The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Unique effects of Stat3 on the early phase of hematopoietic stem cell regeneration
Abstract
Self-renewal of hematopoietic stem cells (HSCs) is key to their reconstituting ability, but the signaling pathways that regulate this process remain poorly understood. Here we show that transduction of adult mouse bone marrow cells with a constitutively activated form of Stat3 (Stat3-C) increased their regenerative activity in lethally irradiated recipients. Conversely, transduction of these cells with a dominant-negative form of Stat3 suppressed their regenerative activity. Serial transplantation and clonal tracking of the HSC progeny regenerated in vivo from STAT3-C-transduced HSCs demonstrated that the major effect of forced expression of STAT3-C was to enhance HSC self-renewal during the initial phase of hematopoietic recovery. This acquired potential for enhanced self-renewal divisions then became latent, but was reactivated when the cells were transferred to new irradiated recipients. Increased levels of activated STAT3 were also found to be associated with greater preservation of primitive hematopoietic cells in short-term cultures. These results indicate a novel biphasic regulation of HSC self-renewal in vivo in which activated STAT3 promotes HSC self-renewal under stimulated, but not homeostatic, conditions. STAT3 may thus be an important regulator of hematopoietic regeneration and a novel target for HSC engineering.
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“Unaltered basal hematopoiesis; impaired stem cell regeneration after 5-FU”
From Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 To Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution (2020) · cites this paper as Chung et al., 2006
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Bharadwaj, U., Kasembeli, M. M., Robinson, P., & Tweardy, D. J. (2020) · Pharmacological Reviews · doi:10.1124/pr.119.018440 · Cited by 314
STAT3, stem cells, cancer stem cells and p63
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Metadata
- Authors
- Chung, Y.-J., Park, B.-B., Kang, Y.-J., Kim, T.-M., Eaves, C. J., & Oh, I.-H.
- Affiliations
- BC Cancer Agency (CA)
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2006-08-15
- Volume
- 108
- Issue
- 4
- Pages
- 1208-1215
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2166180289
- Semantic Scholar
- 5d35bdca0b6f9dfa9fac5e3966d0a3779f0ec0a0
- Cited by
- 107
- References
- 40
- Citations by year
- 2025: 4 · 2024: 1 · 2023: 4 · 2022: 5 · 2021: 4 · 2020: 7 · 2019: 5 · 2018: 7 · 2017: 7 · 2016: 7 · 2015: 5 · 2014: 6 · 2013: 9 · 2012: 4
- FWCI
- 5.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Blood (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
- Keywords
- STAT3, hematopoietic stem cells, self-renewal, hematopoietic regeneration, STAT3 activation, dominant-negative STAT3, bone marrow transplantation, irradiation, clonal tracking, serial transplantation
- MeSH terms
- Animals, Cell Division, Cells, Cultured, Enzyme Activation, Gene Expression Regulation, Hematopoietic Stem Cells, Mice, Transgenic, Regeneration, Transduction, Genetic, Whole-Body Irradiation, Signal Transduction, Bone Marrow Transplantation, STAT3 Transcription Factor, Mice
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