The DOI matches its Crossref record; 142 of the 142 references it cites were found in a registry or an index.
Insights into the Secretome of Mesenchymal Stem Cells and Its Potential Applications
Open accessAbstract
Mesenchymal stem cells (MSCs) have regenerative, immunoregulatory properties and can be easily isolated and expanded in vitro. Despite being a powerful tool for clinical applications, they present limitations in terms of delivery, safety, and variability of therapeutic response. Interestingly, the MSC secretome composed by cytokines, chemokines, growth factors, proteins, and extracellular vesicles, could represent a valid alternative to their use. It is noteworthy that MSC-derived extracellular vesicles (MSC-EVs) have the same effect and could be advantageous compared to the parental cells because of their specific miRNAs load. MiRNAs could be useful both in diagnostic procedures such as “liquid biopsy” to identify early pathologies and in the therapeutic field. Not only are MSC-EVs’ preservation, transfer, and production easier, but their administration is also safer, hence some clinical trials are ongoing. However, much effort is required to improve the characterization of EVs to avoid artifacts and guarantee reproducibility of the studies.
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1 retracted
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MicroRNA genes are transcribed by RNA polymerase II
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Cited by
Therapeutically harnessing extracellular vesicles
Cheng, L., & Hill, A. F. (2022) · Nature Reviews Drug Discovery · doi:10.1038/s41573-022-00410-w · Cited by 737
Mesenchymal stem cell secretome for regenerative medicine: Where do we stand?
Trigo, C. M., Rodrigues, J. S., Camões, S. P., Solá, S., & Miranda, J. P. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2024.05.004 · Cited by 252
“For all of this, the interest of MSC-derived secretome is notably increasing, specially the secretome-derived EVs for its easily mode of preservation and transference [58] as well as their biocompatibility.”
Stem cell secretome, regeneration, and clinical translation: a narrative review
Gwam, C., Mohammed, N., & Ma, X. (2021) · Annals of Translational Medicine · doi:10.21037/atm-20-5030 · Cited by 72
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“detailed and complex picture of their secretome, including the shedding of extracellular vesicles [49] and microRNAs [50], the mitochondrial and metabolic properties [51], together with other aspects of their immunomodulatory properties not addressed in this study, might highlight further attributes aligned with desir…”
BackgroundYarahmadi, A., Dorri Giv, M., Hosseininejad, R., Rezaie, A., Mohammadi, N., Afkhami, H., & Farokhi, A. (2025) · Frontiers in Neurology · doi:10.3389/fneur.2025.1472679 · Cited by 21
Metadata
- Authors
- Eleuteri, S., & Fierabracci, A.
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2019-09-17
- Volume
- 20
- Issue
- 18
- Pages
- 4597
- ISSN
- 1422-0067 (ISSN-L)
- OpenAlex
- W2973263520
- Cited by
- 303
- References
- 142
- FWCI
- 17.02
- Type
- journal article
- Language
- en
- Open access
- gold
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
