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Cited by 263Cerebral Venous Sinus ThrombosisBlood Coagulation and Thrombosis MechanismsVenous Thromboembolism Diagnosis and Management

Thrombophilic abnormalities, oral contraceptives, and risk of cerebral vein thrombosis: a meta-analysis

Dentali, Francesco, Crowther, Mark, Ageno, Walter·2006·Blood
DOI 10.1182/blood-2005-09-3578
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Abstract

Recent studies suggest that thrombophilic abnormalities and the use of oral contraceptives (OCs) are the leading causes of cerebral vein thrombosis (CVT). The purpose of this study was to assess the association between CVT and thrombophilic states, OCs, and their interaction. For data sources, we used the MEDLINE, EMBASE, and Cochrane Library databases (January 1994 to March 2005), reference lists of retrieved articles, and contact with content experts. We selected studies comparing the prevalence of OC use and the prevalence of prothrombitic abnormalities in patients with CVT compared with healthy controls. Two reviewers independently selected studies and extracted study characteristics, quality, and outcomes. Odds ratios (ORs) were calculated for each trial and pooled using the Mantel-Haenszel method. Seventeen studies were included. There was an increased risk of CVT in patients using OCs (OR 5.59; 95% confidence interval [CI] 3.95 to 7.91; P < .001), and in patients with factor V Leiden (OR 3.38; 95% CI 2.27 to 5.05; P < .001), with mutation G20 210A of prothrombin (OR 9.27; 95% CI 5.85 to 14.67; P < .001) and with hyperhomocysteinemia (OR 4.07; 95% CI 2.54 to 6.52; P < .001). We concluded that OC users, and patients with factor V Leiden, the prothrombin G20 120A mutation, and hyperhomocysteinemia are at a significantly increased risk of CVT.

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Crossref · 10.1182/blood-2005-09-3578

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  • Estrogen is associated with increased risk of unusual site thromboses.

    “Estrogen has also been associated with increased risk of “unusual site” thromboses, as well as arterial thrombosis.”

    From Estrogen and thrombosis: a bench to bedside review (2020) · cites this paper as [91]

  • CHC use is associated with an increased risk of cerebral venous sinus thrombosis, with OR 5.59 (95% CI 3.95-7.91) and 7.59 (95% CI 3.82-15.09) in two separate meta-analyses.

    “Multiple studies show an increase in the risk of cerebral venous sinus thrombosis, with an OR of 5.59 (95% CI 3.95 – 7.91) and 7.59 (95% CI 3.82—15.09) in two separate meta-analyses [91, 92].”

    From Estrogen and thrombosis: a bench to bedside review (2020) · cites this paper as [91]

  • The absolute risk of cerebral venous sinus thrombosis remains very low, estimated around 2 per 100,000.

    “However, the absolute risk remains very low, estimated around 2 per 100,000.”

    From Estrogen and thrombosis: a bench to bedside review (2020) · cites this paper as [91]

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Authors
Dentali, F., Crowther, M., & Ageno, W.
Affiliations
University of Insubria (IT)
ORCID
Venue
Blood
Publisher
American Society of Hematology
Published
2006-04-01
Volume
107
Issue
7
Pages
2766-2773
ISSN
  • 0006-4971 (ISSN-L)
  • 1528-0020
DOI
10.1182/blood-2005-09-3578
OpenAlex
W2141196602
Cited by
263
References
56
Citations by year
2026: 4 · 2025: 6 · 2024: 13 · 2023: 16 · 2022: 16 · 2021: 17 · 2020: 12 · 2019: 9 · 2018: 11 · 2017: 16 · 2016: 16 · 2015: 15 · 2014: 5 · 2013: 16 · 2012: 21
FWCI
1.63
Type
journal article
Language
en
Open access
closed
Locations
  • Blood (publishedVersion)
  • PubMed (publishedVersion)
  • IrInSubria (University of Insubria) (submittedVersion)
Topics
  • Health Sciences › Medicine › Neurology › Cerebral Venous Sinus Thrombosis
  • Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
  • Health Sciences › Medicine › Internal Medicine › Venous Thromboembolism Diagnosis and Management
Keywords
cerebral venous thrombosis, thrombophilia, oral contraceptives, factor V Leiden, prothrombin G20210A, hyperhomocysteinemia, thrombosis risk factors, drug-induced thrombosis
MeSH terms
Adolescent, Adult, Aged, Cerebral Veins, Contraceptives, Oral, Female, Humans, Middle Aged, Risk Factors, Reproducibility of Results, Confidence Intervals, Thrombophilia, Intracranial Thrombosis

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