The DOI matches its Crossref record; 73 of the 73 references it cites were found in a registry or an index.
Human mesenchymal stem cells modulate allogeneic immune cell responses
Open accessAbstract
Mesenchymal stem cells (MSCs) are multipotent cells found in several adult tissues. Transplanted allogeneic MSCs can be detected in recipients at extended time points, indicating a lack of immune recognition and clearance. As well, a role for bone marrow-derived MSCs in reducing the incidence and severity of graft-versus-host disease (GVHD) during allogeneic transplantation has recently been reported; however, the mechanisms remain to be investigated. We examined the immunomodulatory functions of human MSCs (hMSCs) by coculturing them with purified subpopulations of immune cells and report here that hMSCs altered the cytokine secretion profile of dendritic cells (DCs), naive and effector T cells (T helper 1 [TH1] and TH2), and natural killer (NK) cells to induce a more anti-inflammatory or tolerant phenotype. Specifically, the hMSCs caused mature DCs type 1 (DC1) to decrease tumor necrosis factor α (TNF-α) secretion and mature DC2 to increase interleukin-10 (IL-10) secretion; hMSCs caused TH1 cells to decrease interferon γ (IFN-γ) and caused the TH2 cells to increase secretion of IL-4; hMSCs caused an increase in the proportion of regulatory T cells (TRegs) present; and hMSCs decreased secretion of IFN-γ from the NK cells. Mechanistically, the hMSCs produced elevated prostaglandin E2 (PGE2) in co-cultures, and inhibitors of PGE2 production mitigated hMSC-mediated immune modulation. These data offer insight into the interactions between allogeneic MSCs and immune cells and provide mechanisms likely involved with the in vivo MSC-mediated induction of tolerance that could be therapeutic for reduction of GVHD, rejection, and modulation of inflammation. (Blood. 2005;105:1815-1822)
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Multilineage potential of adult human mesenchymal stem cells
Pittenger, M. F., Mackay, A. M., Beck, S. C., Jaiswal, R. K., Douglas, R., Mosca, J. D., Moorman, M. A., Simonetti, D. W., Craig, S., & Marshak, D. R. (1999) · Science · doi:10.1126/science.284.5411.143 · Cited by 21,052
Self-citationCaplan, A. I. (1991) · Journal of Orthopaedic Research® · doi:10.1002/jor.1100090504 · Cited by 6,559
Di Nicola, M., Carlo-Stella, C., Magni, M., Milanesi, M., Longoni, P. D., Matteucci, P., Grisanti, S., & Gianni, A. M. (2002) · Blood · doi:10.1182/blood.v99.10.3838 · Cited by 3,226
Le Blanc, K., Rasmusson, I., Sundberg, B., Götherström, C., Hassan, M., Uzunel, M., & Ringdén, O. (2004) · The Lancet · doi:10.1016/s0140-6736(04)16104-7 · Cited by 2,734
Friedenstein, A. J., Chailakhjan, R. K., & Lalykina, K. S. (1970) · Cell Proliferation · doi:10.1111/j.1365-2184.1970.tb00347.x · Cited by 2,724
Human Mesenchymal Stem Cells Differentiate to a Cardiomyocyte Phenotype in the Adult Murine Heart
Toma, C., Pittenger, M. F., Cahill, K. S., Byrne, B. J., & Kessler, P. (2002) · Circulation · doi:10.1161/hc0102.101442 · Cited by 2,234
Self-citationCD4+CD25+ suppressor T cells: more questions than answers
Shevach, E. M. (2002) · Nature reviews. Immunology · doi:10.1038/nri821 · Cited by 2,097
Horwitz, E. M., Gordon, P. L., Koo, W. K. K., Marx, J. C., Neel, M. D., McNall, R. Y., Muul, L., & Hofmann, T. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.132252399 · Cited by 1,650
Kopen, G. C., Prockop, D. J., & Phinney, D. G. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.19.10711 · Cited by 1,643
Meisel, R., Zibert, A., Laryea, M. D., Göbel, U., Däubener, W., & Dilloo, D. (2004) · Blood · doi:10.1182/blood-2003-11-3909 · Cited by 1,638
Research works printed but not linked: 1
- Archambault MP, McIntosh KR, Duty A, Peter SJ. Allogeneic rat mesenchymal stem cells do not elicit an immune response after implantation in immunocompetent recipients [abstract]. Blood.2000;96: 762a. Abstract 3295.
Cited by
Sorted by citations
Items 601–700 of 1,012
RGD-modified acellular bovine pericardium as a bioprosthetic scaffold for tissue engineering
Dong, X., Wei, X., Yi, W., Gu, C., Kang, X., Liu, Y., Li, Q., & Ding-hua, Y. (2009) · Journal of Materials Science Materials in Medicine · doi:10.1007/s10856-009-3791-4 · Cited by 127
Renner, P., Eggenhofer, E., Rosenauer, A., Popp, F., Steinmann, J., Slowik, P., Geissler, E. K., Piso, P., Schlitt, H. J., & Dahlke, M. H. (2009) · Transplantation Proceedings · doi:10.1016/j.transproceed.2009.06.119 · Cited by 127
Guan, X., Song, L., Han, F., Cui, Z., Chen, X., Guo, X., & Xu, W. (2012) · Journal of Cellular Biochemistry · doi:10.1002/jcb.24377 · Cited by 128
Li, J., Zhang, Q., Wang, W., Lin, F., Wang, S., & Zhao, J. (2021) · Journal of Neurology · doi:10.1007/s00415-020-10138-5 · Cited by 128
Neural differentiation potential of peripheral blood- and bone-marrow-derived precursor cells
Kim, S., Honmou, O., Kato, K., Nonaka, T., Houkin, K., Hamada, H., & Kocsis, J. D. (2006) · Brain Research · doi:10.1016/j.brainres.2006.09.044 · Cited by 127
Tobin, L. M., Healy, M. E., English, K., & Mahon, B. P. (2012) · Clinical & Experimental Immunology · doi:10.1111/cei.12056 · Cited by 126
Bone marrow stromal cells inhibit mast cell function via a COX2‐dependent mechanism
Brown, J. M., Németh, K., Kushnir‐Sukhov, N. M., Metcalfe, D. D., & Mezey, É. (2011) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2010.03685.x · Cited by 126
Dawson, J. I., Kanczler, J. M., Tare, R. S., Kassem, M. S., & Oreffo, R. O. C. (2013) · Stem Cells · doi:10.1002/stem.1559 · Cited by 126
Zhao, F., Zhang, Y. F., Liu, Y. G., Zhou, J., Li, Z. K., Wu, C., & Qi, H. (2008) · Transplantation Proceedings · doi:10.1016/j.transproceed.2008.01.080 · Cited by 126
Early modulation of inflammation by mesenchymal stem cell after acute kidney injury
Semedo, P., Palasio, C. G., Donizetti-Oliveira, C., Feitoza, C. Q., Gonçalves, G. M., Cenedeze, M. A., Wang, P. H. M., Teixeira, V. P. A., dos Reis, M. A., Pacheco‐Silva, Á., et al. (2009) · International Immunopharmacology · doi:10.1016/j.intimp.2008.12.008 · Cited by 126
Elman, J. S., Li, M., Wang, F., Gimble, J. M., & Parekkadan, B. (2014) · Journal of Inflammation · doi:10.1186/1476-9255-11-1 · Cited by 126
How stem cells speak with host immune cells in inflammatory brain diseases
Pluchino, S., & Cossetti, C. (2013) · Glia · doi:10.1002/glia.22500 · Cited by 128
Kim, J. H., Jo, C. H., Kim, H., & Hwang, Y. (2018) · Stem Cells International · doi:10.1155/2018/8429042 · Cited by 134
Gomzikova, M. O., James, V. H., & Rizvanov, A. A. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02663 · Cited by 124
Solari, M. G., Srinivasan, S., Boumaza, I., Unadkat, J., Harb, G., Garcı́a-Ocaña, A., & Feili‐Hariri, M. (2009) · Journal of Autoimmunity · doi:10.1016/j.jaut.2009.01.003 · Cited by 126
Gieseke, F., Kruchen, A., Tzaribachev, N., Bentzien, F., Dominici, M., & Müller, I. (2013) · European Journal of Immunology · doi:10.1002/eji.201343335 · Cited by 127
Innate Immune System and Preeclampsia
Pérez‐Sepúlveda, A., Torres, M. J., Khoury, M., & Illanes, S. E. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00244 · Cited by 129
Forostyak, S., Jendelová, P., & Syková, E. (2013) · Biochimie · doi:10.1016/j.biochi.2013.08.004 · Cited by 124
Interplay between Mesenchymal Stem Cells and Lymphocytes
Wang, L., Zhao, Y., & Shi, S. (2012) · Journal of Dental Research · doi:10.1177/0022034512460404 · Cited by 128
Mesenchymal stem cells: potential for therapy and treatment of chronic non-healing skin wounds
Marfia, G., Navone, S. E., Vito, C. D., Ughi, N., Tabano, S. M., Miozzo, M. R., Tremolada, C., Bolla, G. B., Crotti, C., Ingegnoli, F., et al. (2015) · Organogenesis · doi:10.1080/15476278.2015.1126018 · Cited by 128
Implications of mesenchymal stem cells in regenerative medicine
Kariminekoo, S., Movassaghpour, A. A., Rahimzadeh, A., Talebi, M., Shamsasenjan, K., & Akbarzadeh, A. (2016) · Artificial Cells Nanomedicine and Biotechnology · doi:10.3109/21691401.2015.1129620 · Cited by 125
Harrell, C. R., Gazdic, M., Fellabaum, C., Volarevic, A., Djonov, V., Arsenijević, A., & Volarević, V. (2018) · Advances in experimental medicine and biology · doi:10.1007/5584_2018_306 · Cited by 127
Pang, Q.-M., Chen, S., Xu, Q.-J., Fu, S.-P., Yang, Y.-C., Zou, W.-H., Zhang, M., Liu, J., Wan, W.-H., Peng, J., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.751021 · Cited by 130
Sabapathy, V., & Kumar, S. (2016) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12839 · Cited by 129
Mechanisms of tumor escape from immune system: Role of mesenchymal stromal cells
Poggi, A. D., Musso, A., Dapino, I., & Zocchi, M. R. (2014) · Immunology Letters · doi:10.1016/j.imlet.2014.03.001 · Cited by 126
The potential use of mesenchymal stem cells and their exosomes in Parkinson’s disease treatment
Mosaddeghi-Heris, R., Shirvaliloo, M., Abbaspour‐Aghdam, S., Hazrati, A., Shariati, A., Youshanlouei, H. R., Jadidi‐Niaragh, F., Valizadeh, H., & Ahmadi, M. (2022) · Stem Cell Research & Therapy · doi:10.1186/s13287-022-03050-4 · Cited by 123
Two steps to functional mesenchymal stromal cells for clinical application
Bartmann, C., Rohde, E., Schallmoser, K., Pürstner, P., Lanzer, G., Linkesch, W., & Strunk, D. (2007) · Transfusion · doi:10.1111/j.1537-2995.2007.01219.x · Cited by 123
Boelens, J. J., Prasad, V. K., Tolar, J., Wynn, R. F., & Peters, C. (2010) · Pediatric Clinics of North America · doi:10.1016/j.pcl.2009.11.004 · Cited by 121
Mesenchymal stromal cells and regulatory T cells: the Yin and Yang of peripheral tolerance?
Burr, S. P., Dazzi, F., & Garden, O. A. (2012) · Immunology and Cell Biology · doi:10.1038/icb.2012.60 · Cited by 122
Kuzmina, L. A., Петинати, Н. А., Parovichnikova, E. N., Lubimova, L. S., Gribanova, E. O., Gaponova, T. V., Shipounova, I. N., Zhironkina, O. A., Bigildeev, A., Svinareva, D. A., et al. (2011) · Stem Cells International · doi:10.1155/2012/968213 · Cited by 122
Wu, C.-C., Liu, F.-L., Sytwu, H., Tsai, C., & Chang, D. (2016) · Stem Cell Research & Therapy · doi:10.1186/s13287-016-0285-4 · Cited by 123
Current understanding of the immunosuppressive properties of mesenchymal stromal cells
de Castro, L. L., Lopes‐Pacheco, M., Weiss, D. J., Cruz, F. F., & Rocco, P. R. M. (2019) · Journal of Molecular Medicine · doi:10.1007/s00109-019-01776-y · Cited by 127
Chemical Engineering of Mesenchymal Stem Cells to Induce a Cell Rolling Response
Sarkar, D., Vemula, P. K., Teo, G. S. L., Spelke, D. P., Karnik, R., Wee, L. Y., & Karp, J. M. (2008) · Bioconjugate Chemistry · doi:10.1021/bc800345q · Cited by 120
The Wnt Signal Transduction Pathway in Stem Cells and Cancer Cells: Influence on Cellular Invasion
Neth, P., Ries, C., Karow, M., Egea, V., Ilmer, M., & Jochum, M. (2007) · Stem Cell Reviews and Reports · doi:10.1007/s12015-007-0001-y · Cited by 125
The secretome of mesenchymal stem cells: Potential implications for neuroregeneration
Paul, G., & Anisimov, S. V. (2013) · Biochimie · doi:10.1016/j.biochi.2013.07.013 · Cited by 121
Characterization of endothelial‐like cells derived from human mesenchymal stem cells
Liu, J. W., Dunoyer-Geindre, S., Serre‐Beinier, V., Mai, G., LAMBERT, J. ‐., Fish, R. J., Pernod, G., Buehler, L. H., Bounameaux, H., & Kruithof, E. K. O. (2007) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2007.02381.x · Cited by 121
Mesenchymal Stem Cells Ameliorate Sepsis-associated Acute Kidney Injury in Mice
Luo, C., Zhang, F., Zhang, L., Geng, Y.-Q., Li, Q., Hong, Q., Fu, B., Zhu, F., Cui, S., Feng, Z., et al. (2013) · Shock · doi:10.1097/shk.0000000000000080 · Cited by 121
Tissue regeneration: The crosstalk between mesenchymal stem cells and immune response
Qi, K., Li, N., Zhang, Z., & Melino, G. (2017) · Cellular Immunology · doi:10.1016/j.cellimm.2017.11.010 · Cited by 122
Mesenchymal stem cells and cardiac repair
Neßelmann, C., Ma, N., Bieback, K., Wagner, W., Ho, A. D., Konttinen, Y. T., Zhang, H., Hinescu, M. E., & Steinhoff, G. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00457.x · Cited by 121
Potential of mesenchymal stem cell therapy
Dazzi, F., & Horwood, N. J. (2007) · Current Opinion in Oncology · doi:10.1097/cco.0b013e3282f0e116 · Cited by 118
Wound management of chronic diabetic foot ulcers
Andrews, K. L., Houdek, M. T., & Kiemele, L. J. (2015) · Prosthetics and Orthotics International · doi:10.1177/0309364614534296 · Cited by 122
Zhou, H., Yi, D., Yu, S., Sun, G., Cui, Q., Zhu, H., Liu, J. C., Zhang, J., & Wu, T.-C. (2006) · Transplantation Proceedings · doi:10.1016/j.transproceed.2006.10.002 · Cited by 120
Human palatine tonsil: a new potential tissue source of multipotent mesenchymal progenitor cells
Janjanin, S., Djouad, F., Shanti, R. M., Baksh, D., Gollapudi, K., Prgomet, D., Rackwitz, L., Joshi, A. S., & Tuan, R. S. (2008) · Arthritis Research & Therapy · doi:10.1186/ar2459 · Cited by 120
Chen, M., Li, X., Zhang, X., He, X., Lai, L., Liu, Y., Zhu, G., Li, W. S., Li, H., Fang, Q., et al. (2015) · Journal of Neuroinflammation · doi:10.1186/s12974-015-0284-x · Cited by 119
Svobodová, E., Krulová, M., Zajı́cová, A., Pokorná, K., Procházková, J., Trošan, P., & Holáň, V. (2011) · Stem Cells and Development · doi:10.1089/scd.2011.0157 · Cited by 117
Pal, R., Hanwate, M., Jan, M., & Totey, S. M. (2009) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.143 · Cited by 119
Mesenchymal Stem Cell-Derived Extracellular Vesicles in Liver Immunity and Therapy
Wu, R., Fan, X., Wang, Y., Shen, M., Zheng, Y., Zhao, S., & Yang, L. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.833878 · Cited by 125
Mesenchymal stem cells and adaptive immune responses
Cao, W., Cao, K., Cao, J., Wang, Y., & Shi, Y. (2015) · Immunology Letters · doi:10.1016/j.imlet.2015.06.003 · Cited by 119
The role and potential of umbilical cord blood in an era of new therapies: a review
Roura, S., Pujal, J. M., Gálvez‐Montón, C., & Bayés‐Genís, A. (2015) · Stem Cell Research & Therapy · doi:10.1186/s13287-015-0113-2 · Cited by 118
Immunomodulatory effects of stem cells
Wada, N., Gronthos, S., & Bartold, P. M. (2013) · Periodontology 2000 · doi:10.1111/prd.12024 · Cited by 118
van den Akker, F., de Jager, S. C. A., & Sluijter, J. P. G. (2013) · Mediators of Inflammation · doi:10.1155/2013/181020 · Cited by 118
The effects of hypoxia on the stemness properties of human dental pulp stem cells (DPSCs)
Ahmed, N. E.-M. B., Murakami, M., Kaneko, S., & Nakashima, M. (2016) · Scientific Reports · doi:10.1038/srep35476 · Cited by 123
Bone Marrow Stromal Stem Cells in Tissue Engineering and Regenerative Medicine
Polymeri, A., Giannobile, W. V., & Kaigler, D. (2016) · Hormone and Metabolic Research · doi:10.1055/s-0042-118458 · Cited by 119
Human embryonic stem cell-derived mesenchymal stem cells improved premature ovarian failure
Bahrehbar, K., Valojerdi, M. R., Esfandiari, F., Fathi, R., Hassani, S., & Baharvand, H. (2020) · World Journal of Stem Cells · doi:10.4252/wjsc.v12.i8.857 · Cited by 118
Mesenchymal Stem Cell Therapy: Hope for Patients With Systemic Lupus Erythematosus
Li, A., Guo, F., Pan, Q., Chen, J., Chen, J., Liu, H.-F., & Pan, Q. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.728190 · Cited by 124
Gleeson, B. M., Martin, K., Ali, M. T., Kumar, A. H. S., Pillai, M. G.-K., Kumar, S. P. G., O’Sullivan, J., Whelan, D., Stocca, A., Khider, W., et al. (2015) · Stem Cells · doi:10.1002/stem.2050 · Cited by 118
Recent discoveries concerning the tumor - mesenchymal stem cell interactions
Lazennec, G., & Lam, P. Y. (2016) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2016.10.004 · Cited by 117
Amann, E., Wolff, P., Breel, E. J., van Griensven, M., & Balmayor, E. R. (2017) · Acta Biomaterialia · doi:10.1016/j.actbio.2017.01.064 · Cited by 117
Therapeutic application of multipotent stem cells
Mirzaei, H., Sahebkar, A., Sichani, L. S., Moridikia, A., Nazari, S., Nahand, J. S., Salehi, H., Stenvang, J., Masoudifar, A., Mirzaei, H. R., et al. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.25990 · Cited by 121
Razmkhah, M., Jaberipour, M., Erfani, N., Habibagahi, M., Talei, A.-R., & Ghaderi, A. (2011) · Cellular Immunology · doi:10.1016/j.cellimm.2010.09.005 · Cited by 116
Allogeneic mesenchymal stem cells transplantation in treatment of multiple sclerosis
Liang, J., Zhang, H., Hua, B., Wang, H., Wang, J., Han, Z., & Sun, L. (2009) · Multiple Sclerosis Journal · doi:10.1177/1352458509104590 · Cited by 116
Li, T., Yi, S., Liu, W., Jia, C., Wang, G., Hua, X., Tai, Y., Zhang, Q., & Chen, G. (2013) · Medical Oncology · doi:10.1007/s12032-013-0663-z · Cited by 120
Lee, C., Chen, Y.-F., Wu, H.-H., & Lee, O. K. (2017) · Gastroenterology · doi:10.1053/j.gastro.2017.09.049 · Cited by 115
New and emerging therapies for acute and chronic graft versus host disease
Hill, L. C., Alousi, A. M., Kebriaei, P., Mehta, R. S., Rezvani, K., & Shpall, E. J. (2017) · Therapeutic Advances in Hematology · doi:10.1177/2040620717741860 · Cited by 121
The Role of TNF-α induced MSCs on Suppressive Inflammation by Increasing TGF-β and IL-10
Putra, A. B., Ridwan, F. B., Putridewi, A. I., Kustiyah, A. R., Wirastuti, K., Sadyah, N. A. C., Rosdiana, I., & Munir, D. (2018) · Open Access Macedonian Journal of Medical Sciences · doi:10.3889/oamjms.2018.404 · Cited by 116
Min, C.-K., Kim, B.-G., Park, G., Cho, B., & Oh, I.-H. (2007) · Bone Marrow Transplantation · doi:10.1038/sj.bmt.1705644 · Cited by 116
Immune restoration following hematopoietic stem cell transplantation: an evolving target
Auletta, J. J., & Lazarus, H. M. (2005) · Bone Marrow Transplantation · doi:10.1038/sj.bmt.1704966 · Cited by 117
Immune Regulation by Mesenchymal Stem Cells Derived from Adult Spleen and Thymus
Krampera, M., Sartoris, S., Liotta, F., Pasini, A., Angeli, R., Cosmi, L., Andreini, A., Mosna, F., Bonetti, B., Rebellato, E., et al. (2007) · Stem Cells and Development · doi:10.1089/scd.2007.0024 · Cited by 118
Recent Advances in Mesenchymal Stem Cell Immunomodulation: The Role of Microvesicles
Fierabracci, A., Fattore, A. D., Luciano, R., Muraca, M., Teti, A. M., & Muraca, M. (2013) · Cell Transplantation · doi:10.3727/096368913x675728 · Cited by 116
Ljujić, B., Milovanović, M., Volarević, V., Murray, B. A., Bugarski, D. S., Przyborski, S. A., Arsenijević, N., Lukić, M. L., & Stojković, M. (2013) · Scientific Reports · doi:10.1038/srep02298 · Cited by 122
Liang, L., Dong, C., Chen, X., Fang, Z., Xu, J., Liu, M., Zhang, X., Gu, D. S., Wang, D., Du, W., et al. (2011) · Cell Transplantation · doi:10.3727/096368910x557245 · Cited by 116
Mesenchymal Stem Cells for Therapeutic Purposes
Sensebé, L., & Bourin, P. (2009) · Transplantation · doi:10.1097/tp.0b013e3181a28635 · Cited by 115
Karaöz, E., Genc, Z., Demircan, P., Aksoy, A., & Duruksu, G. (2010) · Cell Death and Disease · doi:10.1038/cddis.2010.14 · Cited by 117
Bacigalupo, A. P., Valle, M., Podestà, M., Pitto, A., Zocchi, E., FLORA, A. D., Pozzi, S., Luchetti, S., Frassoni, F., Lint, M. T. V., et al. (2005) · Experimental Hematology · doi:10.1016/j.exphem.2005.05.006 · Cited by 115
Voswinkel, J., François, S., Simon, J.-M., Benderitter, M., Gorin, N. C., Mohty, M., Fouillard, L., & Chapel, A. (2013) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-012-8347-6 · Cited by 126
Walker, N., Badri, L., Wettlaufer, S. H., Flint, A., Sajjan, U. S., Krebsbach, P. H., Keshamouni, V. G., Peters-Golden, M. L., & Lama, V. N. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2011.01.058 · Cited by 114
Khubutiya, M. S., Vagabov, A. V., Темнов, А. А., & Склифас, А. Н. (2013) · Cytotherapy · doi:10.1016/j.jcyt.2013.07.017 · Cited by 114
Mesenchymal stem cells and their use in therapy: What has been achieved?
Vallone, V. B. F., Romaniuk, M. A., Choi, H., Labovsky, V., Otaegui, J., & Chasseing, N. A. (2013) · Differentiation · doi:10.1016/j.diff.2012.08.004 · Cited by 114
Mesenchymal stromal cells for cartilage repair in osteoarthritis
Mamidi, M. K., Das, A. K., Zakaria, Z., & Bhonde, R. R. (2016) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2016.03.003 · Cited by 114
Lunyak, V. V., Amaro-Ortiz, A., & Gaur, M. (2017) · Frontiers in Genetics · doi:10.3389/fgene.2017.00220 · Cited by 119
New Era of Cell-Based Orthopedic Therapies
Caplan, A. I. (2009) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2008.0515 · Cited by 114
Adult stem cells in the repair of the injured renal tubule
Cantley, L. G. (2005) · Nature Reviews Nephrology · doi:10.1038/ncpneph0021 · Cited by 114
Mesenchymal stem cells inhibit Th17 cell differentiation by IL-10 secretion
Qu, X., Liu, X., Cheng, K., Yang, R., & Zhao, R. C. (2012) · Experimental Hematology · doi:10.1016/j.exphem.2012.05.006 · Cited by 118
Dang, S., Xu, H., Xu, C., Cai, W., Li, Q., Cheng, Y., Jin, M., Wang, R., Peng, Y., Zhang, Y., et al. (2014) · Autophagy · doi:10.4161/auto.28771 · Cited by 115
Mesenchymal Stem Cells: Potential in Treatment of Neurodegenerative Diseases
Tanna, T., & Sachan, V. (2014) · Current Stem Cell Research & Therapy · doi:10.2174/1574888x09666140923101110 · Cited by 114
Mesenchymal stem cells and the lung
Sinclair, K. A., Yerkovich, S. T., & Chambers, D. C. (2013) · Respirology · doi:10.1111/resp.12050 · Cited by 112
Stem Cells in Skin Wound Healing: Are We There Yet?
Cerqueira, M. T., Pirraco, R. P., & Marques, A. P. (2015) · Advances in Wound Care · doi:10.1089/wound.2014.0607 · Cited by 115
Wan, S., Fu, X., Ji, Y., Li, M., Shi, X., & Wang, Y. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.04.035 · Cited by 112
Therapeutic potential of bone marrow-derived mesenchymal stem cells for cutaneous wound healing
Chen, J., Wong, V., & Gurtner, G. C. (2012) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00192 · Cited by 117
Articular Cartilage Regeneration Using Cell Sheet Technology
Sato, M., Yamato, M., Hamahashi, K., Okano, T., & Mochida, J. (2013) · The Anatomical Record · doi:10.1002/ar.22829 · Cited by 111
Multipotent mesenchymal stromal cells for autoimmune diseases: teaching new dogs old tricks
Tyndall, A., & Uccelli, A. (2009) · Bone Marrow Transplantation · doi:10.1038/bmt.2009.63 · Cited by 110
Stem Cells and Healing: Impact on Inflammation
Ennis, W. J., Sui, A., & Bartholomew, A. M. (2013) · Advances in Wound Care · doi:10.1089/wound.2013.0449 · Cited by 112
Poggi, A. D., Varesano, S., & Zocchi, M. R. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00262 · Cited by 113
Hyvärinen, K., Holopainen, M., Skirdenko, V., Ruhanen, H., Lehenkari, P., Korhonen, M., Käkelä, R., Laitinen, S., & Kerkelä, E. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00771 · Cited by 111
The Role of Innate and Adaptive Immune Cells in Skeletal Muscle Regeneration
Ziemkiewicz, N., Hilliard, G. M., Pullen, N., & Garg, K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22063265 · Cited by 124
Hsu, W.-T., Lin, C.-H., Chiang, B., Jui, H., Wu, K. K., & Lee, C. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1202996 · Cited by 111
Bone Marrow Mesenchymal Stromal Cells Attenuate Organ Injury Induced by LPS and Burn
Yagi, H., Soto–Gutiérrez, A., Kitagawa, Y., Tilles, A. W., Tompkins, R. G., & Yarmush, M. L. (2010) · Cell Transplantation · doi:10.3727/096368910x508942 · Cited by 113
Cuerquis, J., Romieu, R., François, M., Routy, J., Young, Y. K., Zhao, J., & Eliopoulos, N. (2014) · Cytotherapy · doi:10.1016/j.jcyt.2013.11.008 · Cited by 111
Mesenchymal stem cell and regenerative medicine: regeneration versus immunomodulatory challenges.
Law, S., & Chaudhuri, S. (2013) · Europe PMC (PubMed Central) · Cited by 110
Human Mesenchymal Stem Cells Are Susceptible to Lysis by CD8 + T Cells and NK Cells
Crop, M. J., Korevaar, S. S., de Kuiper, R., IJzermans, J. N. M., van Besouw, N. M., Baan, C. C., Weimar, W., & Hoogduijn, M. J. (2011) · Cell Transplantation · doi:10.3727/096368910x564076 · Cited by 110
Metadata
- Authors
- Aggarwal, S., & Pittenger, M. F.
- Affiliations
- Osiris Therapeutics (United States) (US)
- ORCID
- Pittenger, Mark F.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2005-02-15
- Volume
- 105
- Issue
- 4
- Pages
- 1815-1822
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2095666785
- Cited by
- 4,511
- References
- 73
- Citations by year
- 2026: 51 · 2025: 82 · 2024: 118 · 2023: 158 · 2022: 187 · 2021: 253 · 2020: 236 · 2019: 209 · 2018: 233 · 2017: 251 · 2016: 312 · 2015: 284 · 2014: 299 · 2013: 338 · 2012: 328
- FWCI
- 47.59
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Blood (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Osiris Therapeutics
- Defense Advanced Research Projects Agency
- Advanced Research Projects Agency
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Keywords
- mesenchymal stem cells, immunomodulation, graft-versus-host disease, allogeneic transplantation, dendritic cells, T helper cells, natural killer cells, regulatory T cells, prostaglandin E2, cytokine production, immune tolerance, bone marrow-derived stem cells
- MeSH terms
- Cell Communication, Cells, Cultured, Dendritic Cells, Humans, Immunologic Factors, Immunosuppression Therapy, Killer Cells, Natural, Leukocytes, Mononuclear, Lymphocyte Activation, Mesoderm, T-Lymphocytes, Transplantation, Homologous, Dinoprostone, Coculture Techniques, Multipotent Stem Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
