The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Thrombus formation induced by antibodies to β2-glycoprotein I is complement dependent and requires a priming factor
Open accessAbstract
We monitored the number of intravascular platelet-leukocyte aggregates (PLAs) and thrombotic occlusions (TOs) by intravascular microscopy in the mesentery of rats receiving antiphospholipid (aPL) immunoglobulin G (IgG) purified from the sera of patients with antiphospholipid syndrome. aPL IgG had no procoagulant effect, but it caused rapid endothelial deposition of fibrinogen, followed by PLA and TO in rats receiving an intraperitoneal injection of bacterial lipopolysaccharide 3 hours before IgG infusion. Anti-β2-glycoprotein I-depleted aPL IgG failed to induce PLAs and TOs. C3 and C9 colocalized with aPL IgG on the mesenteric vessels. The number of PLAs and TOs was markedly reduced in C6-deficient rats and in animals treated with anti-C5 miniantibody, suggesting the contribution of the terminal complement (C) complex to the aPL antibody-mediated intravascular thrombosis. In conclusion, our data indicate that antibodies to β2-glycoprotein I trigger coagulation subsequent to a priming proinflammatory factor and that the terminal C complex is the main mediator of the coagulation process.
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Cites
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Complement C3 Activation Is Required for Antiphospholipid Antibody-induced Fetal Loss
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Complement C5a receptors and neutrophils mediate fetal injury in the antiphospholipid syndrome
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Complement C5a receptors and neutrophils mediate fetal injury in the antiphospholipid syndrome
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Self-citationComplement-mediated regulation of tissue factor activity in endothelium.
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Cited by
Interplay between inflammation and thrombosis in cardiovascular pathology
Stark, K., & Massberg, S. (2021) · Nature Reviews Cardiology · doi:10.1038/s41569-021-00552-1 · Cited by 1,033
The Pathogenesis of the Antiphospholipid Syndrome
Giannakopoulos, B., & Krilis, S. A. (2013) · New England Journal of Medicine · doi:10.1056/nejmra1112830 · Cited by 688
Pathogenesis of antiphospholipid syndrome: understanding the antibodies
Meroni, P. L., Borghi, M. O., Raschi, E., & Tedesco, F. (2011) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2011.52 · Cited by 620
Self-citationRitis, K., Doumas, M., Mastellos, D., Micheli, A., Giaglis, S., Magotti, P., Rafail, S., Kartalis, G., Sideras, P., & Lambris, J. D. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.7.4794 · Cited by 489
Schreiber, K., Sciascia, S., de Groot, P. G., Devreese, K., Jacobsen, S., Ruiz-Irastorza, G., Salmon, J. E., Shoenfeld, Y., Shovman, O., & Hunt, B. J. (2018) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2017.103 · Cited by 359
Metadata
- Authors
- Fischetti, F., Durigutto, P., Pellis, V., Debeus, A., Macor, P., Bulla, R., Bossi, F., Ziller, F., Sblattero, D., Meroni, P., & Tedesco, F.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2005-10-01
- Volume
- 106
- Issue
- 7
- Pages
- 2340-2346
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2109060641
- Cited by
- 351
- References
- 36
- FWCI
- 7.70
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Fischetti, F., Durigutto, P., Pellis, V., Debeus, A., Macor, P., Bulla, R., Bossi, F., Ziller, F., Sblattero, D., Meroni, P., & Tedesco, F. (2005). Thrombus formation induced by antibodies to β2-glycoprotein I is complement dependent and requires a priming factor. Blood. https://doi.org/10.1182/blood-2005-03-1319
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