The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
NK-dependent DC maturation is mediated by TNFα and IFNγ released upon engagement of the NKp30 triggering receptor
Open accessAbstract
Natural killer (NK) cells were recently shown to play a relevant role in the process of dendritic cell (DC) maturation. This function is exerted either by direct DC stimulation or through killing those DCs that did not properly acquire a mature phenotype. While killing of immature DCs is dependent on the function of the NKp30 triggering receptor, the mechanism by which NK cells induce DC maturation is still unclear. In this study, we show that also the NK-mediated induction of DC maturation is dependent on NKp30. Upon NK/DC interaction, resulting in NKp30 engagement, NK cells produced tumor necrosis factor α (TNFα) (and interferon γ [IFNγ]) that, in turn, promoted DC maturation. Masking of NKp30 with specific monoclonal antibodies (mAbs) strongly reduced maturation of DCs cocultured with NK cells. In addition, supernatant from NK cells stimulated via NKp30 induced DC maturation, and this effect was neutralized by anti-TNFα antibodies (Abs). This NKp30 function is controlled by the HLA-specific inhibitory NK receptors. Accordingly, the ability to promote maturation was essentially confined to NK cells expressing the killer immunoglobulin-like receptor–negative (KIR–) NKG2Adull phenotype. Finally, the analysis of perforin-deficient NK cells allowed the dissection of the 2 NKp30-mediated NK-cell functions, since NKp30 could induce cytokine-dependent DC maturation in the absence of NK-mediated DC killing.
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Cites
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RECEPTORS FOR HLA CLASS-I MOLECULES IN HUMAN NATURAL KILLER CELLS
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Dong Kim, K., Zhao, J., Auh, S., Yang, X., Du, P., Tang, H., & Fu, Y.-X. (2007) · Nature Medicine · doi:10.1038/nm1633 · Cited by 348
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Bancos, I., Hazeldine, J., Chortis, V., Hampson, P., Taylor, A. E., Lord, J. M., & Arlt, W. (2017) · European Journal of Endocrinology · doi:10.1530/eje-16-0969 · Cited by 110
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Hazeldine, J., & Lord, J. M. (2015) · Biogerontology · doi:10.1007/s10522-014-9514-3 · Cited by 104
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Metadata
- Authors
- Vitale, M., Chiesa, M. D., Carlomagno, S., Pende, D., Aricò, M., Moretta, L., & Moretta, A.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2005-07-15
- Volume
- 106
- Issue
- 2
- Pages
- 566-571
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2002197941
- Cited by
- 414
- References
- 29
- FWCI
- 10.41
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Vitale, M., Chiesa, M. D., Carlomagno, S., Pende, D., Aricò, M., Moretta, L., & Moretta, A. (2005). NK-dependent DC maturation is mediated by TNFα and IFNγ released upon engagement of the NKp30 triggering receptor. Blood. https://doi.org/10.1182/blood-2004-10-4035
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