The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Identification of a common gene signature for type II cytokine–associated myeloid cells elicited in vivo in different pathologic conditions
Open accessAbstract
Compared with type I cytokine–associated myeloid (M1) cells, the molecular repertoire and mechanisms underlying functional properties of type II cytokine–associated myeloid (M2) cells are poorly characterized. Moreover, most studies have been limited to in vitro–elicited M2 cells. Here, comparative gene expression profiling of M1 and M2 cells, elicited in murine models of parasitic infections and cancer, yielded a common signature for in vivo–induced M2 populations independent of disease model, mouse strain, and organ source of cells. Some of these genes, such as cadherin-1, selenoprotein P, platelet-activating factor acetylhydrolase, and prosaposin, had not been documented as associated with M2. Overall, the common signature genes provide a molecular basis for a number of documented or suggested properties of M2, including immunomodulation, down-regulation of inflammation, protection against oxidative damage, high capacity for phagocytosis, and tissue repair. Interestingly, several common M2 signature genes encode membrane-associated markers that could be useful for the identification and isolation of M2. Some of these genes were not induced by IL-4/IL-13 or IL-10 under various in vitro settings and thus were missed in approaches based on in vitro–activated cells, validating our choice of in vivo models for expression profiling of myeloid cells.
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Macrophage polarization in tumour progression
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Metadata
- Authors
- Hassanzadeh Ghassabeh, G., De Baetselier, P., Brys, L., Noël, W., Van Ginderachter, J. A., Meerschaut, S., Beschin, A., Brombacher, F., & Raes, G.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2006-07-15
- Volume
- 108
- Issue
- 2
- Pages
- 575-583
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2125378800
- Cited by
- 177
- References
- 7
- FWCI
- 6.09
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Hassanzadeh Ghassabeh, G., De Baetselier, P., Brys, L., Noël, W., Van Ginderachter, J. A., Meerschaut, S., Beschin, A., Brombacher, F., & Raes, G. (2006). Identification of a common gene signature for type II cytokine–associated myeloid cells elicited in vivo in different pathologic conditions. Blood. https://doi.org/10.1182/blood-2005-04-1485
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