacology · doi:10.1016/j.bcp.2010.04.003 · Cited by 100
Stem Cell Therapies for the Treatment of Radiation-Induced Normal Tissue Side Effects
Benderitter, M., Caviggioli, F., Chapel, A., Coppes, R. P., Guha, C., Klinger, M. E. A., Malard, O., Stewart, F., Tamarat, R., van Luijk, P., et al. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5652 · Cited by 101
Mesenchymal stromal cells inhibit Th17 but not regulatory T-cell differentiation
Tatara, R., Ozaki, K., Kikuchi, Y., Hatanaka, K., Oh, I., Meguro, A., Matsu, H., Sato, K., & Ozawa, K. (2010) · Cytotherapy · doi:10.3109/14653249.2010.542456 · Cited by 101
Su, W., Wan, Q., Huang, J., Han, L., Chen, X., Chen, G., Olsen, N. J., Zheng, S. G., & Liang, D. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.12.1926 · Cited by 98
Condor, J. M., Rodrigues, C. E., Moreira, R. D. S., Canale, D., Volpini, R. A., Shimizu, M. H. M., Câmara, N. O. S., Noronha, I. D. L., & Andrade, L. (2016) · Stem Cells Translational Medicine · doi:10.5966/sctm.2015-0138 · Cited by 99
Toh, W. S., Zhang, B., Lai, R. C., & Lim, S. K. (2018) · Cytotherapy · doi:10.1016/j.jcyt.2018.09.008 · Cited by 97
Engineering nanoparticles to overcome immunological barriers for enhanced drug delivery
Malachowski, T., & Hassel, A. (2020) · Engineered Regeneration · doi:10.1016/j.engreg.2020.06.001 · Cited by 99
Fernández-Francos, S., Eiró, N., Costa, L. A., Escudero-Cernuda, S., Fernández‐Sánchez, M. L., & Vizoso, F. J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073576 · Cited by 99
Shining the light on clinical application of mesenchymal stem cell therapy in autoimmune diseases
Jasim, S. A., Yumashev, A. V., Abdelbasset, W. K., Margiana, R., Markov, A. A., Suksatan, W., Pineda, B., Thangavelu, L. P., & Ahmadi, S. H. (2022) · Stem Cell Research & Therapy · doi:10.1186/s13287-022-02782-7 · Cited by 98
Pigott, J. H., Ishihara, A., Wellman, M. L., Russell, D. S., & Bertone, A. L. (2013) · Veterinary Immunology and Immunopathology · doi:10.1016/j.vetimm.2013.09.003 · Cited by 98
A regulatory cross‐talk between Vγ9Vδ2 T lymphocytes and mesenchymal stem cells
Martinet, L., Fleury‐Cappellesso, S., Gadelorge, M., Dietrich, G., Bourin, P., Fournié, J., & Poupot, R. (2009) · European Journal of Immunology · doi:10.1002/eji.200838812 · Cited by 98
Jumah, M. A., & Abumaree, M. (2012) · International Journal of Molecular Sciences · doi:10.3390/ijms13079298 · Cited by 98
MicroRNAs: The Role in Autoimmune Inflammation
Baulina, N., Кулакова, О. Г., & Favorova, O. O. (2016) · Acta Naturae · doi:10.32607/20758251-2016-8-1-21-33 · Cited by 99
Human mesenchymal stromal cells modulate T‐cell responses through TNF‐α‐mediated activation of NF‐κB
Dorronsoro, A., Ferrin, I., Salcedo, J. M., Jakobsson, E., Fernández‐Rueda, J., Lang, V., Sepúlveda, P., Fechter, K., Pennington, D. J., & Trigueros, C. (2013) · European Journal of Immunology · doi:10.1002/eji.201343668 · Cited by 97
Kong, Q., Sun, B., Bai, S., Zhai, D., Wang, G., Liu, Y., Zhang, S., Li, R., Zhao, W., Sun, Y., et al. (2009) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2008.12.005 · Cited by 101
Surdo, J. L., & Bauer, S. R. (2012) · Tissue Engineering Part C Methods · doi:10.1089/ten.tec.2011.0736 · Cited by 97
Current Stem Cell Delivery Methods for Myocardial Repair
Sheng, C. C., Zhou, L., & Hao, J. (2012) · BioMed Research International · doi:10.1155/2013/547902 · Cited by 99
Sun, J., Han, Z., Liao, W., Yang, S. G., Yang, Z., Yu, J., Meng, L., Wu, R., & Han, Z. (2011) · Cellular Physiology and Biochemistry · doi:10.1159/000329980 · Cited by 96
Jellema, R. K., Wolfs, T. G. A. M., Passos, V. L., Zwanenburg, A., Ophelders, D. R. M. G., Kuypers, E., Hopman, A. H. N., Dudink, J., Steinbusch, H. W. M., Andriessen, P., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0073031 · Cited by 97
Toll-like receptors as a key regulator of mesenchymal stem cell function: An up-to-date review
Shirjang, S., Mansoori, B., Solali, S., Hagh, M. F., & Shamsasenjan, K. (2016) · Cellular Immunology · doi:10.1016/j.cellimm.2016.12.005 · Cited by 100
Galindo, S., Herreras, J. M., López‐Paniagua, M., Rey, E., de la Mata, A., Plata-Cordero, M., Calonge, M., & Nieto-Miguel, T. (2017) · Stem Cells · doi:10.1002/stem.2672 · Cited by 97
Corradi, G., Baldazzi, C., Očadlíková, D., Marconi, G., Parisi, S., Testoni, N., Finelli, C., Cavo, M., Curti, A., & Ciciarello, M. (2018) · Stem Cell Research & Therapy · doi:10.1186/s13287-018-1013-z · Cited by 102
Tsai, A., Jeske, R., Chen, X., Yuan, X., & Li, Y. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.00640 · Cited by 102
The Promising Potential of Menstrual Stem Cells for Antenatal Diagnosis and Cell Therapy
Khoury, M., Alcayaga‐Miranda, F., Illanes, S. E., & Figueroa, F. E. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00205 · Cited by 98
Ochs, K., Sahm, F., Opitz, C. A., Lanz, T. V., Oezen, I., Couraud, P., von Deimling, A., Wick, W., & Platten, M. (2013) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2013.09.011 · Cited by 99
Guo, Z., Li, H., Li, X., Yu, X., Wang, H., Tang, P.-H., & Mao, N. (2006) · Stem Cells · doi:10.1634/stemcells.2005-0224 · Cited by 97
Nasef, A., ZHANG, Y. Z., Mazurier, C., Bouchet, S., Bensidhoum, M., François, S., Gorin, N. C., Lopez, M., Thierry, D., Fouillard, L., et al. (2007) · International Journal of Laboratory Hematology · doi:10.1111/j.1751-553x.2007.00997.x · Cited by 97
Metadata
- Authors
- Aggarwal, S., & Pittenger, M. F.
- Affiliations
- Osiris Therapeutics (United States) (US)
- ORCID
- Pittenger, Mark F.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2005-02-15
- Volume
- 105
- Issue
- 4
- Pages
- 1815-1822
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2095666785
- Cited by
- 4,511
- References
- 73
- Citations by year
- 2026: 51 · 2025: 82 · 2024: 118 · 2023: 158 · 2022: 187 · 2021: 253 · 2020: 236 · 2019: 209 · 2018: 233 · 2017: 251 · 2016: 312 · 2015: 284 · 2014: 299 · 2013: 338 · 2012: 328
- FWCI
- 47.59
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Blood (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Osiris Therapeutics
- Defense Advanced Research Projects Agency
- Advanced Research Projects Agency
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Keywords
- mesenchymal stem cells, immunomodulation, graft-versus-host disease, allogeneic transplantation, dendritic cells, T helper cells, natural killer cells, regulatory T cells, prostaglandin E2, cytokine production, immune tolerance, bone marrow-derived stem cells
- MeSH terms
- Cell Communication, Cells, Cultured, Dendritic Cells, Humans, Immunologic Factors, Immunosuppression Therapy, Killer Cells, Natural, Leukocytes, Mononuclear, Lymphocyte Activation, Mesoderm, T-Lymphocytes, Transplantation, Homologous, Dinoprostone, Coculture Techniques, Multipotent Stem Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
