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Heme oxygenase-1 expression inhibits dendritic cell maturation and proinflammatory function but conserves IL-10 expression

Chauveau, Christine, Rémy, Séverine, Royer, Pierre Joseph, Hill, Marcelo, Tanguy-Royer, Séverine, Hubert, François-Xavier, Tesson, Laurent, Brion, Régis, Beriou, Gaëlle, Gregoire, Marc, Josien, Régis, Cuturi, Maria Cristina, Anegon, Ignacio·2005·Blood
DOI 10.1182/blood-2005-02-0494
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Abstract

Heme oxygenase-1 (HO-1) is an intracellular enzyme that degrades heme and inhibits immune responses and inflammation in vivo. In most cell types, HO-1 is inducible by inflammatory stimuli and oxidative stress. Here we demonstrate that human monocyte-derived immature dendritic cells (iDCs) and several but not all freshly isolated rat splenic DC subsets and rat bone marrow-derived iDCs, spontaneously express HO-1. HO-1 expression drastically decreases during human and rat DC maturation induced in vitro. In human tissues, iDCs also express HO-1, whereas mature DCs do not. Induction of HO-1 expression with cobalt protoporphyrin (CoPP) in human and rat DCs inhibits lipopolysaccharide (LPS)-induced phenotypic maturation and secretion of proinflammatory cytokines, resulting in the inhibition of alloreactive T-cell proliferation. CoPP-treated DCs, however, retain the ability to produce the anti-inflammatory cytokine interleukin 10 (IL-10). Reactive oxygen species induced by LPS in DCs were inhibited by induction of HO-1. In conclusion, we identify, for the first time, the capacity of HO-1 to block maturation of DCs and to inhibit proinflammatory and allogeneic immune responses while preserving IL-10 production. This novel immune function for HO-1 may be of interest for the inhibition of immune responses in autoimmune diseases, transplantation, and other conditions involving activation of the immune system. (Blood. 2005;106:1694-1702)

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Metadata

Authors
Chauveau, C., Rémy, S., Royer, P. J., Hill, M., Tanguy-Royer, S., Hubert, F.-X., Tesson, L., Brion, R., Beriou, G., Gregoire, M., Josien, R., Cuturi, M. C., & Anegon, I.
Venue
Blood
Publisher
American Society of Hematology
Published
2005-09-01
Volume
106
Issue
5
Pages
1694-1702
ISSN
  • 0006-4971 (ISSN-L)
  • 1528-0020
DOI
10.1182/blood-2005-02-0494
OpenAlex
W2133790929
Cited by
342
References
5
FWCI
6.68
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Heme oxygenase-1 expression inhibits dendritic cell maturation and proinflammatory function but conserves IL-10 expression. https://app.cochat.ai/papers/10.1182/blood-2005-02-0494
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Chauveau, C., Rémy, S., Royer, P. J., Hill, M., Tanguy-Royer, S., Hubert, F.-X., Tesson, L., Brion, R., Beriou, G., Gregoire, M., Josien, R., Cuturi, M. C., & Anegon, I. (2005). Heme oxygenase-1 expression inhibits dendritic cell maturation and proinflammatory function but conserves IL-10 expression. Blood. https://doi.org/10.1182/blood-2005-02-0494

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