Pathogenesis of antiphospholipid syndrome: understanding the antibodies

International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS)

MIYAKIS, S., LOCKSHIN, M. D., ATSUMI, T., BRANCH, D. W., BREY, R. L., CERVERA, R., DERKSEN, R. H. W. M., DE GROOT, P. G., KOIKE, T., MERONI, P. L., et al. (2006) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2006.01753.x · Cited by 7,203 · see citing works

Antiphospholipid syndrome

Ruiz‐Irastorza, G., Crowther, M. A., Branch, W. D., & Khamashta, M. A. (2010) · The Lancet · doi:10.1016/s0140-6736(10)60709-x · Cited by 864 · see citing works

Pivotal role for neuronal Toll-like receptors in ischemic brain injury and functional deficits

Tang, S., Arumugam, T. V., Xu, X. Z. S., Cheng, A., Mughal, M. R., Jo, D., Lathia, J. D., Siler, D. A., Chigurupati, S., Ouyang, X., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0702553104 · Cited by 765 · see citing works

Complement C5a receptors and neutrophils mediate fetal injury in the antiphospholipid syndrome

Girardi, G., Berman, J., Redecha, P. B., Spruce, L. A., Thurman, J. M., Kraus, D., Hollmann, T. J., Casali, P., Caroll, M. C., Wetsel, R. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci18817 · Cited by 685 · see citing works

Heparin prevents antiphospholipid antibody–induced fetal loss by inhibiting complement activation

Girardi, G., Redecha, P. B., & Salmon, J. E. (2004) · Nature Medicine · doi:10.1038/nm1121 · Cited by 680 · see citing works

Complement C3 Activation Is Required for Antiphospholipid Antibody-induced Fetal Loss

Holers, V. M., Girardi, G., Mo, L., Guthridge, J. M., Molina, H. D., Pierangeli, S. S., Espinola, R. G., Xiaowei, L. E., Mao, D., Vialpando, C. G., et al. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.200116116 · Cited by 625 · see citing works

Complement C5a receptors and neutrophils mediate fetal injury in the antiphospholipid syndrome

Girardi, G., Berman, J., Redecha, P. B., Spruce, L. A., Thurman, J. M., Kraus, D., Hollmann, T. J., Casali, P., Caroll, M. C., Wetsel, R. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200318817 · Cited by 593 · see citing works

Repeated fetal losses associated with antiphospholipid antibodies: A collaborative randomized trial comparing prednisone with low-dose heparin treatment

Cowchock, F. S., Reece, E. A., Balaban, D. J., Branch, D. W., & Plouffe, L. (1992) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(92)91596-3 · Cited by 585 · see citing works

Complement activation induces dysregulation of angiogenic factors and causes fetal rejection and growth restriction

Girardi, G., Yarilin, D. A., Thurman, J. M., Holers, V. M., & Salmon, J. E. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20061022 · Cited by 508 · see citing works

Anti–β2-glycoprotein I, antiprothrombin antibodies, and the risk of thrombosis in the antiphospholipid syndrome

Galli, M., Luciani, D., Bertolini, G., & Barbui, T. (2003) · Blood · doi:10.1182/blood-2002-11-3334 · Cited by 413 · see citing works

Requirement of activation of complement C3 and C5 for antiphospholipid antibody–mediated thrombophilia

Pierangeli, S. S., Girardi, G., Vega-Ostertag, M. E., Liu, X., Espinola, R. G., & Salmon, J. E. (2005) · Arthritis & Rheumatism · doi:10.1002/art.21157 · Cited by 362 · see citing works

Evidence of Toll‐like receptor molecules on human platelets

Cognasse, F., Hamzeh, H., Chavarin, P., Acquart, S., Genin, C., & Garraud, O. (2005) · Immunology and Cell Biology · doi:10.1111/j.1440-1711.2005.01314.x · Cited by 361 · see citing works

Thrombus formation induced by antibodies to β2-glycoprotein I is complement dependent and requires a priming factor

Fabio Fischetti, I., Durigutto, P., Pellis, V., Debeus, A., Macor, P., Bulla, R., Bossi, F., Ziller, F., Sblattero, D., Meroni, P. L., et al. (2005) · Blood · doi:10.1182/blood-2005-03-1319 · Cited by 352 · see citing works

The Cytolytically Inactive Terminal Complement Complex Activates Endothelial Cells to Express Adhesion Molecules and Tissue Factor Procoagulant Activity

Tedesco, F., Pausa, M., Nardon, E., Introna, M., Mantovani, A., & Dobrina, A. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.185.9.1619 · Cited by 316 · see citing works

Role of the MyD88 transduction signaling pathway in endothelial activation by antiphospholipid antibodies

Raschi, E., Testoni, C., Bosisio, D., Borghi, M. O., Koike, T., Mantovani, A., & Meroni, P. L. (2003) · Blood · doi:10.1182/blood-2002-08-2349 · Cited by 304 · see citing works

Tissue factor: a link between C5a and neutrophil activation in antiphospholipid antibody–induced fetal injury

Redecha, P. B., Tilley, R. E., Tencati, M., Salmon, J. E., Kirchhofer, D., Mackman, N., & Girardi, G. (2007) · Blood · doi:10.1182/blood-2007-01-070631 · Cited by 293 · see citing works

The association between circulating antibodies against domain I of beta2‐glycoprotein I and thrombosis: an international multicenter study

DE LAAT, B., PENGO, V., PABINGER, I., MUSIAL, J., VOSKUYL, A. E., BULTINK, I. E. M., RUFFATTI, A., ROZMAN, B., KVEDER, T., DE MOERLOOSE, P., et al. (2009) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2009.03588.x · Cited by 291 · see citing works

REVIEW ARTICLE: Toll‐Like Receptors at the Maternal–Fetal Interface in Normal Pregnancy and Pregnancy Disorders

Koga, K., & Mor, G. (2010) · American Journal of Reproductive Immunology · doi:10.1111/j.1600-0897.2010.00848.x · Cited by 288 · see citing works

β2-Glycoprotein I can exist in 2 conformations: implications for our understanding of the antiphospholipid syndrome

Ağar, Ç., OS, G. M. A. V., Mörgelin, M., Sprenger, R. R., Marquart, J. A., Urbanus, R. T., Derksen, R. H. W. M., Meijers, J. C. M., & de Groot, P. G. (2010) · Blood · doi:10.1182/blood-2009-12-260976 · Cited by 262 · see citing works

TNF-α Is a Critical Effector and a Target for Therapy in Antiphospholipid Antibody-Induced Pregnancy Loss

Berman, J., Girardi, G., & Salmon, J. E. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.1.485 · Cited by 242 · see citing works

The Th1/Th2 paradigm: still important in pregnancy?

Chaouat, G. (2007) · Seminars in Immunopathology · doi:10.1007/s00281-007-0069-0 · Cited by 231 · see citing works

Reduction of annexin-V (placental anticoagulant protein-I) on placental villi of women with antiphos pholipid antibodies and recurrent spontaneous abortion

Rand, J. H., Wu, X.-X., Guller, S. M., Gil, J., Guha, A., Scher, J., & Lockwood, C. J. (1994) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(94)90403-0 · Cited by 229 · see citing works

Complement activation in patients with primary antiphospholipid syndrome

Oku, K., Atsumi, T., Bohgaki, M., Amengual, O., Kataoka, H., Horita, T., Yasuda, S., & Koike, T. (2008) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2008.090670 · Cited by 219 · see citing works

Antiphospholipid Antibodies and the Antiphospholipid Syndrome: Pathogenic Mechanisms

Pierangeli, S. S., Chen, P. P., Raschi, E., Scurati, S., Grossi, C., Borghi, M. O., Palomo, I. F., Harris, E. N., & Meroni, P. L. (2008) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-0028-1082267 · Cited by 218 · see citing works

Toll-like receptor and antiphospholipid mediated thrombosis: in vivo studies

Pierangeli, S. S., Vega-Ostertag, M. E., Raschi, E., Liu, X., Romay‐Penabad, Z., Micheli, V. D., Galli, M., Moia, M., Tincani, A., Borghi, M. O., et al. (2007) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2006.065037 · Cited by 218 · see citing works

Current concepts on the pathogenesis of the antiphospholipid syndrome

Giannakopoulos, B., Passam, F. H., Rahgozar, S., & Krilis, S. A. (2006) · Blood · doi:10.1182/blood-2006-04-001206 · Cited by 217 · see citing works

Annexin A2 mediates endothelial cell activation by antiphospholipid/anti-β2 glycoprotein I antibodies

Zhang, J., & McCrae, K. R. (2004) · Blood · doi:10.1182/blood-2004-05-1708 · Cited by 212 · see citing works

ORIGINAL ARTICLE: Antiphospholipid Antibodies Induce a Pro‐Inflammatory Response in First Trimester Trophoblast Via the TLR4/MyD88 Pathway

Mulla, M. J., Brosens, J. J., Chamley, L., Giles, I., Pericleous, C., Rahman, A., Joyce, S. K., Panda, B., Paidas, M. J., & Abrahams, V. M. (2009) · American Journal of Reproductive Immunology · doi:10.1111/j.1600-0897.2009.00717.x · Cited by 207 · see citing works

Infectious origin of the antiphospholipid syndrome

Shoenfeld, Y., Blank, M., Cervera, R., Font, J., Raschi, E., & Meroni, P. L. (2005) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2005.045443 · Cited by 206 · see citing works

Excessive complement activation is associated with placental injury in patients with antiphospholipid antibodies

Shamonki, J. M., Salmon, J. E., Hyjek, E. M., & Baergen, R. N. (2007) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2006.10.879 · Cited by 203 · see citing works

Neutrophil activation by the tissue factor/Factor VIIa/PAR2 axis mediates fetal death in a mouse model of antiphospholipid syndrome

Redecha, P. B., Franzke, C.-W., Ruf, W., Mackman, N., & Girardi, G. (2008) · Journal of Clinical Investigation · doi:10.1172/jci36089 · Cited by 201 · see citing works

Antiphospholipid antibodies promote leukocyte–endothelial cell adhesion and thrombosis in mice by antagonizing eNOS via β2GPI and apoER2

Ramesh, S., Morrell, C. N., Tarango, C., Thomas, G. D., Yuhanna, I. S., Girardi, G., Herz, J., Urbanus, R. T., de Groot, P. G., Thorpe, P. E., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci39828 · Cited by 195 · see citing works

Protection against inflammation- and autoantibody-caused fetal loss by the chemokine decoy receptor D6

Martinez de la Torre, Y., Buracchi, C., Borroni, E. M., Dupor, J., Bonecchi, R., Nebuloni, M., Pasqualini, F., Doni, A., Lauri, E., Agostinis, C., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607514104 · Cited by 178 · see citing works

Thrombogenicity of β2-glycoprotein I–dependent antiphospholipid antibodies in a photochemically induced thrombosis model in the hamster

Jankowski, M., Vreys, I., Wittevrongel, C., Boon, D., Vermylen, J., Hoylaerts, M., & Arnout, J. (2002) · Blood · doi:10.1182/blood-2002-05-1310 · Cited by 175 · see citing works

Clinical significance of different antiphospholipid antibodies in the WAPS (warfarin in the antiphospholipid syndrome) study

Galli, M., Borrelli, G., Jacobsen, E. M., Marfisi, R. M., Finazzi, G., Marchioli, R., Wisloff, F., Marziali, S., Morboeuf, O., & Barbui, T. (2007) · Blood · doi:10.1182/blood-2007-01-066043 · Cited by 170 · see citing works

A novel inhibitor of the alternative complement pathway prevents antiphospholipid antibody-induced pregnancy loss in mice

Thurman, J. M., Kraus, D., Girardi, G., Hourcade, D. E., Kang, H. J., Royer, P. A., Mitchell, L. M., Giclas, P. C., Salmon, J. E., Gilkeson, G. S., et al. (2004) · Molecular Immunology · doi:10.1016/j.molimm.2004.07.043 · Cited by 162 · see citing works

The annexin A5-mediated pathogenic mechanism in the antiphospholipid syndrome: role in pregnancy losses and thrombosis

Rand, J., Xx, W., Quinn, A., & Taatjes, D. J. (2010) · Lupus · doi:10.1177/0961203310361485 · Cited by 143 · see citing works

The anti-beta2-glycoprotein I activity in human anti-phospholipid syndrome sera is due to monoreactive low-affinity autoantibodies directed to epitopes located on native β2-glycoprotein I and preserved during species' evolution

Tincani, A., Spatola, L., Prati, E., Allegri, F., Ferremi, P., Cattaneo, R., Meroni, P. L., & Balestrieri, G. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.157.12.5732 · Cited by 133 · see citing works

Annexin A2 is involved in antiphospholipid antibody-mediated pathogenic effects in vitro and in vivo

Romay‐Penabad, Z., Montiel-Manzano, M. G., Shilagard, T., Papalardo, E., Vargas, G., Deora, A. B., Wang, M., Jacovina, A. T., Garcı́a-Latorre, E., Reyes‐Maldonado, E., et al. (2009) · Blood · doi:10.1182/blood-2008-11-188698 · Cited by 132 · see citing works

In vivo inhibition of antiphospholipid antibody-induced pathogenicity utilizing the antigenic target peptide domain I of β2-glycoprotein I: proof of concept

Ioannou, Y., Penabad, Z. R., Pericleous, C., Giles, I., Papalardo, E., Vargas, G., Shilagard, T., Latchman, D. S., Isenberg, D. A., Rahman, A., et al. (2009) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2009.03316.x · Cited by 130 · see citing works

Platelet activation by dimeric β2‐glycoprotein I requires signaling via both glycoprotein Ibα and apolipoprotein E receptor 2′

Urbanus, R. T., Pennings, M. T. T., Derksen, R. H. W. M., & de Groot, P. G. (2008) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2008.03021.x · Cited by 129 · see citing works

Apolipoprotein E receptor 2 is involved in the thrombotic complications in a murine model of the antiphospholipid syndrome

Romay‐Penabad, Z., Aguilar‐Valenzuela, R., Urbanus, R. T., Derksen, R. H. W. M., Pennings, M. T. T., Papalardo, E., Shilagard, T., Vargas, G., Hwang, Y. G., de Groot, P. G., et al. (2010) · Blood · doi:10.1182/blood-2010-07-299099 · Cited by 124 · see citing works

Pathogenic role of anti-β2-glycoprotein I antibodies in antiphospholipid associated fetal loss: characterisation of β2-glycoprotein I binding to trophoblast cells and functional effects of anti-β2-glycoprotein I antibodies in vitro

Simone, N. D., Raschi, E., Testoni, C., Castellani, R., D'Asta, M., Shi, T., Krilis, S. A., Caruso, A., & Meroni, P. L. (2004) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2004.021444 · Cited by 124 · see citing works

Beta 2 glycoprotein I and placental anticoagulant protein I in placentae from patients with antiphospholipid syndrome.

Rosa, L. L., Meroni, P. L., Tincani, A., Balestrieri, G., Faden, D. F., Lojacono, A., Morassi, L., Brocchi, E., Papa, N. D., & Gharavi, A. E. (1994) · PubMed · Cited by 123 · see citing works

Thrombogenic Properties of Murine Anti-Cardiolipin Antibodies Induced by β 2 Glycoprotein 1 and Human Immunoglobulin G Antiphospholipid Antibodies

Pierangeli, S. S., Liu, X. W., Anderson, G., Barker, J. H., & Harris, E. N. (1996) · Circulation · doi:10.1161/01.cir.94.7.1746 · Cited by 118 · see citing works

Activated protein C ligation of ApoER2 (LRP8) causes Dab1-dependent signaling in U937 cells

Yang, X. V., Banerjee, Y., Fernández, J. A., Deguchi, H., Xu, X., Mosnier, L. O., Urbanus, R. T., de Groot, P. G., White-Adams, T. C., McCarty, O. J. T., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0807594106 · Cited by 116 · see citing works

Functional Proteomics: Examining the Effects of Hypoxia on the Cytotrophoblast Protein Repertoire

Hoang, V. M., Foulk, R. A., Clauser, K. R., Burlingame, A. L., Gibson, B. W., & Fisher, S. J. (2001) · Biochemistry · doi:10.1021/bi0023910 · Cited by 115 · see citing works

Antiprothrombin antibodies detected in two different assay systems

Atsumi, T., Koike, T., Hughes, G. R. V., Khamashta, M. A., & Bertolaccini, M. L. (2005) · Thrombosis and Haemostasis · doi:10.1160/th04-06-0382 · Cited by 113 · see citing works

Heparan Sulfate Proteoglycans Function as Receptors for Fibroblast Growth Factor-2 Activation of Extracellular Signal–Regulated Kinases 1 and 2

Chua, C. C., Rahimi, N., Forsten‐Williams, K., & Nugent, M. A. (2003) · Circulation Research · doi:10.1161/01.res.0000112965.70691.ac · Cited by 101 · see citing works

Placental changes in a first trimester missed abortion in maternal systemic lupus erythematosus with antiphospholipid syndrome: A case report and review of the literature

Nayar, R., & Lage, J. M. (1996) · Human Pathology · doi:10.1016/s0046-8177(96)90377-9 · Cited by 95 · see citing works

Impaired Fibrinolysis in the Antiphospholipid Syndrome

Krone, K. A., Allen, K. L., & McCrae, K. R. (2010) · Current Rheumatology Reports · doi:10.1007/s11926-009-0075-4 · Cited by 91 · see citing works

E-Selectin mediates pathogenic effects of antiphospholipid antibodies

Espinola, R. G., Liu, X., Colden‐Stanfield, M., Hall, J., Harris, E. N., & Pierangeli, S. S. (2003) · Journal of Thrombosis and Haemostasis · doi:10.1046/j.1538-7836.2003.00119.x · Cited by 91 · see citing works

Mechanisms of Disease: antiphospholipid antibodies—from clinical association to pathologic mechanism

de Laat, B., Mertens, K., & de Groot, P. G. (2008) · Nature Clinical Practice Rheumatology · doi:10.1038/ncprheum0740 · Cited by 90 · see citing works

The role of TLR2 in the inflammatory activation of mouse fibroblasts by human antiphospholipid antibodies

Satta, N., Dunoyer-Geindre, S., Reber, G., Fish, R. J., Boehlen, F., Kruithof, E. K. O., & de Moerloose, P. (2006) · Blood · doi:10.1182/blood-2005-03-024463 · Cited by 86 · see citing works

Impaired expression of endometrial differentiation markers and complement regulatory proteins in patients with recurrent pregnancy loss associated with antiphospholipid syndrome

Francis, J. (2006) · Molecular Human Reproduction · doi:10.1093/molehr/gal048 · Cited by 86 · see citing works

Antiendothelial cell antibodies in systemic lupus erythematosus

Renaudineau, Y., Dugué, C., Dueymes, M., & Youinou, P. (2002) · Autoimmunity Reviews · doi:10.1016/s1568-9972(02)00063-0 · Cited by 83 · see citing works

TLR2 Is One of the Endothelial Receptors for β2-Glycoprotein I

Alard, J.-É., Gaillard, F., Daridon, C., Shoenfeld, Y., Jamin, C., & Youinou, P. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1000526 · Cited by 80 · see citing works

Role of tissue factor in a mouse model of thrombotic microangiopathy induced by antiphospholipid antibodies

Seshan, S. V., Franzke, C.-W., Redecha, P. B., Monestier, M., Mackman, N., & Girardi, G. (2009) · Blood · doi:10.1182/blood-2009-01-199117 · Cited by 80 · see citing works

Role of p38 mitogen‐activated protein kinase in antiphospholipid antibody‐mediated thrombosis and endothelial cell activation

Vega-Ostertag, M. E., Ferrara, D. E., Romay‐Penabad, Z., Xiang‐dong, L. I. U., Taylor, W. R., Colden‐Stanfield, M., & Pierangeli, S. S. (2007) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2007.02680.x · Cited by 79 · see citing works

Effects of Polyclonal IgG Derived from Patients with Different Clinical Types of the Antiphospholipid Syndrome on Monocyte Signaling Pathways

Lambrianides, A., Carroll, C. J., Pierangeli, S. S., Pericleous, C., Branch, W. D., Rice, J., Latchman, D. S., Townsend, P. A., Isenberg, D. A., Rahman, A., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0902765 · Cited by 78 · see citing works

Pathogenesis of the antiphospholipid syndrome: An additional example of the mosaic of autoimmunity

Meroni, P. L. (2008) · Journal of Autoimmunity · doi:10.1016/j.jaut.2007.11.014 · Cited by 76 · see citing works

Complement activation in anti-phospholipid syndrome: A clue for an inflammatory process?

Cavazzana, I., Nebuloni, M., Cetin, I., Acaia, B., Sara, S., Borghi, M. O., Tincani, A., Tedesco, F., & Meroni, P. L. (2007) · Journal of Autoimmunity · doi:10.1016/j.jaut.2007.02.013 · Cited by 73 · see citing works

A peptide that mimics the Vth region of β2glycoprotein I reverses antiphospholipid-mediated thrombosis in mice

Vega-Ostertag, M. E., Liu, X., Henderson, V. J., & Pierangeli, S. S. (2006) · Lupus · doi:10.1191/0961203306lu2315oa · Cited by 72 · see citing works

Cell surface proteoglycan expression during maturation of human monocytes-derived dendritic cells and macrophages

Wegrowski, Y., Milard, A.-L., Kotlarz, G., Toulmonde, E., Maquart, F.-X., & Bernard, J. (2006) · Clinical and Experimental Immunology · doi:10.1111/j.1365-2249.2006.03059.x · Cited by 70 · see citing works

Beta 2 glycoprotein I is a substrate of thiol oxidoreductases

Passam, F. H., Rahgozar, S., Qi, M., Raftery, M. J., Wong, J. W. H., Tanaka, K., Ioannou, Y., Zhang, J. Y., Gemmell, R., Qi, J. C., et al. (2010) · Blood · doi:10.1182/blood-2010-02-271494 · Cited by 70 · see citing works

Prevalence and Clinical Correlations of Antibodies Against Six β2-Glycoprotein-I-Related Peptides in the Antiphospholipid Syndrome

Shoenfeld, Y., Krause, I., Kvapil, F., Sulkes, J., Lev, S., von Landenberg, P., Font, J., Zaech, J., Cervera, R., Pietté, J. C., et al. (2003) · Journal of Clinical Immunology · doi:10.1023/a:1025321617304 · Cited by 68 · see citing works

Antiphospholipid syndrome and systemic lupus erythematosus: are they separate entities or just clinical presentations on the same scale?

Shoenfeld, Y., Meroni, P. L., & Toubi, E. (2009) · Current Opinion in Rheumatology · doi:10.1097/bor.0b013e32832effdd · Cited by 66 · see citing works

Phospholipid Binding Plasma Proteins Required for Antiphospholipid Antibody Detection—An Overview

McIntyre, J. A., Wagenknecht, D. R., & Sugi, T. (1997) · American Journal of Reproductive Immunology · doi:10.1111/j.1600-0897.1997.tb00198.x · Cited by 63 · see citing works

A human monoclonal antiprothrombin antibody is thrombogenic in vivo and upregulates expression of tissue factor and E‐selectin on endothelial cells

Vega-Ostertag, M. E., Liu, X., Kwan‐Ki, H., Chen, P. P., & Pierangeli, S. S. (2006) · British Journal of Haematology · doi:10.1111/j.1365-2141.2006.06283.x · Cited by 62 · see citing works

Natural Catalytic Antibodies in Norm, Autoimmune, Viral, and Bacterial Diseases

Nevinsky, G. A., & Buneva, V. N. (2010) · The Scientific World JOURNAL · doi:10.1100/tsw.2010.98 · Cited by 58 · see citing works

The Pathogenesis of Neural Injury in Animal Models of the Antiphospholipid Syndrome

Katzav, A., Shoenfeld, Y., & Chapman, J. (2009) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-009-8154-x · Cited by 57 · see citing works

The effect of immunoglobulin G fractions from patients with lupus anticoagulant on placental prostacyclin and thromboxane production

Peaceman, A. M., & Rehnberg, K. A. (1993) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(93)90408-b · Cited by 55 · see citing works

Anti-phospholipid antibody mediated fetal loss: still an open question from a pathogenic point of view

Meroni, P. L., Tedesco, F., Locati, M., Vecchi, A., Simone, N. D., Acaia, B., Pierangeli, S., & Borghi, M. O. (2010) · Lupus · doi:10.1177/0961203309361351 · Cited by 55 · see citing works

Annexin A2: biology and relevance to the antiphospholipid syndrome

Cockrell, E., Espinola, R., & McCrae, K. (2008) · Lupus · doi:10.1177/0961203308095329 · Cited by 50 · see citing works

An international multicentre‐laboratory evaluation of a new assay to detect specifically lupus anticoagulants dependent on the presence of anti‐beta2‐glycoprotein autoantibodies

de Laat, B., Derksen, R. H. W. M., Reber, G., Musiał, J., Swadźba, J., Božič, B., Čučnik, S., Regnault, V., Forastiero, R. R., Woodhams, B. J., et al. (2010) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2010.04068.x · Cited by 49 · see citing works

Neonatal effects of maternal antiphospholipid syndrome

Tincani, A., Rebaioli, C. B., Andréoli, L., Lojacono, A., & Motta, M. (2009) · Current Rheumatology Reports · doi:10.1007/s11926-009-0010-8 · Cited by 40 · see citing works

Detection of Complement-fixing Antiphospholipid Antibodies in Association with Thrombosis

Saitô, T., Matsuda, K., Seino, J., Shibata, S., Sasaki, T., & Munakata, Y. (2000) · Thrombosis and Haemostasis · doi:10.1055/s-0037-1613900 · Cited by 37 · see citing works

Identification of anti-prothrombin antibodies in the anti-phospholipid syndrome that display the prothrombinase activity

Yang, Y., Chang, C., Chuang, Y., Hsu, H.-Y., Chen, P. P., & Chiang, B. (2009) · Rheumatology · doi:10.1093/rheumatology/kep328 · Cited by 35 · see citing works

Domain I of β2-glycoprotein I: its role as an epitope and the potential to be developed as a specific target for the treatment of the antiphospholipid syndrome

Ioannou, Y., & Rahman, A. (2010) · Lupus · doi:10.1177/0961203309360544 · Cited by 33 · see citing works

Antibodies to Serine Proteases in the Antiphospholipid Syndrome

Chen, P. P., & Giles, I. (2010) · Current Rheumatology Reports · doi:10.1007/s11926-009-0072-7 · Cited by 33 · see citing works

Role of Tissue Factor in the Maternal Immunological Attack of the Embryo in the Antiphospholipid Syndrome

Girardi, G. (2009) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-009-8187-1 · Cited by 32 · see citing works

Heparan Sulfate Proteoglycans in the Basement Membranes of the Human Placenta and Decidua

Chen, C.-P., Liu, S.-H., Lee, M.-Y., & Chen, Y.-Y. (2008) · Placenta · doi:10.1016/j.placenta.2008.01.002 · Cited by 28 · see citing works

Expression and function of syndecan-4 in human platelets

Kaneider, N. C., Feistritzer, C., Gritti, D., Mosheimer, B. A., Ricevuti, G., Patsch, J. R., & Wiedermann, C. J. (2005) · Thrombosis and Haemostasis · doi:10.1160/th04-11-0763 · Cited by 25 · see citing works

Glypican-1, Phosphacan/Receptor Protein-Tyrosine Phosphatase-ζ/β and its Ligand, Tenascin-C, are Expressed by Neural Stem Cells and Neural Cells Derived from Embryonic Stem Cells

Abaskharoun, M., Bellemare, M., Lau, E., & Margolis, R. U. (2010) · ASN NEURO · doi:10.1042/an20100001 · Cited by 23 · see citing works

Annexin A2 mediates anti-β2GPI/β2GPI-induced tissue factor expression on monocytes

Zhou (2009) · International Journal of Molecular Medicine · doi:10.3892/ijmm_00000265 · Cited by 22 · see citing works

Placental Pathology in Antiphospholipid Syndrome

Parke, A. L. (2006) · Springer eBooks · doi:10.1007/1-84628-009-5_29 · Cited by 19 · see citing works

Reelin and apolipoprotein E receptor 2 in the embryonic and mature brain: effects of an evolutionary change in the apoER2 gene

Myant, N. B. (2009) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2009.1412 · Cited by 19 · see citing works

Reply

Martínez‐Lavín, M. (2008) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2007.09.006 · Cited by 3 · see citing works

Untitled work

Atsumi (2000) · doi:10.1002/1529-0131(200009)43:9

The Pathogenesis of the Antiphospholipid Syndrome

Giannakopoulos, B., & Krilis, S. A. (2013) · New England Journal of Medicine · doi:10.1056/nejmra1112830 · Cited by 682 · see citing works

Neutrophil extracellular traps (NETs) in autoimmune diseases: A comprehensive review

Lee, K. H., Kronbichler, A., Park, D. D.-Y., Park, Y. M., Moon, H., Kim, H., Choi, J. H., Choi, Y., Shim, S., Lyu, I. S., et al. (2017) · Autoimmunity Reviews · doi:10.1016/j.autrev.2017.09.012 · Cited by 626 · see citing works

Recurrent pregnancy loss: current perspectives

Hachem, H. E., Crepaux, V., May‐Panloup, P., Descamps, P., Legendre, G., & Bouet, P. (2017) · International Journal of Women s Health · doi:10.2147/ijwh.s100817 · Cited by 465 · see citing works

Estimated Frequency of Antiphospholipid Antibodies in Patients With Pregnancy Morbidity, Stroke, Myocardial Infarction, and Deep Vein Thrombosis: A Critical Review of the Literature

Andréoli, L., Chighizola, C. B., Banzato, A., Pons‐Estel, G., de Jesús, G. R., Erkan, D., & ACTION, O. B. O. A. (2013) · Arthritis Care & Research · doi:10.1002/acr.22066 · Cited by 363 · see citing works

Cardiovascular disease in autoimmune rheumatic diseases

Hollan, I., Meroni, P. L., Ahearn, J. M., Tervaert, J. W. C., Curran, S., Goodyear, C. S., Hestad, K. A., Kahaleh, B., Riggio, M. P., Shields, K. J., et al. (2013) · Autoimmunity Reviews · doi:10.1016/j.autrev.2013.03.013 · Cited by 273 · see citing works

Tumor Necrosis Factor-Alpha and Pregnancy: Focus on Biologics. An Updated and Comprehensive Review

Alijotas‐Reig, J., Esteve‐Valverde, E., Ferrer‐Oliveras, R., Llurba, E., & Gris, J. M. (2017) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-016-8596-x · Cited by 236 · see citing works

In Vivo Role of Neutrophil Extracellular Traps in Antiphospholipid Antibody–Mediated Venous Thrombosis

Meng, H., Yalavarthi, S., Kanthi, Y. M., Mazza, L. F., Elfline, M. A., Luke, C. E., Pinsky, D. J., Henke, P. K., & Knight, J. S. (2016) · Arthritis & Rheumatology · doi:10.1002/art.39938 · Cited by 233 · see citing works

Progesterone and autoimmune disease

Hughes, G. C. (2011) · Autoimmunity Reviews · doi:10.1016/j.autrev.2011.12.003 · Cited by 224 · see citing works

State of the art: Reproduction and pregnancy in rheumatic diseases

Østensen, M., Andréoli, L., Brucato, A. L., Cetin, I., Chambers, C., Clowse, M. E. B., Costedoat-Chalumeau, N., Cutolo, M., Dolhain, R. J. E. M., Fenstad, M. H., et al. (2014) · Autoimmunity Reviews · doi:10.1016/j.autrev.2014.12.011 · Cited by 207 · see citing works

14th International Congress on Antiphospholipid Antibodies Task Force Report on Obstetric Antiphospholipid Syndrome

de Jesús, G. R., Agmon‐Levin, N., de Andrade, C. A. F., Andréoli, L., Chighizola, C. B., Porter, T. F., Salmon, J. E., Silver, R. M., Tincani, A., & Branch, D. W. (2014) · Autoimmunity Reviews · doi:10.1016/j.autrev.2014.02.003 · Cited by 187 · see citing works

Antiphospholipid Syndrome

Corban, M., Duarte‐García, A., McBane, R. D., Matteson, E. L., Lerman, L. O., & Lerman, A. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.02.058 · Cited by 182 · see citing works

The role of beta-2-glycoprotein I in health and disease associating structure with function: More than just APS

McDonnell, T. C. R., Wincup, C., Buchholz, I., Pericleous, C., Giles, I., Ripoll, V. M., Cohen, H., Delcea, M., & Rahman, A. (2019) · Blood Reviews · doi:10.1016/j.blre.2019.100610 · Cited by 169 · see citing works

The role of complement in kidney disease: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference

Vivarelli, M., Barratt, J., Beck, L. H., Fakhouri, F., Gale, D. P., de Jorge, E. G., Mosca, M., Noris, M., Pickering, M. C., Suszták, K., et al. (2024) · Kidney International · doi:10.1016/j.kint.2024.05.015 · Cited by 153 · see citing works

Obstetric and vascular antiphospholipid syndrome: same antibodies but different diseases?

Meroni, P. L., Borghi, M. O., Grossi, C., Chighizola, C. B., Durigutto, P., & Tedesco, F. (2018) · Nature Reviews Rheumatology · doi:10.1038/s41584-018-0032-6 · Cited by 150 · see citing works

Seronegative antiphospholipid syndrome: refining the value of “non-criteria” antibodies for diagnosis and clinical management

Pignatelli, P., Ettorre, E., Menichelli, D., Pani, A., Violi, F., & Pastori, D. (2020) · Haematologica · doi:10.3324/haematol.2019.221945 · Cited by 141 · see citing works

A non–complement-fixing antibody to β2 glycoprotein I as a novel therapy for antiphospholipid syndrome

Agostinis, C., Durigutto, P., Sblattero, D., Borghi, M. O., Grossi, C., Guida, F., Bulla, R., Macor, P., Pregnolato, F., Meroni, P. L., et al. (2014) · Blood · doi:10.1182/blood-2013-11-537704 · Cited by 138 · see citing works

Detection of Antibodies in Blood Plasma Using Bioluminescent Sensor Proteins and a Smartphone

Arts, R., den Hartog, I., Zijlema, S. E., Thijssen, V., van der Beelen, S. H. E., & Merkx, M. (2016) · Analytical Chemistry · doi:10.1021/acs.analchem.6b00534 · Cited by 138 · see citing works

In vivo distribution of β2 glycoprotein I under various pathophysiologic conditions

Agostinis, C., Biffi, S., Garrovo, C., Durigutto, P., Lorenzon, A., Bek, A., Bulla, R., Grossi, C., Borghi, M. O., Meroni, P. L., et al. (2011) · Blood · doi:10.1182/blood-2011-01-333617 · Cited by 137 · see citing works

Aspirin: The Mechanism of Action Revisited in the Context of Pregnancy Complications

Cadavid, Á. P. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00261 · Cited by 134 · see citing works

HYdroxychloroquine to Improve Pregnancy Outcome in Women with AnTIphospholipid Antibodies (HYPATIA) Protocol: A Multinational Randomized Controlled Trial of Hydroxychloroquine versus Placebo in Addition to Standard Treatment in Pregnant Women with Antiphospholipid Syndrome or Antibodies

Schreiber, K. I., Breen, K. A., Cohen, H., Jacobsen, S., Middeldorp, S., Pavord, S. R., Regan, L., Roccatello, D., Robinson, S. E., Sciascia, S., et al. (2017) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-0037-1603359 · Cited by 128 · see citing works

Movement disorders in autoimmune diseases

Baizabal‐Carvallo, J. F., & Jankovic, J. J. (2012) · Movement Disorders · doi:10.1002/mds.25011 · Cited by 125 · see citing works

Autoimmune diseases and venous thromboembolism: a review of the literature.

Zöller, B., Li, X., Sundquist, J., & Sundquist, K. (2012) · Europe PMC (PubMed Central) · Cited by 123 · see citing works

Catastrophic antiphospholipid syndrome: a clinical review.

Nayer, A., & Ortega, L. M. (2014) · Europe PMC (PubMed Central) · doi:10.12860/jnp.2014.03 · Cited by 123 · see citing works

Cardiovascular disease risk in antiphospholipid syndrome: Thrombo-inflammation and atherothrombosis

Tektonidou, M. G. (2022) · Journal of Autoimmunity · doi:10.1016/j.jaut.2022.102813 · Cited by 122 · see citing works

The adjusted global antiphospholipid syndrome score (aGAPSS) and the risk of recurrent thrombosis: Results from the APS ACTION cohort

Radin, M., Sciascia, S., Erkan, D., Pengo, V., Tektonidou, M. G., Ugarte, A., Meroni, P. L., Ji, L., Belmont, M. H., Cohen, H., et al. (2019) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2019.04.009 · Cited by 121 · see citing works

Platelets are required for enhanced activation of the endothelium and fibrinogen in a mouse thrombosis model of APS

Proulle, V., Furie, R. A., Merrill‐Skoloff, G., Furie, B. C., & Furie, B. (2014) · Blood · doi:10.1182/blood-2014-02-554980 · Cited by 120 · see citing works

Microvascular thrombosis: experimental and clinical implications

Bray, M. A., Sartain, S. E., Gollamudi, J., & Rumbaut, R. E. (2020) · Translational research · doi:10.1016/j.trsl.2020.05.006 · Cited by 119 · see citing works

Systemic lupus erythematosus and cardiovascular disease

Frostegård, J. (2022) · Journal of Internal Medicine · doi:10.1111/joim.13557 · Cited by 116 · see citing works

Antiphospholipid syndrome in 2014: more clinical manifestations, novel pathogenic players and emerging biomarkers

Meroni, P. L., Chighizola, C. B., Rovelli, F., & Gerosa, M. (2014) · Arthritis Research & Therapy · doi:10.1186/ar4549 · Cited by 113 · see citing works

Complement activation in patients with isolated antiphospholipid antibodies or primary antiphospholipid syndrome

Seed, P. T., Parmar, K., Moore, G. W., Stuart‐Smith, S., Hunt, B. J., & Breen, K. A. (2012) · Thrombosis and Haemostasis · doi:10.1160/th11-08-0554 · Cited by 111 · see citing works

Current treatment of antiphospholipid syndrome: lights and shadows

Espinosa, G., & Cervera, R. (2015) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2015.88 · Cited by 110 · see citing works

Thrombotic antiphospholipid syndrome: A practical guide to diagnosis and management

Sayar, Z., Moll, R., Isenberg, D. A., & Cohen, H. (2020) · Thrombosis Research · doi:10.1016/j.thromres.2020.10.010 · Cited by 110 · see citing works

Use of Direct Oral Anticoagulants in Patients With Antiphospholipid Syndrome: A Systematic Review and Comparison of the International Guidelines

Pastori, D., Menichelli, D., Cammisotto, V., & Pignatelli, P. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.715878 · Cited by 109 · see citing works

A Role for Uric Acid and the Nalp3 Inflammasome in Antiphospholipid Antibody-Induced IL-1β Production by Human First Trimester Trophoblast

Mulla, M. J., Salmon, J. E., Chamley, L., Brosens, J. J., Boeras, C., Kavathas, P., & Abrahams, V. M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0065237 · Cited by 109 · see citing works

Computer Assisted Tomography of the Head

Baker, H. L., Campbell, J. K., Houser, O. W., Reese, D. F., Sheedy, P. F., Holman, C. B., & Kurland, R. L. (1974) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(25)16645-7 · Cited by 107 · see citing works

Clinical Characterization of Antiphospholipid Syndrome by Detection of IgG Antibodies Against β 2 ‐Glycoprotein I Domain 1 and Domain 4/5: Ratio of Anti–Domain 1 to Anti–Domain 4/5 As a Useful New Biomarker for Antiphospholipid Syndrome

Andréoli, L., Chighizola, C. B., Nalli, C., Gerosa, M., Borghi, M. O., Pregnolato, F., Grossi, C., Zanola, A., Allegri, F., Norman, G. L., et al. (2015) · Arthritis & Rheumatology · doi:10.1002/art.39187 · Cited by 105 · see citing works

Movement disorders in systemic lupus erythematosus and the antiphospholipid syndrome

Baizabal‐Carvallo, J. F., Bonnet, C., & Jankovic, J. J. (2013) · Journal of Neural Transmission · doi:10.1007/s00702-013-1023-z · Cited by 104 · see citing works

Autoantibodies to domain 1 of beta 2 glycoprotein 1: A promising candidate biomarker for risk management in antiphospholipid syndrome

Mähler, M., Norman, G. L., Meroni, P. L., & Khamashta, M. A. (2012) · Autoimmunity Reviews · doi:10.1016/j.autrev.2012.05.006 · Cited by 102 · see citing works

Smoking and the Pathophysiology of Peripheral Artery Disease

Wang, W., Zhao, T., Geng, K., Yuan, G., Chen, Y., & Xu, Y. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.704106 · Cited by 98 · see citing works

Non-specific binding in solid phase immunoassays for autoantibodies correlates with inflammation markers

Güven, E., Duus, K., Lydolph, M. C., Jørgensen, C. S., Laursen, I., & Houen, G. (2013) · Journal of Immunological Methods · doi:10.1016/j.jim.2013.11.014 · Cited by 98 · see citing works

Standardization of autoantibody testing: a paradigm for serology in rheumatic diseases

Meroni, P. L., Biggioggero, M., Pierangeli, S. S., Sheldon, J., Zegers, I., & Borghi, M. O. (2014) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2013.180 · Cited by 92 · see citing works

Diagnosis and management of catastrophic antiphospholipid syndrome

Carmi, O., Berla, M., Shoenfeld, Y., & Levy, Y. (2017) · Expert Review of Hematology · doi:10.1080/17474086.2017.1300522 · Cited by 91 · see citing works

Hydroxychloroquine restores trophoblast fusion affected by antiphospholipid antibodies

Marchetti, T., Ruffatti, A., Wuillemin, C., de Moerloose, P., & Cohen, M. (2014) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.12570 · Cited by 91 · see citing works

Failure of dabigatran and rivaroxaban to prevent thromboembolism in antiphospholipid syndrome: a case series of three patients

Schaefer, J. K., McBane, R. D., Black, D. M., Williams, L. N., Moder, K. G., & Wysokiński, W. E. (2014) · Thrombosis and Haemostasis · doi:10.1160/th14-03-0272 · Cited by 90 · see citing works

Antiphospholipid syndrome and the heart: A case series and literature review

Denas, G., Jose, S. P., Bracco, A., Zoppellaro, G., & Pengo, V. (2014) · Autoimmunity Reviews · doi:10.1016/j.autrev.2014.11.003 · Cited by 88 · see citing works

Pregnancy implications for systemic lupus erythematosus and the antiphospholipid syndrome

Andréoli, L., Fredi, M., Nalli, C., Reggia, R., Lojacono, A., Motta, M., & Tincani, A. (2011) · Journal of Autoimmunity · doi:10.1016/j.jaut.2011.11.010 · Cited by 86 · see citing works

Pediatric Antiphospholipid Syndrome

Cimaz, R., & Descloux, É. (2006) · Rheumatic Disease Clinics of North America · doi:10.1016/j.rdc.2006.05.005 · Cited by 81 · see citing works

Complement activation in antiphospholipid syndrome and its inhibition to prevent rethrombosis after arterial surgery

Meroni, P. L., Macor, P., Durigutto, P., Maso, L. D., Gerosa, M., Ferraresso, M., Borghi, M. O., Mollnes, T. E., & Tedesco, F. (2015) · Blood · doi:10.1182/blood-2015-09-672139 · Cited by 80 · see citing works

Cigarette smoking, antiphospholipid antibodies and vascular events in Systemic Lupus Erythematosus

Gustafsson, J. T., Gunnarsson, I., Källberg, H., Pettersson, S., Zickert, A., Vikerfors, A., Möller, S., Rönnelid, J., Elvin, K., & Svenungsson, E. (2014) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2013-205159 · Cited by 79 · see citing works

Pathogenic Role of Complement in Antiphospholipid Syndrome and Therapeutic Implications

Tedesco, F., Borghi, M. O., Gerosa, M., Chighizola, C. B., Macor, P., Lonati, P. A., Gulino, A., Belmonte, B., & Meroni, P. L. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01388 · Cited by 78 · see citing works

ApoE Receptor 2 Mediation of Trophoblast Dysfunction and Pregnancy Complications Induced by Antiphospholipid Antibodies in Mice

Ulrich, V., Gelber, S. E., Vukelic, M., Sacharidou, A., Herz, J., Urbanus, R. T., de Groot, P. G., Natale, D. R. C., Harihara, A., Redecha, P. B., et al. (2015) · Arthritis & Rheumatology · doi:10.1002/art.39453 · Cited by 77 · see citing works

The Pathophysiology of The Antiphospholipid Syndrome: A Perspective From The Blood Coagulation System

Arreola‐Diaz, R., Majluf‐Cruz, A., Sanchez-Torres, L., & Hernández‐Juárez, J. (2022) · Clinical and Applied Thrombosis/Hemostasis · doi:10.1177/10760296221088576 · Cited by 76 · see citing works

The skin and hypercoagulable states

Thornsberry, L. A., LoSicco, K., & English, J. C. (2013) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2013.01.043 · Cited by 76 · see citing works

Beyond thrombosis: Anti-β2GPI domain 1 antibodies identify late pregnancy morbidity in anti-phospholipid syndrome

Chighizola, C. B., Pregnolato, F., Andréoli, L., Bodio, C., Cesana, L., Comerio, C., Gerosa, M., Grossi, C., Kumar, R., Lazzaroni, M. G., et al. (2018) · Journal of Autoimmunity · doi:10.1016/j.jaut.2018.02.002 · Cited by 75 · see citing works

Guidelines on the investigation and management of antiphospholipid syndrome

Arachchillage, D. J., Platton, S., Hickey, K. P., Chu, J., Pickering, M. C., Sommerville, P., MacCallum, P., & Breen, K. A. (2024) · British Journal of Haematology · doi:10.1111/bjh.19635 · Cited by 74 · see citing works

The pathogenic role of autoantibodies in recurrent pregnancy loss

D’Ippolito, S., Ticconi, C., Tersigni, C., Garofalo, S., Martino, C., Lanzone, A., Scambia, G., & Simone, N. D. (2019) · American Journal of Reproductive Immunology · doi:10.1111/aji.13200 · Cited by 72 · see citing works

Antiphospholipid Syndrome and the Kidney

Sciascia, S., Baldovino, S., Schreiber, K. I., Solfietti, L., & Roccatello, D. (2015) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2015.08.009 · Cited by 71 · see citing works

The Complement System in the Pathophysiology of Pregnancy and in Systemic Autoimmune Rheumatic Diseases During Pregnancy

Chighizola, C. B., Lonati, P. A., Trespìdi, L., Meroni, P. L., & Tedesco, F. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.02084 · Cited by 71 · see citing works

Longterm Outcome of Patients with Primary Antiphospholipid Syndrome: A Retrospective Multicenter Study

Taraborelli, M., Reggia, R., Dall’Ara, F., Fredi, M., Andréoli, L., Gerosa, M., Hoxha, A., Massaro, L., Tonello, M., Costedoat-Chalumeau, N., et al. (2017) · The Journal of Rheumatology · doi:10.3899/jrheum.161364 · Cited by 71 · see citing works

Cellular and Molecular Mechanisms of Anti-Phospholipid Syndrome

Radic, M. Z., & Pattanaik, D. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00969 · Cited by 70 · see citing works

Antiphospholipid Syndrome in Pregnancy: New and Old Pathogenetic Mechanisms

D’Ippolito, S., Barbaro, G., Paciullo, C., Tersigni, C., Scambia, G., & Simone, N. D. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043195 · Cited by 69 · see citing works

Catastrophic Antiphospholipid Syndrome

Bitsadze, V. O., Yakubova, F. E., Khizroeva, J. K., Владимировна, Л. А., Владимировна, С. П., Vorobеv, A. V., Tretyakova, M. V., Degtyareva, N. D., Grigoreva, K. N., Gashimova, N. R., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25010668 · Cited by 69 · see citing works

Treatment of refractory obstetric antiphospholipid syndrome: the state of the art and new trends in the therapeutic management

Alijotas‐Reig, J. (2012) · Lupus · doi:10.1177/0961203312465782 · Cited by 69 · see citing works

Clinical Evaluation and Management of Thrombotic Microangiopathy

Leisring, J. M., Brodsky, S. V., & Parikh, S. V. (2023) · Arthritis & Rheumatology · doi:10.1002/art.42681 · Cited by 68 · see citing works

Prevalence and Thrombotic Risk Assessment of Anti-β2 Glycoprotein I Domain I Antibodies: A Systematic Review

Radin, M., Cecchi, I., Roccatello, D., Meroni, P. L., & Sciascia, S. (2017) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-0037-1603936 · Cited by 68 · see citing works

Treatment of Thrombotic Antiphospholipid Syndrome: The Rationale of Current Management—An Insight into Future Approaches

Chighizola, C. B., Ubiali, T., & Meroni, P. L. (2015) · Journal of Immunology Research · doi:10.1155/2015/951424 · Cited by 67 · see citing works

Anti-phospholipid induced murine fetal loss: Novel protective effect of a peptide targeting the β2 glycoprotein I phospholipid-binding site. Implications for human fetal loss

de la Torre, Y. M., Pregnolato, F., D’Amelio, F., Grossi, C., Simone, N. D., Pasqualini, F., Nebuloni, M., Chen, P. P., Pierangeli, S. S., Bassani, N., et al. (2011) · Journal of Autoimmunity · doi:10.1016/j.jaut.2011.11.009 · Cited by 67 · see citing works

Delineating the deranged immune system in the antiphospholipid syndrome

van den Hoogen, L. L., van Roon, J. A. G., Radstake, T. R. D. J., Fritsch-Stork, R. D. E., & Derksen, R. H. W. M. (2015) · Autoimmunity Reviews · doi:10.1016/j.autrev.2015.08.011 · Cited by 66 · see citing works

Cofactor-independent antiphospholipid antibodies activate the NLRP3-inflammasome via endosomal NADPH-oxidase: implications for the antiphospholipid syndrome

Müller‐Calleja, N., Köhler, A., Siebald, B., Canisius, A., Orning, C., Radsak, M. P., Stein, P., Mönnikes, R., & Lackner, K. J. (2015) · Thrombosis and Haemostasis · doi:10.1160/th14-07-0628 · Cited by 66 · see citing works

Antiphospholipid syndrome management: a 2023 update and practical algorithm-based approach

Ambati, A., Knight, J. S., & Zuo, Y. (2023) · Current Opinion in Rheumatology · doi:10.1097/bor.0000000000000932 · Cited by 65 · see citing works

Recurrent thrombosis in patients with antiphospholipid antibodies and arterial thrombosis on antithrombotic therapy

Jackson, W. G., Oromendia, C., Ünlü, O., Erkan, D., & DeSancho, M. T. (2017) · Blood Advances · doi:10.1182/bloodadvances.2017008185 · Cited by 65 · see citing works

New Tests to Detect Antiphospholipid Antibodies: Anti-Domain I Beta-2-Glycoprotein-I Antibodies

Chighizola, C. B., Gerosa, M., & Meroni, P. L. (2014) · Current Rheumatology Reports · doi:10.1007/s11926-013-0402-7 · Cited by 64 · see citing works

Obstetric antiphospholipid syndrome: A recent classification for an old defined disorder

D’Ippolito, S., Meroni, P. L., Koike, T., Veglia, M., Scambia, G., & Simone, N. D. (2014) · Autoimmunity Reviews · doi:10.1016/j.autrev.2014.05.004 · Cited by 64 · see citing works

Coagulopathy in COVID-19: Focus on vascular thrombotic events

Shi, W., Lv, J., & Lin, L. (2020) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2020.07.003 · Cited by 63 · see citing works

Endothelial Dysfunction in Systemic Lupus Erythematosus and Systemic Sclerosis: A Common Trigger for Different Microvascular Diseases

Moschetti, L., Piantoni, S., Vizzardi, E., Sciatti, E., Riccardi, M., Franceschini, F., & Cavazzana, I. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.849086 · Cited by 62 · see citing works

β2-glycoprotein I, lipopolysaccharide and endothelial TLR4: Three players in the two hit theory for anti-phospholipid-mediated thrombosis

Raschi, E., Chighizola, C. B., Grossi, C., Ronda, N., Gatti, R., Meroni, P. L., & Borghi, M. O. (2014) · Journal of Autoimmunity · doi:10.1016/j.jaut.2014.03.001 · Cited by 62 · see citing works

Mechanisms of thrombosis in systemic lupus erythematosus and antiphospholipid syndrome

de Groot, P. G., & de Laat, B. (2017) · Best Practice & Research Clinical Rheumatology · doi:10.1016/j.berh.2017.09.008 · Cited by 62 · see citing works

Antiphospholipid syndrome

Khamashta, M. A., Taraborelli, M., Sciascia, S., & Tincani, A. (2016) · Best Practice & Research Clinical Rheumatology · doi:10.1016/j.berh.2016.04.002 · Cited by 62 · see citing works

Anti-phosphatidylserine/prothrombin antibodies: an additional diagnostic marker for APS?

Pregnolato, F., Chighizola, C. B., Encabo, S., Shums, Z., Norman, G. L., Tripodi, A., Chantarangkul, V., Bertero, T., Micheli, V. D., Borghi, M. O., et al. (2013) · Immunologic Research · doi:10.1007/s12026-013-8421-z · Cited by 61 · see citing works

Autoantibodies Present in Hidradenitis Suppurativa Correlate with Disease Severity and Promote the Release of Proinflammatory Cytokines in Macrophages

Carmona‐Rivera, C., O’Neil, L. J., Patiño‐Martínez, E., Shipman, W. D., Zhu, C., Li, Q., Kerns, M. L., Barnes, L. A., Caffrey, J. A., Kang, S., et al. (2021) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2021.07.187 · Cited by 60 · see citing works

Acute Cutaneous Necrosis: A Guide to Early Diagnosis and Treatment

Karimi, K., Odhav, A., Kollipara, R., Fike, J., Stanford, C. W., & Hall, J. C. (2017) · Journal of Cutaneous Medicine and Surgery · doi:10.1177/1203475417708164 · Cited by 60 · see citing works

Isolated IgA Anti-<i>β</i>2 Glycoprotein I Antibodies in Patients with Clinical Criteria for Antiphospholipid Syndrome

Ruiz-García, R., Serrano, M., Ángel Martínez-Flores, J., Mora, S., Morillas, L., Martín-Mola, M. Á., Morales, J. M., Paz-Artal, E., & Serrano, A. (2014) · Journal of Immunology Research · doi:10.1155/2014/704395 · Cited by 59 · see citing works

Thrombosis in VEXAS syndrome

Oo, T. M., Koay, J. T. J., Lee, S. F., Lee, S. S. M., Lim, X. R., & Fan, B. E. (2021) · Journal of Thrombosis and Thrombolysis · doi:10.1007/s11239-021-02608-y · Cited by 59 · see citing works

Antiphospholipid Antibodies Affect Human Endometrial Angiogenesis: Protective Effect of a Synthetic Peptide (TIFI) Mimicking the Phospholipid Binding Site of β2glycoprotein I

Simone, N. D., D’Ippolito, S., Marana, R., Nicuolo, F. D., Castellani, R., Pierangeli, S. S., Chen, P. P., Tersigni, C., Scambia, G., & Meroni, P. L. (2013) · American Journal of Reproductive Immunology · doi:10.1111/aji.12130 · Cited by 59 · see citing works

Immunogenetic contributions to recurrent pregnancy loss

Grimstad, F. W., & Krieg, S. A. (2016) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-016-0720-6 · Cited by 59 · see citing works

Anti-β2GPI/β2GPI induces neutrophil extracellular traps formation to promote thrombogenesis via the TLR4/MyD88/MAPKs axis activation

Zha, C., Zhang, W., Gao, F., Xu, J., Jia, R., Cai, J., & Liu, Y. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.06.001 · Cited by 59 · see citing works

Antiphospholipid antibody‐activated NETs exacerbate trophoblast and endothelial cell injury in obstetric antiphospholipid syndrome

Lu, Y., Dong, Y., Zhang, Y., Shen, D., Wang, X., Ge, R., Zhang, M., Xia, Y., & Wang, X. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.15321 · Cited by 58 · see citing works

Anti-phospholipid syndrome and COVID-19 thrombosis: connecting the dots

Tung, M. L., Tan, B. W. Q., Cherian, R., & Chandra, B. (2021) · Rheumatology Advances in Practice · doi:10.1093/rap/rkaa081 · Cited by 58 · see citing works

Cofactor‐independent human antiphospholipid antibodies induce venous thrombosis in mice

Manukyan, D., Müller‐Calleja, N., Jäckel, S., Luchmann, K., Mönnikes, R., Kiouptsi, K., Reinhardt, C., Jurk, K., Walter, U., & Lackner, K. J. (2016) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.13263 · Cited by 58 · see citing works

The Diagnostics and Treatment of Recurrent Pregnancy Loss

Tomkiewicz, J., & Darmochwał-Kolarz, D. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12144768 · Cited by 57 · see citing works

Effect of Low Molecular Weight Heparins (LMWHs) on antiphospholipid Antibodies (aPL) – Mediated Inhibition of Endometrial Angiogenesis

D’Ippolito, S., Marana, R., Nicuolo, F. D., Castellani, R., Veglia, M., Stinson, J. C., Scambia, G., & Simone, N. D. (2012) · PLoS ONE · doi:10.1371/journal.pone.0029660 · Cited by 57 · see citing works

Antiphospholipid syndrome pathogenesis in 2023: an update of new mechanisms or just a reconsideration of the old ones?

Raschi, E., Borghi, M. O., Tedesco, F., & Meroni, P. L. (2024) · Rheumatology · doi:10.1093/rheumatology/kead603 · Cited by 56 · see citing works

The Complement System at the Embryo Implantation Site: Friend or Foe?

Bulla, R., Bossi, F., & Tedesco, F. (2012) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00055 · Cited by 56 · see citing works

New insight into antiphospholipid syndrome: antibodies to β2glycoprotein I-domain 5 fail to induce thrombi in rats

Durigutto, P., Grossi, C., Borghi, M. O., Macor, P., Pregnolato, F., Raschi, E., Myers, M. P., de Groot, P. G., Meroni, P. L., & Tedesco, F. (2018) · Haematologica · doi:10.3324/haematol.2018.198119 · Cited by 55 · see citing works

Hydroxychloroquine as an Immunomodulatory and Antithrombotic Treatment in Antiphospholipid Syndrome

Arachchillage, D. J., Laffan, M., & Pericleous, C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021331 · Cited by 53 · see citing works

Endosomal NADPH-oxidase is critical for induction of the tissue factor gene in monocytes and endothelial cells

Prinz, N., Clemens, N., Canisius, A., & Lackner, K. J. (2013) · Thrombosis and Haemostasis · doi:10.1160/th12-06-0421 · Cited by 53 · see citing works

Current insights in obstetric antiphospholipid syndrome

Schreiber, K. I., Radin, M., & Sciascia, S. (2017) · Current Opinion in Obstetrics & Gynecology · doi:10.1097/gco.0000000000000406 · Cited by 53 · see citing works

Pathophysiology of thrombosis and pregnancy morbidity in the antiphospholipid syndrome

Oku, K., Amengual, O., & Atsumi, T. (2012) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2012.02697.x · Cited by 50 · see citing works

Obstetric and vascular APS: Same autoantibodies but different diseases?

Meroni, P. L., Raschi, E., Grossi, C., Pregnolato, F., Trespìdi, L., Acaia, B., & Borghi, M. O. (2012) · Lupus · doi:10.1177/0961203312438116 · Cited by 50 · see citing works

Antiphospholipid antibodies and risk of post-COVID-19 vaccination thrombophilia: The straw that breaks the camel's back?

Talotta, R., & Robertson, E. S. (2021) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2021.05.001 · Cited by 50 · see citing works

Pathophysiology of the antiphospholipid syndrome (APS)

Meroni, P. L., & Chighizola, C. B. (2012) · La Revue de Médecine Interne · doi:10.1016/j.revmed.2012.09.010 · Cited by 11 · see citing works

PReS13-SPK-1240: New aspects on APS pathogenesis

Meroni, P. L. (2013) · Pediatric Rheumatology · doi:10.1186/1546-0096-11-s2-i11 · Cited by 1 · see citing works

Mechanisms of Action of the Antiphospholipid Antibodies

Chighizola, C. B., Raschi, E., Borghi, M. O., & Meroni, P. L. (2016) · Technical report · doi:10.1016/b978-0-444-63655-3.00003-x · Cited by 4 · see citing works

Pathogenesis of antiphospholipid syndrome

Hisada, R., Amengual, O., & Atsumi, T. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-33957-8.00062-7

An insight into the pathophysiology of thrombosis in antiphospholipid syndrome

Palomo, I. F. (2007) · Frontiers in bioscience · doi:10.2741/2297 · Cited by 15 · see citing works