Rho-mediated regulation of tight junctions during monocyte migration across the blood-brain barrier in HIV-1 encephalitis (HIVE)

Size-selective loosening of the blood-brain barrier in claudin-5–deficient mice

Nitta, T., Hata, M., Gotoh, S., Seo, Y., Sasaki, H., Hashimoto, N., Furuse, M., & Tsukita, S. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200302070 · Cited by 1,917

The Tight Junction Protein ZO-1 Establishes a Link between the Transmembrane Protein Occludin and the Actin Cytoskeleton

Fanning, A. S., Jameson, B. J., Jesaitis, L. A., & Anderson, J. M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.45.29745 · Cited by 1,432

Formation of actin stress fibers and focal adhesions enhanced by Rho-kinase

Amano, M., Chihara, K., Kimura, K., Fukata, Y., Nakamura, N., Matsuura, Y., & Kaibuchi, K. (1997) · Science · doi:10.1126/science.275.5304.1308 · Cited by 1,077

THE CELL BIOLOGY OF THE BLOOD-BRAIN BARRIER

Rubin, L. L., & Staddon, J. M. (1999) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.22.1.11 · Cited by 1,017

Regulation of the Cytoskeleton and Cell Adhesion by the Rho Family GTPases in Mammalian Cells

Kaibuchi, K., Kuroda, S., & Amano, M. (1999) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.68.1.459 · Cited by 1,017

Endothelial Claudin

Morita, K., Sasaki, H., Furuse, M., & Tsukita, S. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.147.1.185 · Cited by 867

Leukocyte–endothelial-cell interactions in leukocyte transmigration and the inflammatory response

Müller, W. A. (2003) · Trends in Immunology · doi:10.1016/s1471-4906(03)00117-0 · Cited by 824

Efficient isolation and propagation of human immunodeficiency virus on recombinant colony-stimulating factor 1-treated monocytes.

Gendelman, H. E., Orenstein, J. M., Martin, M. A., Ferrua, C., Mitra, R., Phipps, T. J., Wahl, L. A., Lane, H. C., Fauci, A. S., & Burke, D. (1988) · The Journal of Experimental Medicine · doi:10.1084/jem.167.4.1428 · Cited by 781

Brain metabolism: a perspective from the blood-brain barrier

Pardridge, W. M. (1983) · Physiological Reviews · doi:10.1152/physrev.1983.63.4.1481 · Cited by 745

ICAM-1 regulates neutrophil adhesion and transcellular migration of TNF-α-activated vascular endothelium under flow

Yang, L., Froio, R. M., Sciuto, T. E., Dvořàk, A. M., Alon, R., & Luscinskas, F. W. (2005) · Blood · doi:10.1182/blood-2004-12-4942 · Cited by 735

Secoisolariciresinol diglucoside is a blood-brain barrier protective and anti-inflammatory agent: implications for neuroinflammation

Rom, S., Zuluaga‐Ramirez, V., Reichenbach, N. L., Erickson, M. A., Winfield, M., Gajghate, S., Christofidou‐Solomidou, M., Jordan‐Sciutto, K. L., & Persidsky, Y. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1065-0 · Cited by 58

Modeling HIV-1 Induced Neuroinflammation in Mice: Role of Platelets in Mediating Blood-Brain Barrier Dysfunction

Jones, L. D., Jackson, J. W., & Maggirwar, S. B. (2016) · PLoS ONE · doi:10.1371/journal.pone.0151702 · Cited by 57

Leukocyte transmigration across the blood-brain barrier: perspectives on neuroAIDS

Roberts, T. K. (2009) · Frontiers in bioscience · doi:10.2741/3631 · Cited by 56

Antiretroviral Treatment with Efavirenz Disrupts the Blood-Brain Barrier Integrity and Increases Stroke Severity

Bertrand, L., Dygert, L., & Toborek, M. J. (2016) · Scientific Reports · doi:10.1038/srep39738 · Cited by 57

Activation of Cannabinoid Type Two Receptors (CB2) Diminish Inflammatory Responses in Macrophages and Brain Endothelium

Persidsky, Y., Fan, S., Dykstra, H., Reichenbach, N. L., Rom, S., & Ramirez, S. H. (2015) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-015-9591-3 · Cited by 53

Limited role of COX-2 in HIV Tat-induced alterations of tight junction protein expression and disruption of the blood–brain barrier

Pu, H., Hayashi, K., Andras, I. E., Eum, S. Y., Hennig, B., & Toborek, M. J. (2007) · Brain Research · doi:10.1016/j.brainres.2007.09.063 · Cited by 48

Tumor Treating Fields (TTFields) Reversibly Permeabilize the Blood–Brain Barrier In Vitro and In Vivo

Salvador, E., Kessler, A. F., Domröse, D., Hörmann, J., Schaeffer, C. M., Giniunaite, A., Burek, M., Tempel-Brami, C., Voloshin, T., Volodin, A., et al. (2022) · Biomolecules · doi:10.3390/biom12101348 · Cited by 52

Claudin‐5a in developing zebrafish brain barriers: another brick in the wall

Abdelilah‐Seyfried, S. (2010) · BioEssays · doi:10.1002/bies.201000045 · Cited by 45

Age-associated changes in microglia and astrocytes ameliorate blood-brain barrier dysfunction

Pan, J., Ma, N., Zhong, J., Yu, B., Wan, J., & Zhang, W. (2021) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2021.08.030 · Cited by 43

Biodegradable Nanoparticles for Delivery of Therapeutics in CNS Infection

DeMarino, C., Schwab, A., Pleet, M. L., Mathiesen, A. H., Friedman, J. M., El‐Hage, N., & Kashanchi, F. (2016) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-016-9692-7 · Cited by 42

Differential role of Rho GTPases in endothelial barrier regulation dependent on endothelial cell origin

Baumer, Y., Burger, S., CURRY, F. E., Golenhofen, N., Drenckhahn, D., & Waschke, J. (2007) · Histochemistry and Cell Biology · doi:10.1007/s00418-007-0358-7 · Cited by 42

HIV-1-Induced Alterations of Claudin-5 Expression at the Blood–Brain Barrier Level

Andras, I. E., & Toborek, M. J. (2011) · Methods in molecular biology · doi:10.1007/978-1-61779-185-7_26 · Cited by 41

Role of anti-inflammatory compounds in human immunodeficiency virus-1 glycoprotein120-mediated brain inflammation

Ashraf, T., Jiang, W., Hoque, M. T., Henderson, J., Wu, C., & Bendayan, R. (2014) · Journal of Neuroinflammation · doi:10.1186/1742-2094-11-91 · Cited by 40

Exercise maintains blood–brain barrier integrity during early stages of brain metastasis formation

Wolff, G., Davidson, S. J., Wrobel, J. K., & Toborek, M. J. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.04.153 · Cited by 40

The role of Smo-Shh/Gli signaling activation in the prevention of neurological and ageing disorders

Prajapati, A., Mehan, S., & Khan, Z. (2023) · Biogerontology · doi:10.1007/s10522-023-10034-1 · Cited by 40

Methamphetamine induces trace amine-associated receptor 1 (TAAR1) expression in human T lymphocytes: role in immunomodulation

Sriram, U., Cenna, J. M., Haldar, B., Fernandes, N. C., Razmpour, R., Fan, S., Ramirez, S. H., & Potula, R. (2015) · Journal of Leukocyte Biology · doi:10.1189/jlb.4a0814-395rr · Cited by 37

Hybrid stem cell-derived bioresponsive vesicles for effective inflamed blood-brain barrier targeting delivery

Wu, H., Jiang, X., Li, Y., Dong, Y., Zheng, J., Li, L., Li, Y., Wang, J., Lin, X., Zhang, X., et al. (2023) · Nano Today · doi:10.1016/j.nantod.2023.101800 · Cited by 37

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Günzel, D., & Fromm, M. (2012) · Comprehensive physiology · doi:10.1002/j.2040-4603.2012.tb00450.x · Cited by 37

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Manda, V. K., Mittapalli, R. K., Geldenhuys, W. J., & Lockman, P. R. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.06948.x · Cited by 36

Evidence for differential changes of junctional complex proteins in murine neurocysticercosis dependent upon CNS vasculature

Alvarez, J. I., & Teale, J. M. (2007) · Brain Research · doi:10.1016/j.brainres.2007.07.010 · Cited by 36

HIV-1 Tat and opioids act independently to limit antiretroviral brain concentrations and reduce blood–brain barrier integrity

Leibrand, C. R., Paris, J. J., Jones, A. M., Masuda, Q. N., Halquist, M. S., Kim, W., Knapp, P. E., Kashuba, A. D. M., Hauser, K. F., & McRae, M. (2019) · Journal of NeuroVirology · doi:10.1007/s13365-019-00757-8 · Cited by 36

Polychlorinated biphenyls impair blood–brain barrier integrity via disruption of tight junction proteins in cerebrum, cerebellum and hippocampus of female Wistar rats

Selvakumar, K., Prabha, R. L., Saranya, K., Bavithra, S., Krishnamoorthy, G., & Arunakaran, J. (2012) · Human & Experimental Toxicology · doi:10.1177/0960327112464798 · Cited by 36

Methylphenidate-triggered ROS generation promotes caveolae-mediated transcytosis via Rac1 signaling and c-Src-dependent caveolin-1 phosphorylation in human brain endothelial cells

Coelho-Santos, V., Socodato, R., Portugal, C., Leitão, R. A., Rito, M., Barbosa, M., Couraud, P.-O., Romero, I. A., Weksler, B., Minshall, R. D., et al. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2301-3 · Cited by 36

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Deracinois, B., Lenfant, A., Dehouck, M., & Flahaut, C. (2015) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-94-017-7197-9_7 · Cited by 37

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Dörfel, M. J., & Huber, O. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06536.x · Cited by 34

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Yan, B. C., Xu, P., Gao, M., Wang, J., Jiang, D., Zhu, X., Won, M., & Su, P. Q. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.00775 · Cited by 34

Undetectable gadolinium brain retention in individuals with an age‐dependent blood‐brain barrier breakdown in the hippocampus and mild cognitive impairment

Montagne, A., Huuskonen, M. T., Rajagopal, G., Sweeney, M. D., Nation, D. A., Sepehrband, F., D’Orazio, L. M., Harrington, M. G., Chui, H. C., Law, M., et al. (2019) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2019.07.012 · Cited by 33

Cerebral Cavernous Malformation Proteins in Barrier Maintenance and Regulation

Wei, S., Li, Y., Polster, S. P., Weber, C. R., Awad, I. A., & Shen, L. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21020675 · Cited by 32

Function of Multidrug Resistance Transporters is Disrupted by Infection Mimics in Human Brain Endothelial Cells

Império, G. E., Lye, P., Bloise, E., & Matthews, S. G. (2021) · Tissue Barriers · doi:10.1080/21688370.2020.1860616 · Cited by 30

Rho‐associated protein kinases as therapeutic targets for both vascular and parenchymal pathologies in Alzheimer's disease

Lai, A. Y., & McLaurin, J. (2017) · Journal of Neurochemistry · doi:10.1111/jnc.14130 · Cited by 31

PCBs and tight junction expression

Eum, S. Y., Andras, I. E., Couraud, P., Hennig, B., & Toborek, M. J. (2007) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2007.10.019 · Cited by 30

Blood–brain barrier abnormalities caused by exposure to HIV-1 gp120 — Protection by gene delivery of antioxidant enzymes

Louboutin, J., Reyes, B. A. S., Agrawal, L., Maxwell, C. R., Bockstaele, E. J. V., & Strayer, D. S. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2010.02.007 · Cited by 30

Cryopreservation of Brain Endothelial Cells Derived from Human Induced Pluripotent Stem Cells Is Enhanced by Rho-Associated Coiled Coil-Containing Kinase Inhibition

Wilson, H. K., Faubion, M. G., Hjortness, M. K., Palecek, S. P., & Shusta, E. V. (2016) · Tissue Engineering Part C: Methods · doi:10.1089/ten.tec.2016.0345 · Cited by 29

Polarised VEGFA Signalling at Vascular Blood–Neural Barriers

Dragoni, S., & Turowski, P. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19051378 · Cited by 29

Pitavastatin Strengthens the Barrier Integrity in Primary Cultures of Rat Brain Endothelial Cells

Morofuji, Y., Nakagawa, S., So, G., Hiu, T., Horai, S., Hayashi, K., Tanaka, K., Suyama, K., Deli, M. A., Nagata, I., et al. (2010) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-010-9497-9 · Cited by 28

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Unique and differential protein signatures within the mononuclear cells of HIV-1 and HCV mono-infected and co-infected patients

Boukli, N. M., Shetty, V., Cubano, L. A., Ricaurte, M., Coelho-dos-Reis, J. G. A., Nickens, Z., Shah, P., Talal, A. H., Philip, R., & Jain, P. (2012) · Clinical Proteomics · doi:10.1186/1559-0275-9-11 · Cited by 27

Viral sensing at the blood–brain barrier: New roles for innate immunity at the CNS vasculature

Daniels, B., & Klein, R. (2015) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.75 · Cited by 26

Increased activity of Rho kinase contributes to hemoglobin-induced early disruption of the blood-brain barrier in vivo after the occurrence of intracerebral hemorrhage.

Fu, Z., Chen, Y., Qin, F., Yang, S., Deng, X., Ding, R., Feng, L., Li, W., & Zhu, J. (2014) · Europe PMC (PubMed Central) · Cited by 26

Adding Fuel to the Fire: Methamphetamine Enhances HIV Infection

Potula, R., & Persidsky, Y. (2008) · American Journal Of Pathology · doi:10.2353/ajpath.2008.080130 · Cited by 26

Circulating Fibroblast Growth Factor-2, HIV-Tat, and Vascular Endothelial Cell Growth Factor-A in HIV-Infected Children with Renal Disease Activate Rho-A and Src in Cultured Renal Endothelial Cells

Das, J. R., Gutkind, J. S., & Ray, P. E. (2016) · PLoS ONE · doi:10.1371/journal.pone.0153837 · Cited by 26

Role of ROS/RhoA/PI3K/PKB Signaling in NS1619-Mediated Blood–Tumor Barrier Permeability Increase

Gu, Y.-T., Xue, Y., Wang, Y., Wang, J., ShangGuan, Q.-R., Zhang, J.-X., & Qin, L. (2012) · Journal of Molecular Neuroscience · doi:10.1007/s12031-012-9789-2 · Cited by 26

NeuroAIDS, Drug Abuse, and Inflammation: Building Collaborative Research Activities

Berman, J. W., Carson, M. J., Chang, L., Cox, B. M., Fox, H. S., González, R. G., Hanson, G. R., Hauser, K. F., Ho, W., Hong, J., et al. (2006) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-006-9048-9 · Cited by 25

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Heldt, N. A., Reichenbach, N. L., McGary, H. M., & Persidsky, Y. (2020) · American Journal Of Pathology · doi:10.1016/j.ajpath.2020.11.007 · Cited by 27

Tight junction modulator and drug delivery

Matsuhisa, K., Kondoh, M., Takahashi, A., & Yagi, K. (2009) · Expert Opinion on Drug Delivery · doi:10.1517/17425240902902315 · Cited by 25

Magnetic nanotherapeutics for dysregulated synaptic plasticity during neuroAIDS and drug abuse

Sagar, V., Atluri, V. S. R., Pilakka‐Kanthikeel, S., & Nair, M. (2016) · Molecular Brain · doi:10.1186/s13041-016-0236-0 · Cited by 23

HIV-1 Tat-induced cerebrovascular toxicity is enhanced in mice with amyloid deposits

Chen, L., Choi, J. J., Choi, Y. J., Hennig, B., & Toborek, M. J. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.06.004 · Cited by 20

Cannabinoid receptor 2 agonist attenuates blood‑brain barrier damage in a rat model of intracerebral hemorrhage by activating the Rac1 pathway

Wang, Z., Li, Y., Cai, S., Li, R., & Cao, G. (2018) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2018.3834 · Cited by 19

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Gopal, S. S., Kaur, M., Lanzkron, S., & Srivastava, A. K. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05592-z · Cited by 20

The Regulation of the Metastatic Cascade by Physical Activity: A Narrative Review

de ten Ryen, S. V. D., & Deldicque, L. (2020) · Cancers · doi:10.3390/cancers12010153 · Cited by 18

Claudins and pathogenesis of viral infection

Tawar, R. G., Colpitts, C. C., Lupberger, J., Saghire, H. E., Zeisel, M. B., & Baumert, T. F. (2015) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2015.04.011 · Cited by 18

Nanomaterials‐Mediated Structural and Physiological Modulation of Blood Brain Barrier for Therapeutic Purposes

Ghouri, M. D., Saleem, J., Ren, J., Liu, J., Umer, A., Cai, R., & Chen, C. (2021) · Advanced Materials Interfaces · doi:10.1002/admi.202101391 · Cited by 16

Successful Isolation of Infectious and High Titer Human Monocyte-Derived HIV-1 from Two Subjects with Discontinued Therapy

Wang, T., Xu, Y., Zhu, H., Andrus, T., Ivanov, S. B., Pan, C., Dolores, J. S., Dann, G. C., Zhou, M., Forte, D. M., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0065071 · Cited by 14

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Burgener, A., Sainsbury, J., Plummer, F. A., & Ball, T. B. (2010) · Current HIV/AIDS Reports · doi:10.1007/s11904-010-0039-3 · Cited by 15

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Kim, J. H., Hossain, F. M. A., Patil, A. M., Choi, J. Y., Kim, S. B., Uyangaa, E., Park, S., Lee, J. H., Kim, B., Kim, K., et al. (2016) · Comparative Immunology Microbiology and Infectious Diseases · doi:10.1016/j.cimid.2016.07.007 · Cited by 15

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Rom, S., Gajghate, S., Winfield, M., Reichenbach, N. L., & Persidsky, Y. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21134663 · Cited by 15

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Torices, S., Daire, L., Simon, S., Naranjo, O., Mendoza, L., Téglás, T., Fattakhov, N. S., Adesse, D., & Toborek, M. J. (2023) · Fluids and Barriers of the CNS · doi:10.1186/s12987-023-00476-7 · Cited by 16

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Yu, A., Zeng, J., Yu, J., Cao, S., & Li, A. (2024) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14563 · Cited by 15

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Iyengar, S., Zhan, C., Lu, J., Korngold, R., & Schwartz, D. H. (2014) · Transplantation and Cellular Therapy · doi:10.1016/j.bbmt.2014.04.029 · Cited by 15

Effects of hyperbaric oxygen on the expression of claudins after cerebral ischemia–reperfusion in rats

Zhao, H., Zhang, Q., Xue, Y., Chen, X., & Haun, R. S. (2011) · Experimental Brain Research · doi:10.1007/s00221-011-2702-3 · Cited by 13

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Annadurai, N., & Kanmogne, G. D. (2024) · Cells · doi:10.3390/cells13171415 · Cited by 12

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Lazăr, M., Moroti, R., Barbu, E. C., Chițu, C. E., Tilişcan, C., Erculescu, T. M., Rosca, R. R., Frasila, S., Schmilevschi, E. T., Simion, V., et al. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13237031 · Cited by 12

Reprint of “The role of cytoskeleton in the regulation of vascular endothelial barrier function” [Microvascular Research 76 (2008) 202–207]

Bogatcheva, N. V., & Verin, A. D. (2009) · Microvascular Research · doi:10.1016/s0026-2862(09)00021-1 · Cited by 12

Signaling events evoked by domain III of envelop glycoprotein of tick-borne encephalitis virus and West Nile virus in human brain microvascular endothelial cells

Bhide, K., Mochnáčová, E., Tkáčová, Z., Petroušková, P., Kulkarni, A. D., & Bhide, M. R. (2022) · Scientific Reports · doi:10.1038/s41598-022-13043-1 · Cited by 10

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Fohmann, I., Weinmann, A., Schumacher, F., Peters, S., Prell, A., Weigel, C., Spiegel, S., Kleuser, B., & Schubert‐Unkmeir, A. (2023) · PLoS Pathogens · doi:10.1371/journal.ppat.1011842 · Cited by 10

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Jia, D., Rahbar, R., & Fish, E. N. (2007) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2007.0014 · Cited by 9

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Chen, X., Wei, J., Zhang, Y., Zhang, Y., & Zhang, T. (2024) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2024.122889 · Cited by 10

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Miyazaki, Y., Yusa, T., Matsuo, S., Terauchi, Y., & Miyazaki, S. (2014) · Virulence · doi:10.4161/viru.29786 · Cited by 8

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Haorah, J., Samikkannu, M., Iyappan, H., & Samikkannu, T. (2025) · Frontiers in Medicine · doi:10.3389/fmed.2024.1505440 · Cited by 10

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Goncharov, N. V., Popova, P. I., Головкин, А. С., Zalutskaya, N. M., Palchikova, E. I., Zanin, K., & Avdonin, Р. V. (2020) · V M BEKHTEREV REVIEW OF PSYCHIATRY AND MEDICAL PSYCHOLOGY · doi:10.31363/2313-7053-2020-3-11-26 · Cited by 7

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Weiss, N., Miller, F., Cazaubon, S. M., & Couraud, P. (2009) · Revue Neurologique · doi:10.1016/j.neurol.2009.04.013 · Cited by 6

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Laloux, L., Polet, M., & Schneider, Y. (2017) · Wiley eBooks · doi:10.1002/9783527697724.ch18 · Cited by 6

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Ahmad, F., Rankawat, S., & Pathak, U. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-91287-7.00012-0 · Cited by 5

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Kumar, R., & Patil, R. D. (2017) · Veterinary World · doi:10.14202/vetworld.2017.1427-1438 · Cited by 7

Human‐BasedIn VitroBrain Endothelial Cell Models

Wilson, H. K., & Shusta, E. V. (2015) · Wiley eBooks · doi:10.1002/9781118788523.ch11 · Cited by 5

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Chihara, N., Tsuji, A., & Matsumoto, R. (2023) · Clinical and Experimental Neuroimmunology · doi:10.1111/cen3.12747 · Cited by 4

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Rada, C. C., Yuki, K., Ding, J., & Kuo, C. J. (2023) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a041191 · Cited by 4

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Butz, S., & Vestweber, D. (2007) · Birkhäuser Basel eBooks · doi:10.1007/978-3-7643-7975-9_11 · Cited by 3

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Mahajan, S. D., Aalinkeel, R., Reynolds, J. L., Nair, B. B., Mammen, M. J., Dai, L., Prasad, P. N., & Schwartz, S. A. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-801317-5.00015-3 · Cited by 2

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